Recent Publications

picture of Dr. Shawn Li


Jan 2019   Feb 2019   Mar 2019   Apr 2019   May 2019   June 2019

July 2019   Aug 2019   Sept 2019   Oct 2019   Nov 2019   Dec 2019


Jan 2020   Feb 2020   Mar 2020   Apr 2020   May 2020   June2020

July 2020


July 2020

  1. Aliyari E, Konermann L. Formation of Gaseous Proteins via the Ion Evaporation Model (IEM) in Electrospray Mass Spectrometry. Anal Chem. 2020 Jul 1.

June 2020

  1. Aref-Eshghi E, McGee JD, Pedro VP, Kerkhof J, Stuart A, Ainsworth PJ, Lin H, Volodarsky M, McLachlin CM, Sadikovic B. Genetic and epigenetic profiling of BRCA1/2 in ovarian tumors reveals additive diagnostic yield and evidence of a genomic BRCA1/2 DNA methylation signature. J Hum Genet. 2020 Jun 1.
  2. Tajoddin NN, Konermann L. Analysis of Temperature-Dependent H/D Exchange Mass Spectrometry Experiments. Anal Chem. 2020 Jun 19.
  3. Youssef A, Clark JR, Koschinsky ML, Boffa MB Lipoprotein(a): Expanding Our Knowledge of Aortic Valve Narrowing. Trends Cardiovasc Med. 2020 Jun 7:S1050-1738(20)30080-3. 
  4. Abu Shehab M, Biggar K, Kakadia JH, Dhruv M, Jain B, Nandi P, Nygard K, Jansson T, Gupta MB. Inhibition of decidual IGF-1 signaling in response to hypoxia and leucine deprivation is mediated by mTOR and AAR pathways and increased IGFBP-1 phosphorylation. Mol Cell Endocrinol. 2020 Jun 2;512:110865.
  5. Khera AV, Hegele RA. What Is Familial Hypercholesterolemia, and Why Does It Matter? Circulation. 2020 June 2;141(22):1760‐1763.
  6. Lazarte J, Hegele RA. Can genetic testing help in the management of dyslipidaemias? Curr Opin Lipidol. 2020 Jun 8.
  7. Dron JS, Dilliott AA, Lawson A, McIntyre AD, Davis BD, Wang J, Cao H, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia. Arterioscler Thromb Vasc Biol. 2020 Jun 25:ATVBAHA120314168.
  8. Ramirez J, Dilliott AA, Binns MA, Breen DP, Evans EC, Beaton D, McLaughlin PM, Kwan D, Holmes MF, Ozzoude M, Scott CJM, Strother SC, Symons S, Swartz RH, Grimes D, Jog M, Masellis M, Black SE, Joutel A, Marras C, Rogaeva E, Hegele RA, Lang AE; Ontario Neurodegenerative Disease Research Initiative Investigators. Parkinson's Disease, NOTCH3 Genetic Variants, and White Matter Hyperintensities. Mov Disord. 2020 Jun 23.
  9. Varga A, Hegele RA. Triglyceride-rich particles: new actors in valvular aortic stenosis. Eur Heart J. 2020 Jun 21;41(24):2300-2303.
  10. Saeed SG, Bain J, Khoo E, Siqueira WL. COVID-19: Finding silver linings for dental education. J Dent Educ. 2020 Jun 2.
  11. Verma S, Chanchlani R, Siu VM, Filler G. Transient hyponatremia of prematurity caused by mild Bartter syndrome type II: a case report. BMC Pediatr. 2020 Jun 26;20(1):311.
  12. Kelman MJ, Renaud JB, Seifert KA, Mack J, Yeung KK, Sumarah MW. Chemotaxonomic Profiling of Canadian Alternaria Populations Using High-Resolution Mass Spectrometry. Metabolites. 2020 Jun 9;10(6):E238. 

May 2020

  1. Zhu Y, Berg MD, Yang P, Loll-Krippleber R, Brown GW, Brandl CJ. Mistranslating tRNA identifies a deleterious S213P mutation in the Saccharomyces cerevisiae eco1-1 allele. Biochem Cell Biol. 2020 May 30.
  2. Singha B, Laski J, Ramos Valdés Y, Liu E, DiMattia GE, Shepherd TG. Inhibiting ULK1 kinase decreases autophagy and cell viability in high-grade serous ovarian cancer spheroids. Am J Cancer Res. 2020 May 1;10(5):1384-1399.
  3. Powell JT, Hegele RA. From Laundry List to Rating Scheme: Selection of the Best Scientific Method. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1018-1019.
  4. Brown EE, Sturm AC, Cuchel M, Braun LT, Duell PB, Underberg JA, Jacobson TA, Hegele RA. Genetic testing in dyslipidemia: A scientific statement from the National Lipid Association. J Clin Lipidol. 2020 May 7:S1933-2874(20)30081-7. 
  5. Castilla-Vallmanya L, Selmer KK, Dimartino C, Rabionet R, Blanco-Sánchez B, Yang S, Reijnders MRF, van Essen AJ, Oufadem M, Vigeland MD, Stadheim B, Houge G, Cox H, Kingston H, Clayton-Smith J, Innis JW, Iascone M, Cereda A, Gabbiadini S, Chung WK, Sanders V, Charrow J, Bryant E, Millichap J, Vitobello A, Thauvin C, Mau-Them FT, Faivre L, Lesca G, Labalme A, Rougeot C, Chatron N, Sanlaville D, Christensen KM, Kirby A, Lewandowski R, Gannaway R, Aly M, Lehman A, Clarke L, Graul-Neumann L, Zweier C, Lessel D, Lozic B, Aukrust I, Peretz R, Stratton R, Smol T, Dieux-Coëslier A, Meira J, Wohler E, Sobreira N, Beaver EM, Heeley J, Briere LC, High FA, Sweetser DA, Walker MA, Keegan CE, Jayakar P, Shinawi M, Kerstjens-Frederikse WS, Earl DL, Siu VM, Reesor E, Yao T, Hegele RA, Vaske OM, Rego S; Undiagnosed Diseases Network, Care4Rare Canada Consortium, Shapiro KA, Wong B, Gambello MJ, McDonald M, Karlowicz D, Colombo R, Serretti A, Pais L, O'Donnell-Luria A, Wray A, Sadedin S, Chong B, Tan TY, Christodoulou J, White SM, Slavotinek A, Barbouth D, Morel Swols D, Parisot M, Bole-Feysot C, Nitschké P, Pingault V, Munnich A, Cho MT, Cormier-Daire V, Balcells S, Lyonnet S, Grinberg D, Amiel J, Urreizti R, Gordon CT. Phenotypic spectrum and transcriptomic profile associated with germline variants in TRAF7. Genet Med. 2020 May 7.
  6. Rabi DM, McBrien KA, Sapir-Pichhadze R, et al. (including Hegele RA) Hypertension Canada's 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children. Can J Cardiol. 2020;36(5):596‐624.
  7. Lau P, Soubeyrand S, Hegele RA, Lagace TA, McPherson R. Molecular mechanism linking a novel PCSK9 copy number variant to severe hypercholesterolemia. Atherosclerosis. 2020 May 28;304:39-43.
  8. Yin V, Konermann L. Probing the Effects of Heterogeneous Oxidative Modifications on the Stability of Cytochrome c in Solution and in the Gas Phase. J Am Soc Mass Spectrom. 2020 May 13.
  9. Tarnopolsky MA, Kerkhof J, Stuart A, Bujak A, Nilsson MI, Hettinga B, May L, Rupar CA, Sadikovic B. Bone
    marrow-derived mitochondrial DNA has limited capacity for inter-tissue transfer in vivo. FASEB J. 2020 May 22.
  10. Rodrigues RPCB, de Andrade Vieira W, Siqueira WL, Blumenberg C, de Macedo Bernardino Í, Cardoso SV, Flores-Mir C, Paranhos LR. Saliva as an alternative to blood in the determination of uremic state in adult patients with chronic kidney disease: a systematic review and meta-analysis. Clin Oral Investig. 2020 May 23.
  11. Hauser-Kawaguchi A, Tolg C, Peart T, Milne M, Turley EA, Luyt LG. Corrigendum to "A truncated RHAMM protein for discovering novel therapeutic peptides" [Bioorg. Med. Chem. 26 (2018) 5194-5203] Bioorg Med Chem. 2020 May 16;115543. 
  12. Turley EA. HIPPO and Hyaluronan: Partners in Tumor Resistance? Bioessays. 2020 May 24:e2000090.

