Recent Publications

picture of Dr. Shawn Li


Jan 2021   Feb 2021   Mar 2021   Apr 2021   May 2021   June 2021

July 2021   Aug 2021   Sept 2021


Sept 2021

  1. Zheng B, Seltzsam S, Wang C, Schierbaum L, Schneider S, Wu CW, Dai R, Connaughton DM, Nakayama M, Mann N, Stajic N, Mane S, Bauer SB, Tasic V, Nam HJ, Shril S, Hildebrandt F. Whole exome sequencing identifies FOXL2, FOXA2 and FOXA3 as candidate genes for monogenic congenital anomalies of the kidneys and urinary tract. Nephrol Dial Transplant. 2021 Sep 2:gfab253. \
  2. Zheng B, Wang C, Seltzsam S, Schneider S, Schierbaum L, Wu W, Dai R, Connaughton DM, Nakayama M, Mann N, Bauer SB, Awad HS, Eid LA, Tasic V, Shril S, Hildebrandt F. A truncating NRIP1 variant in an Arabic family with congenital anomalies of the kidneys and urinary tract. Am J Med Genet A. 2021 Sep 15.
  3. Kakadia J, Biggar K, Jain B, Chen AW, Nygard K, Li C, Nathanielsz PW, Jansson T, Gupta MB. Mechanisms linking hypoxia to phosphorylation of insulin-like growth factor binding protein-1 in baboon fetuses with intrauterine growth restriction and in cell culture. FASEB J. 2021 Sep;35(9):e21788.
  4. Ginsberg HN, Packard CJ, Chapman MJ, Borén J, Aguilar-Salinas CA, Averna M, Ference BA, Gaudet D, Hegele RA, Kersten S, Lewis GF, Lichtenstein AH, Moulin P, Nordestgaard BG, Remaley AT, Staels B, Stroes ESG, Taskinen MR, Tokgözoğlu LS, Tybjaerg-Hansen A, Stock JK, Catapano AL. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society. Eur Heart J. 2021 Sep 2:ehab551. 
  5. Berberich AJ, Ouédraogo AM, Shariff SZ, Hegele RA, Clemens KK. Incidence, predictors and patterns of care of patients with very severe hypertriglyceridemia in Ontario, Canada: a population-based cohort study. Lipids Health Dis. 2021 Sep 3;20(1):98.
  6. (includes Hegele RA) EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Lancet. 2021 Sep 7:S0140-6736(21)01122-3.
  7. Shimizu-Albergine M, Basu D, Kanter JE, Kramer F, Kothari V, Barnhart S, Thornock C, Mullick AE, Clouet-Foraison N, Vaisar T, Heinecke JW, Hegele RA, Goldberg IJ, Bornfeldt KE. CREBH normalizes dyslipidemia and halts atherosclerosis in diabetes by decreasing circulating remnant lipoproteins. J Clin Invest. 2021 Sep 7:153285.
  8. Heidari A, Hermann M, Hudson RHE. A simple fluorescent assay for the detection of peptide nucleic acid-directed double strand duplex invasion. Biopolymers. 2021 Sep 16:e23475.
  9. Aliyari E, Konermann L. Atomistic Insights into the Formation of Nonspecific Protein Complexes during Electrospray Ionization. Anal Chem. 2021 Sep 8.
  10. Maitland MER, Kuljanin M, Wang X, Lajoie GA, Schild-Poulter C. Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis. FASEB J. 2021 Sep;35(9):e21825. 
  11. Qin L, Cao X, Kaneko T, Voss C, Liu X, Wang G, Li SS. Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors. J Biol Chem. 2021 Sep 1:101161. 

