Medical Sciences 4100F/G

Medical Sciences 4100F/G is an introduction to the field of laboratory animal science and comparative human and animal pathology. Major topics include animal biology and disease, animals as models of human diseases, genetic manipulation of research animals, and major intrinsic and extrinsic factors affecting biomedical research.

The interplay between cells, tissues, and organs is complex and coordinated. As a result, animals are used in scientific research to examine biological processes that cannot be recreated in vitro. The changing focus to reduce animal use in experimental science has provided opportunity to reconsider the applicability of different species in research and explore alternative options for disease models.

In Medical Sciences 4100G, students will explore animal models for human disease, both naturally occurring and experimental, along with comparative pathology of various animal species. The course will conclude with an introduction to regulatory oversight for animal-based research. This course will be of special interest to students who are interested in biomedical research.

2 lecture hours; 0.5 course

Enrolment in Year 4 of a BMSc degree or an Honours BSc degree.

Learning Outcomes:
Upon successful completion of this course, students will be able to:

  • Describe the difference between spontaneous and experimental animal models
  • Critically assess species applicability as a model for disease
  • List major regulatory agencies that govern animal based research in Canada and the United States


Participation 10%
Written assignments 20%
Examinations 30% (Exam 1); 30% (Exam 2)
Weekly online quiz 10%

Course Syllabus