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Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery

Callum J, Farkouh ME, Scales DC, Heddle NM, Harle C, et al.; FIBRES Research Group.

JAMA. 2019 Oct 21:1-11.


Question  Is fibrinogen concentrate noninferior to cryoprecipitate for treatment of bleeding related to acquired hypofibrinogenemia in cardiac surgery?

Findings  In this randomized trial of 735 adult patients who underwent cardiac surgery and developed clinically significant bleeding and hypofibrinogenemia post cardiopulmonary bypass, the mean number of blood components transfused within 24 hours post bypass was 16.3 units in the fibrinogen concentrate group and 17.0 units in the cryoprecipitate group; ratio of the mean number of units transfused was 0.96, which met the prespecified noninferiority margin ratio of less than 1.2.

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Read the full article in JAMA