Aug 2021

  1. Koschinsky ML, Boffa MB. Genetics to the Rescue: Sophisticated Approaches Provide Critical Insights Into the Determination of Lp(a) Levels. J Am Coll Cardiol. 2021 Aug 3;78(5):450-452.
  2. Kolvenbach CM, van der Ven AT, Kause F, Shril S, Scala M, Connaughton DM, Mann N, Nakayama M, Dai R, Kitzler TM, Schneider R, Schierbaum L, Schneider S, Accogli A, Torella A, Piatelli G, Nigro V, Capra V, Hoppe B, Märzheuser S, Schmiedeke E, Rehm HL, Mane S, Lifton RP, Dworschak GC, Hilger AC, Reutter H, Hildebrandt F. Exome survey of individuals affected by VATER/VACTERL with renal phenotypes identifies phenocopies and novel candidate genes. Am J Med Genet A. 2021 Aug 2. 
  3. Brunham LR, Hegele RA. What Is the Prevalence of Familial Hypercholesterolemia? Arterioscler Thromb Vasc Biol. 2021 Aug 26:ATVBAHA121316862.
  4. Paquette M, Bernard S, Cariou B, Hegele RA, Genest J, Trinder M, Brunham LR, Béliard S, Baass A. Familial Hypercholesterolemia-Risk-Score: A New Score Predicting Cardiovascular Events and Cardiovascular Mortality in Familial Hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2021 Aug 26:ATVBAHA121316106.
  5. Mitteaux J, Lejault P, Wojciechowski F, Joubert A, Boudon J, Desbois N, Gros CP, Hudson RHE, Boulé JB, Granzhan A, Monchaud D. Identifying G-Quadruplex-DNA-Disrupting Small Molecules. J Am Chem Soc. 2021 Aug 4.
  6. Miquel J, Huang TB, Athwal GS, Faber KJ, O'Gorman DB. Vancomycin is Effective in Preventing C. acnes Growth in a Shoulder Arthroplasty Mimetic. J Shoulder Elbow Surg. 2021 Aug 2:S1058-2746(21)00573-5.
  7. Yan X, Kumar K, Miclette Lamarche R, Youssef H, Shaw GS, Marcotte I, DeWolf CE, Warschawski DE, Boisselier E. Interactions between the Cell Membrane Repair Protein S100A10 and Phospholipid Monolayers and Bilayers. Langmuir. 2021 Aug 2. 
  8. Moussa DG, Siqueira WL. Bioinspired caries preventive strategy via customizable pellicles of saliva-derived protein/peptide constructs. Sci Rep. 2021 Aug 20;11(1):17007.

July 2021

  1. Maani N, Panabaker K, McCuaig JM, Buckley K, Semotiuk K, Farncombe KM, Ainsworth P, Panchal S, Sadikovic B, Armel SR, Lin H, Kim RH. Incidental findings from cancer next generation sequencing panels. NPJ Genom Med. 2021 Jul 19;6(1):63.
  2. Bhai P, Levy MA, Rooney K, Carere DA, Reilly J, Kerkhof J, Volodarsky M, Stuart A, Kadour M, Panabaker K, Schenkel LC, Lin H, Ainsworth P, Sadikovic B. Analysis of Sequence and Copy Number Variants in Canadian Patient Cohort With Familial Cancer Syndromes Using a Unique Next Generation Sequencing Based Approach. Front Genet. 2021 Jul 13;12:698595.
  3. Bourgeois R, Bourgault J, Despres AA, Perrot N, Guertin J, Girard A, Mitchell PL, Gotti C, Bourassa S, Scipione CA, Gaudreault N, Boffa MB, Koschinsky ML, Pibarot P, Droit A, Thériault S, Mathieu P, Bossé Y, Arsenault BJ. Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis. Metabolites. 2021 Jul 16;11(7):459. 
  4. Karunatilleke NC, Fast CS, Ngo V, Brickenden A, Duennwald ML, Konermann L, Choy WY. Nrf2, the Major Regulator of the Cellular Oxidative Stress Response, is Partially Disordered. Int J Mol Sci. 2021 Jul 11;22(14):7434.
  5. Chen AW, Biggar K, Nygard K, Singal S, Zhao T, Li C, Nathanielsz PW, Jansson T, Gupta MB. IGFBP-1 hyperphosphorylation in response to nutrient deprivation is mediated by activation of protein kinase Cα (PKCα). Mol Cell Endocrinol. 2021 Jul 24;536:111400.
  6. Lazarte J, Hegele RA. Volanesorsen for treatment of familial chylomicronemia syndrome. Expert Rev Cardiovasc Ther. 2021 Jul 15. 
  7. Lazarte J, Wang J, McIntyre AD, Hegele RA. Prevalence of severe hypertriglyceridemia and pancreatitis in familial partial lipodystrophy type 2. J Clin Lipidol. 2021 Jul 19:S1933-2874(21)00118-5.
  8. Chung CZ, Balasuriya N, Siddika T, Frederick MI, Heinemann IU. Gld2 activity and RNA specificity is dynamically regulated by phosphorylation and interaction with QKI-7. RNA Biol. 2021 Jul 21:1-12.
  9. O'Donoghue P, Heinemann IU, Fan C. Editorial: Synthetic Nucleic Acids for Expanding Genetic Codes and Probing Living Cells. Front Bioeng Biotechnol. 2021 Jul 2;9:720534.
    St-Denis NA, Derksen DR, Litchfield DW. Correction for St-Denis et al., "Evidence for Regulation of Mitotic Progression through Temporal Phosphorylation and Dephosphorylation of CK2α". Mol Cell Biol. 2021 Jul 23;41(8):e0027421.
  10. Gonga-Cavé BC, Pena Diaz AM, O'Gorman DB. Biomimetic analyses of interactions between macrophages and palmar fascia myofibroblasts derived from Dupuytren's disease reveal distinct inflammatory cytokine responses. Wound Repair Regen. 2021 Jul;29(4):627-636. 
  11. Huang TB, Pena Diaz AM, Faber KJ, Athwal GS, Woolman M, Nygard K, Keenliside L, O'Gorman DB. Development of a 3D Bioartificial Shoulder Joint Implant Mimetic of Periprosthetic Joint Infection. Tissue Eng Part A. 2021 Jul 26.
  12. Siqueira WL, Canales MP, Crosara KTB, Marin LM, Xiao Y. Proteome difference among the salivary proteins adsorbed onto metallic orthodontic brackets and hydroxyapatite discs. PLoS One. 2021 Jul 28;16(7):e0254909.
  13. Moraes G, Zambom C, Siqueira WL. Nanoparticles in Dentistry: A Comprehensive Review. Pharmaceuticals (Basel). 2021 Jul 30;14(8):752.

