Schulich school of Medicine and Dentistry logo Department of Biochemistry Schulich School of Medicine & Dentistry

Recent Publications

 

picture of Dr. Shawn Li

Jan 2017   Feb 2017   Mar 2017   Apr 2017   May 2017   June 2017

July 2017   Aug 2017   Sept 2017   Oct 2017   Nov 2017   Dec 2017

Jan 2018   Feb 2018   Mar 2018   Apr 2018


Apr 2018

  1. Berg MD, Genereaux J, Karagiannis J, Brandl CJ. The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes. G3 (Bethesda). 2018 Apr 6. pii:g3.200288.2018.
  2. Parajuli RP, Goodrich JM, Chan LHM, Ayotte P, Lemire M, Hegele RA, Basu N. Genetic polymorphisms are associated with exposure biomarkers for metals and persistent organic pollutants among Inuit from the Inuvialuit Settlement Region, Canada. Sci Total Environ. 2018 Apr 7;634:569-578.
  3. Diabetes Canada Clinical Practice Guidelines Expert Committee, Mancini GBJ, Hegele RA, Leiter LA. Dyslipidemia. Can J Diabetes. 2018 Apr;42 Suppl 1:S178-S185.
  4. Konermann L, Metwally H, McAllister RG, Popa V. How to Run Molecular Dynamics Simulations on Electrospray Droplets and Gas Phase Proteins: Basic Guidelines and Selected Applications. Methods. 2018 Apr 17. pii: S1046-2023(17)30464-4.
  5. Abdallah MN, Abughanam G, Tran SD, Sheikh Z, Mezour MA, Basiri T, Xiao Y, Cerruti M, Siqueira WL, Tamimi F. Comparative adsorption profiles of basal lamina proteome and gingival cells onto dental and titanium surfaces. Acta Biomater. 2018 Apr 13. pii: S1742-7061(18)30220-4.

Mar 2018

  1. Boffa MB, Koschinsky ML. The journey towards understanding lipoprotein(a) and cardiovascular disease risk: are we there yet? Curr Opin Lipidol. 2018 Mar 9.
  2. Wang LR, McIntyre AD, Hegele RA. Complex genetic architecture in severe hypobetalipoproteinemia. Lipids Health Dis. 2018 Mar 14;17(1):48.
  3. McQuaid JB, Kustka AB, Oborník M, Horák A, McCrow JP, Karas BJ, Zheng H, Kindeberg T, Andersson AJ, Barbeau KA, Allen AE. Carbonate-sensitive phytotransferrin controls high-affinity iron uptake in diatoms. Nature. 2018 Mar 14.
  4. Aguirre JD, Dunkerley KM, Lam R, Rusal M, Shaw GS. Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin. J Biol Chem. 2018 Mar 12. pii: jbc.RA117.000605.
  5. Tikhonova S, Booij L, D'Souza V, Crosara KTB, Siqueira WL, Emami E. Investigating the association between stress, saliva and dental caries: a scoping review. BMC Oral Health. 2018 Mar 13;18(1):41.
  6. Jarrett P, Easton A, Rockwood K, Dyack S, McCollum A, Siu V, Mirsattari SM, Massot-Tarrús A, Beis MJ, D'Souza N, Darvesh S. Evidence for Cholinergic Dysfunction in Autosomal Dominant Kufs Disease. Can J Neurol Sci. 2018 Mar;45(2):150-157.
  7. Caughlin S, Maheshwari S, Agca Y, Agca C, Harris AJ, Jurcic K, Yeung KK, Cechetto DF, Whitehead SN. Membrane-lipid homeostasis in a prodromal rat model of Alzheimer's disease: Characteristic profiles in ganglioside distributions during aging detected using MALDI imaging mass spectrometry. Biochim Biophys Acta. 2018 Mar 12. pii: S0304-4165(18)30073-4.
  8. Wang JSH, Freitas-Andrade M, Bechberger JF, Naus C, Yeung KK, Whitehead SN. MALDI IMS of Intraperitoneally Injected Danegaptide (ZP1609) for Treatment of Stroke-Reperfusion Injury in Mice. Rapid Commun Mass Spectrom. 2018 Mar 25.

Feb 2018

  1. Schenkel LC, Aref-Eshghi E, Skinner C, Ainsworth P, Lin H, Paré G, Rodenhiser DI, Schwartz C, Sadikovic B. Peripheral blood epi-signature of Claes-Jensen syndrome enables sensitive and specific identification of patients and healthy carriers with pathogenic mutations in KDM5C. Clin Epigenetics. 2018 Feb 14;10:21.
  2. Boffa MB, Koschinsky ML. Therapeutic Lowering of Lipoprotein(a): A Role for Pharmacogenetics? Circ Genom Precis Med. 2018 Feb;11(2):e002052.
  3. Ishak CA, Cecchini MJ, Howlett CJ, Dick FA. Immunohistochemical Detection of the Retinoblastoma Protein. Methods Mol Biol. 2018;1726:65-75.
  4. Egozcue JJ, Pawlowsky-Glahn V, Gloor GB. Linear Association in Compositional Data Analysis. Austrian J Stats. 2018 Feb;47:3.
  5. Chassen SS, Ferchaud-Roucher V, Gupta MB, Jansson T, Powell TL. Alterations in Placental Long Chain Polyunsaturated Fatty Acid Metabolism in Human Intrauterine Growth Restriction. Clin Sci (Lond). 2018 Feb 20. pii: CS20171340.
  6. Linke AC, Wild C, Zubiaurre-Elorza L, Herzmann C, Duffy H, Han VK, Lee DSC, Cusack R. Disruption to functional networks in neonates with perinatal brain injury predicts motor skills at 8 months. Neuroimage Clin. 2018 Feb 3;18:399-406.
  7. Berberich AJ, Hegele RA. Secondary causes of chylomicronemia: defining the underside of the iceberg. J Intern Med. 2018 Feb 2.
  8. Berberich AJ, Ho R, Hegele RA. Whole genome sequencing in the clinic: empowerment or too much information? CMAJ. 2018 Feb 5;190(5):E124-E125.
  9. Yanagi M, Suzuki A, Hudson RHE, Saito Y. A fluorescent 3,7-bis-(naphthalen-1-ylethynylated)-2'-deoxyadenosine analogue reports thymidine in complementary DNA by a large emission Stokes shift. Org Biomol Chem. 2018 Feb 8.
  10. Burke AC, Telford DE, Sutherland BG, Edwards JY, Sawyez CG, Barrett PHR, Newton RS, Pickering JG, Huff MW. Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR(+/-) and LDLR(-/-) ) Yucatan Miniature Pigs. Arterioscler Thromb Vasc Biol. 2018 Feb 15. pii: ATVBAHA.117.310676.
  11. Leighton TL, Mok MC, Junop MS, Howell PL, Burrows LL. Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function. Sci Rep. 2018 Feb 8;8(1):2600.
  12. Metwally H, Konermann L. Crown Ethers Modulate the Location of Charge Carriers in Electrospray Droplets: Implications for the Mechanism of Protein Charging and Supercharging. Anal Chem. 2018 Feb 28.
  13. Yin H, Pickering JG. Aortic smooth muscle cells and myocardial infarction: Does the ascending aorta feel a heart attack? Atherosclerosis. 2018 Feb 10. pii: S0021-9150(18)30080-7.
  14. Zhao JZL, Mucaki EJ and Rogan PK. Predicting ionizing radiation exposure using biochemically-inspired genomic machine learning [version 1; referees: awaiting peer review]. F1000Research 2018, 7:233.
  15. Brady L, Sadikovic B, Rupar CA, Tarnopolsky MA. Complete elimination of a pathogenic homoplasmic mtDNA mutation in one generation. Mitochondrion. 2018 Feb 1. pii: S1567-7249(17)30328-8.
  16. Huang B, Siqueira W, Cvitkovitch DG, Finer Y. Esterase from a Cariogenic Bacterium Hydrolyzes Dental Resins. Acta Biomater. 2018 Feb 26. pii: S1742-7061(18)30091-6.
  17. Valente MT, Moffa EB, Crosara KTB, Xiao Y, de Oliveira TM, Machado MAAM, Siqueira WL. Acquired Enamel Pellicle Engineered Peptides: Effects on Hydroxyapatite Crystal Growth. Sci Rep. 2018 Feb 28;8(1):3766.
  18. Zarate YA, Smith-Hicks CL, Greene C, Abbott MA, Siu VM, Calhoun ARUL, Pandya A, Li C, Sellars EA, Kaylor J, Bosanko K, Kalsner L, Basinger A, Slavotinek AM, Perry H, Saenz M, Szybowska M, Wilson LC, Kumar A, Brain C, Balasubramanian M, Dubbs H, Ortiz-Gonzalez XR, Zackai E, Stein Q, Powell CM, Schrier Vergano S, Britt A, Sun A, Smith W, Bebin EM, Picker J, Kirby A, Pinz H, Bombei H, Mahida S, Cohen JS, Fatemi A, Vernon HJ, McClellan R, Fleming LR, Knyszek B, Steinraths M,  Velasco Gonzalez C, Beck AE, Golden-Grant KL, Egense A, Parikh A, Raimondi C, Angle B, Allen W, Schott S, Algrabli A, Robin NH, Ray JW, Everman DB, Gambello MJ, Chung WK. Natural history and genotype-phenotype correlations in 72 individuals with SATB2-associated syndrome. Am J Med Genet A. 2018 Feb 13.
  19. Wang JS, Whitehead SN, Yeung KK. Detection of Amyloid Beta (Aβ) Oligomeric Composition Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS). J Am Soc Mass Spectrom. 2018 Feb 20.

