Recent Publications

 picture of Dr. Shawn Li

Jan 2018   Feb 2018   Mar 2018   Apr 2018   May 2018  June 2018   

July 2018   Aug 2018   Sept 2018   Oct 2018   Nov 2018

Nov 2018

  1. Macklaim JM, Gloor GB. From RNA-seq to Biological Inference: Using Compositional Data Analysis in Meta-Transcriptomics. Methods Mol Biol. 2018;1849:193-213.
  2. Iacocca MA, Chora JR, Carrié A, Freiberger T, Leigh SE, Defesche JC, Kurtz CL, DiStefano MT, Santos RD, Humphries SE, Mata P, Jannes CE, Hooper AJ, Wilemon KA, Benlian P, O'Connor R, Garcia J, Wand H, Tichy L, Sijbrands EJ, Hegele RA, Bourbon M, Knowles JW; ClinGen FH Variant Curation Expert Panel. ClinVar database of global familial hypercholesterolemia-associated DNA variants. Hum Mutat. 2018 Nov;39(11):1631-1640.
  3. Dron JS, Lazarte J, Hegele RA. Recent Highlights of ATVB. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):e185-e197.

Oct 2018

  1. Watts GF, Boffa MB. Lipoprotein(a): lodestar for future clinical trials. Lancet. 2018 Oct 4. pii: S0140-6736(18)31922-6.
  2. Murcia Rios A, Vahidi S, Dunn SD, Konermann L. Evidence for a Partially Stalled Gamma Rotor in F1-ATPase from H/D Exchange Experiments and Molecular Dynamics Simulations. J Am Chem Soc. 2018 Oct 19.
  3. McMurrough TA, Brown CM, Zhang K, Hausner G, Junop MS, Gloor GB, Edgell DR. Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res. 2018 Oct 24.
  4. Geller AS, Polisecki EY, Diffenderfer MR, Asztalos BF, Karathanasis SK, Hegele RA, Schaefer EJ. Genetic and secondary causes of severe HDL deficiency and cardiovascular disease. J Lipid Res. 2018 Oct 17. pii: jlr.M088203.
  5. Kapur A, Singh N, Mete O, Hegele RA, Fantus IG. A Young Male with Parafibromin-Deficient Parathyroid Carcinoma Due to a Rare Germline HRPT2/CDC73 Mutation. Endocr Pathol. 2018 Oct 25. 
  6. Brunham LR, Ruel I, Khoury E, Hegele RA, Couture P, Bergeron J, Baass A, Dufour R, Francis GA, Cermakova L, Mancini GBJ, Brophy JM, Brisson D, Gaudet D, Genest J. Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry. Atherosclerosis. 2018 Oct;277:419-424.
  7. Corral P, Geller AS, Polisecki EY, Lopez GI, Bañares VG, Cacciagiu L, Berg G, Hegele RA, Schaefer EJ, Schreier LE. Unusual genetic variants associated with hypercholesterolemia in Argentina. Atherosclerosis. 2018 Oct;277:256-261.
  8. Iacocca MA, Wang J, Sarkar S, Dron JS, Lagace T, McIntyre AD, Lau P, Robinson JF, Yang P, Knoll JH, Cao H, McPherson R, Hegele RA. Whole-Gene Duplication of PCSK9 as a Novel Genetic Mechanism for Severe Familial Hypercholesterolemia. Can J Cardiol. 2018 Oct;34(10):1316-1324.
  9. Ho R, Hegele RA. Complex effects of laminopathy mutations on nuclear structure and function. Clin Genet. 2018 Oct 3.
  10. Perera U, Kennedy BA, Hegele RA. Multiple Symmetric Lipomatosis (Madelung Disease) in a Large Canadian Family With the Mitochondrial MTTK c.8344A>G Variant. J Investig Med High Impact Case Rep. 2018 Sep 29;6:2324709618802867.Mancini GBJ, Hegele RA, Leiter LA. Erratum to "Dyslipidemia": Canadian Journal of Diabetes 2018;42(S1):S178-S185. Can J Diabetes. 2018 Oct;42(5):574.
  11. Lu HS, Schmidt AM, Hegele RA, Mackman N, Rader DJ, Weber C, Daugherty A. Reporting Sex and Sex Differences in Preclinical Studies. Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):e171-e184.
  12. Kaneko T, Stogios PJ, Ruan X, Voss C, Evdokimova E, Skarina T, Chung A, Liu X, Li L, Savchenko A, Ensminger AW, Li SS. Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun. 2018 Oct 31;9(1):4549.
  13. Jha V, Ling H. 2.0-Å resolution crystal structure of human polkappa reveals a new catalytic function of N-clasp in DNA replication. Sci Rep. 2018 Oct 11;8(1):15125. 
  14. Klapak D, Broadfoot S, Penner G, Singh A, Inapuri E. Development of novel aptamers for low-density lipoprotein particle quantification. PLoS One. 2018 Oct 11;13(10):e0205460.
  15. Tejada MG, Sudhakar S, Kim NK, Aoyama H, Shilton BH, Bai D. Variants with increased negative electrostatic potential in the Cx50 gap junction pore increased unitary channel conductance and magnesium modulation. Biochem J. 2018 Oct 4. pii: BCJ20180523.
  16. Francisco PA, Delboni MG, Lima AR, Xiao Y, Siqueira WL, Gomes BPFA. Proteomic profile of root canal contents in teeth with post-treatment endodontic disease. Int Endod J. 2018 Oct 4.
  17. Walsh JP, Renaud JB, Hoogstra S, McMullin DR, Ibrahim A, Visagie C, Tanney JB, Yeung KK, Sumarah MW. Diagnostic Fragmentation Filtering for the Discovery of New Chaetoglobosins and Cytochalasins. Rapid Commun Mass Spectrom. 2018 Oct 16.