June 2021

  1. Aref-Eshghi E, Kerkhof J, Pedro VP, France GD, Barat-Houari M, Ruiz-Pallares N, Andrau JC, Lacombe D, Van-Gils J, Fergelot P, Dubourg C, Cormier-Daire V, Rondeau S, Lecoquierre F, Saugier-Veber P, Nicolas G, Lesca G, Chatron N, Sanlaville D, Vitobello A, Faivre L, Thauvin-Robinet C, Laumonnier F, Raynaud M, Alders M, Mannens M, Henneman P, Hennekam RC, Velasco G, Francastel C, Ulveling D, Ciolfi A, Pizzi S, Tartaglia M, Heide S, Héron D, Mignot C, Keren B, Whalen S, Afenjar A, Bienvenu T, Campeau PM, Rousseau J, Levy MA, Brick L, Kozenko M, Balci TB, Siu VM, Stuart A, Kadour M, Masters J, Takano K, Kleefstra T, de Leeuw N, Field M, Shaw M, Gecz J, Ainsworth PJ, Lin H, Rodenhiser DI, Friez MJ, Tedder M, Lee JA, DuPont BR, Stevenson RE, Skinner SA, Schwartz CE, Genevieve D, Sadikovic B. Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders. Am J Hum Genet. 2021 Jun 3;108(6):1161-1163.
  2. Voss C, Esmail S, Liu X, Knauer MJ, Ackloo S, Kaneko T, Lowes LE, Stogios PJ, Seitova A, Hutchinson A, Yusifov F, Skarina T, Evdokimova E, Loppnau P, Ghiabi P, Hajian T, Zhong S, Abdoh H, Hedley BD, Bhayana V, Martin CM, Slessarev M, Chin-Yee B, Fraser DD, Chin-Yee I, Li SS. Epitope-specific antibody responses differentiate COVID-19 outcome and variants of concern. JCI Insight. 2021 Jun 3:148855.
  3. Ikeda KM, House AA, Connaughton DM, Pautler SE, Siu VM, Jones ML. Potential Pitfalls in Pre-implantation Genetic Diagnosis in a Patient with Tuberous Sclerosis and Isolated Mosaicism for a TSC2 Variant in Renal Tissue. Mol Syndromol. 2021 Jun;12(3):154-158. 
  4. Lazarte J, Kanagalingam T, Hegele RA. Lipid effects of sodium-glucose cotransporter 2 inhibitors. Curr Opin Lipidol. 2021 Jun 1;32(3):183-190.
  5. Berberich AJ, Hegele RA. Lipid effects of glucagon-like peptide 1 receptor analogs. Curr Opin Lipidol. 2021 Jun 1;32(3):191-199.
  6. Awan ZA, Rashidi OM, Al-Shehri BA, Jamil K, Elango R, Al-Aama JY, Hegele RA, Banaganapalli B, Shaik NA. Saudi Familial Hypercholesterolemia Patients With Rare LDLR Stop Gain Variant Showed Variable Clinical Phenotype and Resistance to Multiple Drug Regimen. Front Med (Lausanne). 2021 Jun 25;8:694668. 
  7. Yin H, Arpino JM, Lee JJ, Pickering JG. Regenerated Microvascular Networks in Ischemic Skeletal Muscle. Front Physiol. 2021 Jun 11;12:662073. 
  8. Lambrughi M, Maiani E, Aykac Fas B, Shaw GS, Kragelund BB, Lindorff-Larsen K, Teilum K, Invernizzi G, Papaleo E. Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs. Front Mol Biosci. 2021 Jun 28;8:676235. 
  9. Saeed SG, Bain JL, Khoo E, Siqueira WL, van der Hoeven R. Should attendance for preclinical simulation and clinical education be mandatory? J Dent Educ. 2021 Jun 24. 
  10. Tolg C, Cowman M, Turley EA. Hyaluronan Isolation from Mouse Mammary Gland. Bio Protoc. 2018 Jun 5;8(11):e2865.