Apr 2020

  1. Hegele RA, Knowles JW, Horton JD. Delisting STAP1: The Rise and Fall of a Putative Hypercholesterolemia Gene. Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):847-849.
  2. Heidari A, Ghorbani-Choghamarani A, Hajjami M, Hudson RHE. Fluorescent Biaryl Uracils with C5-Dihydro- and Quinazolinone Heterocyclic Appendages in PNA. Molecules. 2020 Apr 24;25(8). pii: E1995.
  3. Sever AIM, Konermann L. Gas Phase Protein Folding Triggered by Proton Stripping Generates Inside-Out Structures: A Molecular Dynamics Simulation Study. J Phys Chem B. 2020 Apr 14.
  4. Sherman SE, Kuljanin M, Cooper TT, Lajoie G, Hess DA. Purification and functional characterization of CD34-expressing cell subsets following ex vivo expansion of umbilical cord blood-derived endothelial colony forming cells. Stem Cells Dev. 2020 Apr 25.
  5. Balasuriya N, Davey NE, Johnson JL, Liu H, Biggar KK, Cantley LC, Li SS, O'Donoghue P. Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1). J Biol Chem. 2020 Apr 29. pii: jbc.RA119.012425.
  6. Rogan PK, Mucaki EJ, Lu R, Shirley BC, Waller E, Knoll JHM. Meeting radiation dosimetry capacity requirements of population-scale exposures by geostatistical sampling. PLoS One. 2020 Apr 24;15(4):e0232008.
  7. Hassan HM, Isovic M, Kolendowski B, Bauer-Maison N, Onabote O, Cecchini M, Haig A, Maleki Vareki S, Underhill TM, Torchia J. Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma. Cell Rep. 2020 Apr 7;31(1):107475.

Mar 2020

  1. Berberich AJ, Hegele RA. Research digest: next-generation lipoprotein therapeutics. Lancet Diabetes Endocrinol. 2020 Mar;8(3):190.
  2. Ueda M, Wolska A, Burke FM, Escobar M, Walters L, Lalic D, Hegele RA, Remaley AT, Rader DJ, Dunbar RL. Experimental Therapeutics for Challenging Clinical Care of a Patient with an Extremely Rare Homozygous APOC2 Mutation. Case Rep Endocrinol. 2020 Mar 27;2020:1865489.
  3. Schnitzler J, Hoogeveen RM, Ali L, Prange KH, Waissi F, Van Weeghel MV, Bachmann JC, Versloot M, Borrelli MJ, Yeang C, de Kleijn D, Houtkooper RH, Koschinsky M, de Winther MP, Groen AK, Witztum JL, Tsimikas S, Stroes ES, Kroon J. Atherogenic Lipoprotein(A) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation. Circ Res. 2020 Mar 12.
  4. Mucaki EJ, Shirley BC, Rogan PK. Expression Changes Confirm Genomic Variants Predicted to Result in Allele-Specific, Alternative mRNA Splicing. Front Genet. 2020 Mar 5;11:109.
  5. Melo IS, Candeia-Medeiros N, Ferro JNS, Cavalcante-Araújo PM, Oliveira TL, Santos CEA, Cardoso-Sousa L, Aguiar EMG, Wutke Oliveira S, Castro OW, Alves-Balvedi RP, Rodrigues LP, Hickmann JM, Alves DA, Santos IA, Jardim ACG, Siqueira WL, Pipi ARF, Goulart LR, Barreto EO, Sabino-Silva R. Restoration of Cyclo-Gly-Pro-induced salivary hyposecretion and submandibular composition bynaloxone in mice. PLoS One. 2020 Mar 10;15(3):e0229761.
  6. Caixeta DC, Aguiar EMG, Cardoso-Sousa L, Coelho LMD, Oliveira SW, Espindola FS, Raniero L, Crosara KTB, Baker MJ, Siqueira WL, Sabino-Silva R. Salivary molecular spectroscopy: A sustainable, rapid and non-invasive monitoring tool for diabetes mellitus during insulin treatment. PLoS One. 2020 Mar 17;15(3):e0223461.
  7. Tolg C, Liu M, Cousteils K, Telmer P, Alam K, Ma J, Medina L, McCarthy JB, Morris VL, Turley EA. Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization. J Biol Chem. 2020 Mar 12. pii: jbc.RA119.010002. 

Feb 2020

  1. Aref-Eshghi E, Kerkhof J, Pedro VP; Groupe DI France, Barat-Houari M, Ruiz-Pallares N, Andrau JC, Lacombe D, Van-Gils J, Fergelot P, Dubourg C, Cormier-Daire V, Rondeau S, Lecoquierre F, Saugier-Veber P, Nicolas G, Lesca G, Chatron N, Sanlaville D, Vitobello A, Faivre L, Thauvin-Robinet C, Laumonnier F, Raynaud M, Alders M, Mannens M, Henneman P, Hennekam RC, Velasco G, Francastel C, Ulveling D, Ciolfi A, Pizzi S, Tartaglia M, Heide S, Héron D, Mignot C, Keren B, Whalen S, Afenjar A, Bienvenu T, Campeau PM, Rousseau J, Levy MA, Brick L, Kozenko M, Balci TB, Siu VM, Stuart A, Kadour M, Masters J, Takano K, Kleefstra T, de Leeuw N, Field M, Shaw M, Gecz J, Ainsworth PJ, Lin H, Rodenhiser DI, Friez MJ, Tedder M, Lee JA, DuPont BR, Stevenson RE, Skinner SA, Schwartz CE, Genevieve D, Sadikovic B. Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders. Am J Hum Genet. 2020 Feb 26. pii: S0002-9297(20)30019-7.
  2. Hooper AJ, Hegele RA, Burnett JR. Tangier disease: update for 2020. Curr Opin Lipidol. 2020 Feb 4.
  3. Borén J, Chapman MJ, Krauss RM, Packard CJ, Bentzon JF, Binder CJ, Daemen MJ, Demer LL, Hegele RA, Nicholls SJ, Nordestgaard BG, Watts GF, Bruckert E, Fazio S, Ference BA, Graham I, Horton JD, Landmesser U, Laufs U, Masana L, Pasterkamp G, Raal FJ, Ray KK, Schunkert H, Taskinen MR, van de Sluis B, Wiklund O, Tokgozoglu L, Catapano AL, Ginsberg HN. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2020 Feb 13. pii: ehz962.
  4. Dron JS, Wang J, McIntyre AD, Iacocca MA, Robinson JF, Ban MR, Cao H, Hegele RA. Six years' experience with LipidSeq: clinical and research learnings from a hybrid, targeted sequencing panel for dyslipidemias. BMC Med Genomics. 2020 Feb 10;13(1):23.
  5. Lazarte J, Hegele RA. Regression of Xanthelasmas With Statin Treatment in a Normolipidemic Patient. Ann Intern Med. 2020 Feb 18.
  6. Duez Q, Metwally H, Hoyas S, Lemaur V, Cornil J, De Winter J, Konermann L, Gerbaux P. Effects of electrospray mechanisms and structural relaxation on polylactide ion conformations in the gas phase: insights from ion mobility spectrometry and molecular dynamics simulations. Phys Chem Chem Phys. 2020 Feb 10.
  7. Mucaki EJ, Shirley BC, Rogan PK. Expression Changes Confirm Genomic Variants Predicted to Result in Allele-Specific, Alternative mRNA Splicing. Front. Genet. 2020; 11:109.
  8. Baudier J, Deloulme JC, Shaw GS. The Zn(2+) and Ca(2+) -binding S100B and S100A1 proteins: beyond the myths. Biol Rev Camb Philos Soc. 2020 Feb 6.
  9. Cook BW, Lacoursiere RE, Shaw GS. Recruitment of Ubiquitin within an E2 Chain Elongation Complex. Biophys J. 2020 Feb 15. pii: S0006-3495(20)30133-8.
  10. Sabino-Silva R, Jardim ACG, Siqueira WL. Coronavirus COVID-19 impacts to dentistry and potential salivary diagnosis. Clin Oral Investig. 2020 Feb 20.