Sept 2018

  1. Boffa MB, Stranges S, Klar N, Moriarty PM, Watts GF, Koschinsky ML. Lipoprotein(a) and secondary prevention of atherothrombotic events: A critical appraisal. J Clin Lipidol. 2018 Sep 11. pii: S1933-2874(18)30371-4.
  2. Cheng X, Jobin-Robitaille O, Billon P, Buisson R, Niu H, Lacoste N, Abshiru N, Côté V, Thibault P, Kron SJ, Sung P, Brandl CJ, Masson JY, Côté J. Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection. Proc Natl Acad Sci U S A. 2018 Sep 17. pii: 201806513.
  3. Chyzhyk V, Kozmic S, Brown AS, Hudgins LC, Starc TJ, Davila AD, Blevins TC, Diffenderfer MR, He L, Geller AS, Rush C, Hegele RA, Schaefer EJ. Extreme hypertriglyceridemia: Genetic diversity, pancreatitis, pregnancy, and prevalence. J Clin Lipidol. 2018 Sep 18. pii: S1933-2874(18)30405-7.
  4. Xiao Y, Li M, Larocque R, Zhang F, Malhotra A, Chen J, Linhardt RJ, Konermann L, Xu D. Dimerization Interface of Osteoprotegerin Revealed by Hydrogen-deuterium Exchange Mass Spectrometry. J Biol Chem. 2018 Sep 25. pii: jbc.RA118.004489.
  5. Chu B, He A, Tian Y, He W, Chen P, Hu J, Xu R, Zhou W, Zhang M, Yang P, Li SSC, Sun Y, Li P, Hunter T, Tian R. Photoaffinity-engineered protein scaffold for systematically exploring native phosphotyrosine signaling complexes in tumor samples. Proc Natl Acad Sci U S A. 2018 Sep 6.
  6. Walliser C, Wist M, Hermkes E, Zhou Y, Schade A, Haas J, Deinzer J, Désiré L, Li SSC, Stilgenbauer S, Milner JD, Gierschik P. Functional characterization of phospholipase C-γ(2) mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder. Oncotarget. 2018 Sep 28;9(76):34357-34378.
  7. Balasuriya N, McKenna M, Liu X, Li SSC, O'Donoghue P. Phosphorylation-Dependent Inhibition of Akt1. Genes (Basel). 2018 Sep 7;9(9). pii: E450.
  8. Burke LJ, Sevcik J, Gambino G, Tudini E, Mucaki EJ, Shirley BC, Whiley P, Parsons MT, De Leeneer K, Gutiérrez-Enríquez S, Santamariña M, Caputo SM, Santana Dos Santos E, Soukupova J, Janatova M, Zemankova P, Lhotova K, Stolarova L, Borecka M, Moles-Fernández A, Manoukian S, Bonanni B; ENIGMA Consortium, Edwards SL, Blok MJ, van Overeem Hansen T, Rossing M, Diez O, Vega A, Claes KBM, Goldgar DE, Rouleau E, Radice P, Peterlongo P, Rogan PK, Caligo M, Spurdle AB, Brown MA. BRCA1 and BRCA2 5' non-coding region variants identified in breast cancer patients alter promoter activity and protein binding. Hum Mutat. 2018 Sep 11.
  9. Huang B, Sadeghinejad L, Adebayo OIA, D M, Xiao Y, Siqueira WL, Cvitkovitch DG, Finer Y. Gene Expression and Protein Synthesis of Esterase from Streptococcus mutans are affected by Biodegradation By-product from Methacrylate Resin Composites and Adhesives. Acta Biomater. 2018 Sep 27. pii: S1742-7061(18)30579-8.
  10. Luo B, Edge AK, Tolg C, Turley EA, Dean CB, Hill KA, Kulperger RJ. Spatial statistical tools for genome-wide mutation cluster detection under a microarray probe sampling system. PLoS One. 2018 Sep 25;13(9):e0204156.
  11. Hauser-Kawaguchi A, Tolg C, Peart T, Milne M, Turley EA, Luyt LG. A truncated RHAMM protein for discovering novel therapeutic peptides. Bioorg Med Chem. 2018 Sep 18. pii: S0968-0896(18)30558-3.
  12. McCarthy JB, El-Ashry D, Turley EA. Corrigendum: Hyaluronan, Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression. Front Cell Dev Biol. 2018 Sep 24;6:112.