May 2021

  1. Chang CA, Perrier R, Kurek KC, Estrada-Veras J, Lehman A, Yip S, Hendson G, Diamond C, Pinchot JW, Tran JM, Arkin LM, Drolet BA, Napier MP, O'Neill SA, Balci TB, Keppler-Noreuil KM. Novel findings and expansion of phenotype in a mosaic RASopathy caused by somatic KRAS variants. Am J Med Genet A. 2021 May 30.
  2. Esmail S, Knauer MJ, Abdoh H, Voss C, Chin-Yee B, Stogios P, Seitova A, Hutchinson A, Yusifov F, Skarina T, Evdokimova E,  Ackloo S, Lowes L, Hedley BD, Bhayana V, Chin-Yee I, Li SSC. Rapid and accurate agglutination-based testing for SARS-CoV-2 antibodies. Cell Rep Met. 2021 May 12.
  3. Wilson CJ, Chang M, Karttunen M, Choy WY. KEAP1 Cancer Mutants: A Large-Scale Molecular Dynamics Study of Protein Stability. Int J Mol Sci. 2021 May 20;22(10):5408.
  4. Grieves LA, Gloor GB, Kelly TR, Bernards MA, MacDougall-Shackleton EA. Preen gland microbiota of songbirds differ across populations but not sexes. J Anim Ecol. 2021 May 18.
  5. Vlasschaert C, McIntyre AD, Thomson LA, Kennedy BA, Ratko S, Prasad C, Hegele RA. Abetalipoproteinemia Due to a Novel Splicing Variant in MTTP in 3 Siblings. J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211022484.
  6. Parajuli RP, Goodrich JM, Chan HM, Lemire M, Ayotte P, Hegele RA, Basu N. Variation in biomarker levels of metals, persistent organic pollutants, and omega-3 fatty acids in association with genetic polymorphisms among Inuit in Nunavik, Canada. Environ Res. 2021 May 29;200:111393.
  7. Dron JS, Hegele RA. Discussing polygenic risk with lipid clinic patients. Curr Opin Lipidol. 2021 May 28.
  8. Gill PK, Dron JS, Hegele RA. Genetics of hypertriglyceridemia and atherosclerosis. Curr Opin Cardiol. 2021 May 1;36(3):264-271.
  9. Burnett JR, Hooper AJ, Hegele RA. APOB-Related Familial Hypobetalipoproteinemia. 2021 May 13. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mirzaa G, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2021.
  10. Leclerc CJ, Cooper TT, Bell GI, Lajoie GA, Flynn LE, Hess DA. Decellularized adipose tissue scaffolds guide hematopoietic differentiation and stimulate vascular regeneration in a hindlimb ischemia model. Biomaterials. 2021 May 8;274:120867.
  11. Ha SD, Lewin N, Li SSC, Kim SO. HDAC8 Activates AKT through Upregulating PLCB1 and Suppressing DESC1 Expression in MEK1/2 Inhibition-Resistant Cells. Cells. 2021 May 4;10(5):1101.
  12. Postma JK, Altamirano-Diaz L, Rupar CA, Siu VM. Symptomatic mosaicism for a novel FBN1 splice site variant in a parent causing inherited neonatal Marfan syndrome. Am J Med Genet A. 2021 May 14.
  13. Caixeta DC, Oliveira SW, Cardoso-Sousa L, Cunha TM, Goulart LR, Martins MM, Marin LM, Jardim ACG, Siqueira WL, Sabino-Silva R. One-Year Update on Salivary Diagnostic of COVID-19. Front Public Health. 2021 May 21;9:589564.

