Dr. Mahesh Nagappa

Assistant Professor


Dr. Nagappa received his MD in Anesthesia from JIPMER, University of Puducherry in India in 2008. He joins us from Toronto Western Hospital, University of Toronto, following a fellowship in Perioperative Medicine and Ambulatory Anesthesia. Nagappa has several publications in Journals such as the Anesthesia Analgesia, PLOS, Chest Journal, Current opinion in Anesthesiology and Canadian Journal of Anesthesia.

At the 2014 Annual IARS Meeting in Montreal, Canada, Dr. Nagappa received the “best of the category award” and nominated for the “best of the meeting award”.

His current research interests include Ambulatory Anesthesia, perioperative patient management, screening, treatment and perioperative complications associated with obesity/OSA, also systematic review, meta-analysis and meta-regression analysis. Dr. Nagappa is an avid presenter with many poster and power point presentations at annual anesthesia meetings such as: IARS, ASA, SASM, ISPCOP, CSS and CAS. Many of his meeting presentations have been published in “Anesthesiology News” circulated to more than 45,000 anesthesiologists in North America.


Nagappa M, Subramani Y, Chung F. Best perioperative practice in management of ambulatory patients with obstructive sleep apnea. Curr Opin Anaesthesiol. 2018 Dec;31(6):700-706. doi: 10.1097/ACO.0000000000000661.

Gupta K, Nagappa M, Prasad A, Abrahamyan L, Wong J, Weingarten TN, Chung F. Risk factors for opioid-induced respiratory depression in surgical patients: a systematic review and meta-analyses. BMJ Open. 2018 Dec 14;8(12):e024086. doi: 10.1136/bmjopen-2018-024086.

Nagappa M, Wong DT, Cozowicz C, Ramachandran SK, Memtsoudis SG, Chung F. Is obstructive sleep apnea associated with difficult airway? Evidence from a systematic review and meta-analysis of prospective and retrospective cohort studies. PLoS One. 2018 Oct 4;13(10):e0204904. doi: 10.1371/journal.pone.0204904

Gupta K, Prasad A, Nagappa M, Wong J, Abrahamyan L, Chung FF. Risk factors for opioid-induced respiratory depression and failure to rescue: a review. Curr Opin Anaesthesiol. 2018 Feb;31(1):110-119. doi: 10.1097/ACO.0000000000000541.

Memtsoudis SG, Cozowicz C, Nagappa M, Wong J, Joshi GP, Wong DT, Doufas AG, Yilmaz M, Stein MH, Krajewski ML, Singh M, Pichler L, Ramachandran SK, Chung F. Society of Anesthesia and Sleep Medicine Guideline on Intraoperative Management of Adult Patients With Obstructive Sleep Apnea. Anesth Analg. 2018 Jun 25. doi: 10.1213/ANE.0000000000003434. [Epub ahead of print]

Cozowicz C, Chung F, Doufas AG, Nagappa M, Memtsoudis SG. Opioids for Acute Pain Management in Patients With Obstructive Sleep Apnea: A Systematic Review. Anesth Analg. 2018 Jun 28. doi: 10.1213/ANE.0000000000003549. [Epub ahead of print]

Nagappa M, Weingarten TN, Montandon G, Sprung J, Chung F. Opioids, respiratory depression, and sleep-disordered breathing. Best Pract Res Clin Anaesthesiol. 2017 Dec;31(4):469-485. doi: 10.1016/j.bpa.2017.05.004. Epub 2017 May 22.

Lam T, Nagappa M, Wong J, Singh M, Wong D, Chung F. Continuous Pulse Oximetry and Capnography Monitoring for Postoperative Respiratory Depression and Adverse Events: A Systematic Review and Meta-analysis. Anesth Analg. 2017 Dec;125(6):2019-2029.

Nagappa M, Ho G, Patra J, Wong J, Singh M, Kaw R, Cheng D, Chung F. Postoperative Outcomes in Obstructive Sleep Apnea Patients Undergoing Cardiac Surgery: A Systematic Review and Meta-analysis of Comparative Studies. Anesth Analg. 2017 Dec;125(6):2030-2037.

Gupta K, Prasad A, Nagappa M, Wong J, Abrahamyan L, Chung F. Risk factors for opioid-induced respiratory depression and failure to rescue: a review. Curr Opin Anaesthesiol. 2017 Nov 7. PubMed PMID: 29120929.

Subramani Y, Nagappa M, Wong J, Patra J, Chung F. Death or near-death in patients with obstructive sleep apnoea: a compendium of case reports of critical complications. Br J Anaesth. 2017 Nov 1;119(5):885-899.

Nagappa M, Patra J, Wong J, Subramani Y, Singh M, Ho G, Wong DT, Chung F. Association of STOP-Bang Questionnaire as a Screening Tool for Sleep Apnea and Postoperative Complications: A Systematic Review and Bayesian Meta-analysis of Prospective and Retrospective Cohort Studies. Anesth Analg. 2017 Oct;125(4):1301-1308.

Subramani Y, Wong J, Nagappa M, Chung F. The Benefits of Perioperative Screening for Sleep Apnea in Surgical Patients. Sleep Med Clin. 2017 Mar;12(1):123-135. doi: 10.1016/j.jsmc.2016.10.003. Review. PubMed PMID: 28159091.

Sheshadri V, Tiwari AK, Nagappa M, Venkatraghavan L. Accuracy in Blood Pressure Monitoring: The Effect of Noninvasive Blood Pressure Cuff Inflation on Intra-arterial Blood Pressure Values. Anesth Essays Res. 2017 Jan-Mar;11(1):169-173.

Chung F, Memtsoudis SG, Ramachandran SK, Nagappa M, Opperer M, et al. Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Assessment of Adult Patients With Obstructive Sleep Apnea. Anesth Analg. 2016 Aug;123(2):452-73.

Nagappa M, Mokhlesi B, Wong J et al. The effects of continuous positive airway pressure on postoperative outcomes in obstructive sleep apnea patients undergoing surgery: A systematic review and meta-analysis. Anesth Analg 2015;120:1013–23.

Nagappa M, Liao P, Wong J et al. Validation of the STOP-Bang Questionnaire as a Screening Tool for Obstructive Sleep Apnea among Different Populations: A Systematic Review and Meta-Analysis. PLoS One 2015;10.

Abdullah HR, Nagappa M, Siddiqui N et al. Diagnosis and treatment of obstructive sleep apnea during pregnancy. Curr Opin Anaesthesiol 2016;29:317–24.

Chung F, Nagappa M, Singh M, Mokhlesi B. CPAP in the perioperative setting: Evidence of support. Chest 2016;149:586–97.

For more PubMed publications, please visit: http://www.ncbi.nlm.nih.gov/pubmed/?term=Mahesh+nagappa