Luciano Sposato, MD, MBA, FRCPC

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Professor of Neurology, Western University
Office: University Hospital A10-322
Phone: 519-663-3110
Secretary: Jennifer Moussa

 

 

 

Bio Sketch

Dr. Luciano Sposato is a Professor of Neurology and Head of the Stroke Program at the Department of Clinical Neurological Sciences, London Health Sciences Centre (LHSC), Western University, London, ON, Canada. He is a stroke neurologist and clinician-researcher, with cross appointments with the Departments of Epidemiology & Biostatistics and Anatomy and Cell Biology (Western University). 

Dr. Sposato is the inaugural Kathleen and Henry Barnett Chair in Stroke Research, is the Director of the Heart & Brain Lab at Western University, Associate Scientist at Robarts Research Institute, and Adjunct Scientist at Lawson Health Research Institute.

Dr. Sposato is the Inaugural Chair of the World Stroke Organisation Brain & Heart Task Force. Dr. Sposato holds several editorial roles in leading peer-reviewed journals in the field of Stroke and Cardiology. He is member of the Editorial Board and serves as Editor of the Neurocardiology Section of STROKE (American Heart Association), is member of the Editorial Board of NEUROLOGY (American Academy of Neurology) and JAHA, and serves as Associate Guest Editor for JAHA. 

Research

Dr. Sposato’s research focuses on the Brain & Heart connection. He leads a multidisciplinary and translational research program involving epidemiological, clinical, and experimental studies. Among his most impactful contributions, he described the clinical and pathophysiological concept of AFDAS (atrial fibrillation detected after stroke) and the pathophysiological process leading to cardiovascular complications in stroke patients, called SIHI (stroke-induced heart injury), conditions that affect over 5 million people per year globally. Dr. Sposato also focuses on the association between stroke and dementia, trying to understand how strokes cause cognitive impairment beyond stroke-related brain damage. He has published over 150 papers in Stroke and Neurocardiology and has been invited to lecture in 300 national and international conferences in over 43 countries from 4 continents. 


Medical Interests

Stroke, atrial fibrillation, Neurocardiology, brain-heart interactions, patent foramen ovale, relationship between stroke and dementia, oral anticoagulants.


 Honours and Awards


  • Dr. Sposato was received several awards for his research impact. He has been interviewed by The Lancet Neurology and International Journal of Stroke.
  • 2020, Outstanding Reviewer Award, STROKE Journal (top 20 member of the Editorial Board)
  • 2020, Top Reviewer Award, NEUROLOGY Journal
  • 2018, Best of Cerebrovascular Neurology, Annual Meeting of the American Academy of Neurology.
  • 2017, Co-Chair's Award for Impact, Canadian Stroke Congress
  • 2016, Researcher Profile Highlight, International Journal of Stroke
  • 2015, Researcher Profile Highlight, Lancet Neurology
  • 2008, Mentoring Program Research Award, American Heart Association
  • 2001, Casasco Award, Hospital de Clinicas Medical Association
  • 2001, CEO's Annual Award, Hospital de Clinicas Medical Association
  • 1997, Best Scientific Study in Oncology, National Congress of Internal Medicine
  • 1997, Best Scientific Study in Dermatology, National Congress of Internal Medicine

 

 

Publications

PubMed Publications Listing

Publications

Sposato LA, Gurol ME. Advances in Neurocardiology: Focus on Atrial Fibrillation. Stroke. 2021 Nov;52(11):3696-3699. doi: 10.1161/STROKEAHA.121.033970. Epub 2021 Oct 25. PMID: 34694865.

Sparrow R, Sanjoy S, Choi YH, Elgendy IY, Jneid H, Villablanca PA, Holmes DR, Pershad A, Alraies C, Sposato LA, Mamas MA, Bagur R. Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure. Heart. 2021 Apr 1:heartjnl-2020-318650. doi: 10.1136/heartjnl-2020-318650. Epub ahead of print. PMID: 33795381.

Jimenez-Ruiz A, Racosta JM, Kimpinski K, Hilz MJ, Sposato LA. Cardiovascular autonomic dysfunction after stroke. Neurol Sci. 2021 May;42(5):1751-1758. doi: 10.1007/s10072-021-05128-y. Epub 2021 Mar 9. PMID: 33687612.