Aug 2018

  1. Pignanelli M, Bogiatzi C, Gloor G, Allen-Vercoe E, Reid G, Urquhart BL, Ruetz KN, Velenosi TJ, Spence JD. Moderate Renal Impairment and Toxic Metabolites Produced by the Intestinal Microbiome: Dietary Implications. J Ren Nutr. 2018 Aug 9. pii: S1051-2276(18)30128-6.
  2. Gupta MB, Abu Shehab M, Nygard K, Biggar K, Singal SS, Santoro N, Powell TL, Jansson T. IUGR is associated with marked hyperphosphorylation of decidual and maternal plasma IGFBP-1. J Clin Endocrinol Metab. 2018 Aug 16.
  3. Baass A, Hegele RA. Getting Real With PCSK9 Inhibitors in Familial Hypercholesterolemia. Can J Cardiol. 2018 Aug;34(8):959-961.
  4. Low-Kam C, Rhainds D, Lo KS, Barhdadi A, Boulé M, Alem S, Pedneault-Gagnon V, Rhéaume E, Dubé MP, Busseuil D, Hegele RA, Lettre G, Tardif JC. Variants at the APOE /C1/C2/C4 Locus Modulate Cholesterol Efflux Capacity Independently of High-Density Lipoprotein Cholesterol. J Am Heart Assoc. 2018 Aug 21;7(16):e009545.
  5. Buzon B, Grainger R, Huang S, Rzadki C, Junop MS. Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink. Nucleic Acids Res. 2018 Aug 27.
  6. Albatany M, Meakin S, Bartha R. The Monocarboxylate transporter inhibitor Quercetin induces intracellular acidification in a mouse model of Glioblastoma Multiforme: in-vivo detection using magnetic resonance imaging. Invest New Drugs. 2018 Aug 13.
  7. O'Donoghue P, Ling J, Söll D. Transfer RNA function and evolution. RNA Biol. 2018;15(4-5):423-426.
  8. Caughlin S, Hepburn J, Liu Q, Wang L, Yeung KK, Cechetto DF, Whitehead SN. Chloroquine Restores Ganglioside Homeostasis and Improves Pathological and Behavioral Outcomes Post-stroke in the Rat. Mol Neurobiol. 2018 Aug 25.

July 2018

  1. Romagnuolo R, DeMarco K, Scipione CA, Boffa MB, Koschinsky ML. Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells. Thromb Res. 2018 Jul 4;169:1-7.
  2. Pereira CV, Bacman SR, Arguello T, Zekonyte U, Williams SL, Edgell DR, Moraes CT. mitoTev-TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels. EMBO Mol Med. 2018 Jul 16. pii: e8084.
  3. Berberich AJ, Hegele RA. The complex molecular genetics of familial hypercholesterolaemia. Nat Rev Cardiol. 2018 Jul 4.
  4. Wang LR, Radonjic A, Dilliott AA, McIntyre AD, Hegele RA. A De Novo POLD1 Mutation Associated With Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy Syndrome in a Family With Werner Syndrome. J Investig Med High Impact Case Rep. 2018 Jul 12;6:2324709618786770.
  5. Rosenson RS, Hegele RA, Fazio S, Cannon CP. The Evolving Future of PCSK9 Inhibitors. J Am Coll Cardiol. 2018 Jul 17;72(3):314-329. Burke AC, Sutherland BG, Telford DE, Morrow MR, Sawyez CG, Edwards JY, Drangova M, Huff MW. Intervention with citrus flavonoids reverses obesity, and improves metabolic syndrome and atherosclerosis in obese Ldlr-/- mice. J Lipid Res. 2018 Jul 15. pii: jlr.M087387.
  6. Xiao Y, Shaw GS, Konermann L. Correction to "Calcium-Mediated Control of S100 Proteins: Allosteric Communication via an Agitator/Signal Blocking Mechanism". J Am Chem Soc. 2018 Jul 5.
  7. Duez Q, Metwally H, Konermann L. Electrospray Ionization of Polypropylene Glycol: Rayleigh-Charged Droplets, Competing Pathways, and Charge State-Dependent Conformations. Anal Chem. 2018 Jul 19.
  8. Metwally H, Duez Q, Konermann L. Chain Ejection Model for Electrospray Ionization of Unfolded Proteins: Evidence from Atomistic Simulations and Ion Mobility Spectrometry. Anal Chem. 2018 Jul 24.
  9. Liu AD, Xu H, Gao YN, Luo DN, Li ZF, Voss C, Li SSC, Cao X. (Arg)(9)-SH2 superbinder: a novel promising anticancer therapy to melanoma by blocking phosphotyrosine signaling. J Exp Clin Cancer Res. 2018 Jul 5;37(1):138.
  10. Bowie LE, Maiuri T, Alpaugh M, Gabriel M, Arbez N, Galleguillos D, Hung CLK, Patel S, Xia J, Hertz NT, Ross CA, Litchfield DW, Sipione S, Truant R. N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation. Proc Natl Acad Sci U S A. 2018 Jul 9. pii: 201801772. 