Apr 2021

  1. Chowdhury F, Wang L, Al-Raqad M, Amor DJ, Baxová A, Bendová Š, Biamino E, Brusco A, Caluseriu O, Cox NJ, Froukh T, Gunay-Aygun M, Hančárová M, Haynes D, Heide S, Hoganson G, Kaname T, Keren B, Kosaki K, Kubota K, Lemons JM, Magriña MA, Mark PR, McDonald MT, Montgomery S, Morley GM, Ohnishi H, Okamoto N, Rodriguez-Buritica D, Rump P, Sedláček Z, Schatz K, Streff H, Uehara T, Walia JS, Wheeler PG, Wiesener A, Zweier C, Kawakami K, Wentzensen IM, Lalani SR, Siu VM, Bi W, Balci TB. Haploinsufficiency of PRR12 causes a spectrum of neurodevelopmental, eye, and multisystem abnormalities. Genet Med. 2021 Apr 6.
  2. Chang M, Wilson CJ, Karunatilleke NC, Moselhy MH, Karttunen M, Choy WY. Exploring the Conformational Landscape of the Neh4 and Neh5 Domains of Nrf2 Using Two Different Force Fields and Circular Dichroism. J Chem Theory Comput. 2021 Apr 16.
  3. Renaud JB, DesRochers N, Hoogstra S, Garnham CP, Sumarah MW. Structure Activity Relationship for Fumonisin Phytotoxicity. Chem Res Toxicol. 2021 Apr 23.
  4. Walker RH, Hegele RA, Danek A. Comment on "A New Allelic Variant in the PANK2 Gene in a Patient with Incomplete HARP Syndrome". J Mov Disord. 2021 Apr 6.
  5. Narayanan DL, Tuteja M, McIntyre AD, Hegele RA, Calmels N, Obringer C, Laugel V, Mandal K, Phadke SR. Clinical and Mutation Spectra of Cockayne Syndrome in India. Neurol India. 2021 Mar-Apr;69(2):362-366.
  6. Dilliott AA, Sunderland KM, McLaughlin PM, Roberts AC, Evans EC, Abrahao A, Binns MA, Black SE, Borrie M, Casaubon LK, Dowlatshahi D, Finger E, Fischer CE, Frank A, Freedman M, Grimes D, Hassan A, Jog M, Kumar S, Kwan D, Lang AE, Mandzia J, Marras C, Masellis M, McIntyre AD, Pasternak S, Pollock BG, Rajji TK, Robinson JF, Rogaeva E, Sahlas DJ, Saposnik G, Sato C, Seitz D, Shoesmith C, Steeves T, Strother SC, Swartz RH, Tan B, Tang-Wai D, Tartaglia MC, Troyer AK, Turnbull J, Zinman L; ONDRI Investigators, Hegele RA. Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses. Neurobiol Aging. 2021 Apr 24:S0197-4580(21)00126-3.
  7. Konermann L, Aliyari E, Lee JH. Mobile Protons Limit the Stability of Salt Bridges in the Gas Phase: Implications for the Structures of Electrosprayed Protein Ions. J Phys Chem B. 2021 Apr 13.
  8. Abbasi S, Parmar G, Kelly RD, Balasuriya N, Schild-Poulter C. The Ku complex: recent advances and emerging roles outside of non-homologous end-joining. Cell Mol Life Sci. 2021 Apr 15.
  9. Lacoursiere RE, Shaw GS. Acetylated Ubiquitin Modulates the Catalytic Activity of the E1 Enzyme Uba1. Biochemistry. 2021 Apr 13.
  10. Zhu Y, Marin LM, Xiao Y, Gillies ER, Siqueira WL. pH-Sensitive Chitosan Nanoparticles for Salivary Protein Delivery. Nanomaterials (Basel). 2021 Apr 17;11(4):1028.