Sposato LA, Saposnik G. Author Response: First-Ever Ischemic Stroke and Increased Risk of Incident Heart Disease in Older Adults. Neurology. 2021 Apr 13;96(15):724. doi: 10.1212/WNL.0000000000011785. PMID: 33846168.

Sposato LA, Aspberg S, Scheitz JF, Fisher M. The World Stroke Organization Brain & Heart Task Force: collaborations between stroke physicians and cardiologists. Eur Heart J. 2021 Sep 21;42(36):3594-3596. doi: 10.1093/eurheartj/ehab198. Erratum in: Eur Heart J. 2021 May 09;: PMID: 33855349.

Jiménez-Ruiz A, Shah P, Gibson A, Vargas-González JC, Sposato LA. Determinants of in-hospital death in patients with a thrombus straddling a patent foramen ovale: protocol of a systematic review. F1000Res. 2020 Dec 10;9:1437. doi: 10.12688/f1000research.27622.2. PMID: 34055321; PMCID: PMC8138489.

Spence DJ, Sposato LA. The intriguing association between patent foramen ovale and atrial fibrillation. Kardiol Pol. 2021;79(7-8):725-727. doi: 10.33963/KP.a2021.0028. Epub 2021 Jun 1. PMID: 34060639.

Jimenez-Ruiz A, Vargas-Gonzalez JC, Fridman S, Sposato LA. Phenotypes of atrial fibrillation diagnosed before-versus-after ischaemic stroke and TIA: study protocol for a systematic review and meta-analysis. BMJ Open. 2021 Jul 2;11(7):e044288. doi: 10.1136/bmjopen-2020-044288. PMID: 34215597; PMCID: PMC8256738.

Bres-Bullrich M, Fridman S, Sposato LA. Relative Effect of Stroke Severity and Age on Outcomes of Mechanical Thrombectomy in Acute Ischemic Stroke. Stroke. 2021 Aug;52(9):2846-2848. doi: 10.1161/STROKEAHA.121.034946. Epub 2021 Jul 8. PMID: 34233461.

Shah P, Jimenez-Ruiz A, Gibson A, Vargas-González JC, Bres-Bullrich M, Bagur R, Sposato LA. Association between acute myocardial infarction and death in 386 patients with a thrombus straddling a patent foramen ovale. Int J Cardiol. 2021 Nov 1;342:1-6. doi: 10.1016/j.ijcard.2021.07.007. Epub 2021 Jul 7. PMID: 34245792.

De Marchis GM, Sposato LA, Kühne M, Dittrich TD, Bonati LH, Fischer U, Chaturvedi S. New Avenues for Optimal Treatment of Atrial Fibrillation and Stroke Prevention. Stroke. 2021 Apr;52(4):1490-1499. doi: 10.1161/STROKEAHA.120.032060. Epub 2021 Feb 25. PMID: 33626906.

Bagur R, Sposato LA. Cerebral embolic protection during TAVI: the game is not over. EuroIntervention. 2021 Feb 19;16(14):1123-1125. doi: 10.4244/EIJV16I14A201. PMID: 33605879.

Sposato LA, Seiffge DJ. Atrial Fibrillation Detected After Stroke and Increased Risk of Death. Neurology. 2021 Mar 23;96(12):557-559. doi: 10.1212/WNL.0000000000011640. Epub 2021 Feb 10. PMID: 33568549.

Jimenez-Ruiz A, Fridman S, Sposato LA. Study protocol for a systematic review and meta-analysis of comorbidities and stroke characteristics associated with troponin elevation after acute stroke. BMJ Open. 2021 Jan 26;11(1):e043613. doi: 10.1136/bmjopen-2020-043613. PMID: 33500289; PMCID: PMC7839849.

Fridman S, Burneo JG, Sposato LA. Letter by Fridman et al Regarding Article, "Incidence and Association of Reperfusion Therapies With Poststroke Seizures: a Systematic Review and Meta-Analysis". Stroke. 2021 Jan;52(1):e32-e33. doi: 10.1161/STROKEAHA.120.032403. Epub 2020 Dec 28. PMID: 33370192.

Sposato LA, Hilz MJ, Aspberg S, Murthy SB, Bahit MC, Hsieh CY, Sheppard MN, Scheitz JF; World Stroke Organisation Brain & Heart Task Force. Post-Stroke Cardiovascular Complications and Neurogenic Cardiac Injury: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 Dec 8;76(23):2768-2785. doi: 10.1016/j.jacc.2020.10.009. PMID: 33272372.