Jan 2018

  1. Aref-Eshghi E, Rodenhiser DI, Schenkel LC, Lin H, Skinner C, Ainsworth P, Paré G, Hood RL, Bulman DE, Kernohan KD; Care4Rare Canada Consortium, Boycott KM, Campeau PM, Schwartz C, Sadikovic B. Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes. Am J Hum Genet. 2018 Jan 4;102(1):156-174.
  2. Mohamed HT, El-Husseiny N, El-Ghonaimy EA, Ibrahim SA, Bazzi ZA, Cavallo-Medved D, Boffa MB, El-Shinawi M, Mohamed MM. IL-10 correlates with the expression of carboxypeptidase B2 and lymphovascular invasion in inflammatory breast cancer: The potential role of tumor infiltrated macrophages. Curr Probl Cancer. 2018 Jan 10. pii: S0147-0272(17)30120-4.
  3. Slattery SS, Diamond A, Wang H, Therrien JA, Lant JT, Jazey T, Lee K, Klassen Z, Desgagné-Penix I, Karas BJ, Edgell DR. An expanded plasmid-based genetic toolbox enables Cas9 genome editing and stable maintenance of synthetic pathways in Phaeodactylum tricornutum. ACS Synth Biol. 2018 Jan 3.
  4. Kaiser JC, King AN, Grigg JC, Sheldon JR, Edgell DR, Murphy MEP, Brinsmade SR, Heinrichs DE. Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide. PLoS Genet. 2018 Jan 22;14(1):e1007159.
  5. Zubiaurre-Elorza L, Linke AC, Herzmann C, Wild CJ, Duffy H, Lee DSC, Han VK, Cusack R. Auditory structural connectivity in preterm and healthy term infants during the first postnatal year. Dev Psychobiol. 2018 Jan 22.
  6. Aboalola D, Han VKM. Different Effects of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-2 on Myogenic Differentiation of Human Mesenchymal Stem Cells. Stem Cells Int. 2017;2017:8286248.
  7. Iacocca MA, Hegele RA. Role of DNA copy number variation in dyslipidemias. Curr Opin Lipidol. 2018 Jan 4.
  8. Clemens KK, Shariff SZ, McArthur E, Hegele RA. Ezetimibe prescriptions in older Canadian adults after an acute myocardial infarction: a population-based cohort study. Lipids Health Dis. 2018 Jan 8;17(1):8.
  9. Dron JS, Hegele RA. Polygenic influences on dyslipidemias. Curr Opin Lipidol. 2018 Jan 2.
  10. Hegele RA. Learning From Patients With Ultrarare Conditions: Cholesterol Hoof Beats. J Am Coll Cardiol. 2018 Jan 23;71(3):289-291.
  11. Paquette M, Hegele RA, Paré G, Baass A. A novel mutation in GPIHBP1 causes familial chylomicronemia syndrome. J Clin Lipidol. 2018 Jan 31. pii: S1933-2874(18)30031-X.
  12. Snir JA, Suchy M, Bindseil GA, Kovacs M, Chronik BA, Hudson RHE, Pasternak SH, Bartha R. An Aspartyl Cathepsin Targeted PET Agent: Application in an Alzheimer's Disease Mouse Model. J Alzheimers Dis. 2018;61(3):1241-1252.
  13. Morrow NM, Huff MW. Knockdown of Δ-5 Fatty Acid Desaturase Is More Than Just a Fad. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):6-8.
  14. Burke AC, Huff MW. Regression of atherosclerosis: lessons learned from genetically modified mouse models. Curr Opin Lipidol. 2018 Jan 24.
  15. Tsimikas S, Fazio S, Ferdinand KC, Ginsberg HN, Koschinsky ML, Marcovina SM, Moriarty PM, Rader DJ, Remaley AT, Reyes-Soffer G, Santos RD, Thanassoulis G, Witztum JL, Danthi S, Olive M, Liu L. NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis. J Am Coll Cardiol. 2018 Jan 16;71(2):177-192.
  16. Cooper TT, Sherman SE, Kuljanin M, Bell GI, Lajoie GA, Hess DA. Inhibition Of Aldehyde Dehydrogenase-Activity Expands Multipotent Myeloid Progenitor Cells With Vascular Regenerative Function. Stem Cells. 2018 Jan 27.
  17. Lecocq S, Spinella K, Dubois B, Lista S, Hampel H, Penner G. Aptamers as biomarkers for neurological disorders. Proof of concept in transgenic mice. PLoS One. 2018 Jan 5;13(1):e0190212.
  18. O'Connor K, Jukes T, Goobie S, DiRaimo J, Moran G, Potter BK, Chakraborty P, Rupar CA, Gannavarapu S, Prasad C. Psychosocial impact on mothers receiving expanded newborn screening results. Eur J Hum Genet. 2018 Jan 29.
  19. Datar R, Prasad AN, Tay KY, Rupar CA, Ohorodnyk P, Miller M, Prasad C. Magnetic resonance imaging in the diagnosis of white matter signal abnormalities. Neuroradiol J. 2018 Jan 1:1971400918764016.
  20. Crosara KTB, Zuanazzi D, Moffa EB, Xiao Y, Machado MAAM, Siqueira WL. Revealing the Amylase Interactome in Whole Saliva Using Proteomic Approaches. Biomed Res Int. 2018 Jan 31;2018:6346954.
  21. Kolendowski B, Hassan H, Krstic M, Isovic M, Thillainadesan G, Chambers AF, Tuck AB, Torchia J. Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization. Epigenetics Chromatin. 2018 Jan 29;11(1):5. 
  22. Hauser-Kawaguchi A, Luyt LG, Turley E. Design of peptide mimetics to block pro-inflammatory functions of HA fragments. Matrix Biol. 2018 Jan 30. pii: S0945-053X(17)30444-4.