Jan 2020

  1. Llaurado Fernandez M, Dawson A, Kim H, Lam N, Russell H, Bruce M, Bittner M, Hoenisch J, Scott SA, Talhouk A, Chiu D, Provencher D, Nourmoussavi M, DiMattia G, Lee CH, Gilks CB, Köbel M, Carey MS. Hormone receptor expression and outcomes in low-grade serous ovarian carcinoma. Gynecol Oncol. 2020 Jan 14. pii: S0090-8258(19)31680-4.
  2. Yang S, Reid G, Challis JRG, Gloor GB, Asztalos E, Money D, Seney S, Bocking AD. Effect of Oral Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the Vaginal Microbiota, Cytokines and Chemokines in Pregnant Women. Nutrients. 2020 Jan 30;12(2). pii: E368.
  3. Awamleh Z, Han VKM. Identification of miR-210-5p in human placentae from pregnancies complicated by preeclampsia and intrauterine growth restriction, and  its potential role in the pregnancy complications. Pregnancy Hypertens. 2020 Jan 14;19:159-168.
  4. Lu HS, Schmidt AM, Hegele RA, Mackman N, Rader DJ, Weber C, Daugherty A. Annual Report on Sex in Preclinical Studies: Arteriosclerosis, Thrombosis, and Vascular Biology Publications in 2018. Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):e1-e9.
  5. Berberich AJ, Hegele RA. LDL cholesterol: lower, faster, younger? Lancet Diabetes Endocrinol. 2020 Jan;8(1):5-7.
  6. Dron JS, Wang J, McIntyre AD, Cao H, Hegele RA. The polygenic nature of mild-to-moderate hypertriglyceridemia. J Clin Lipidol. 2020 Jan 14. pii: S1933-2874(20)30003-9.
  7. Ashraf AP, Miyashita K, Nakajima K, Murakami M, Hegele RA, Ploug M, Fong LG, Young SG, Beigneux AP. Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies. J Clin Lipidol. 2020 Jan 31. pii: S1933-2874(20)30012-X.
  8. Morrow NM, Burke AC, Samsoondar JP, Seigel KE, Wang A, Telford DE, Sutherland BG, O'Dwyer C, Steinberg GR, Fullerton MD, Huff MW. The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat fed- mice independent of AMPK. J Lipid Res. 2020 Jan 21. pii: jlr.RA119000542.
  9. Cooper TT, Sherman SE, Bell GI, Ma J, Kuljanin M, Jose SE, Lajoie GA, Hess DA. Characterization of a Vimentin(high) /Nestin(high) proteome and tissue regenerative secretome generated by human pancreas-derived mesenchymal stromal cells. Stem Cells. 2020 Jan 6.
  10. Ciolfi A, Aref-Eshghi E, Pizzi S, Pedace L, Miele E, Kerkhof J, Flex E, Martinelli S, Radio FC, Ruivenkamp CAL, Santen GWE, Bijlsma E, Barge-Schaapveld D, Ounap K, Siu VM, Kooy RF, Dallapiccola B, Sadikovic B, Tartaglia M. Frameshift mutations at the C-terminus of HIST1H1E result in a specific DNA hypomethylation
    signature. Clin Epigenetics. 2020 Jan 7;12(1):7.
  11. Truong JL, Liu M, Tolg C, Barr M, Dai C, Raissi TC, Wong E, DeLyzer T, Yazdani A, Turley EA. Creating a Favorable Microenvironment for Fat Grafting in a Novel Model of Radiation-Induced Mammary Fat Pad Fibrosis. Plast Reconstr Surg. 2020 Jan;145(1):116-126.
  12. Shortt C, Luyt LG, Turley EA, Cowman MK, Kirsch T. A Hyaluronan-binding Peptide (P15-1) Reduces Inflammatory and Catabolic Events in IL-1β-treated Human Articular Chondrocytes. Sci Rep. 2020 Jan 29;10(1):1441.
  13. DesRochers N, Walsh JP, Renaud JB, Seifert KA, Yeung KK, Sumarah MW. Metabolomic Profiling of Fungal Pathogens Responsible for Root Rot in American Ginseng. Metabolites. 2020 Jan 14;10(1). pii: E35.
  14. Harris A, Roseborough A, Mor R, Yeung KK, Whitehead SN. Ganglioside detection from Formalin Fixed Human Brain Tissue Utilizing MALDI Imaging Mass Spectrometry. J Am Soc Mass Spectrom. 2020 Jan 21.

