DNA Replication and Repair; Transcription; Mobile DNA

This group focuses on understanding the underlying cellular mechanisms that regulate chromosome structure and function, as well as gene expression, in normal and diseased states. Techniques used include bioinformatics, proteomics, genomics, molecular biology, structural biology, epigenetics, and genetics of model organisms.

Faculty Researcher	Research Area
Nathalie Berube	ATRX protein
Christopher Brandl	Transcriptional regulation in eukaryotic cells
Fred Dick	Retinoblastoma protein (pRB)
Gabriel DiMattia	Growth factor signalling in ovarian cancer
David Edgell	Mobile genetic elements
Gregory Gloor	Protein coevolution
Victor Han	Fetal, placental, newborn growth/development
David Haniford	DNA transposition
Ilka Heinemann	RNA turnover and polymerases
Murray Junop	DNA repair
Bogumil Karas	Synthetic biology, designer microbes, DNA replacement strategies
Hong Ling	DNA damage response and regulation
Geoffrey Pickering	Smooth muscle cells in vascular disease
Peter Rogan	Inherited genetic diseases and cancer
Caroline Schild-Poulter	Cellular response to DNA damage
Joseph Torchia	Eukaryotic gene regulation in oncogenesis

Disease-Based Research; Clinical Studies

Scientists in the Human Genetics and Clinical Biochemistry group perform basic research of the molecular causes behind specific human diseases and/or clinical studies involving specific human diseases. This research integrates state-of-the-art molecular technologies and bioinformatics with clinical work, so that basic research discoveries can be translated into effective treatments and cures for patients.

Faculty Researcher	Research Area
Nathalie Berube	ATRX protein
Fred Dick	Retinoblastoma protein (pRB)
Gabriel DiMattia	Growth factor signalling in ovarian cancer
Madhulika Gupta	Perinatal diseases
Victor Han	Fetal, placental, newborn growth/development
Robert Hegele	Genetic basis of specific human diseases
Murray Huff	Lipoprotein metabolism and atherosclerosis
David O'Gorman	Wound healing and Dupuytren's contracture
Geoffrey Pickering	Smooth muscle cells in vascular disease
Peter Rogan	Inherited genetic diseases and cancer
Anthony Rupar	Therapies for metachromatic leukodystrophy
Caroline Schild-Poulter	Cellular response to DNA damage
Walter Siqueira	Salivary components and biomarkers
Joseph Torchia	Eukaryotic gene regulation in oncogenesis
Eva Turley	Signalling paths of cell motility and tumour invasion

Signalling Pathways

Researchers in the field of Signal Transduction and Intracellular Communication investigate the mechanisms and role of cellular signalling pathways in the regulation of fundamental biological processes. These events include cell proliferation, cell survival, differentiation, and development. This research exploits such techniques as bioinformatics, genomics, proteomics, cellular and molecular biology, structural biology, and transgenic and knockout technologies.

Faculty Researcher	Research Area
Fred Dick	Retinoblastoma protein (pRB)
Harvey Goldberg	Bone proteins
Murray Huff	Lipoprotein metabolism and atherosclerosis
Marlys Koschinsky	Lipoprotein(a) structure and regulation
Shawn Li	Structure, function, connectivity of cellular proteins
Hong Ling	DNA damage response and regulation
David Litchfield	Signalling events in cell proliferation and survival
Patrick O'Donoghue	Synthesis of proteins containing atypical amino acids
David O'Gorman	Wound healing and Dupuytren's contracture
Geoffrey Pickering	Smooth muscle cells in vascular disease
Gary Shaw	Calcium signalling proteins; protein degradation
Eva Turley	Signalling paths of cell motility and tumour invasion

Protein Biochemistry; Structural Biology

Members of the Macromolecular Structure and Dynamics Group study the role that specific proteins and protein systems play in certain diseases, with a focus on understanding protein function at the atomic and molecular levels. This group frequently uses biophysical techniques and conventional molecular biology to determine the 3-D structure, dynamics, and interactions of biomolecules. Methods include NMR spectroscopy, crystallography, proteomics, and mass spectrometry.

Faculty Researcher	Research Area
Michael Boffa	Proteolysis in fibrinolysis and cancer
James Choy	Intrinsically disordered proteins
Stanley Dunn	ATP synthase
Christopher Garnham	management of agricultural crop pests
Harvey Goldberg	Bone proteins
Robert Hudson	Bioorganic chemistry of nucleic acids and peptides
Murray Junop	DNA repair
Lars Konermann	Protein folding, dynamics, function; biocomputing
Marlys Koschinsky	Lipoprotein(a) structure and regulation
Gilles Lajoie	Mass spectrometry/proteomics: biomolecules
Shawn Li	Structure, function, connectivity of cellular proteins
Hong Ling	DNA damage response and regulation
David Litchfield	Signalling events in cell proliferation and survival
Patrick O'Donoghue	Synthesis of proteins containing atypical amino acids
David O'Gorman	Wound healing and Dupuytren's contracture
Gary Shaw	Calcium signalling proteins; protein degradation
Brian Shilton	Enzyme structure, mechanism, and biological function
Walter Siqueira	Salivary components and biomarkers
Ken Yeung	Microscale protein analysis

Biomolecular Characterization; Disease-Based Research

This group uses proteomic techniques to understand normal cellular processes and alterations in these processes in diseases such as cancer, fetal disorders, and oral diseases. Through biomolecular identification and characterization, this group aims to develop prognostics, diagnostics, and therapeutics for these diseases.

Faculty Researcher	Research Area
Madhulika Gupta	Perinatal diseases
Victor Han	Fetal, placental, newborn growth/development
Lars Konermann	Protein folding, dynamics, function; biocomputing
Gilles Lajoie	Mass spectrometry/proteomics: biomolecules
Shawn Li	Structure, function, connectivity of cellular proteins
David Litchfield	Signalling events in cell proliferation and survival
Walter Siqueira	Salivary components and biomarkers
Ken Yeung	Microscale protein analysis

Disease Prediction; Protein Coevolution; Biocomputing

This group applies bioinformatic approaches to further understanding of biological processes. In addition to computational and information technologies, this group uses genomics, molecular biology, and high-throughput sequencing.

Faculty Researcher	Research Area
James Choy	Intrinsically disordered proteins
Stanley Dunn	ATP synthase
David Edgell	Mobile genetic elements
Gregory Gloor	Protein coevolution
Bogumil Karas	Synthetic biology, designer microbes, DNA replacement strategies
Gilles Lajoie	Mass spectrometry/proteomics: biomolecules
Shawn Li	Structure, function, connectivity of cellular proteins
Patrick O'Donoghue	Synthesis of proteins containing atypical amino acids
Peter Rogan	Inherited genetic diseases and cancer