Dec 2017

  1. Scipione CA, Koschinsky ML, Boffa MB. Lipoprotein(a) in clinical practice: New perspectives from basic and translational science. Crit Rev Clin Lab Sci. 2017 Dec 20:1-22.
  2. Defesche JC, Gidding SS, Harada-Shiba M, Hegele RA, Santos RD, Wierzbicki AS. Familial hypercholesterolaemia. Nat Rev Dis Primers. 2017 Dec 7;3:17093.
  3. McLean CC, Teft WA, Morse BL, Gryn SE, Hegele RA, Kim RB. Food Effect on Rosuvastatin Disposition and Low-Density Lipoprotein Cholesterol. Clin Pharmacol Ther. 2017 Dec 8.
  4. Hussain I, Patni N, Ueda M, Sorkina E, Valerio CM, Cochran E, Brown RJ, Peeden J, Tikhonovich Y, Tiulpakov A, Stender SRS, Klouda E, Tayeh MK, Innis J, Meyer A, Lal P, Godoy-Matos AF, Teles MG, Adams-Huet B, Rader DJ, Hegele RA, Oral EA, Garg A. A Novel Generalized Lipodystrophy-associated Progeroid Syndrome due to recurrent heterozygous LMNA p.T10I Mutation. J Clin Endocrinol Metab. 2017 Dec 15.
  5. Berberich AJ, Hegele RA. Nutraceuticals in 2017: Nutraceuticals in endocrine disorders. Nat Rev Endocrinol. 2017 Dec 22.
  6. Stahel P, Xiao C, Hegele RA, Lewis GF. The Atherogenic Dyslipidemia Complex and Novel Approaches to Cardiovascular Disease Prevention in Diabetes. Can J Cardiol. 2017 Dec 15. pii: S0828-282X(17)31216-3.
  7. Biggar KK, Wang Z, Li SS. SnapShot: Lysine Methylation beyond Histones. Mol Cell. 2017 Dec 7;68(5):1016-1016.e1.
  8. Zhu J, Zhou Q, Shang Y, Li H, Peng M, Ke X, Weng Z, Zhang R, Huang X, Li SSC, Feng G, Lu Y, Zhang M. Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs. Cell Rep. 2017 Dec 26;21(13):3781-3793.
  9. Dos Santos ES, Caputo SM, Castera L, Gendrot M, Briaux A, Breault M, Krieger S, Rogan PK, Mucaki EJ, Burke LJ; ENIGMA consortium, Bièche I, Houdayer C, Vaur D, Stoppa-Lyonnet D, Brown MA, Lallemand F, Rouleau E. Assessment of the functional impact of germline BRCA1/2 variants located in non-coding regions in families with breast and/or ovarian cancer predisposition. Breast Cancer Res Treat. 2017 Dec 13.
  10. El Shatoury MG, DeYoung L, Turley E, Yazdani A, Dave S. Early experimental results of using a novel delivery carrier, hyaluronan-phosphatidylethanolamine (HA-PE), which may allow simple bladder instillation of botulinum toxin A as effectively as direct detrusor muscle injection. J Pediatr Urol. 2017 Dec 30. pii: S1477-5131(17)30496-5.

Nov 2017

  1. Iwase S, Bérubé NG, Zhou Z, Kasri NN, Battaglioli E, Scandaglia M, Barco A. Epigenetic Etiology of Intellectual Disability. J Neurosci. 2017 Nov 8;37(45):10773-10782.
  2. Paquet M, Cerasuolo JO, Thorburn V, Fridman S, Alsubaie R, Lopes RD, Cipriano LE, Salamone P, Melling CWJ, Khan AR, Sedeño L, Fang J, Drangova M, Montero-Odasso M, Mandzia J, Khaw AV, Racosta JM, Paturel J, Samoilov L, Stirling D, Balint B, Jaremek V, Koschinsky ML, Boffa MB, Summers K, Ibañez A, Mrkobrada M, Saposnik G, Kimpinski K, Whitehead SN, Sposato LA. Pathophysiology and Risk of Atrial Fibrillation Detected after Ischemic Stroke (PARADISE): A Translational, Integrated, and Transdisciplinary Approach. J Stroke Cerebrovasc Dis. 2017 Nov 13. pii: S1052-3057(17)30522-0.
  3. Guha TK, Edgell DR. Applications of Alternative Nucleases in the Age of CRISPR/Cas9. Int J Mol Sci. 2017 Nov 29;18(12). pii: E2565.
  4. Gloor GB, Macklaim JM, Pawlowsky-Glahn V, Egozcue JJ. Microbiome Datasets Are Compositional: And This Is Not Optional. Front Microbiol. 2017 Nov 15;8:2224.
  5. Al KF, Bisanz JE, Gloor GB, Reid G, Burton JP. Evaluation of sampling and storage procedures on preserving the community structure of stool microbiota: A simple at-home toilet-paper collection method. J Microbiol Methods. 2017 Nov 16. pii: S0167-7012(17)30308-1.
  6. Aboalola D, Han VKM. Insulin-Like Growth Factor Binding Protein-6 Alters Skeletal Muscle Differentiation of Human Mesenchymal Stem Cells. Stem Cells Int. 2017;2017:2348485.
  7. Youssef A, Han VKM. Regulation of Osteogenic Differentiation of Placental-Derived Mesenchymal Stem Cells by Insulin-Like Growth Factors and Low Oxygen Tension. Stem Cells Int. 2017;2017:4576327.
  8. Ellis MJ, Carfrae LA, Macnair CR, Trussler RS, Brown ED, Haniford DB. Silent but deadly: IS200 promotes pathogenicity in Salmonella Typhimurium. RNA Biol. 2017 Nov 9:0.
  9. O'Donoghue P, Heinemann IU. Biochemistry of Synthetic Biology - Recent Developments. Biochim Biophys Acta. 2017 Nov;1861(11 Pt B):2945-2947.
  10. Fast CS, Vahidi S, Konermann L. Changes in Enzyme Structural Dynamics Studied by Hydrogen Exchange-Mass Spectrometry: Ligand Binding Effects or Catalytically Relevant Motions? Anal Chem. 2017 Nov 18.
  11. Kravic B, Harbauer AB, Romanello V, Simeone L, Vögtle FN, Kaiser T, Straubinger M, Huraskin D, Böttcher M, Cerqua C, Martin ED, Poveda-Huertes D, Buttgereit A, Rabalski AJ, Heuss D, Rudolf R, Friedrich O, Litchfield D, Marber M, Salviati L, Mougiakakos D, Neuhuber W, Sandri M, Meisinger C, Hashemolhosseini S. In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Autophagy. 2017 Nov 22:1-65.
  12. Albatany M, Li A, Meakin S, Bartha R. Dichloroacetate induced intracellular acidification in glioblastoma: in vivo detection using AACID-CEST MRI at 9.4 Tesla. J Neurooncol. 2017 Nov 16.
  13. Wright D, Altaany Z, Bi Y, Alperstein Z, O'Donoghue P. Acetylation regulates thioredoxin reductase oligomerization and activity. Antioxid Redox Signal. 2017 Nov 8.
  14. Lüscher B, Bütepage M, Eckei L, Krieg S, Verheugd P, Shilton BH. ADP-Ribosylation, a Multifaceted Posttranslational Modification Involved in the Control of Cell Physiology in Health and Disease. Chem Rev. 2017 Nov 27.
  15. Reijnders MRF, Janowski R, Alvi M, Self JE, van Essen TJ, Vreeburg M, Rouhl RPW, Stevens SJC, Stegmann APA, Schieving J, Pfundt R, van Dijk K, Smeets E, Stumpel CTRM, Bok LA, Cobben JM, Engelen M, Mansour S, Whiteford M, Chandler KE, Douzgou S, Cooper NS, Tan EC, Foo R, Lai AHM, Rankin J, Green A, Lönnqvist T, Isohanni P, Williams S, Ruhoy I, Carvalho KS, Dowling JJ, Lev DL, Sterbova K, Lassuthova P, Neupauerová J, Waugh JL, Keros S, Clayton-Smith J, Smithson SF, Brunner HG, van Hoeckel C, Anderson M, Clowes VE, Siu VM, Ddd Study T, Selber P, Leventer RJ, Nellaker C, Niessing D, Hunt D, Baralle D. PURA syndrome: clinical delineation and genotype-phenotype study in 32 individuals with review of published literature. J Med Genet. 2017 Nov 2. pii: jmedgenet-2017-104946.
  16. Ibrahim H, Jurcic K, Wang JS, Whitehead SN, Yeung KK. 1,6-Diphenyl-1,3,5-hexatriene (DPH) as a Novel Matrix for MALDI MS Imaging of Fatty Acids, Phospholipids and Sulfatides in Brain Tissues. Anal Chem. 2017 Nov 2.
  17. Caughlin S, Maheshwari S, Weishaupt N, Yeung KK, Cechetto DF, Whitehead SN. Age-dependent and regional heterogeneity in the long-chain base of A-series gangliosides observed in the rat brain using MALDI Imaging. Sci Rep. 2017 Nov 23;7(1):16135.