Dec 2019

  1. Jansson T, Castillo-Castrejon M, Gupta MB, Powell TL, Rosario FJ. Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction. Clin Sci (Lond). 2019 Dec 11. pii: CS20190794.
  2. O'Dea LSL, MacDougall J, Alexander VJ, Digenio A, Hubbard B, Arca M, Moriarty PM, Kastelein JJP, Bruckert E, Soran H, Witztum JL, Hegele RA, Gaudet D. Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles. J Endocr Soc. 2019 Oct 11;3(12):2397-2410.
  3. Baass A, Paquette M, Bernard S, Hegele RA. Familial Chylomicronemia Syndrome: an under-recognized cause of severe hypertriglyceridemia. J Intern Med. 2019 Dec 16.
  4. Geiger M, Brown C, Wichers JS, Strauss J, Lill A, Thuenauer R, Liffner B, Wilcke L, Lemcke S, Heincke D, Pazicky S, Bachmann A, Löw C, Wilson D, Filarsky M, Burda PC, Zhang K, Junop M, Gilberger TW. Structural insights into PfARO and characterization of its interaction with PfAIP. J Mol Biol. 2019 Dec 23. pii: S0022-2836(19)30733-8.
  5. Lacoursiere RE, O'Donoghue P, Shaw GS. Programmed ubiquitin acetylation using genetic code expansion reveals altered ubiquitination patterns. FEBS Lett. 2019 Dec 2.
  6. Tao J, Rupar CA, Miller MR, Ratko S, Prasad C. Use of complementary and alternative medicine in patients with inborn errors of metabolism: A single-center study. JIMD Rep. 2019 Dec 18;51(1):105-112.
  7. Esteves CV, de Campos WG, Amorim Dos Santos J, Kobayashi Velasco S, Guerra ENS, Siqueira WL, Lemos CA. Proteomic profile of saliva collected directly from ducts: a systematic review. Clin Oral Investig. 2019 Dec 12.
  8. Szot JO, Campagnolo C, Cao Y, Iyer KR, Cuny H, Drysdale T, Flores-Daboub JA, Bi W, Westerfield L, Liu P, Leung TN, Choy KW, Chapman G, Xiao R, Siu VM, Dunwoodie SL. Bi-Allelic Mutations in NADSYN1 Cause Multiple Organ Defects and Expand the Genotypic Spectrum of Congenital NAD Deficiency Disorders. Am J Hum Genet. 2019 Dec 19. pii: S0002-9297(19)30470-7.

Nov 2019

  1. Buensuceso A, Ramos Valdes Y, DiMattia GE, Shepherd TG. AMPK-independent LKB1 activity is required for efficient epithelial ovarian cancer metastasis. Mol Cancer Res. 2019 Nov 19. pii: molcanres.0530.2019.
  2. Giguere DJ, Macklaim JM, Lieng BY, Gloor GB. omicplotR: visualizing omic datasets as compositions. BMC Bioinformatics. 2019 Nov 15;20(1):580.
  3. Ueda M, Burke FM, Remaley AT, Hegele RA, Rader DJ, Dunbar RL. Familial Chylomicronemia Syndrome With a Novel Homozygous LPL Mutation Identified in Three Siblings in Their 50s. Ann Intern Med. 2019 Nov 19.
  4. Laufs U, Parhofer KG, Ginsberg HN, Hegele RA. Clinical review on triglycerides. Eur Heart J. 2019 Nov 25. pii: ehz785.

Oct 2019

  1. Boffa MB, Koschinsky ML. Proprotein convertase subtilisin/kexin type 9 inhibitors and lipoprotein(a)-mediated risk of atherosclerotic cardiovascular disease: more than meets the eye? Curr Opin Lipidol. 2019 Oct 1.
  2. Hamilton TA, Pellegrino GM, Therrien JA, Ham DT, Bartlett PC, Karas BJ, Gloor GB, Edgell DR. Efficient inter-species conjugative transfer of a CRISPR nuclease for targeted bacterial killing. Nat Commun. 2019 Oct 4;10(1):4544.
  3. Laforet M, McMurrough TA, Vu M, Brown CM, Zhang K, Junop MS, Gloor GB, Edgell DR. Modifying a covarying protein-DNA interaction changes substrate preference of a site-specific endonuclease. Nucleic Acids Res. 2019 Oct 11. pii: gkz866.
  4. Soltysiak MPM, Meaney RS, Hamadache S, Janakirama P, Edgell DR, Karas BJ. Trans-Kingdom Conjugation within Solid Media from Escherichia coli to Saccharomyces cerevisiae. Int J Mol Sci. 2019 Oct 21;20(20). pii: E5212.
  5. Hegele RA. Research digest: observing risks and benefits of diet and supplements. Lancet Diabetes Endocrinol. 2019 Oct;7(10):752.
  6. Carfrae LA, MacNair CR, Brown CM, Tsai CN, Weber BS, Zlitni S, Rao VN, Chun J, Junop MS, Coombes BK, Brown ED. Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens. Nat Microbiol. 2019 Oct 28.
  7. Ostrov N, Beal J, Ellis T, Gordon DB, Karas BJ, Lee HH, Lenaghan SC, Schloss JA, Stracquadanio G, Trefzer A, Bader JS, Church GM, Coelho CM, Efcavitch JW, Güell M, Mitchell LA, Nielsen AAK, Peck B, Smith AC, Stewart CN Jr, Tekotte H. Technological challenges and milestones for writing genomes. Science. 2019 Oct 18;366(6463):310-312.
  8. Rodrigues RP, Aguiar EM, Cardoso-Sousa L, Caixeta DC, Guedes CC, Siqueira WL, Maia YCP, Cardoso SV, Sabino-Silva R. Differential Molecular Signature of Human Saliva Using ATR-FTIR Spectroscopy for Chronic Kidney Disease Diagnosis. Braz Dent J. 2019 Oct 7;30(5):437-445.

Sept 2019

  1. Boffa MB, Marar TT, Yeang C, Viney NJ, Xia S, Witztum JL, Koschinsky ML, Tsimikas SL. Potent reduction of plasma lipoprotein(a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis. J Lipid Res. 2019 Sep 24. pii: jlr.P094763.
  2. Berg MD, Zhu Y, Genereaux J, Ruiz BY, Rodriguez-Mias RA, Allan T, Bahcheli A, Villén J, Brandl CJ. Modulating Mistranslation Potential of tRNA(Ser) in Saccharomyces cerevisiae. Genetics. 2019 Sep 4. pii: genetics.302525.2019.
  3. Elwood C, Albert AYK, McClymont E, Wagner E, Mahal D, Devakandan K, Quiqley BL, Pakzad Z, Yudin MH, Hill JE, Money D; VOGUE Research Group, Bocking A, Dumonceaux T, Gloor G, Hemmingsen S, Hill JE, Links M, Money D, O'Doherty K, Reid G, van Schalkwyk J, Tang P, Yudin MH. Different and diverse anaerobic microbiota were seen in women living with HIV with unsuppressed HIV viral load and in women with recurrent bacterial vaginosis: a cohort study. BJOG. 2019 Sep 9.
  4. Radford BN, Han VKM. Insights image for "Evidence of increased hypoxia signalling in fetal liver from maternal nutrient restriction in mice". Pediatr Res. 2019 Sep 4.
  5. Dron JS, Wang J, McIntyre AD, Cao H, Robinson JF, Duell B, Manjoo P, Feng J, Movsesyan I, Malloy MJ, Pullinger CR, Kane J, Hegele RA. Partial LPL deletions: rare copy-number variants contributing towards the polygenic form of severe hypertriglyceridemia. J Lipid Res. 2019 Sep 13. pii: jlr.P119000335.
  6. Le R, Abbas M, McIntyre AD, Hegele RA. Severe Combined Dyslipidemia With a Complex Genetic Basis. J Investig Med High Impact Case Rep. 2019 Jan-Dec;7:2324709619877050.
  7. Popovic V, Morrison E, Rosanally AZ, Balachandran N, Senson AW, Szabla R, Junop MS, Berti PJ. NeuNAc oxime: A slow-binding and effectively irreversible inhibitor of the sialic acid synthase NeuB. Biochemistry. 2019 Sep 24.
  8. Konermann L, Metwally H, Duez Q, Peters I. Charging and supercharging of proteins for mass spectrometry: recent insights into the mechanisms of electrospray ionization. Analyst. 2019 Sep 27.
  9. Esmail S, Li SS. Single-Layer β Sheets as Versatile Protein-Binding Modules. Structure. 2019 Sep 3;27(9):1352-1354.
  10. Abbasian B, Shair A, O'Gorman DB, Pena-Diaz AM, Brennan L, Engelbrecht K, Koenig DW, Reid G, Burton JP. Potential Role of Extracellular ATP Released by Bacteria in Bladder Infection and Contractility. mSphere. 2019 Sep 4;4(5). pii: e00439-19.
  11. Shirley BC, Mucaki EJ, Rogan PK. Pan-cancer repository of validated natural and cryptic mRNA splicing mutations. Version 3. F1000Res. 2018 Dec 7 [revised 2019 Jan 1];7:1908.
  12. Yan X, Lebel-Beaucage MF, Tremblay S, Cantin L, Shaw GS, Boisselier E. Optimized transformation, overexpression and purification of S100A10. Biotechniques. 2019 Sep 2.
  13. Esteves CV, Campos WG, Souza MM, Lourenço SV, Siqueira WL, Lemos-Júnior CA. Diagnostic potential of saliva proteome analysis: a review and guide to clinical practice. Braz Oral Res. 2019;33:e043.
  14. Krstic M, Hassan HM, Kolendowski B, Hague MN, Anborgh PH, Postenka CO, Torchia J, Chambers AF, Tuck AB. Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis. Lab Invest. 2019 Sep 30.
  15. Truong JL, Liu M, Tolg C, Barr M, Dai C, Raissi TC, Wong E, DeLyzer T, Yazdani A, Turley EA. "Creating a Favorable Micro-Environment for Fat Grafting in a Novel Model of Radiation Induced Mammary Fat Pad Fibrosis." Plast Reconstr Surg. 2019 Sep 30.