Krawczyk M, Barra LJ, Sposato LA, Mandzia JL. Primary CNS vasculitis: A systematic review on clinical characteristics associated with abnormal biopsy and angiography. Autoimmun Rev. 2021 Jan;20(1):102714. doi: 10.1016/j.autrev.2020.102714. Epub 2020 Nov 13. PMID: 33197577.

Fridman S, Bres Bullrich M, Jimenez-Ruiz A, Costantini P, Shah P, Just C, Vela-Duarte D, Linfante I, Sharifi-Razavi A, Karimi N, Bagur R, Debicki DB, Gofton TE, Steven DA, Sposato LA. Stroke risk, phenotypes, and death in COVID-19: Systematic review and newly reported cases. Neurology. 2020 Dec 15;95(24):e3373-e3385. doi: 10.1212/WNL.0000000000010851. Epub 2020 Sep 15. PMID: 32934172.

Bres Bullrich M, Pandey S, Mayich M, McConvey K, Fridman S, Mai LM, Sposato LA. Pearls & Oy-sters: Calcified Cerebral Embolus: A Smoking Gun Guiding Acute Stroke Therapy and Secondary Prevention. Neurology. 2021 Jan 5;96(1):e153-e156. doi: 10.1212/WNL.0000000000010805. Epub 2020 Sep 11. PMID: 32917796.

Sposato LA, Lorenzano S. Real-world data for mechanical thrombectomy in the elderly population: A red flag? Neurology. 2020 Jul 14;95(2):57-58. doi: 10.1212/WNL.0000000000009766. Epub 2020 Jun 11. PMID: 32527968.

Bres Bullrich M, Fridman S, Mandzia JL, Mai LM, Khaw A, Vargas Gonzalez JC, Bagur R, Sposato LA. COVID-19: Stroke Admissions, Emergency Department Visits, and Prevention Clinic Referrals. Can J Neurol Sci. 2020 Sep;47(5):693-696. doi: 10.1017/cjn.2020.101. Epub 2020 May 26. PMID: 32450927; PMCID: PMC7324648.

Bagur R, Sposato LA. Cardiocerebral continuum in cognitive function after transcatheter aortic valve implantation. EuroIntervention. 2020 Apr 3;15(18):e1555-e1557. doi: 10.4244/EIJV15I18A283. PMID: 32234686.

Sposato LA, Lam M, Allen B, Richard L, Shariff SZ, Saposnik G. First-ever ischemic stroke and increased risk of incident heart disease in older adults. Neurology. 2020 Apr 14;94(15):e1559-e1570. doi: 10.1212/WNL.0000000000009234. Epub 2020 Mar 10. PMID: 32156691.

Sposato LA, Lam M, Allen B, Shariff SZ, Saposnik G; PARADISE Study Group. First-Ever Ischemic Stroke and Incident Major Adverse Cardiovascular Events in 93 627 Older Women and Men. Stroke. 2020 Feb;51(2):387-394. doi: 10.1161/STROKEAHA.119.028066. Epub 2020 Jan 9. PMID: 31914883.

Sposato LA, Spence JD. Patent foramen ovale in patients with atrial fibrillation. Int J Cardiol. 2020 Feb 1;300:168-169. doi: 10.1016/j.ijcard.2019.11.125. Epub 2019 Nov 22. PMID: 31785956.

Sposato LA, Brown DL. Sex differences in the use of therapeutic resources and stroke outcomes in 5 randomized trials. Neurology. 2019 Dec 10;93(24):1025-1027. doi: 10.1212/WNL.0000000000008610. Epub 2019 Nov 12. PMID: 31719138.

Krawczyk M, Fridman S, Cheng Y, Fang J, Saposnik G, Sposato LA. Atrial fibrillation diagnosed after stroke and dementia risk: cohort study of first-ever ischaemic stroke patients aged 65 or older. Europace. 2019 Dec 1;21(12):1793-1801. doi: 10.1093/europace/euz237. PMID: 31531673.

Budhram A, Climans SA, Le C, Casserly CS , Mayich M, Lownie SP , Sposato LA . Aseptic meningitis due to reperfusion injury after carotid artery stenting. J Neurol Sci. 2017 Oct 15;381:269-271. doi: 10.1016/j.jns.2017.08.3255. Epub 2017 Aug 31. PubMed PMID: 28991696.