Oct 2017

  1. Singal SS, Nygard K, Dhruv MR, Biggar K, Shehab MA, Shun-Cheng Li S, Jansson T, Gupta MB. Co-Localization of IGFBP-1, Protein Kinase CSNK-2ß, and mTOR in HepG2 Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay. Am J Pathol. 2017 Oct 13. pii: S0002-9440(17)30532-1.
  2. Dron JS, Ho R, Hegele RA. Recent Advances in the Genetics of Atherothrombotic Disease and Its Determinants. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):e158-e166.
  3. Ruel I, Aljenedil S, Sadri I, de Varennes É, Hegele RA, Couture P, Bergeron J, Wanneh E, Baass A, Dufour R, Gaudet D, Brisson D, Brunham LR, Francis GA, Cermakova L, Brophy JM, Ryomoto A, Mancini GBJ, Genest J. Imputation of Baseline LDL Cholesterol Concentration in Patients with Familial Hypercholesterolemia on Statins or Ezetimibe. Clin Chem. 2017 Oct 16. pii: clinchem.2017.279422.
  4. Farhan SMK, Gendron TF, Petrucelli L, Hegele RA, Strong MJ. OPTN p.Met468Arg and ATXN2 intermediate length polyQ extension in families with C9orf72 mediated amyotrophic lateral sclerosis and frontotemporal dementia. Am J Med Genet B Neuropsychiatr Genet. 2017 Oct 28.
  5. Brinton EA, Hopkins PN, Hegele RA, Geller AS, Polisecki EY, Diffenderfer MR, Schaefer EJ. The association between hypercholesterolemia and sitosterolemia, and report of a sitosterolemia kindred. J Clin Lipidol. 2017 Oct 27. pii: S1933-2874(17)30473-7.
  6. Yin V, Shaw GS, Konermann L. Cytochrome c as a Peroxidase: Activation of the Pre-Catalytic Native State by H2O2-Induced Covalent Modifications. J Am Chem Soc. 2017 Oct 19.
  7. Yockey O, Jha V, Ghodke PP, Xu T, Xu W, Ling H, Pradeepkumar PI, Zhao L. Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase k. Chem Res Toxicol. 2017 Oct 3.
  8. Hannouf MB, Winquist E, Mahmud SM, Brackstone M, Sarma S, Rodrigues G, Rogan PK, Hoch JS, Zaric GS. The clinical significance of occult gynecologic primary tumours in metastatic cancer. Curr Oncol. 2017 Oct;24(5):e368-e378.

Sept 2017

  1. Aref-Eshghi E, Schenkel LC, Lin H, Skinner C, Ainsworth P, Paré G, Rodenhiser D, Schwartz C, Sadikovic B. The defining DNA methylation signature of Kabuki syndrome enables functional assessment of genetic variants of unknown clinical significance. Epigenetics. 2017 Sep 21:0.
  2. Ellis KL, Boffa MB, Sahebkar A, Koschinsky ML, Watts GF. The renaissance of lipoprotein(a): Brave new world for preventive cardiology? Prog Lipid Res. 2017 Sep 6. pii: S0163-7827(17)30041-3.
  3. Lant JT, Berg MD, Sze DH, Hoffman KS, Akinpelu IC, Turk M, Heinemann IU, Duennwald ML, Brandl CJ, O'Donoghue P. Visualizing tRNA-dependent mistranslation in human cells. RNA Biol. 2017 Sep 21:0.
  4. Bian G, Gloor GB, Gong A, Jia C, Zhang W, Hu J, Zhang H, Zhang Y, Zhou Z, Zhang J, Burton JP, Reid G, Xiao Y, Zeng Q, Yang K, Li J. The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young. mSphere. 2017 Sep 27;2(5). pii: e00327-17.
  5. Ao M, Chavez MB, Chu EY, Hemstreet KC, Yin Y, Yadav MC, Millán JL, Fisher LW, Goldberg HA, Somerman MJ, Foster BL. Overlapping functions of bone sialoprotein and pyrophosphate regulators in directing cementogenesis. Bone. 2017 Sep 1;105:134-147.
  6. Hegele RA. CETP Inhibitors - A New Inning? N Engl J Med. 2017 Sep 28;377(13):1284-1285.
  7. Iacocca MA, Wang J, Dron JS, Robinson JF, McIntyre AD, Cao H, Hegele RA. Use of next-generation sequencing to detect LDLR gene copy number variation in familial hypercholesterolemia. J Lipid Res. 2017 Sep 5. pii: jlr.D079301.
  8. Dron JS, Wang J, Low-Kam C, Khetarpal SA, Robinson JF, McIntyre AD, Ban MR, Cao H, Rhainds D, Dubé MP, Rader DJ, Lettre G, Tardif JC, Hegele RA. Polygenic determinants in extremes of high-density lipoprotein cholesterol. J Lipid Res. 2017 Sep 4. pii: jlr.M079822.
  9. Sundaram M, Curtis KR, Amir Alipour M, LeBlond ND, Margison KD, Yaworski RA, Parks RJ, McIntyre AD, Hegele RA, Fullerton MD, Yao Z. The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation. J Lipid Res. 2017 Sep 8. pii: jlr.M077313.
  10. Farhan SMK, Gendron TF, Petrucelli L, Hegele RA, Strong MJ. ARHGEF28p.Lys280Metfs40Ter in an amyotrophic lateral sclerosis family with a C9orf72 expansion. Neurol Genet. 2017 Sep 22;3(5):e190.
  11. Jayawardena DP, Heinemann IU, Stillman MJ. Zinc binds non-cooperatively to human liver metallothionein 2a at physiological pH. Biochem Biophys Res Commun. 2017 Sep 1. pii: S0006-291X(17)31722-9.
  12. Desai R, Kim K, Chen HCBAW, Bi Y, Mann MR, Turk MA, Chung CZ, Heinemann IU. Minimal requirements for reverse polymerization and tRNA repair by tRNA(His) guanylyltransferase. RNA Biol. 2017 Sep 13:0.
  13. Suzuki A, Yanagi M, Takeda T, Hudson RHE, Saito Y. The fluorescently responsive 3-(naphthalen-1-ylethynyl)-3-deaza-2'-deoxyguanosine discriminates cytidine via the DNA minor groove. Org Biomol Chem. 2017 Sep 7.
  14. Münzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Stegner D, Aurbach K, Semeniak D, Chatterjee M, Gonzalez Menendez I, Märklin M, Quintanilla-Martinez L, Salih HR, Litchfield DW, Buchou T, Kleinschnitz C, Lang F, Nieswandt B, Pleines I, Schulze H, Gawaz M, Borst O. CK2β critically regulates thrombopoiesis and Ca(2+)-triggered platelet activation in arterial thrombosis in vivo. Blood. 2017 Sep 19. pii: blood-2017-05-784413.
  15. Shirley B, Li Y, Knoll JHM, Rogan PK. Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation. J Vis Exp. 2017 Sep 4;(127).
  16. Hannouf MB, Winquist E, Mahmud SM, Brackstone M, Sarma S, Rodrigues G, Rogan PK, Hoch JS, Zaric GS. The Potential Clinical and Economic Value of Primary Tumour Identification in Metastatic Cancer of Unknown Primary Tumour: A Population-Based Retrospective Matched Cohort Study. PharmacoEconomics Open. 2017.
  17. Khalili Yazdi A, Namjoshi S, Hackett J, Ghonaim N, Shilton BH. Characterization of a Polypeptide Binding Site in the DEAD Motor of the SecA ATPase. FEBS Lett. 2017 Sep 1.
  18. Yazdi AK, Vezina GC, Shilton BH. An alternate mode of oligomerization for E. coli SecA. Sci Rep. 2017 Sep 18;7(1):11747.
  19. Zuanazzi D, Arts EJ, Jorge PK, Mulyar Y, Gibson R, Xiao Y, Bringel Dos Santos M, Machado MAAM, Siqueira WL. Postnatal Identification of Zika Virus Peptides from Saliva. J Dent Res. 2017 Sep;96(10):1078-1084.