Aug 2019

  1. Berg MD, Giguere DJ, Dron JS, Lant JT, Genereaux J, Liao C, Wang J, Robinson JF, Gloor GB, Hegele RA, O’Donoghue P, Brandl CJ. Targeted sequencing reveals expanded genetic diversity of human transfer RNAs. RNA Biology. 2019 Aug 13:1-12.
  2. Hegele RA. Research digest: seeking new lipid drug targets. Lancet Diabetes Endocrinol. 2019 Aug;7(8):594.
  3. Garg A, Garg V, Hegele RA, Lewis GF. Practical definitions of severe versus familial hypercholesterolaemia and hypertriglyceridaemia for adult clinical practice. Lancet Diabetes Endocrinol. 2019 Aug 21. pii: S2213-8587(19)30156-1.
  4. Albatany M, Ostapchenko VG, Meakin S, Bartha R. Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms. J Neurooncol. 2019 Aug 7.
  5. Wright DE, O’Donoghue P. The molecular architecture of unnatural amino acid translation systems. Structure. 2019;27(8):1192-1194.
  6. O'Gorman DB, Pena-Diaz AM, Drosdowech D, Faber KJ, Athwal GS, Burton JP, Al K, Huang T, Qiu B. Response to Long et al regarding: "Cutibacterium acnes and the shoulder microbiome". J Shoulder Elbow Surg. 2019 Aug;28(8):e277-e278.
  7. Rogan PK. Multigene signatures of responses to chemotherapy derived by biochemically inspired machine learning Mol Genet Metab. 2019 Aug 16.
  8. Paik K, Lines MA, Chakraborty P, Khangura SD, Latocki M, Al-Hertani W, Brunel-Guitton C, Khan A, Penny B, Rockman-Greenberg C, Rupar CA, Sondheimer N, Tarnopolsky M, Tingley K, Coyle D, Dyack S, Feigenbaum A, Geraghty MT, Gillis J, van Karnebeek CDM, Kronick JB, Little J, Potter M, Siriwardena K, Sparkes R, Turner LA, Wilson K, Buhas D, Potter BK; Canadian Inherited Metabolic Diseases Research Network. Health care for mitochondrial disorders in Canada: A survey of physicians. Can J Neurol Sci. 2019 Aug 7:1-29.
  9. Hassan HM, Underhill TM, Torchia J. Mapping Retinoic Acid-Dependant 5mC Derivatives in Mouse Embryonic Fibroblasts. Methods Mol Biol. 2019;2019:129-141.

July 2019

  1. Aref-Eshghi E, Bourque DK, Kerkhof J, Carere DA, Ainsworth P, Sadikovic B, Armour CM, Lin H. Genome-wide DNA methylation and RNA analyses enable reclassification of two variants of uncertain significance in a patient with clinical Kabuki syndrome. Hum Mutat. 2019 Jul 3.
  2. Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AAM, Healey JS, Janssen PML, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ. Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy. J Clin Invest. 2019 Jul 2;130. pii: 125538.
  3. Berberich AJ, Mokashi A, McIntyre AD, Robinson JF, Cao H, Wang J, Hegele RA. Bioinformatic detection of copy number variation in HNF4A causing maturity onset diabetes of the young. Clin Genet. 2019 Jul 15.
  4. Jansson-Knodell CL, Gawrieh S, McIntyre AD, Tiebing L, Hegele RA, Chalasani N. APOB and PNPLA3 Double Heterozygosity in a Father-Son Pair with Advanced Nonalcoholic Fatty Liver Disease. Hepatology. 2019 Jul 25.
  5. Lazarte J, Hegele RA. Dyslipidemia Management in Adults With Diabetes. Can J Diabetes. 2019 Jul 12. pii: S1499-2671(19)30373-9.
  6. Zhao PJ, Ban MR, Iacocca MA, McIntyre AD, Wang J, Hegele RA. Genetic Determinants of Myocardial Infarction Risk in Familial Hypercholesterolemia. CJC  Open. 2019 Jul 2;1(5):225-230.
  7. O'Donoghue P, Heinemann IU. Synthetic DNA and RNA Programming. Genes (Basel). 2019 Jul 11;10(7). pii: E523.
  8. Lee JH, Pollert K, Konermann L. Testing the Robustness of Solution Force Fields for MD Simulations on Gaseous Protein Ions. J Phys Chem B. 2019 Jul 15.
  9. Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD. Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. Nat Methods. 2019 Jul;16(7):595-602.
  10. Maitland MER, Onea G, Chiasson CA, Wang X, Ma J, Moor SE, Barber KR, Lajoie GA, Shaw GS, Schild-Poulter C. The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation. Sci Rep. 2019 Jul 8;9(1):9864.
  11. Shirley BC, Mucaki EJ, Rogan PK. Pan-cancer repository of validated natural and cryptic mRNA splicing mutations.[version 2; peer review: 1 approved, 2 approved with reservations]. F1000Res. 2019, 7:1908.
  12. Zapata-Aldana E, McMillan HJ, Rupar T, Brunel-Guitton C, Chakraborty P, Mitchell JJ, Roth J, Tarnopolsky MA, Turner L, Campbell C. Muscle problems in juvenile-onset acid maltase deficiency (Pompe disease). Paediatr Child Health. 2019 Jul;24(4):270-271.