Azarpazhooh MR, Avan A, Cipriano LE, Munoz DG, Sposato LA , Hachinski V . Concomitant vascular and neurodegenerative pathologies double the risk of dementia. Alzheimers Dement. 2017 Sep 30. pii: S1552-5260(17)33686-5. doi: 10.1016/j.jalz.2017.07.755. [Epub ahead of print] PubMed PMID: 28974416.

Fridman S, Saposnik G, Sposato LA. Visual Aids for Improving Patient Decision Making in Severe Symptomatic Carotid Stenosis. J Stroke Cerebrovasc Dis. 2017 Aug 7. pii: S1052-3057(17)30368-3. doi: 10.1016/j.jstrokecerebrovasdis.2017.07.011. [Epub ahead of print] PubMed PMID: 28797613.

Sposato LA , Ruíz Vargas E, Riccio PM, Toledo JB, Trojanowski JQ, Kukull WA, Cipriano LE, Nucera A, Whitehead SN, Hachinski V . Milder Alzheimer's disease pathology in heart failure and atrial fibrillation. Alzheimers Dement. 2017 Jul;13(7):770-777. doi: 10.1016/j.jalz.2016.12.002. Epub 2017 Feb 5. PMID: 28174071

Racosta JM, Sposato LA, Kimpinski K. Subcutaneous versus intravenous immunoglobulin for chronic autoimmune neuropathies: A meta-analysis. Muscle Nerve. 2017 Jun;55(6):802-809. doi: 10.1002/mus.25409. Epub 2017 Feb 9. Review. PMID: 27649063

Sposato LA , Saposnik G. Stroke rates vary substantially across cohorts of patients with atrial fibrillation. Evid Based Med. 2017 Jun;22(3):110. doi: 10.1136/ebmed-2017-110711. Epub 2017 Apr 12. No abstract available. PMID: 28404602

Sposato LA , Fridman S, Saposnik G. Letter by Sposato et al Regarding Article, "Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study". Stroke. 2017 Jun;48(6):e142. doi: 10.1161/STROKEAHA.117.017066. Epub 2017 Apr 17. No abstract available. PMID: 28416625

Birbeck GL, Sposato LA . Hypertension prevention: In need of a grain of salt knowledge. Neurology. 2016 Sep 20;87(12):1192-3. doi: 10.1212/WNL.0000000000003136. Epub 2016 Aug 24. No abstract available. PMID: 27558373

Cerasuolo JO, Montero-Odasso M, Ibañez A, Doocy S, Lip GY, Sposato LA . Decision-making interventions to stop the global atrial fibrillation-related stroke tsunami. Int J Stroke. 2017 Apr;12(3):222-228. doi: 10.1177/1747493016687579. Epub 2017 Jan 1. PMID: 28381196

Cerasuolo JO, Cipriano LE, Sposato LA , Kapral MK, Fang J, Gill SS, Hackam DG, Hachinski V. Population-based stroke and dementia incidence trends: Age and sex variations. Alzheimers Dement. 2017 Mar 28. pii: S1552-5260(17)30095-X. doi: 10.1016/j.jalz.2017.02.010. [Epub ahead of print] PMID: 28363085

Lee SA, Sposato LA , Hachinski V , Cipriano LE. Cost-effectiveness of cerebrospinal biomarkers for the diagnosis of Alzheimer's disease.  Alzheimers Res Ther. 2017 Mar 16;9(1):18. doi: 10.1186/s13195-017-0243-0. PMID: 28302164

Sposato LA , Wardlaw JM, Hachinski V . Response by Sposato et al to Letter Regarding Article, "Effect of Right Insular Involvement on Death and Functional Outcome After Acute Ischemic Stroke in the IST-3 Trial (Third International Stroke Trial)". Stroke. 2017 Mar;48(3):e92. doi: 10.1161/STROKEAHA.116.016387. Epub 2017 Feb 7. No abstract available. PMID: 28174325

Cerasuolo JO, Cipriano LE, Sposato LA. The complexity of atrial fibrillation newly diagnosed after ischemic stroke and transient ischemic attack: advances and uncertainties. Curr Opin Neurol. 2017 Feb;30(1):28-37. doi: 10.1097/WCO.0000000000000410. PMID: 27984303

Sposato LA, Hachinski V. Right insular cortex involvement is consistently associated with death after ischaemic stroke. Eur J Neurol. 2017 Jan;24(1):1-2. doi: 10.1111/ene.13174. Epub 2016 Oct 31. No abstract available. PMID: 27797138

 

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