Aug 2017

  1. Kerkhof J, Schenkel LC, Reilly J, McRobbie S, Aref-Eshghi E, Stuart A, Rupar CA, Adams P, Hegele RA, Lin H, Rodenhiser D, Knoll J, Ainsworth PJ, Sadikovic B. Clinical Validation of Copy Number Variant Detection from Targeted Next-Generation Sequencing Panels. J Mol Diagn. 2017 Aug 14. pii: S1525-1578(17)30207-6.
  2. Aref-Eshghi E, Schenkel LC, Lin H, Skinner C, Ainsworth P, Paré G, Siu V, Rodenhiser D, Schwartz C, Sadikovic B. Clinical Validation of a Genome-Wide DNA Methylation Assay for Molecular Diagnosis of Imprinting Disorders. J Mol Diagn. 2017 Aug 11. pii: S1525-1578(17)30263-5.
  3. Tong JG, Valdes YR, Sivapragasam M, Barrett JW, Bell JC, Stojdl D, DiMattia GE, Shepherd TG. Spatial and temporal epithelial ovarian cancer cell heterogeneity impacts Maraba virus oncolytic potential. BMC Cancer. 2017 Aug 30;17(1):594.
  4. Rosenson RS, Brewer HB Jr, Barter PJ, Björkegren JLM, Chapman MJ, Gaudet D, Kim DS, Niesor E, Rye KA, Sacks FM, Tardif JC, Hegele RA. HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology. Nat Rev Cardiol. 2017 Aug 10.
  5. Farhan SMK, Nixon KCJ, Everest M, Edwards TN, Long S, Segal D, Knip MJ, Arts HH, Chakrabarti R, Wang J, Robinson JF, Lee D, Mirsattari SM, Rupar CA, Siu VM; FORGE Canada Consortium, Poulter MO, Hegele RA, Kramer JM. Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy. Hum Mol Genet. 2017 Aug 16.
  6. Konermann L. Molecular Dynamics Simulations on Gas Phase Proteins with Mobile Protons: Inclusion of All-Atom Charge Solvation. J Phys Chem B. 2017 Aug 4.
  7. Mathieu P, Arsenault BJ, Boulanger MC, Bossé Y, Koschinsky ML. Pathobiology of Lp(a) in calcific aortic valve disease. Expert Rev Cardiovasc Ther. 2017 Aug 17.
  8. Kuljanin M, Brown CFC, Raleigh MJ, Lajoie GA, Flynn LE. Collagenase treatment enhances proteomic coverage of low-abundance proteins in decellularized matrix bioscaffolds. Biomaterials. 2017 Aug 13;144:130-143.
  9. Velker BAM, Denomme MM, Krafty RT, Mann MRW. Maintenance of Mest imprinted methylation in blastocyst-stage mouse embryos is less stable than other imprinted loci following superovulation or embryo culture. Environ Epigenet. 2017 Aug
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  10. Liu J, Li Y, Wilkins R, Flegal F, Knoll JHM, Rogan PK. Accurate cytogenetic biodosimetry through automated dicentric chromosome curation and metaphase cell selection. F1000Res. 2017 Aug 9;6:1396.
  11. Crosara KTB, Moffa EB, Xiao Y, Siqueira WL. Merging in-silico and in vitro salivary protein complex partners using the STRING database: A tutorial. J Proteomics. 2017 Aug 3. pii: S1874-3919(17)30266-X.
  12. Goh E, Guerin A, Lazier J, Goobie S, Nelson TN, Agatep R, Siu VM, Niederhoffer KY, Richer J. Choosing Wisely Canada: The Canadian College of Medical Geneticists' (CCMG) list of five items physicians and patients should question. J Med Genet. 2017 Aug 19. pii: jmedgenet-2017-104924.
  13. Gameiro SF, Kolendowski B, Zhang A, Barrett JW, Nichols AC, Torchia J, Mymryk JS. Human papillomavirus dysregulates the cellular apparatus controlling the methylation status of H3K27 in different human cancers to consistently alter gene expression regardless of tissue of origin. Oncotarget. 2017 Aug 3;8(42):72564-72576.

July 2017

  1. Romagnuolo R, Scipione CA, Marcovina SM, Gemin M, Seidah NG, Boffa MB, Koschinsky ML. Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9. PLoS One. 2017 Jul 27;12(7):e0180869.
  2. Ishak CA, Coschi CH, Roes MV, Dick FA. Disruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitment. Cell Cycle. 2017 Jul 19:0.
  3. Herzmann C, Zubiaurre-Elorza L, Wild CJ, Linke AC, Han VK, Lee DSC, Cusack R. Using Functional Magnetic Resonance Imaging to Detect Preserved Function in a Preterm Infant with Brain Injury. J Pediatr. 2017 Jul 20. pii: S0022-3476(17)30913-7.
  4. Blom DJ, Averna MR, Meagher EA, du Toit Theron H, Sirtori CR, Hegele RA, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Larrey D, Bloedon LT, Foulds P, Rader DJ, Cuchel M. Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia. Circulation. 2017 Jul 18;136(3):332-335.
  5. Dron JS, Hegele RA. Genetics of Triglycerides and the Risk of Atherosclerosis. Curr Atheroscler Rep. 2017 Jul;19(7):31.
  6. Stahel P, Xiao C, Hegele RA, Lewis GF. Polygenic Risk for Hypertriglyceridemia Can Mimic a Major Monogenic Mutation. Ann Intern Med. 2017 Jul 25.
  7. Diner RE, Noddings CM, Lian NC, Kang AK, McQuaid JB, Jablanovic J, Espinoza JL, Nguyen NA, Anzelmatti MA Jr, Jansson J, Bielinski VA, Karas BJ, Dupont CL, Allen AE, Weyman PD. Diatom centromeres suggest a mechanism for nuclear DNA acquisition. Proc Natl Acad Sci U S A. 2017 Jul 3. pii: 201700764.
  8. Konermann L. Addressing a Common Misconception: Ammonium Acetate as Neutral pH "Buffer" for Native Electrospray Mass Spectrometry. J Am Soc Mass Spectrom. 2017 Jul 14.
  9. Xiao Y, Shaw GS, Konermann L. Calcium-Mediated Control of S100 Proteins: Allosteric Communication via an Agitator/Signal Blocking Mechanism. J Am Chem Soc. 2017 Jul 31.
  10. Kuljanin M, Bell GI, Sherman SE, Lajoie GA, Hess DA. Proteomic characterisation reveals active Wnt-signalling by human multipotent stromal cells as a key regulator of beta cell survival and proliferation. Diabetologia. 2017 Jul 14.
  11. George S, Wang SM, Bi Y, Treidlinger M, Barber KR, Shaw GS, O'Donoghue P. Ubiquitin phosphorylated at Ser57 hyper-activates parkin. Biochim Biophys Acta. 2017 Jul 6. pii: S0304-4165(17)30213-1.
  12. Salemi LM, Maitland MER, Yefet ER, Schild-Poulter C. Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex. BMC Cancer. 2017 Jul;17:460.