June 2018

  1. Rowland ME, Jiang Y, Beier F, Bérubé NG. Inactivation of hepatic ATRX in Atrx Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine. Aging (Albany NY). 2018 Jun 7.
  2. Zarghami N, Murrell DH, Jensen MD, Dick FA, Chambers AF, Foster PJ, Wong E. Half brain irradiation in a murine model of breast cancer brain metastasis: magnetic resonance imaging and histological assessments of dose-response. Radiat Oncol. 2018 Jun 1;13(1):104.
  3. Pignanelli M, Just C, Bogiatzi C, Dinculescu V, Gloor GB, Allen-Vercoe E, Reid G, Urquhart BL, Ruetz KN, Velenosi TJ, Spence JD. Mediterranean Diet Score: Associations with Metabolic Products of the Intestinal Microbiome, Carotid Plaque Burden, and Renal Function. Nutrients. 2018 Jun 16;10(6). pii: E779.
  4. McMillan A, Rulisa S, Gloor GB, Macklaim JM, Sumarah M, Reid G. Pilot assessment of probiotics for pregnant women in Rwanda. PLoS One. 2018 Jun 18;13(6):e0195081.
  5. Petrova MI, Macklaim JM, Wuyts S, Verhoeven T, Vanderleyden J, Gloor GB, Lebeer S, Reid G. Comparative Genomic and Phenotypic Analysis of the Vaginal Probiotic Lactobacillus rhamnosus GR-1. Front Microbiol. 2018 Jun 15;9:1278.
  6. Chen YY, Gupta MB, Grattton R, Powell TL, Jansson T. Down-regulation of placental folate transporters in intrauterine growth restriction. J Nutr Biochem. 2018 Jun 11;59:136-141.
  7. Daugherty A, Lu HS, Hegele RA, Mackman N, Rader DJ, Schmidt AM, Weber C. Response by Daugherty et al to Letter Regarding Article, "Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the Arteriosclerosis, Thrombosis, and Vascular Biology Council". Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):e101-e102.
  8. Dron JS, Wang J, Berberich AJ, Iacocca MA, Cao H, Yang P, Knoll J, Tremblay K, Brisson D, Netzer C, Gouni-Berthold I, Gaudet D, Hegele RA. Large-scale deletions of the ABCA1 gene in patients with hypoalphalipoproteinemia. J Lipid Res. 2018 Jun 4. pii: jlr.P086280.
  9. Wójcik C, Fazio S, McIntyre AD, Hegele RA. Co-occurrence of heterozygous CREB3L3 and APOA5 nonsense variants and polygenic risk in a patient with severe hypertriglyceridemia exacerbated by estrogen administration. J Clin Lipidol. 2018 Jun 1. pii: S1933-2874(18)30243-5.
  10. Turk MA, Chung CZ, Manni E, Zukowski SA, Engineer A, Badakhshi Y, Bi Y, Heinemann IU. MiRAR-miRNA Activity Reporter for Living Cells. Genes (Basel). 2018 Jun 19;9(6). pii: E305.
  11. Qiu B, Al K, Pena-Diaz AM, Athwal GS, Drosdowech D, Faber KJ, Burton JP, O'Gorman DB. Cutibacterium acnes and the shoulder microbiome. J Shoulder Elbow Surg. 2018 Jun 13. pii: S1058-2746(18)30304-5.