June 2019

  1. Levy MA, Santos S, Kerkhof J, Stuart A, Aref-Eshghi E, Guo F, Hedley B, Wong H, Rauh M, Feilotter H, Berardi P, Semenuk L, Yang P, Knoll J, Ainsworth P, Meg McLachlin C, Chin-Yee I, Kovacs M, Deotare U, Lazo-Langner A, Hsia C, Keeney M, Xenocostas A, Howlett C, Lin H, Sadikovic B. Implementation of an NGS-based sequencing and gene fusion panel for clinical screening of patients with suspected hematologic malignancies. Eur J Haematol. 2019 Jun 8.
  2. Brumwell SL, MacLeod MR, Huang T, Cochrane RR, Meaney RS, Zamani M, Matysiakiewicz O, Dan KN, Janakirama P, Edgell DR, Charles TC, Finan TM, Karas BJ. Designer Sinorhizobium meliloti strains and multi-functional vectors enable inter-kingdom DNA transfer. PLoS One. 2019 Jun 17;14(6):e0206781.
  3. Chahine S, Plouffe RA, Goldberg HA, Sadler K, Drosdowech N, Bohay R, Garcia B, Hammond R. Do Factors from Admissions and Dental School Predict Performance on National Board Exams? A Multilevel Modeling Study. J Dent Educ. 2019 Jun 10.
  4. Awamleh Z, Gloor GB, Han VKM. Placental microRNAs in pregnancies with early onset intrauterine growth restriction and preeclampsia: potential impact on gene expression and pathophysiology. BMC Med Genomics. 2019 Jun 27;12(1):91.
  5. Radford BN, Han VKM. Evidence of increased hypoxia signaling in fetal liver from maternal nutrient restriction in mice. Pediatr Res. 2019 Jun 11.
  6. Gulilat M, Lamb T, Teft WA, Wang J, Dron JS, Robinson JF, Tirona RG, Hegele RA, Kim RB, Schwarz UI. Targeted next generation sequencing as a tool for precision medicine. BMC Med Genomics. 2019 Jun 3;12(1):81.
  7. Dilliott AA, Farhan SM, Ghani M, Sato C, Zhang M, McIntyre AD, Cao H, Racacho L, Robinson JF, Strong MJ, Masellis M, Bulman DE, Rogaeva E, Black SE, Finger E, Frank A, Freedman M, Hassan A, Lang A, Shoesmith C, Swartz RH, Tang-Wai D, Tartaglia MC, Turnbull J, Zinman L; ONDRI Investigators, Hegele RA. Genetic variation in the Ontario Neurodegenerative Disease Research Initiative. Can J Neurol Sci. 2019 Jun 20:1-24.
  8. Alothman L, Zawadka M, Aljenedil S, Kajil M, Bewick D, Gaudet D, Hegele RA, Lonn E, Ngui D, Ruel I, Tsigoulis M, Singh N, Genest J, Gupta M. Prediction of Familial Hypercholesterolemia in Patients at High Atherosclerotic Cardiovascular Disease Risk Using a Recently Validated Algorithm. CJC Open. 2019 Jun
  9. Penner G, Lecocq S, Chopin A, Vedoya X, Lista S, Vergallo A, Lejeune FX, Hampel H. Blood-based diagnostics of Alzheimer's disease. Expert Rev Mol Diagn. 2019 Jun 8:1-9.

May 2019

  1. Christiansen SD, Liu J, Boffa MB, Drangova M. Simultaneous R(2*) and quantitative susceptibility mapping measurement enables differentiation of thrombus hematocrit and age: an in vitro study at 3 T. J Neurointerv Surg. 2019 May 14. pii: neurintsurg-2019-014802.
  2. Marshall AE, Roes MV, Passos DT, DeWeerd MC, Chaikovsky AC, Sage J, Howlett CJ, Dick FA. RB1 deletion in RB-pathway disrupted cells results in DNA damage and cancer progression. Mol Cell Biol. 2019 May 28. pii: MCB.00105-19.
  3. Sunderland KM, Beaton D, Fraser J, Kwan D, McLaughlin PM, Montero-Odasso M, Peltsch AJ, Pieruccini-Faria F, Sahlas DJ, Swartz RH; ONDRI Investigators (includes Hegele RA), Strother SC, Binns MA. The utility of multivariate outlier detection techniques for data quality evaluation in large studies: an application within the ONDRI project. BMC Med Res Methodol. 2019 May 15;19(1):102.
  4. Berberich AJ, Ziada A, Zou GY, Hegele RA. Conservative management in hypertriglyceridemia-associated pancreatitis. J Intern Med. 2019 May 11.
  5. Hartz J, Hegele RA, Wilson DP. Low LDL cholesterol-Friend or foe? J Clin Lipidol. 2019 May 16. pii: S1933-2874(19)30182-5.
  6. Chung CZ, Balasuriya N, Manni E, Liu X, Li SS, O'Donoghue P, Heinemann IU. Gld2 activity is regulated by phosphorylation in the N-terminal domain. RNA Biol. 2019 May 5:1-12.
  7. Burke AC, Sutherland BG, Telford DE, Morrow MR, Sawyez CG, Edwards JY, Huff MW. Naringenin enhances the regression of atherosclerosis induced by a chow diet in Ldlr(-/-) mice. Atherosclerosis. 2019 May 9;286:60-70.
  8. Peters I, Metwally H, Konermann L. Mechanism of Electrospray Supercharging for Unfolded Proteins: Solvent-Mediated Stabilization of Protonated Sites During Chain Ejection. Anal Chem. 2019 May 2.
  9. Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR. Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis. J Am Coll Cardiol. 2019 May 7;73(17):2150-2162.
  10. Wilson DP, Jacobson TA, Jones PH, Koschinsky ML, McNeal CJ, Nordestgaard BG, Orringer CE. Use of lipoprotein(a) in clinical practice: A biomarker whose time has come. A scientific statement from the National Lipid Association. Don P. Wilson, MD, on behalf of the Writing group. J Clin Lipidol. 2019 May 17. pii: S1933-2874(19)30086-8.
  11. Velenosi TJ, Thomson BKA, Tonial NC, RaoPeters AAE, Mio MA, Lajoie GA, Garg AX, House AA, Urquhart BL. Untargeted metabolomics reveals N, N, N-trimethyl-L-alanyl-L-proline betaine (TMAP) as a novel biomarker of kidney function. Sci Rep. 2019 May 2;9(1):6831.
  12. Balint B, Yin H, Nong Z, Arpino JM, O'Neil C, Rogers SR, Randhawa VK, Fox SA, Chevalier J, Lee JJ, Chu MWA, Pickering JG. Seno-destructive smooth muscle cells in the ascending aorta of patients with bicuspid aortic valve disease. EBioMedicine. 2019 May 8. pii: S2352-3964(19)30299-3.
  13. Peters KM, Zhang R, Park C, Nong Z, Yin H, Wilson RB, Sutherland BG, Sawyez CG, Pickering JG, Borradaile NM. Vitamin D intervention does not improve vascular regeneration in diet-induced obese male mice with peripheral ischemia. J NutrBiochem. 2019 May 10;70:65-74.
  14. Le C, Prasad AN, Rupar CA, Debicki D, Andrade A, Prasad C. Infantile-Onset Multisystem Neurologic, Endocrine, and Pancreatic Disease: Case and Review. Can J Neurol Sci. 2019 May 6:1-5.
  15. Ferreira EO, Mendes INVF, Monteiro SG, Crosara KTB, Siqueira WL, de Maria Pedroso Silva de Azevedo C, Moffa EB, de Andrade Monteiro C. Virulence properties and sensitivity profile of Candida parapsilosis complex species and Kodamaea ohmeri isolates from onychomycosis of HIV/AIDS patients. Microb Pathog. 2019 May 11;132:282-292.
  16. Cano IP, Dionisio TJ, Cestari TM, Calvo AM, Colombini-Ishikiriama BL, Faria FAC, Siqueira WL, Santos CF. Losartan and isoproterenol promote alterations in the local renin-angiotensin system of rat salivary glands. PLoS One. 2019 May 22;14(5):e0217030.
  17. Liu M, Tolg C, Turley E. Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment. Front Immunol. 2019 May 10;10:947.