June 2017

  1. Scipione CA, McAiney JT, Simard DJ, Bazzi ZA, Gemin M, Romagnuolo R, Macrae FL, Ariëns RA, Hegele RA, Auld J, Gauld JW, Boffa MB, Koschinsky ML. Characterization of the I4399M variant of apolipoprotein(a): Implications for altered prothrombotic properties of lipoprotein(a). J Thromb Haemost. 2017 Jun 20.
  2. Berg MD, Hoffman KS, Genereaux J, Mian S, Trussler RS, Haniford DB, O'Donoghue P, Brandl CJ. Evolving Mistranslating tRNAs Through a Phenotypically Ambivalent Intermediate in Saccharomyces cerevisiae. Genetics. 2017 Jun 2. pii: genetics.117.203232.
  3. Wild CJ, Linke AC, Zubiaurre-Elorza L, Herzmann C, Duffy H, Han VK, Lee DSC, Cusack R. Adult-like processing of naturalistic sounds in auditory cortex by 3-and 9-month old infants. Neuroimage. 2017 Jun 22. pii: S1053-8119(17)30506-2.
  4. Berberich AJ, Hegele RA. Lomitapide for the treatment of hypercholesterolemia. Expert Opin Pharmacother. 2017 Jun 9.
  5. Montero-Odasso M, Pieruccini-Faria F, Bartha R, Black SE, Finger E, Freedman M, Greenberg B, Grimes DA, Hegele RA, Hudson C, Kleinstiver PW, Lang AE, Masellis M, McLaughlin PM, Munoz DP, Strother S, Swartz RH, Symons S, Tartaglia MC, Zinman L, Strong MJ; ONDRI Investigators, McIlroy W. Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI). J Alzheimers Dis. 2017 Jun 27.
  6. Karamichalis R, Kari L. MoDMaps3D: An interactive webtool for the quantification and 3D visualization of interrelationships in a dataset of DNA sequences. Bioinformatics. 2017 Jun 10.
  7. McClatchie T, Meredith M, Ouédraogo MO, Slow S, Lever M, Mann MRW, Zeisel SH, Trasler JM, Baltz JM. Betaine is accumulated via transient choline dehydrogenase activation during Mouse oocyte meiotic maturation. J Biol Chem. 2017 Jun 29. pii: jbc.M117.803080.
  8. Athwal GS, Faber KJ, O'Gorman DB. Response to: Can 16S rRNA PCR be the solution for a rapid detection of Propionibacterium acnes in surgical shoulder or spine samples? Comments on "A rapid method for detecting Propionibacterium acnes in surgical biopsy specimens from the shoulder". J Shoulder Elbow Surg. 2017 Jun;26(6):e205.
  9. Yang XR, Devi BCR, Sung H, Guida J, Mucaki EJ, Xiao Y, Best A, Garland L, Xie Y, Hu N, Rodriguez-Herrera M, Wang C, Jones K, Luo W, Hicks B, Tang TS, Moitra K, Rogan PK, Dean M. Prevalence and spectrum of germline rare variants in BRCA1/2 and PALB2 among breast cancer cases in Sarawak, Malaysia. Breast Cancer Res Treat. 2017 Jun 29.
  10. Abbott JA, Guth E, Kim C, Regan C, Siu VM, Rupar CA, Demeler B, Francklyn CS, Robey-Bond SM. The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity. Biochemistry. 2017 Jun 20.
  11. Salemi LM, Maitland MER, McTavish CJ, Schild-Poulter C. Cell signalling pathway regulation by RanBPM: molecular insights and disease implications. Open Biol. 2017 Jun;7(6). pii: 170081.
  12. Dunkerley KM, Shaw GS. RBR Ubiquitin Transfer: Not Simply an "Open" and "Closed" Case? Structure. 2017 Jun 6;25(6):817-819.
  13. Renaud JB, Kelman MJ, McMullin DR, Yeung KK, Sumarah MW. Application of C8 liquid chromatography-tandem mass spectrometry for the analysis of enniatins and bassianolides. J Chromatogr A. 2017 Jun 3. pii: S0021-9673(17)30832-4.

May 2017

  1. Lackie RE, Maciejewski A, Ostapchenko VG, Marques-Lopes J, Choy WY, Duennwald ML, Prado VF, Prado MAM. The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases. Front Neurosci. 2017 May 16;11:254.
  2. Leung AA, Daskalopoulou SS, Dasgupta K, McBrien K, Butalia S, Zarnke KB, Nerenberg K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Tobe SW, Ruzicka M, Burns KD, Vallée M, Prasad GVR, Gryn SE, Feldman RD, Selby P, Pipe A, Schiffrin EL, McFarlane PA, Oh P, Hegele RA, Khara M, Wilson TW, Penner SB, Burgess E, Sivapalan P, Herman RJ, Bacon SL, Rabkin SW, Gilbert RE, Campbell TS, Grover S, Honos G, Lindsay P, Hill MD, Coutts SB, Gubitz G, Campbell NRC, Moe GW, Howlett JG, Boulanger JM, Prebtani A, Kline G, Leiter LA, Jones C, Côté AM, Woo V, Kaczorowski J, Trudeau L, Tsuyuki RT, Hiremath S, Drouin D, Lavoie KL, Hamet P, Grégoire JC, Lewanczuk R, Dresser GK, Sharma M, Reid D, Lear SA, Moullec G, Gupta M, Magee LA, Logan AG, Dionne J, Fournier A, Benoit G, Feber J, Poirier L, Padwal RS, Rabi DM; Hypertension Canada. Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults. Can J Cardiol. 2017 May;33(5):557-576.
  3. Hegele RA. Insulin affordability. Lancet Diabetes Endocrinol. 2017 May;5(5):324.
  4. Hegele RA. PCSK9 inhibitors: smooth sailing or a little turbulence ahead? Lancet Diabetes Endocrinol. 2017 May 5. pii: S2213-8587(17)30150-X.
  5. Iacocca MA, Hegele RA. Recent advances in genetic testing for familial hypercholesterolemia. Expert Rev Mol Diagn. 2017 May 19.
  6. Liu Y, Conlon DM, Bi X, Slovik KJ, Shi J, Edelstein HI, Millar JS, Javaheri A, Cuchel M, Pashos EE, Iqbal J, Hussain MM, Hegele RA, Yang W, Duncan SA, Rader DJ, Morrisey EE. Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress. Cell Rep. 2017 May 16;19(7):1456-1466.
  7. Hooper AJ, McCormick SPA, Hegele RA, Burnett JR. Clinical utility gene card for: Tangier disease. Eur J Hum Genet. 2017 May 24.
  8. Jackson C, Geraghty MT, Hegele RA, El Demellawy D, Jimenez-Rivera C. Fatty liver in a non-obese patient. Paediatr Child Health. 2017 May;22(2):59-60. 
  9. Chung CZ, Seidl LE, Mann MR, Heinemann IU. Tipping the balance of RNA stability by 3' editing of the transcriptome. Biochim Biophys Acta. 2017 May 5. pii: S0304-4165(17)30147-2.
  10. Nsaibia MJ, Boulanger MC, Bouchareb R, Mkannez G, Le Quang K, Hadji F, Argaud D, Dahou A, Bossé Y, Koschinsky ML, Pibarot P, Arsenault BJ, Marette A, Mathieu P. OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA-NF-κB pathway. Cardiovasc Res. 2017 May 4.
  11. Sun W, Liu Y, Lajoie G, Ma B, Zhang K. An Improved Approach for N-linked Glycan Structure Identification from HCD MS/MS Spectra. IEEE/ACM Trans Comput Biol Bioinform. 2017 May 5.
  12. Thandapani P, Couturier AM, Yu Z, Li X, Couture JF, Li S, Masson JY, Richard S. Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress. Oncotarget. 2017 May 22.
  13. Okumu DO, East MP, Levine M, Herring LE, Zhang R, Gilbert TSK, Litchfield DW, Zhang Y, Graves LM. BIRC6 mediates imatinib resistance independently of Mcl-1. PLoS One. 2017 May 16;12(5):e0177871.
  14. Huang J, Khan A, Au BC, Barber DL, López-Vásquez L, Prokopishyn NL, Boutin M, Rothe M, Rip JW, Abaoui M, Nagree MS, Dworski S, Schambach A, Keating A, West ML, Klassen J, Turner PV, Sirrs S, Rupar CA, Auray-Blais C, Foley R, Medin JA. Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease. Mol Ther Methods Clin Dev. 2017 May 12;5:241-258.
  15. Mucaki EJ, Baranova K, Pham HQ, Rezaeian I, Angelov D, Ngom A, Rueda L, Rogan PK. Predicting Outcomes of Hormone and Chemotherapy in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) Study by Biochemically-inspired Machine Learning [version 3; referees: 2 approved]. F1000Research 2017, 5:2124.
  16. Basiri T, Johnson ND, Moffa EB, Mulyar Y, Serra Nunes PL, Machado MAAM, Siqueira WL. Duplicated or Hybridized Peptide Functional Domains Promote Oral Homeostasis. J Dent Res. 2017 May 1:22034517708552.
  17. Hassan HM, Kolendowski B, Isovic M, Bose K, Dranse HJ, Sampaio AV, Underhill TM, Torchia J. Regulation of Active DNA Demethylation through RAR-Mediated Recruitment of a TET/TDG Complex. Cell Rep. 2017 May 23;19(8):1685-1697. 