Mar 2021

  1. Glodowski M, Christen S, Saxon DR, Hegele RA, Eckel RH. Novel PPARG mutation in multiple family members with chylomicronemia. J Clin Lipidol. 2021 Mar 26:S1933-2874(21)00057-X.
  2. Gouni-Berthold I, Alexander VJ, Yang Q, Hurh E, Steinhagen-Thiessen E, Moriarty PM, Hughes SG, Gaudet D, Hegele RA, O'Dea LSL, Stroes ESG, Tsimikas S, Witztum JL; COMPASS study group. Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol. 2021 Mar 30:S2213-8587(21)00046-2.
  3. Volkening K, Farhan SMK, Kao J, Leystra-Lantz C, Ang LC, McIntyre A, Wang J, Hegele RA, Strong MJ. Evidence of synergism among three genetic variants in a patient with LMNA-related lipodystrophy and amyotrophic lateral sclerosis leading to a remarkable nuclear phenotype. Mol Cell Biochem. 2021 Mar 4.
  4. Wand H, Lambert SA, Tamburro C, Iacocca MA, O'Sullivan JW, Sillari C, Kullo IJ, Rowley R, Dron JS, Brockman D, Venner E, McCarthy MI, Antoniou AC, Easton DF, Hegele RA, Khera AV, Chatterjee N, Kooperberg C, Edwards K, Vlessis K, Kinnear K, Danesh JN, Parkinson H, Ramos EM, Roberts MC, Ormond KE, Khoury MJ, Janssens ACJW, Goddard KAB, Kraft P, MacArthur JAL, Inouye M, Wojcik GL. Improving reporting standards for polygenic scores in risk prediction studies. Nature. 2021 Mar;591(7849):211-219.
  5. Lazarte J, Laksman ZW, Wang J, Robinson JF, Dron JS, Leach E, Liew J, McIntyre AD, Skanes AC, Gula LJ, Leong-Sit P, Cao H, Trost B, Scherer SW, Hegele RA, Roberts JD. Enrichment of loss-of-function and copy number variants in ventricular cardiomyopathy genes in 'lone' atrial fibrillation. Europace. 2021 Mar 3:euaa421.
  6. Pearson GJ, Thanassoulis G, Anderson TJ, Barry AR, Couture P, Dayan N, Francis GA, Genest J, Grégoire J, Grover SA, Gupta M, Hegele RA, Lau D, Leiter LA, Leung AA, Lonn E, Mancini GBJ, Manjoo P, McPherson R, Ngui D, Piché ME, Poirier P, Sievenpiper J, Stone J, Ward R, Wray W. 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult. Can J Cardiol. 2021 Mar 26:S0828-282X(21)00165-3.
  7. Buzon B, Grainger RA, Rzadki C, Huang SYM, Junop M. Identification of Bioactive SNM1A Inhibitors. ACS Omega. 2021 Mar 31;6(14):9352-9361.
  8. Pelletier JF, Sun L, Wise KS, Assad-Garcia N, Karas BJ, Deerinck TJ, Ellisman MH, Mershin A, Gershenfeld N, Chuang RY, Glass JI, Strychalski EA. Genetic requirements for cell division in a genomically minimal cell. Cell. 2021 Mar 26:S0092-8674(21)00293-2.
  9. Dieters-Castator D, Dantonio PM, Piaseczny M, Zhang G, Liu J, Kuljanin M, Sherman S, Jewer M, Quesnel K, Kang EY, Köbel M, Siegers GM, Leask A, Hess D, Lajoie G, Postovit LM. Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes. Neoplasia. 2021 Mar 27;23(4):375-390.
  10. Liu AD, Zhou J, Bi XY, Hou GQ, Li SS, Chen Q, Xu H, Cao X. Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma. Clin Transl Med. 2021 Mar;11(3):e337.
  11. Fraser DD, Cepinskas G, Slessarev M, Martin CM, Daley M, Patel MA, Miller MR, Patterson EK, O'Gorman DB, Gill SE, Oehler S, Miholits M, Webb B. Detection and Profiling of Human Coronavirus Immunoglobulins in Critically Ill Coronavirus Disease 2019 Patients. Crit Care Explor. 2021 Mar 12;3(3):e0369.
  12. Rogan PK, Mucaki EJ, Shirley BC, Li Y, Wilkins RC, Norton F, Sevriukova O, Pham N-D, Waller E, Knoll JHM. Automated Cytogenetic Biodosimetry at Population-Scale. Radiation. 2021; 1(2):79-94.
  13. Abbasi S, Schild-Poulter C. Identification of Ku70 Domain-Specific Interactors Using BioID2. Cells. 2021 Mar 14;10(3):646.
  14. Tokarew JM, El-Kodsi DN, Lengacher NA, Fehr TK, Nguyen AP, Shutinoski B, O'Nuallain B, Jin M, Khan JM, Ng ACH, Li J, Jiang Q, Zhang M, Wang L, Sengupta R, Barber KR, Tran A, Im DS, Callaghan S, Park DS, Zandee S, Dong X, Scherzer CR, Prat A, Tsai EC, Takanashi M, Hattori N, Chan JA, Zecca L, West AB, Holmgren A, Puente L, Shaw GS, Toth G, Woulfe JM, Taylor P, Tomlinson JJ, Schlossmacher MG. Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites. Acta Neuropathol. 2021 Mar 10.
  15. Gundogdu M, Tadayon R, Salzano G, Shaw GS, Walden H. A mechanistic review of Parkin activation. Biochim Biophys Acta Gen Subj. 2021 Mar 20;1865(6):129894.
  16. Pellissari CVG, Jorge JH, Marin LM, Sabino-Silva R, Siqueira WL. Statherin-derived peptides as antifungal strategy against Candida albicans. Arch Oral Biol. 2021 Mar 16;125:105106.
  17. Chen C, Laviolette SR, Whitehead SN, Renaud JB, Yeung KK. Imaging of Neurotransmitters and Small Molecules in Brain Tissues Using Laser Desorption/Ionization Mass Spectrometry Assisted with Zinc Oxide Nanoparticles. J Am Soc Mass Spectrom. 2021 Mar 30.