May 2018

  1. Kotsopoulos J, Gronwald J, Lynch HT, Eisen A, Neuhausen SL, Tung N, Ainsworth P, Weitzel JN, Pal T, Foulkes WD, Eng C, Singer CF, Senter L, Sun P, Lubinski J, Narod SA; Hereditary Breast Cancer Clinical Study Group. Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat. 2018 May 17.
  2. Kotsopoulos J, Gronwald J, Karlan B, Rosen B, Huzarski T, Moller P, Lynch HT, Singer CF, Senter L, Neuhausen SL, Tung N, Eisen A, Foulkes WD, Ainsworth P, Sun P, Lubinski J, Narod SA; Hereditary Ovarian Cancer Clinical Study Group. Age-specific ovarian cancer risks among women with a BRCA1 or BRCA2 mutation. Gynecol Oncol. 2018 May 21. pii: S0090-8258(18)30898-9.
  3. Romagnuolo R, Scipione CA, Bazzi ZA, Boffa MB, Koschinsky ML. Inhibition of pericellular plasminogen activation by apolipoprotein(a): Roles of urokinase plasminogen activator receptor and integrins αMβ2 and αVβ3. Atherosclerosis. 2018 May 17;275:11-21.
  4. Karttunen M, Choy WY, Cino EA. Prediction of Binding Energy of Keap1 Interaction Motifs in the Nrf2 Antioxidant Pathway and Design of Potential High Affinity Peptides. J Phys Chem B. 2018 May 10.
  5. Gloor GB, Wong RG, Allen-Vercoe E, Dinculescu V, Pignanelli M, Bogiatzi C, Reid G, Spence JD. Data on the gut and saliva microbiota from a cohort of atherosclerosis patients determined by 16S rRNA gene sequencing. Data Brief. 2018 May 11;19:481-485.
  6. Plouffe RA, Hammond R, Goldberg HA, Chahine S. What Matters from Admissions? Identifying Success and Risk Among Canadian Dental Students. J Dent Educ. 2018 May;82(5):515-523.
  7. Singal SS, Nygard K, Gratton R, Jansson T, Gupta MB. Increased Insulin-like Growth Factor Binding Protein-1 Phosphorylation in Decidualized Stromal Mesenchymal Cells in Human Intrauterine Growth Restriction Placentas. J Histochem Cytochem. 2018 May 1:22155418772574.
  8. Mancini GBJ, Hegele RA. Can We Eliminate Low-Density Lipoprotein Cholesterol-Related Cardiovascular Events Through More Aggressive Primary Prevention Therapy? Can J Cardiol. 2018 May;34(5):546-551.
  9. Paquette M, Hegele RA, Baass A. PCSK9 inhibitors in familial hypercholesterolemia: What is the evidence? J Clin Lipidol. 2018 May 26. pii: S1933-2874(18)30238-1.
  10. Feldman RD, Fitchett D, Hegele RA, Poulter NR. Type 2 Diabetes and the Reduction of Cardiovascular Risk: Sorting Out the Actors and the Roles. Can J Cardiol. 2018 May;34(5):532-535.
  11. Nerenberg KA, Zarnke KB, Leung AA, Dasgupta K, Butalia S, McBrien K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Padwal RS, Tran KC, Grover S, Rabkin SW, Moe GW, Howlett JG, Lindsay P, Hill MD, Sharma M, Field T, Wein TH, Shoamanesh A, Dresser GK, Hamet P, Herman RJ, Burgess E, Gryn SE, Grégoire JC, Lewanczuk R, Poirier L, Campbell TS, Feldman RD, Lavoie KL, Tsuyuki RT, Honos G, Prebtani APH, Kline G, Schiffrin EL, Don-Wauchope A, Tobe SW, Gilbert RE, Leiter LA, Jones C, Woo V, Hegele RA, Selby P, Pipe A, McFarlane PA, Oh P, Gupta M, Bacon SL, Kaczorowski J, Trudeau L, Campbell NRC, Hiremath S, Roerecke M, Arcand J, Ruzicka M, Prasad GVR, Vallée M, Edwards C, Sivapalan P, Penner SB, Fournier A, Benoit G, Feber J, Dionne J, Magee LA, Logan AG, Côté AM, Rey E, Firoz T, Kuyper LM, Gabor JY, Townsend RR, Rabi DM, Daskalopoulou SS; Hypertension Canada. Hypertension Canada's 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children. Can J Cardiol. 2018 May;34(5):506-525.
  12. Ruel I, Brisson D, Aljenedil S, Awan Z, Baass A, Bélanger A, Bergeron J, Bewick D, Brophy JM, Brunham LR, Couture P, Dufour R, Francis GA, Frohlich J, Gagné C, Gaudet D, Grégoire JC, Gupta M, Hegele RA, Mancini GBJ, McCrindle BW, Pang J, Raggi P, Tu JV, Watts GF, Genest J. Simplified Canadian Definition for Familial Hypercholesterolemia. Can J Cardiol. 2018 May 19. pii: S0828-282X(18)30383-0.
  13. Cvetkovska M, Szyszka-Mroz B, Possmayer M, Pittock P, Lajoie G, Smith DR, Hüner NPA. Characterization of photosynthetic ferredoxin from the Antarctic alga Chlamydomonas sp. UWO241 reveals novel features of cold adaptation. New Phytol. 2018 May 8.
  14. Balasuriya N, Kunkel MT, Liu X, Biggar KK, Li SS, Newton AC, O'Donoghue P. Genetic code expansion and live cell imaging reveal that Thr308 phosphorylation is irreplaceable and sufficient for Akt1 activity. J Biol Chem. 2018 May 17. pii: jbc.RA118.002357.
  15. Albatany M, Li A, Meakin S, Bartha R. In vivo detection of acute intracellular acidification in glioblastoma multiforme following a single dose of cariporide. Int J Clin Oncol. 2018 May 10.
  16. Grishin AM, Barber KR, Gu RX, Peter Tieleman D, Shaw GS, Cygler M. Regulation of Shigella Effector Kinase OspG through Modulation of its Dynamic Properties. J Mol Biol. 2018 May 16. pii: S0022-2836(18)30419-4.
  17. McCarthy JB, El-Ashry D, Turley EA. Hyaluronan, Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression. Front Cell Dev Biol. 2018 May 8;6:48.
  18. Morrison LM, Renaud JB, Sabourin L, Sumarah MW, Yeung KKC, Lapen DR. High-Throughput Quantitation of Neonicotinoids in Lyophilized Surface Water by LC-APCI-MS/MS. J AOAC Int. 2018 May 21.