Apr 2019 

  1. Aref-Eshghi E, Bend EG, Colaiacovo S, Caudle M, Chakrabarti R, Napier M, Brick L, Brady L, Carere DA, Levy MA, Kerkhof J, Stuart A, Saleh M, Beaudet AL, Li C, Kozenko M, Karp N, Prasad C, Siu VM, Tarnopolsky MA, Ainsworth PJ, Lin H, Rodenhiser DI, Krantz ID, Deardorff MA, Schwartz CE, Sadikovic B. Diagnostic Utility of Genome-wide DNA Methylation Testing in Genetically Unsolved Individuals with Suspected Hereditary Conditions. Am J Hum Genet. 2019 Apr 4;104(4):685-700.
  2. Metcalfe K, Eisen A, Senter L, Armel S, Bordeleau L, Meschino WS, Pal T, Lynch HT, Tung NM, Kwong A, Ainsworth P, Karlan B, Moller P, Eng C, Weitzel JN, Sun P, Lubinski J, Narod SA; Hereditary Breast Cancer Clinical Study Group. International trends in the uptake of cancer risk reduction strategies in women with a BRCA1 or BRCA2 mutation. Br J Cancer. 2019 Apr 11.
  3. Lazo-Langner A, Ainsworth P, McAlister V. Long term follow-up after liver transplantation from a JAK2 mutation positive donor. Hepatobiliary Surg Nutr. 2019 Apr;8(2):189-191.
  4. Postovit LM, Dieters-Castator DZ, Rambau PF, Kelemen LE, Siegers GM, Lajoie GA, Köbel M. Proteomics derived biomarker panel improves diagnostic precision to classify endometrioid and high-grade serous ovarian carcinoma. Clin Cancer Res. 2019 Apr 12. pii: clincanres.3818.2018.
  5. Veras MA, Tenn NA, Kuljanin M, Lajoie GA, Hammond JR, Dixon SJ, Séguin CA. Loss of ENT1 increases cell proliferation in the annulus fibrosus of the intervertebral disc. J Cell Physiol. 2019 Aug;234(8):13705-13719.
  6. Bend EG, Aref-Eshghi E, Everman DB, Rogers RC, Cathey SS, Prijoles EJ, Lyons MJ, Davis H, Clarkson K, Gripp KW, Li D, Bhoj E, Zackai E, Mark P, Hakonarson H, Demmer LA, Levy MA, Kerkhof J, Stuart A, Rodenhiser D, Friez MJ, Stevenson RE, Schwartz CE, Sadikovic B. Gene domain-specific DNA methylation episignatures highlight distinct molecular entities of ADNP syndrome. Clin Epigenetics. 2019 Apr 27;11(1):64.
  7. Lu R and Rogan PK. Transcription factor binding site clusters identify target genes with similar tissue-wide expression and buffer against mutations [version 2; peer review: 2 approved]. F1000Research 2019, 7:1933.

Mar 2019 

  1. Berberich AJ, Huot C, Cao H, McIntyre AD, Robinson JF, Wang J, Hegele RA. Copy Number Variation in GCK in patients with Maturity-Onset Diabetes of the Young. J  Clin Endocrinol Metab. 2019 Mar 26. pii: jc.2018-02574.
  2. Morise AP, Hegele RA. Atypical familial dysbetalipoproteinemia associated with high polygenic cholesterol and triglyceride scores treated with ezetimibe and evolocumab. J Clin Lipidol. 2019 Mar 6. pii: S1933-2874(19)30041-8.
  3. Lee T, Iacocca MA, Ban MR, Hegele RA. Efficacy of Evolocumab in Monogenic vs Polygenic Hypercholesterolemia. CJC Open. 2019 Mar 15;1(3):115-118.
  4. Liu R, Cheng J, Muzlera C, Robinson JF, Ban MR, Hegele RA. Clinical Utility and Practical Considerations of a Coronary Artery Disease Genetic Risk Score. CJC Open. 2019 Mar 29;1(2):69-75.
  5. Chen AW, Jayasinghe MI, Chung CZ, Rao BS, Kenana R, Heinemann IU, Jackman JE. The Role of 3' to 5' Reverse RNA Polymerization in tRNA Fidelity and Repair. Genes (Basel). 2019 Mar 26;10(3). pii: E250.
  6. McLachlin DT. Song: I love ketone bodies (to the tune of "shape of you"). Biochem Mol Biol Educ. 2019 Mar;47(2):211.
  7. Sadikovic B, Aref-Eshghi E, Levy MA, Rodenhiser D. DNA methylation signatures in mendelian developmental disorders as a diagnostic bridge between genotype and phenotype. Epigenomics. 2019 Mar 15.
  8. Colares VLP, Lima SNL, Sousa NCF, Araújo MC, Pereira DMS, Mendes SJF, Teixeira SA, Monteiro CA, Bandeca MC, Siqueira WL, Moffa EB, Muscará MN, Fernandes ES. Hydrogen peroxide-based products alter inflammatory and tissue damage-related proteins in the gingival crevicular fluid of healthy volunteers: a randomized trial. Sci Rep. 2019 Mar 5;9(1):3457.
  9. Khiyani MF, Ahmadi M, Barbeau J, Feine J, de Souza RF, Siqueira WL, Emami E. Salivary Biomarkers in Denture Stomatitis: A Systematic Review. JDR Clin Trans Res. 2019 Mar 7:2380084419830941. 