Feb 2021

  1. Sadikovic B, Levi MA, Kerkhof J, Aref-Eshghi E, Schenkel L, Stuart A, McConkey H, Henneman P, Venema A, Schwartz CE, Stevenson RE, Skinner SA, DuPont BR, Fletcher RS, Balci TB, Siu VM, Granadillo JL, Masters J, Kadour M, Friez MJ, van Haelst MM, Mannens MMAM, Louie RJ, Lee JA, Tedder ML, Alders M. Clinical epigenomics: genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders. Genet Med. 2021 Feb 5.
  2. Sadikovic B, Levy MA, Kerkhof J, Aref-Eshghi E, Schenkel L, Stuart A, McConkey H, Henneman P, Venema A, Schwartz CE, Stevenson RE, Skinner SA, DuPont BR, Fletcher RS, Balci TB, Siu VM, Granadillo JL, Masters J, Kadour M, Friez MJ, van Haelst MM, Mannens MMAM, Louie RJ, Lee JA, Tedder ML, Alders M. Correction: Clinical epigenomics: genome-wide DNA methylation analysis for the diagnosis of Mendelian disorders. Genet Med. 2021 Feb 26.
  3. Marcovina SM, Clouet-Foraison N, Koschinsky ML, Lowenthal MS, Orquillas A, Boffa MB, Hoofnagle AN, Vaisar T. Development of an LC-MS/MS Proposed Candidate Reference Method for the Standardization of Analytical Methods to Measure Lipoprotein(a). Clin Chem. 2021 Feb 1:hvaa324.
  4. Sun B, Yao J, Ni M, Wei J, Zhong X, Guo W, Zhang L, Wang R, Belke D, Chen YX, Lieve KVV, Broendberg AK, Roston TM, Blankoff I, Kammeraad JA, von Alvensleben JC, Lazarte J, Vallmitjana A, Bohne LJ, Rose RA, Benitez R, Hove-Madsen L, Napolitano C, Hegele RA, Fill M, Sanatani S, Wilde AAM, Roberts JD, Priori SG, Jensen HK, Chen SRW. Cardiac ryanodine receptor calcium release deficiency syndrome. Sci Transl Med. 2021 Feb 3;13(579):eaba7287.
  5. Dron JS, Wang M, Patel AP, Kartoun U, Ng K, Hegele RA, Khera AV. Genetic Predictor to Identify Individuals With High Lipoprotein(a) Concentrations. Circ Genom Precis Med. 2021 Feb 1:CIRCGEN120003182.
  6. Lazarte J, Dron JS, McIntyre AD, Skanes AC, Gula LJ, Tang AS, Tadros R, Laksman ZW, Hegele RA, Roberts JD. Role of Common Genetic Variation in Lone Atrial Fibrillation. Circ Genom Precis Med. 2021 Feb 1:CIRCGEN120003179.
  7. May SC, Dron JS, Hegele RA, Sahoo D. Human Variant of Scavenger Receptor BI (R174C) Exhibits Impaired Cholesterol Transport Functions. J Lipid Res. 2021 Feb 9:100045.
  8. Lazarte J, Hegele RA. Editorial comment: hazards of interpreting genetic reports. Curr Opin Lipidol. 2021 Feb 16.
  9. Lazarte J, Dron JS, McIntyre AD, Skanes AC, Gula LJ, Tang AS, Tadros R, Laksman ZW, Hegele RA, Roberts JD. Evaluating Polygenic Risk Scores in "Lone" Atrial Fibrillation. CJC Open. 2021 Feb 6;3(6):751-757.
  10. McKenna M, Balasuriya N, Zhong S, Li SS, O'Donoghue P. Phospho-Form Specific Substrates of Protein Kinase B (AKT1). Front Bioeng Biotechnol. 2021 Feb 3;8:619252.
  11. Khan A, Barber DL, Huang J, Rupar CA, Rip JW, Auray-Blais C, Boutin M, O'Hoski P, Gargulak K, McKillop WM, Fraser G, Wasim S, LeMoine K, Jelinski S, Chaudhry A, Prokopishyn N, Morel CF, Couban S, Duggan PR, Fowler DH, Keating A, West ML, Foley R, Medin JA. Lentivirus-mediated gene therapy for Fabry disease. Nat Commun. 2021 Feb 25;12(1):1178.
  12. Siqueira MF, Brothwell D, Heinrichs A, Siqueira WL. Rapid redesign and implementation of new pre-clinic and clinic scheduled model during COVID-19. J Dent Educ. 2021 Feb 26.
  13. Lima IFP, Matos FR, Bernardino ÍM, Santana ITS, Vieira WA, Blumenberg C, Siqueira WL, Paranhos LR. RANK, RANKL, and OPG in Dentigerous Cyst, Odontogenic Keratocyst, and Ameloblastoma: A Meta-Analysis. Braz Dent J. 2021 Jan-Feb;32(1):16-25.