Apr 2018

  1. Aref-Eshghi E, Schenkel LC, Ainsworth P, Lin H, Rodenhiser DI, Cutz JC, Sadikovic B. Genomic DNA Methylation-Derived Algorithm Enables Accurate Detection of Malignant Prostate Tissues. Front Oncol. 2018 Apr 23;8:100.
  2. Berg MD, Genereaux J, Karagiannis J, Brandl CJ. The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes. G3 (Bethesda). 2018 Apr 6. pii:g3.200288.2018.
  3. Dick FA, Goodrich DW, Sage J, Dyson NJ. Non-canonical functions of the RB protein in cancer. Nat Rev Cancer. 2018 Apr 24.
  4. Bogiatzi C, Gloor G, Allen-Vercoe E, Reid G, Wong RG, Urquhart BL, Dinculescu V, Ruetz KN, Velenosi TJ, Pignanelli M, Spence JD. Metabolic products of the intestinal microbiome and extremes of atherosclerosis. Atherosclerosis. 2018 Apr 17;273:91-97.
  5. Hegele RA, Berberich AJ, Ban MR, Wang J, Digenio A, Alexander VJ, D'Erasmo L, Arca M, Jones A, Bruckert E, Stroes ES, Bergeron J, Civeira F, Witztum JL, Gaudet D. Clinical and biochemical features of different molecular etiologies of familial chylomicronemia. J Clin Lipidol. 2018 Apr 4. pii: S1933-2874(18)30198-3.
  6. Parajuli RP, Goodrich JM, Chan LHM, Ayotte P, Lemire M, Hegele RA, Basu N. Genetic polymorphisms are associated with exposure biomarkers for metals and persistent organic pollutants among Inuit from the Inuvialuit Settlement Region, Canada. Sci Total Environ. 2018 Apr 7;634:569-578.
  7. Diabetes Canada Clinical Practice Guidelines Expert Committee, Mancini GBJ, Hegele RA, Leiter LA. Dyslipidemia. Can J Diabetes. 2018 Apr;42 Suppl 1:S178-S185.
  8. Dilliott AA, Farhan SMK, Ghani M, Sato C, Liang E, Zhang M, McIntyre AD, Cao H, Racacho L, Robinson JF, Strong MJ, Masellis M, Bulman DE, Rogaeva E, Lang A, Tartaglia C, Finger E, Zinman L, Turnbull J, Freedman M, Swartz R, Black SE, Hegele RA. Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease. J Vis Exp. 2018 Apr 4;(134).
  9. Mach F, Ray KK, Wiklund O, Corsini A, Catapano AL, Bruckert E, De Backer G, Hegele RA, Hovingh GK, Jacobson TA, Krauss RM, Laufs U, Leiter LA, März W, Nordestgaard BG, Raal FJ, Roden M, Santos RD, Stein EA, Stroes ES, Thompson PD, Tokgözoglu L, Vladutiu GD, Gencer B, Stock JK, Ginsberg HN, Chapman MJ; European Atherosclerosis Society Consensus Panel. Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract. Eur Heart J. 2018 Apr 27.
  10. Konermann L, Metwally H, McAllister RG, Popa V. How to Run Molecular Dynamics Simulations on Electrospray Droplets and Gas Phase Proteins: Basic Guidelines and Selected Applications. Methods. 2018 Apr 17. pii: S1046-2023(17)30464-4.
  11. Jha V, Ling H. Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender. J Mol Biol. 2018 Apr 28. pii: S0022-2836(18)30296-1.
  12. Abdallah MN, Abughanam G, Tran SD, Sheikh Z, Mezour MA, Basiri T, Xiao Y, Cerruti M, Siqueira WL, Tamimi F. Comparative adsorption profiles of basal lamina proteome and gingival cells onto dental and titanium surfaces. Acta Biomater. 2018 Apr 13. pii: S1742-7061(18)30220-4.

Mar 2018

  1. Boffa MB, Koschinsky ML. The journey towards understanding lipoprotein(a) and cardiovascular disease risk: are we there yet? Curr Opin Lipidol. 2018 Mar 9.
  2. Wang LR, McIntyre AD, Hegele RA. Complex genetic architecture in severe hypobetalipoproteinemia. Lipids Health Dis. 2018 Mar 14;17(1):48.
  3. McQuaid JB, Kustka AB, Oborník M, Horák A, McCrow JP, Karas BJ, Zheng H, Kindeberg T, Andersson AJ, Barbeau KA, Allen AE. Carbonate-sensitive phytotransferrin controls high-affinity iron uptake in diatoms. Nature. 2018 Mar 14.
  4. Aguirre JD, Dunkerley KM, Lam R, Rusal M, Shaw GS. Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin. J Biol Chem. 2018 Mar 12. pii: jbc.RA117.000605.
  5. Tikhonova S, Booij L, D'Souza V, Crosara KTB, Siqueira WL, Emami E. Investigating the association between stress, saliva and dental caries: a scoping review. BMC Oral Health. 2018 Mar 13;18(1):41.
  6. Jarrett P, Easton A, Rockwood K, Dyack S, McCollum A, Siu V, Mirsattari SM, Massot-Tarrús A, Beis MJ, D'Souza N, Darvesh S. Evidence for Cholinergic Dysfunction in Autosomal Dominant Kufs Disease. Can J Neurol Sci. 2018 Mar;45(2):150-157.
  7. Caughlin S, Maheshwari S, Agca Y, Agca C, Harris AJ, Jurcic K, Yeung KK, Cechetto DF, Whitehead SN. Membrane-lipid homeostasis in a prodromal rat model of Alzheimer's disease: Characteristic profiles in ganglioside distributions during aging detected using MALDI imaging mass spectrometry. Biochim Biophys Acta. 2018 Mar 12. pii: S0304-4165(18)30073-4.
  8. Wang JSH, Freitas-Andrade M, Bechberger JF, Naus C, Yeung KK, Whitehead SN. MALDI IMS of Intraperitoneally Injected Danegaptide (ZP1609) for Treatment of Stroke-Reperfusion Injury in Mice. Rapid Commun Mass Spectrom. 2018 Mar 25.