Feb 2019 

  1. Kotsopoulos J, Lubinski J, Lynch HT, Tung N, Armel S, Senter L, Singer CF, Fruscio R, Couch F, Weitzel JN, Karlan B, Foulkes WD, Moller P, Eisen A, Ainsworth P, Neuhausen SL, Olopade O, Sun P, Gronwald J, Narod SA; Hereditary Breast Cancer Clinical Study Group. Oophorectomy and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat. 2019 Feb 12.
  2. Borrelli MJ, Youssef A, Boffa MB, Koschinsky ML. New Frontiers in Lp(a)-Targeted Therapies. Trends Pharmacol Sci. 2019 Feb 4. pii: S0165-6147(19)30015-X.
  3. Jiang Y, Berg MD, Genereaux J, Ahmed K, Duennwald ML, Brandl CJ, Lajoie P. Sfp1 links TORC1 and cell growth regulation to the yeast SAGA-complex component Tra1 in response to polyQ proteotoxicity. Traffic. 2019 Feb 10.
  4. Dick FA, Li SS. Drugging RB1 Deficiency: Synthetic Lethality with Aurora Kinases. Cancer Discov. 2019 Feb;9(2):169-172.
  5. Almeida A, Mitchell AL, Boland M, Forster SC, Gloor GB, Tarkowska A, Lawley TD, Finn RD. A new genomic blueprint of the human gut microbiota. Nature. 2019 Feb 11.
  6. Wootton DG, Cox MJ, Gloor GB, Litt D, Hoschler K, German E, Court J, Eneje O,  Keogan L, Macfarlane L, Wilks S, Diggle PJ, Woodhead M, Moffatt MF, Cookson WOC, Gordon SB. A Haemophilus sp. dominates the microbiota of sputum from UK adults with non-severe community acquired pneumonia and chronic lung disease. Sci Rep. 2019 Feb 20;9(1):2388.
  7. Aboalola D, Han VKM. Insulin-Like Growth Factor Binding Protein-6 Promotes the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle Independent of Insulin-Like Growth Factor Receptor-1 and Insulin Receptor. Stem Cells Int. 2019 Feb 17;2019:9245938.
  8. Chung CZ, Jaramillo JE, Ellis MJ, Bour DYN, Seidl LE, Jo DHS, Turk MA, Mann MR, Bi Y, Haniford DB,  Duennwald ML, Heinemann IU. RNA surveillance by uridylation-dependent RNA decay in Schizosaccharomyces pombe. Nucleic Acids Research. 2019 Feb; gkz043.
  9. Hegele RA, Tsimikas S. Lipid-Lowering Agents. Circ Res. 2019 Feb;124(3):386-404.
  10. Rosenson RS, Hegele RA, Koenig W. Cholesterol-Lowering Agents. Circ Res. 2019 Feb;124(3):364-385.
  11. Silveira CRA, MacKinley J, Coleman K, Li Z, Finger E, Bartha R, Morrow SA, Wells J, Borrie M, Tirona RG, Rupar CA, Zou G, Hegele RA, Mahuran D, MacDonald P, Jenkins ME, Jog M, Pasternak SH. Ambroxol as a novel disease-modifying treatment for Parkinson's disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial. BMC Neurol. 2019 Feb 9;19(1):20.
  12. Lapointe JF, Harvey L, Aziz S, Jordan H, Hegele RA, Lemieux P. A Single-dose, Comparative Bioavailability Study of a Formulation containing OM3 as Phospholipid and Free fatty Acid to an Ethyl Ester Formulation in the Fasting and Fed States. Clin Ther. 2019 Feb 21. pii: S0149-2918(19)30055-4.
  13. Cho SJ, Ghorbani-Choghamarani A, Saito Y, Hudson RHE. 6-Phenylpyrrolocytidine: An Intrinsically Fluorescent, Environmentally Responsive Nucleoside Analogue. Curr Protoc Nucleic Acid Chem. 2019 Feb 6:e75.
  14. Burke AC, Telford DE, Huff MW. Bempedoic acid: effects on lipoprotein metabolism and atherosclerosis. Curr Opin Lipidol. 2019 Feb;30(1):1-9. 
  15. Mok MCY, Campalans A, Pillon MC, Guarné A, Radicella JP, Junop MS. Identification of an XRCC1 DNA binding activity essential for retention at sites of DNA damage. Sci Rep. 2019 Feb 28;9(1):3095.
  16. Bakhtiari M, Konermann L. Protein Ions Generated by Native Electrospray Ionization: Comparison of Gas Phase, Solution, and Crystal Structures. J Phys Chem B. 2019 Feb 6.
  17. Spratt DE, Barber KR, Marlatt NM, Ngo V, Macklin JA, Xiao Y, Konermann L, Duennwald ML, Shaw GS. A Subset of Calcium-binding S100 Proteins Show Preferential Heterodimerization. FEBS J. 2019 Feb 4.
  18. Wei R, Liu X, Voss C, Qin W, Dagnino L, Li L, Vigny M, Li SS. NUMB regulates the endocytosis and activity of the anaplastic lymphoma kinase in an isoform-specific manner. J Mol Cell Biol. 2019 Feb 6.
  19. Said SS, Yin H, Elfarnawany M, Nong Z, O'Neil C, Leong H, Lacefield JC, Mequanint K, Pickering JG. Fortifying Angiogenesis in Ischemic Muscle with FGF9-Loaded Electrospun Poly(Ester Amide) Fibers. Adv Healthc Mater. 2019 Feb 20:e1801294.
  20. McTavish CJ, Bérubé-Janzen W, Wang X, Maitland MER, Salemi LM, Hess DA, Schild-Poulter C. Regulation of c-Raf Stability through the CTLH Complex. Int J Mol Sci. 2019 Feb 21;20(4). pii: E934.
  21. Wang Y, Tadayon R, Shaw GS. Monitoring Interactions Between S100B and the Dopamine D2 Receptor Using NMR Spectroscopy. Methods Mol Biol. 2019;1929:311-324.
  22. Yang J, Price MA, Wanshura LEC, He J, Yi M, Welch DR, Li G, Conner S, Sachs J, Turley EA, McCarthy JB. Chondroitin sulfate proteoglycan 4 enhanced melanoma motility and growth requires a cysteine in the core protein transmembrane domain. Melanoma Res. 2019 Feb 1.

Jan 2019

  1. Boffa MB, Koschinsky ML. Oxidized phospholipids as a unifying theory for lipoprotein(a) and cardiovascular disease. Nat Rev Cardiol. 2019 Jan 23.
  2. Paré G, Caku A, McQueen M, Anand SS, Enas E, Clarke R, Boffa MB, Koschinsky M, Wang X, Yusuf S; INTERHEART Investigators. Lipoprotein(a) Levels and the Risk of Myocardial Infarction Among Seven Ethnic Groups. Circulation. 2019 Jan 22.
  3. Lant JT, Berg MD, Heinemann IU, Brandl CJ, O’Donoghue P. Pathways to disease from natural variations in human cytoplasmic tRNAs. J Biol Chem. 2019 Jan 14. pii: jbc.REV118.002982.
  4. Kim SJ, Asfaha S, Dick FA. CDK4 Inhibitors Thwart Immunity by Inhibiting Phospho-RB-NF-κB Complexes. Mol Cell. 2019 Jan 3;73(1):1-2.
  5. Thwaites MJ, Cecchini MJ, Passos DT, Zakirova K, Dick FA. Context dependent roles for RB-E2F transcriptional regulation in tumor suppression. PLoS One. 2019 Jan 31;14(1):e0203577.
  6. Fernandez ML, Dawson A, Hoenisch J, Kim H, Bamford S, Salamanca C, DiMattia G, Shepherd T, Cremona M, Hennessy B, Anderson S, Volik S, Collins CC, Huntsman DG, Carey MS. Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target. Cancer Cell Int. 2019 Jan 8;19:10.
  7. Joris BR, Gloor GB. Unaccounted risk of cardiovascular disease: the role of the microbiome in lipid metabolism. Curr Opin Lipidol. 2019 Jan 16.
  8. Rosario FJ, Gupta MB, Myatt L, Powell TL, Glenn JP, Cox L, Jansson T. Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis. Sci Rep. 2019 Jan 22;9(1):246.
  9. Hegele RA. Editorial: designing targeted sequencing panels for dyslipidemia. Curr Opin Lipidol. 2019 Jan 16.
  10. Dron JS, Hegele RA. The evolution of genetic-based risk scores for lipids and cardiovascular disease. Curr Opin Lipidol. 2019 Jan 22.
  11. Iacocca MA, Dron JS, Hegele RA. Progress in finding pathogenic DNA copy number variations in dyslipidemia. Curr Opin Lipidol. 2019 Jan 16.
  12. Paquette M, Bernard S, Hegele RA, Baass A. Chylomicronemia: Differences between familial chylomicronemia syndrome and multifactorial chylomicronemia. Atherosclerosis. 2018 Dec 28. pii: S0021-9150(18)31550-8.
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