Clinical Pharmacology

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Western University has a long and distinguished history of activity and excellence in Clinical Pharmacology. The increasingly complicated nature of paediatric care along with the increasing use of pharmacology for the control, cure and prevention of illness among children increases the need for specialists in this critical area.

Paediatric Clinical Pharmacology and Toxicology are sub-specialties of Paediatrics. The first focuses on drugs and their effects on infants, children and mothers, including considerations of efficacy, safety and optimal therapy. Toxicology deals with the toxic effects of drugs and environmental agents on children, mothers and the developing fetus.

There are two outpatient clinics, ADR (Adverse Drug Reaction), and FRAME (Fetal Risk Assessment from Maternal Exposure). Both were established in 1989 and are now located at Children's Hospital. As well the Division has an active in-patient consultation service for drug therapy and toxicology issues.

The Team:
Dr Michael Rieder, Professor, Clinical Pharmacology
Dr Doreen Matsui, Associate Professor, Clinical Pharmacology
Venita Harris, Clinical Pharmacy
Dr Brad Urquhart, Physiology and Pharmacology
Dr Alexandra Zorzi, Assistant Professor, Paediatric Oncology, Clinical Pharmacology

Dr Guido Filler, Professor, Paediatric Nephrology, Clinical Pharmacology

The Facts:
Formed in 1988
Paediatric Clinical Pharmacology provides inpatient coverage on the CTU
Two out-patient services (Adverse Drug Reaction Clinic, Fetal Risk Assessment from Maternal Exposure)
In-patient consulting service
Clinical Pharmacology and Drug Safety Laboratory established in 1989
Supported by external grants
Provides support to the Department of Paediatrics as well as to the Division of Allergy and Clinical Immunology of the Department of Medicine
Activities include expanding basic science research into the area of drug safety, personalized medicine for children and pharmacogenetics and collaborative research program with other researchers both locally and nationally
Clinical Investigation program with collaborations with other child health care specialists in the area of optimal drug therapy for children
Part of the integrated program in Clinical Pharmacology and Personalized Medicine at the University of Western Ontario.