Feb 2018

  1. Schenkel LC, Aref-Eshghi E, Skinner C, Ainsworth P, Lin H, Paré G, Rodenhiser DI, Schwartz C, Sadikovic B. Peripheral blood epi-signature of Claes-Jensen syndrome enables sensitive and specific identification of patients and healthy carriers with pathogenic mutations in KDM5C. Clin Epigenetics. 2018 Feb 14;10:21.
  2. Boffa MB, Koschinsky ML. Therapeutic Lowering of Lipoprotein(a): A Role for Pharmacogenetics? Circ Genom Precis Med. 2018 Feb;11(2):e002052.
  3. Ishak CA, Cecchini MJ, Howlett CJ, Dick FA. Immunohistochemical Detection of the Retinoblastoma Protein. Methods Mol Biol. 2018;1726:65-75.
  4. Egozcue JJ, Pawlowsky-Glahn V, Gloor GB. Linear Association in Compositional Data Analysis. Austrian J Stats. 2018 Feb;47:3.
  5. Chassen SS, Ferchaud-Roucher V, Gupta MB, Jansson T, Powell TL. Alterations in Placental Long Chain Polyunsaturated Fatty Acid Metabolism in Human Intrauterine Growth Restriction. Clin Sci (Lond). 2018 Feb 20. pii: CS20171340.
  6. Linke AC, Wild C, Zubiaurre-Elorza L, Herzmann C, Duffy H, Han VK, Lee DSC, Cusack R. Disruption to functional networks in neonates with perinatal brain injury predicts motor skills at 8 months. Neuroimage Clin. 2018 Feb 3;18:399-406.
  7. Berberich AJ, Hegele RA. Secondary causes of chylomicronemia: defining the underside of the iceberg. J Intern Med. 2018 Feb 2.
  8. Berberich AJ, Ho R, Hegele RA. Whole genome sequencing in the clinic: empowerment or too much information? CMAJ. 2018 Feb 5;190(5):E124-E125.
  9. Yanagi M, Suzuki A, Hudson RHE, Saito Y. A fluorescent 3,7-bis-(naphthalen-1-ylethynylated)-2'-deoxyadenosine analogue reports thymidine in complementary DNA by a large emission Stokes shift. Org Biomol Chem. 2018 Feb 8.
  10. Burke AC, Telford DE, Sutherland BG, Edwards JY, Sawyez CG, Barrett PHR, Newton RS, Pickering JG, Huff MW. Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR(+/-) and LDLR(-/-) ) Yucatan Miniature Pigs. Arterioscler Thromb Vasc Biol. 2018 Feb 15. pii: ATVBAHA.117.310676.
  11. Leighton TL, Mok MC, Junop MS, Howell PL, Burrows LL. Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function. Sci Rep. 2018 Feb 8;8(1):2600.
  12. Metwally H, Konermann L. Crown Ethers Modulate the Location of Charge Carriers in Electrospray Droplets: Implications for the Mechanism of Protein Charging and Supercharging. Anal Chem. 2018 Feb 28.
  13. Yin H, Pickering JG. Aortic smooth muscle cells and myocardial infarction: Does the ascending aorta feel a heart attack? Atherosclerosis. 2018 Feb 10. pii: S0021-9150(18)30080-7.
  14. Zhao JZL, Mucaki EJ and Rogan PK. Predicting ionizing radiation exposure using biochemically-inspired genomic machine learning [version 1; referees: awaiting peer review]. F1000Research 2018, 7:233.
  15. Brady L, Sadikovic B, Rupar CA, Tarnopolsky MA. Complete elimination of a pathogenic homoplasmic mtDNA mutation in one generation. Mitochondrion. 2018 Feb 1. pii: S1567-7249(17)30328-8.
  16. Huang B, Siqueira W, Cvitkovitch DG, Finer Y. Esterase from a Cariogenic Bacterium Hydrolyzes Dental Resins. Acta Biomater. 2018 Feb 26. pii: S1742-7061(18)30091-6.
  17. Valente MT, Moffa EB, Crosara KTB, Xiao Y, de Oliveira TM, Machado MAAM, Siqueira WL. Acquired Enamel Pellicle Engineered Peptides: Effects on Hydroxyapatite Crystal Growth. Sci Rep. 2018 Feb 28;8(1):3766.
  18. Zarate YA, Smith-Hicks CL, Greene C, Abbott MA, Siu VM, Calhoun ARUL, Pandya A, Li C, Sellars EA, Kaylor J, Bosanko K, Kalsner L, Basinger A, Slavotinek AM, Perry H, Saenz M, Szybowska M, Wilson LC, Kumar A, Brain C, Balasubramanian M, Dubbs H, Ortiz-Gonzalez XR, Zackai E, Stein Q, Powell CM, Schrier Vergano S, Britt A, Sun A, Smith W, Bebin EM, Picker J, Kirby A, Pinz H, Bombei H, Mahida S, Cohen JS, Fatemi A, Vernon HJ, McClellan R, Fleming LR, Knyszek B, Steinraths M,  Velasco Gonzalez C, Beck AE, Golden-Grant KL, Egense A, Parikh A, Raimondi C, Angle B, Allen W, Schott S, Algrabli A, Robin NH, Ray JW, Everman DB, Gambello MJ, Chung WK. Natural history and genotype-phenotype correlations in 72 individuals with SATB2-associated syndrome. Am J Med Genet A. 2018 Feb 13.
  19. Wang JS, Whitehead SN, Yeung KK. Detection of Amyloid Beta (Aβ) Oligomeric Composition Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS). J Am Soc Mass Spectrom. 2018 Feb 20.