Jan 2021

  1. Haghshenas S, Levy MA, Kerkhof J, Aref-Eshghi E, McConkey H, Balci T, Siu VM, Skinner CD, Stevenson RE, Sadikovic B, Schwartz C. Detection of a DNA Methylation Signature for the Intellectual Developmental Disorder, X-Linked, Syndromic, Armfield Type. Int J Mol Sci. 2021 Jan 23;22(3):1111.
  2. Nouri-Nejad D, O'Donnell BL, Patil CS, Sanchez-Pupo RE, Johnston D, Sayedyahossein S, Jurcic K, Lau R, Gyenis L, Litchfield DW, Jackson MF, Gloor GB, Penuela S. Pannexin 1 mutation found in melanoma tumour reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein. Mol Biol Cell. 2021 Jan 6:mbcE19100585.
  3. Tadros R, Francis C, Xu X, Vermeer AMC, Harper AR, Huurman R, Kelu Bisabu K, Walsh R, Hoorntje ET, Te Rijdt WP, Buchan RJ, van Velzen HG, van Slegtenhorst MA, Vermeulen JM, Offerhaus JA, Bai W, de Marvao A, Lahrouchi N, Beekman L, Karper JC, Veldink JH, Kayvanpour E, Pantazis A, Baksi AJ, Whiffin N, Mazzarotto F, Sloane G, Suzuki H, Schneider-Luftman D, Elliott P, Richard P, Ader F, Villard E, Lichtner P, Meitinger T, Tanck MWT, van Tintelen JP, Thain A, McCarty D, Hegele RA, Roberts JD, Amyot J, Dubé MP, Cadrin-Tourigny J, Giraldeau G, L'Allier PL, Garceau P, Tardif JC, Boekholdt SM, Lumbers RT, Asselbergs FW, Barton PJR, Cook SA, Prasad SK, O'Regan DP, van der Velden J, Verweij KJH, Talajic M, Lettre G, Pinto YM, Meder B, Charron P, de Boer RA, Christiaans I, Michels M, Wilde AAM, Watkins H, Matthews PM, Ware JS, Bezzina CR. Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect. Nat Genet. 2021 Jan 25.
  4. Hegele RA. Editorial comment: when Mendelian randomization goes astray. Curr Opin Lipidol. 2021 Jan 4.
  5. Cooper TT, Sherman SE, Bell GI, Dayarathna T, McRae DM, Ma J, Lagugné-Labarthet F, Pasternak SH, Lajoie G, Hess DA. Ultrafiltration and Injection of Islet Regenerative Stimuli Secreted by Pancreatic Mesenchymal Stromal Cells. Stem Cells Dev. 2021 Jan 6.
  6. Siddika T, Heinemann IU. Bringing MicroRNAs to Light: Methods for MicroRNA Quantification and Visualization in Live Cells. Front Bioeng Biotechnol. 2021 Jan 18;8:619583. 
  7. Wilson DP, Koschinsky ML, Moriarty PM. Expert position statements: comparison of recommendations for the care of adults and youth with elevated lipoprotein(a). Curr Opin Endocrinol Diabetes Obes. 2021 Jan 28.
  8. Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, Axtman AD. Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem Biol. 2021 Jan 11:S2451-9456(20)30522-5.
  9. Penner G, Lecocq S, Chopin A, Vedoya X, Lista S, Vergallo A, Cavedo E, Lejeune FX, Dubois B, Hampel H; INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI). Aptamarker prediction of brain amyloid-β status in cognitively normal individuals at risk for Alzheimer's disease. PLoS One. 2021 Jan 4;16(1):e0243902. 
  10. Wang Y, Tadayon R, Santamaria L, Mercier P, Forristal CJ, Shaw GS. Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner. Biochem J. 2021 Jan 15;478(1):197-215.
  11. Siqueira MF, Saeed SG, Siqueira WL. Using FacebookTM to increase student engagement. J Dent Educ. 2021 Jan 15.
  12. Rosa V, Ho D, Sabino-Silva R, Siqueira WL, Silikas N. Fighting viruses with materials science: Prospects for antivirus surfaces, drug delivery systems and artificial intelligence. Dent Mater. 2021 Jan 10:S0109-5641(20)30367-5. 
  13. Perampalam P, Hassan HM, Lilly GE, Passos DT, Torchia J, Kiser PK, Bozovic A, Kulasingam V, Dick FA. Disrupting the DREAM transcriptional repressor complex induces apolipoprotein overexpression and systemic amyloidosis in mice. J Clin Invest. 2021 Jan 14:140903.
  14. Walsh JP, DesRochers N, Renaud JB, Seifert KA, Yeung KK, Sumarah MW. Identification of N,N',N″-triacetylfusarinine C as a key metabolite for root rot disease virulence in American ginseng. J Ginseng Res. 2021 Jan;45(1):156-162.
  15. Pinsky W, Harris A, Roseborough AD, Wang W, Khan AR, Jurcic K, Yeung KK, Pasternak SH, Whitehead SN. Regional Lipid Expression Abnormalities Identified Using MALDI IMS Correspond to MRI-Defined White Matter Hyperintensities within Post-mortem Human Brain Tissues. Anal Chem. 2021 Jan 19.