Apr 2017

  1. Maciejewski A, Prado VF, Prado MA, Choy WY. Molecular basis for the interaction between stress-inducible phosphoprotein 1 (STIP1) and S100A1. Biochem J. 2017 Apr 13. pii: BCJ20161055.
  2. Abu Shehab M, Biggar K, Singal SS, Nygard K, Shun-Cheng Li S, Jansson T, Gupta MB. Exposure of decidualized HIESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity. Mol Cell Endocrinol. 2017 Apr 20. pii: S0303-7207(17)30218-6.
  3. Lo M, Zubiaurre-Elorza L, Wild C, Linke AC, Lee DSC, Han VK, Cusack R. Brainstem shape is affected by clinical course in the neonatal intensive care unit. Neuroimage Clin. 2017 Apr 12;15:62-70.
  4. Hegele RA. Editorial introduction. Curr Opin Lipidol. 2017 Apr;28(2):v.
  5. Xiao C, Hegele RA, Lewis GF. Treatment of Severe Hypercholesterolemia in a Woman With Advanced Primary Sclerosing Cholangitis. JAMA Cardiol. 2017 Apr 5.
  6. Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, Hegele RA, Krauss RM, Raal FJ, Schunkert H, Watts GF, Borén J, Fazio S, Horton JD, Masana L, Nicholls SJ, Nordestgaard BG, van de Sluis B, Taskinen MR, Tokgözoglu L, Landmesser U, Laufs U, Wiklund O, Stock JK, Chapman MJ, Catapano AL. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2017 Apr 24.
  7. Liu Y, Ma B, Zhang K, Lajoie G. An Approach for Peptide Identification by De Novo Sequencing of Mixture Spectra. IEEE/ACM Trans Comput Biol Bioinform. 2017 Mar-Apr;14(2):326-336.
  8. Elkerton JS, Xu Y, Pickering JG, Ward AD. Differentiation of arterioles from venules in mouse histology images using machine learning. J Med Imaging (Bellingham). 2017 Apr;4(2):021104.
  9. Kumar A, Chaugule VK, Condos TEC, Barber KR, Johnson C, Toth R, Sundaramoorthy R, Knebel A, Shaw GS, Walden H. Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity. Nat Struct Mol Biol. 2017 Apr 17.
  10. Klank RL, Decker Grunke SA, Bangasser BL, Forster CL, Price MA, Odde TJ, SantaCruz KS, Rosenfeld SS, Canoll P, Turley EA, McCarthy JB, Ohlfest JR, Odde DJ. Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level. Cell Rep. 2017 Apr 18;19(3):668. 

Mar 2017

  1. Schenkel LC, Rodenhiser D, Siu V, McCready E, Ainsworth P, Sadikovic B. Constitutional Epi/Genetic Conditions: Genetic, Epigenetic, and Environmental Factors. J Pediatr Genet. 2017 Mar;6(1):30-41.
  2. Schenkel LC, Kernohan KD, McBride A, Reina D, Hodge A, Ainsworth PJ, Rodenhiser DI, Pare G, Bérubé NG, Skinner C, Boycott KM, Schwartz C, Sadikovic B. Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome. Epigenetics Chromatin. 2017 Mar 10;10:10.
  3. Thwaites MJ, Cecchini MJ, Talluri S, Passos DT, Carnevale J, Dick FA. Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control. Cell Div. 2017 Mar 14;12:3.
  4. Celis JS, Edgell DR, Stelbrink B, Wibberg D, Hauffe T, Blom J, Kalinowski J, Wilke T. Evolutionary and biogeographical implications of degraded LAGLIDADG endonuclease functionality and group I intron occurrence in stony corals (Scleractinia) and mushroom corals (Corallimorpharia). PLoS One. 2017 Mar 9;12(3):e0173734.
  5. Youssef A, Aboalola D, Han VK. The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche. Stem Cells Int. 2017;2017:9453108.
  6. Filler G, Lee M, Hegele RA. Barriers to the Implementation of Lipoprotein Apheresis in Canada. Can J Cardiol. 2017 Mar;33(3):409-411.
  7. Dron JS, Hegele RA. Genetics of Lipid and Lipoprotein Disorders and Traits. Curr Genet Med Rep. 2016;4(3):130-141.
  8. Mandacaru SC, do Vale LH, Vahidi S, Xiao Y, Skinner OS, Ricart CA, Kelleher NL, de Sousa MV, Konermann L. Characterizing the Structure and Oligomerization of Major Royal Jelly Protein 1 (MRJP1) by Mass Spectrometry and Complementary Biophysical Tools. Biochemistry. 2017 Mar 7.
  9. Sherman SE, Kuljanin M, Cooper TT, Putman DM, Lajoie GA, Hess DA. High Aldehyde Dehydrogenase Activity Identifies a Subset of Human Mesenchymal Stromal Cells with Vascular Regenerative Potential. Stem Cells. 2017 Mar 15.
  10. Nuñez de Villavicencio-Diaz T, Rabalski AJ, Litchfield DW. Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks. Pharmaceuticals (Basel). 2017 Mar 5;10(1). pii: E27.
  11. Watson A, Nong Z, Yin H, O'Neil C, Fox S, Balint B, Guo R, Leo O, Chu MW, Gros R, Pickering JG. Nicotinamide Phosphoribosyltransferase in Smooth Muscle Cells Maintains Genome Integrity, Resists Aortic Medial Degeneration and Is Suppressed in Human Thoracic Aortic Aneurysm Disease. Circ Res. 2017 Mar 29. pii: CIRCRESAHA.116.310022.
  12. Hannouf MB, Winquist E, Mahmud SM, Brackstone M, Sarma S, Rodrigues G, Rogan PK, Hoch JS, Zaric GS. The Clinical Significance of Occult Gastrointestinal Primary Tumours in Metastatic Cancer: A Population Retrospective Cohort Study. Cancer Res Treat. 2017 Mar 21.
  13. Abdallah MN, Tran SD, Abughanam G, Laurenti M, Zuanazzi D, Mezour MA, Xiao Y, Cerruti M, Siqueira WL, Tamimi F. Biomaterial surface proteomic signature determines interaction with epithelial cells. Acta Biomater. 2017 Mar 1. pii: S1742-7061(17)30159-9.
  14. Terças AL, Marques SG, Moffa EB, Alves MB, de Azevedo CM, Siqueira WL, Monteiro CA. Antifungal Drug Susceptibility of Candida Species Isolated from HIV-Positive Patients Recruited at a Public Hospital in São Luís, Maranhão, Brazil. Front Microbiol. 2017 Mar 2;8:298.
  15. Caughlin S, Park DH, Yeung KK, Cechetto DF, Whitehead SN. Sublimation of DAN Matrix for the Detection and Visualization of Gangliosides in Rat Brain Tissue for MALDI Imaging Mass Spectrometry. J Vis Exp. 2017 Mar 23;(121).