Jan 2018

  1. Aref-Eshghi E, Rodenhiser DI, Schenkel LC, Lin H, Skinner C, Ainsworth P, Paré G, Hood RL, Bulman DE, Kernohan KD; Care4Rare Canada Consortium, Boycott KM, Campeau PM, Schwartz C, Sadikovic B. Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes. Am J Hum Genet. 2018 Jan 4;102(1):156-174.
  2. Mohamed HT, El-Husseiny N, El-Ghonaimy EA, Ibrahim SA, Bazzi ZA, Cavallo-Medved D, Boffa MB, El-Shinawi M, Mohamed MM. IL-10 correlates with the expression of carboxypeptidase B2 and lymphovascular invasion in inflammatory breast cancer: The potential role of tumor infiltrated macrophages. Curr Probl Cancer. 2018 Jan 10. pii: S0147-0272(17)30120-4.
  3. Slattery SS, Diamond A, Wang H, Therrien JA, Lant JT, Jazey T, Lee K, Klassen Z, Desgagné-Penix I, Karas BJ, Edgell DR. An expanded plasmid-based genetic toolbox enables Cas9 genome editing and stable maintenance of synthetic pathways in Phaeodactylum tricornutum. ACS Synth Biol. 2018 Jan 3.
  4. Kaiser JC, King AN, Grigg JC, Sheldon JR, Edgell DR, Murphy MEP, Brinsmade SR, Heinrichs DE. Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide. PLoS Genet. 2018 Jan 22;14(1):e1007159.
  5. Zubiaurre-Elorza L, Linke AC, Herzmann C, Wild CJ, Duffy H, Lee DSC, Han VK, Cusack R. Auditory structural connectivity in preterm and healthy term infants during the first postnatal year. Dev Psychobiol. 2018 Jan 22.
  6. Aboalola D, Han VKM. Different Effects of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-2 on Myogenic Differentiation of Human Mesenchymal Stem Cells. Stem Cells Int. 2017;2017:8286248.
  7. Iacocca MA, Hegele RA. Role of DNA copy number variation in dyslipidemias. Curr Opin Lipidol. 2018 Jan 4.
  8. Clemens KK, Shariff SZ, McArthur E, Hegele RA. Ezetimibe prescriptions in older Canadian adults after an acute myocardial infarction: a population-based cohort study. Lipids Health Dis. 2018 Jan 8;17(1):8.
  9. Dron JS, Hegele RA. Polygenic influences on dyslipidemias. Curr Opin Lipidol. 2018 Jan 2.
  10. Hegele RA. Learning From Patients With Ultrarare Conditions: Cholesterol Hoof Beats. J Am Coll Cardiol. 2018 Jan 23;71(3):289-291.
  11. Paquette M, Hegele RA, Paré G, Baass A. A novel mutation in GPIHBP1 causes familial chylomicronemia syndrome. J Clin Lipidol. 2018 Jan 31. pii: S1933-2874(18)30031-X.
  12. Snir JA, Suchy M, Bindseil GA, Kovacs M, Chronik BA, Hudson RHE, Pasternak SH, Bartha R. An Aspartyl Cathepsin Targeted PET Agent: Application in an Alzheimer's Disease Mouse Model. J Alzheimers Dis. 2018;61(3):1241-1252.
  13. Morrow NM, Huff MW. Knockdown of Δ-5 Fatty Acid Desaturase Is More Than Just a Fad. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):6-8.
  14. Burke AC, Huff MW. Regression of atherosclerosis: lessons learned from genetically modified mouse models. Curr Opin Lipidol. 2018 Jan 24.
  15. Tsimikas S, Fazio S, Ferdinand KC, Ginsberg HN, Koschinsky ML, Marcovina SM, Moriarty PM, Rader DJ, Remaley AT, Reyes-Soffer G, Santos RD, Thanassoulis G, Witztum JL, Danthi S, Olive M, Liu L. NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis. J Am Coll Cardiol. 2018 Jan 16;71(2):177-192.
  16. Cooper TT, Sherman SE, Kuljanin M, Bell GI, Lajoie GA, Hess DA. Inhibition Of Aldehyde Dehydrogenase-Activity Expands Multipotent Myeloid Progenitor Cells With Vascular Regenerative Function. Stem Cells. 2018 Jan 27.
  17. Lecocq S, Spinella K, Dubois B, Lista S, Hampel H, Penner G. Aptamers as biomarkers for neurological disorders. Proof of concept in transgenic mice. PLoS One. 2018 Jan 5;13(1):e0190212.
  18. O'Connor K, Jukes T, Goobie S, DiRaimo J, Moran G, Potter BK, Chakraborty P, Rupar CA, Gannavarapu S, Prasad C. Psychosocial impact on mothers receiving expanded newborn screening results. Eur J Hum Genet. 2018 Jan 29.
  19. Datar R, Prasad AN, Tay KY, Rupar CA, Ohorodnyk P, Miller M, Prasad C. Magnetic resonance imaging in the diagnosis of white matter signal abnormalities. Neuroradiol J. 2018 Jan 1:1971400918764016.
  20. Crosara KTB, Zuanazzi D, Moffa EB, Xiao Y, Machado MAAM, Siqueira WL. Revealing the Amylase Interactome in Whole Saliva Using Proteomic Approaches. Biomed Res Int. 2018 Jan 31;2018:6346954.
  21. Kolendowski B, Hassan H, Krstic M, Isovic M, Thillainadesan G, Chambers AF, Tuck AB, Torchia J. Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization. Epigenetics Chromatin. 2018 Jan 29;11(1):5. 
  22. Hauser-Kawaguchi A, Luyt LG, Turley E. Design of peptide mimetics to block pro-inflammatory functions of HA fragments. Matrix Biol. 2018 Jan 30. pii: S0945-053X(17)30444-4.