Feb 2017

  1. Ellis MJ, Trussler RS, Charles O, Haniford DB. A transposon-derived small RNA regulates gene expression in Salmonella Typhimurium. Nucleic Acids Res. 2017 Feb 21.
  2. Dron JS, Hegele RA. Complexity of mechanisms among human proprotein convertase subtilisin-kexin type 9 variants. Curr Opin Lipidol. 2017 Feb 2.
  3. Ueda M, Dunbar RL, Wolska A, Sikora TU, Escobar MD, Seliktar N, deGoma E, DerOhannessian S, Morrell L, McIntyre AD, Burke F, Sviridov D, Amar M, Shamburek RD, Freeman L, Hegele RA, Remaley AT, Rader DJ. A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency with Severe Triglyceridemia and Pancreatitis. J Clin Endocrinol Metab. 2017 Feb 13.
  4. Aljenedil S, Hegele RA, Genest J, Awan Z. Estrogen-associated severe hypertriglyceridemia with pancreatitis. J Clin Lipidol. 2017 Jan - Feb;11(1):297-300.
  5. Rosenson RS, Najera SD, Hegele RA. Heterozygous familial hypercholesterolemia presenting as chylomicronemia syndrome. J Clin Lipidol. 2017 Jan - Feb;11(1):294-296.
  6. Samsoondar JP, Burke AC, Sutherland BG, Telford DE, Sawyez CG, Edwards JY, Pinkosky SL, Newton RS, Huff MW. Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr-/- Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid. Arterioscler Thromb Vasc Biol. 2017 Feb 2. pii: ATVBAHA.116.308963.
  7. Deng Z, Dong M, Wang Y, Dong J, Li SS, Zou H, Ye M. Biphasic Affinity Chromatographic Approach for Deep Tyrosine Phosphoproteome Analysis. Anal Chem. 2017 Feb 21;89(4):2405-2410.
  8. Tse WH, Gyenis L, Litchfield DW, Zhang J. Cellular interaction influenced by surface modification strategies of gelatin-based nanoparticles. J Biomater Appl. 2017 Feb;31(7):1087-1096.
  9. Wills MK, Keyvani Chahi A, Lau HR, Tilak M, Guild B, New LA, Lu P, Jacquet K, Meakin SO, Bisson N, Jones N. Signalling Adaptor ShcD Suppresses Erk Phosphorylation Distal to the Ret and Trk Neurotrophic Receptors. J Biol Chem. 2017 Feb 17. pii: jbc.M116.770511.
  10. Szabo PA, Goswami A, Mazzuca DM, Kim K, O'Gorman DB, Hess DA, Welch ID, Young HA, Singh B, McCormick JK, Haeryfar SM. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017 Feb 20. pii: 1601366.
  11. Arpino JM, Nong Z, Li F, Yin H, Ghonaim NW, Milkovich S, Balint B, O'Neil C, Fraser GM, Goldman D, Ellis CG, Pickering JG. 4D Microvascular Analysis Reveals that Regenerative Angiogenesis in Ischemic Muscle Produces a Flawed Microcirculation. Circ Res. 2017 Feb 7. pii: CIRCRESAHA.116.310535.
  12. Xu Y, Pickering JG, Nong Z, Ward AD. Segmentation of digitized histological sections for quantification of the muscularized vasculature in the mouse hind limb. J Microsc. 2017 Feb 20.
  13. Balci TB, Hartley T, Xi Y, Dyment DA, Beaulieu CL, Bernier FP, Dupuis L, Horvath G, Mendoza-Londono R, Prasad C, Richer J, Yang XR, Armour CM, Bareke E, Fernandez BA, McMillan HJ, Lamont R, Majewski J, Parboosingh J, Narayan Prasad A, Rupar T, Schwartzentruber J, Smith AC, Tétreault M, Micheil Innes A, Boycott KM. Debunking Occam's razor: Diagnosing multiple genetic diseases in families by whole exome sequencing. Clin Genet. 2017 Feb 7.
  14. Bahrami SB, Tolg C, Peart T, Symonette C, Veiseh M, Umoh JU, Holdsworth DW, McCarthy JB, Luyt LG, Bissell MJ, Yazdani A, Turley EA. Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis. Integr Biol (Camb). 2017 Feb 20.
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Jan 2017

  1. McGee J, Panabaker K, Leonard S, Ainsworth P, Elit L, Shariff SZ. Genetics Consultation Rates Following a Diagnosis of High-Grade Serous Ovarian Carcinoma in the Canadian Province of Ontario. Int J Gynecol Cancer. 2017 Jan 9.
  2. Tamming RJ, Siu JR, Jiang Y, Prado MA, Beier F, Bérubé NG. Mosaic expression of Atrx in the central nervous system causes memory deficits. Dis Model Mech. 2017 Jan 12. pii: dmm.027482.
  3. Bazzi ZA, Balun J, Cavallo-Medved D, Porter LA, Boffa MB. Activated thrombin-activatable fibrinolysis inhibitor attenuates the angiogenic potential of endothelial cells: potential relevance to the breast tumour microenvironment. Clin Exp Metastasis. 2017 Jan 25.
  4. Hoffman KS, O'Donoghue P, Brandl CJ. Mistranslation: from adaptations to applications. Biochim Biophys Acta. 2017 Jan 30. pii: S0304-4165(17)30039-9.
  5. Ettinger G, Burton JP, Gloor GB, Reid G. Lactobacillus rhamnosus GR-1 Attenuates Induction of Hypertrophy in Cardiomyocytes but Not through Secreted Protein MSP-1 (p75). PLoS One. 2017 Jan 13;12(1):e0168622.
  6. Al K, Sarr O, Dunlop K, Gloor GB, Reid G, Burton J, Regnault TR. Impact of birth weight and postnatal diet on the gut microbiota of young adult guinea pigs. PeerJ. 2017 Jan 3;5:e2840.
  7. Badalato L, Farhan SM, Dilliott AA; Care4Rare Canada Consortium., Bulman DE, Hegele RA, Goobie SL. KMT2D p.Gln3575His segregating in a family with autosomal dominant choanal atresia strengthens the Kabuki/CHARGE connection. Am J Med Genet A. 2017 Jan;173(1):183-189.
  8. Hunter PM, Hegele RA. Functional foods and dietary supplements for the management of dyslipidaemia. Nat Rev Endocrinol. 2017 Jan 30.
  9. Burke AC, Huff MW. ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia. Curr Opin Lipidol. 2017 Jan 5.
  10. Li SS, Li L. SH2 Ligand Prediction-Guidance for In-Silico Screening. Methods Mol Biol. 2017;1555:77-81.
  11. Huang H, Kaneko T, Sidhu SS, Li SS. Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain. Methods Mol Biol. 2017;1555:225-254.
  12. Liu H, Voss C, Li SS. Using Reciprocal Protein-Peptide Array Screening to Unravel Protein Interaction Networks. Methods Mol Biol. 2017;1555:429-436.
  13. Campbell PT, Rebbeck TR, Nishihara R, Beck AH, Begg CB, Bogdanov AA, Cao Y, Coleman HG, Freeman GJ, Heng YJ, Huttenhower C, Irizarry RA, Kip NS, Michor F, Nevo D, Peters U, Phipps AI, Poole EM, Qian ZR, Quackenbush J, Robins H, Rogan PK, Slattery ML, Smith-Warner SA, Song M, VanderWeele TJ, Xia D, Zabor EC, Zhang X, Wang M, Ogino S. Proceedings of the third international molecular pathological epidemiology (MPE) meeting. Cancer Causes Control. 2017 Jan 17.
  14. Klank RL, Decker Grunke SA, Bangasser BL, Forster CL, Price MA, Odde TJ, SantaCruz KS, Rosenfeld SS, Canoll P, Turley EA, McCarthy JB, Ohlfest JR, Odde DJ. Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level. Cell Rep. 2017 Jan 3;18(1):23-31.