Christen Shoesmith, MD, FRCPC

shoesmith

Associate Professor of Neurology, Western University
Office: London Health Sciences Centre, University Hospital C7-128
Phone: 519-663-3597
Secretary: Connie Feke

 

 

Bio Sketch

Dr. Shoesmith earned her Bachelor of Science degree from the University of Winnipeg in 1996 and her MD from the University of Manitoba in 2000. She is the President-Elect of CALS (Canada ALS Reasearch Network). She completed her neurology residency at Western University in 2005. From 2005 to 2007, Dr. Shoesmith completed a neuromuscular clinical fellowship with a specific focus on treatment and care of ALS patients at Western University. Her fellowship was sponsored by the Muscular Dystrophy Association.

In 2007, Dr. Shoesmith joined Dr. Michael Strong in the London Motor Neuron Diseases Clinic, where she focuses on conducting clinical trials in ALS (amyotrophic lateral sclerosis / Lou Gehrig's disease). She also has a general neuromuscular clinic and an EMG clinic. In 2010, Dr. Shoesmith became the Motor Neuron Diseases Clinic Director. Dr. Shoesmith is actively involved in teaching of residents and medical students.  She is the neuromuscular education coordinator for residents and fellows.  She is also a co-director of the neurosciences curriculum for medical students at the Schulich School of Medicine & Dentistry.


Research

Dr. Shoesmith's main research interests are in the field of ALS (amyotrophic lateral sclerosis). She is particularly interested in clinical trials evaluating treatments to improve prognosis in ALS and treatments that ameliorate symptoms in ALS. In addition, she is interested in evaluating prognostic factors in ALS and risk factors for developing ALS.


Medical Interests

Clinical Trials, Motor Neuron Diseases, Neuromuscular Disorders in Pregnancy


Honours and Awards

  • 2021, Schulich Excellence in Education Award for Undergraduate Education
  • 2021, Hippocratic Council Basic Science Teaching Award
  • 2012, Teaching Honour Roll Certificate, Western University Students' Council
  • 2011, Van Praet Family Award in ALS
  • 2009, Teaching Honour Roll Certificate, Western University Students' Council
  • 2008, Teaching Honour Roll Certificate, Western University Students' Council
  • 2006, Teaching Honour Roll Certificate, Western University Students' Council
  • 2005, Teaching Honour Roll Certificate, Western University Students' Council
  • 2004, Teaching Honour Roll Certificate, Western University Students' Council

 

 

Publications

PubMed Publications Listing

Publications

Dilliott AA, Abdelhady A, Sunderland KM, Farhan SMK, Abrahao A, Binns MA, Black SE, Borrie M, Casaubon LK, Dowlatshahi D, Finger E, Fischer CE, Frank A, Freedman M, Grimes D, Hassan A, Jog M, Kumar S, Kwan D, Lang AE, Mandzia J, Masellis M, McIntyre AD, Pasternak SH, Pollock BG, Rajji TK, Rogaeva E, Sahlas DJ, Saposnik G, Sato C, Seitz D, Shoesmith C, Steeves TDL, Swartz RH, Tan B, Tang-Wai DF, Tartaglia MC, Turnbull J, Zinman L; ONDRI Investigators, Hegele RA. Contribution of rare variant associations to neurodegenerative disease presentation. NPJ Genom Med. 2021 Sep 28;6(1):80. doi: 10.1038/s41525-021-00243-3. PMID: 34584092; PMCID: PMC8478934.

Salmon K, Anoja N, Breiner A, Chum M, Dionne A, Dupré N, Fiander A, Fok D, Ghavanini A, Gosselin S, Izenberg A, Johnston W, Kalra S, Matte G, Melanson M, O'Connell C, Ritsma B, Schellenberg K, Shoesmith C, Tremblay S, Williams H, Genge A. Genetic testing for amyotrophic lateral sclerosis in Canada - an assessment of current practices. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Sep 27:1-8. doi: 10.1080/21678421.2021.1980890. Epub ahead of print. PMID: 34569363.

Dilliott AA, Sunderland KM, McLaughlin PM, Roberts AC, Evans EC, Abrahao A, Binns MA, Black SE, Borrie M, Casaubon LK, Dowlatshahi D, Finger E, Fischer CE, Frank A, Freedman M, Grimes D, Hassan A, Jog M, Kumar S, Kwan D, Lang AE, Mandzia J, Marras C, Masellis M, McIntyre AD, Pasternak S, Pollock BG, Rajji TK, Robinson JF, Rogaeva E, Sahlas DJ, Saposnik G, Sato C, Seitz D, Shoesmith C, Steeves T, Strother SC, Swartz RH, Tan B, Tang-Wai D, Tartaglia MC, Troyer AK, Turnbull J, Zinman L; ONDRI Investigators, Hegele RA. Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses. Neurobiol Aging. 2021 Sep;105:378.e1-378.e9. doi: 10.1016/j.neurobiolaging.2021.04.011. Epub 2021 Apr 24. PMID: 34039480.

Slayter J, Hodgkinson V, Lounsberry J, Brais B, Chapman K, Genge A, Izenberg A, Johnston W, Lochmüller H, O'Ferrall E, Pfeffer G, Plamondon S, Rodrigue X, Schellenberg K, Shoesmith C, Stables C, Taillon M, Warman-Chardon J, Korngut L, O'Connell C. A Canadian Adult Spinal Muscular Atrophy Outcome Measures Toolkit: Results of a National Consensus using a Modified Delphi Method. J Neuromuscul Dis. 2021;8(4):579-588. doi: 10.3233/JND-200617. PMID: 33867362; PMCID: PMC8385500.

Shoesmith C, Abrahao A, Benstead T, Chum M, Dupre N, Izenberg A, Johnston W, Kalra S, Leddin D, O'Connell C, Schellenberg K, Tandon A, Zinman L. Canadian best practice recommendations for the management of amyotrophic lateral sclerosis. CMAJ. 2020 Nov 16;192(46):E1453-E1468. doi: 10.1503/cmaj.191721. PMID: 33199452; PMCID: PMC7683000. 

Shefner JM, Andrews JA, Genge A, Jackson C, Lechtzin N, Miller TM, Cockroft BM, Meng L, Wei J, Wolff AA, Malik FI, Bodkin C, Brooks BR, Caress J, Dionne A, Fee D, Goutman SA, Goyal NA, Hardiman O, Hayat G, Heiman-Patterson T, Heitzman D, Henderson RD, Johnston W, Karam C, Kiernan MC, Kolb SJ, Korngut L, Ladha S, Matte G, Mora JS, Needham M, Oskarsson B, Pattee GL, Pioro EP, Pulley M, Quan D, Rezania K, Schellenberg KL, Schultz D, Shoesmith C, Simmons Z, Statland J, Sultan S, Swenson A, Berg LHVD, Vu T, Vucic S, Weiss M, Whyte-Rayson A, Wymer J, Zinman L, Rudnicki SA. A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2021 May;22(3-4):287-299. doi: 10.1080/21678421.2020.1822410. Epub 2020 Sep 24. PMID: 32969758; PMCID: PMC8117790.

Hodgkinson V, Lounsberry J, M'Dahoma S, Russell A, Jewett G, Benstead T, Brais B, Campbell C, Johnston W, Lochmüller H, McCormick A, Nguyen CT, O'Ferrall E, Oskoui M, Abrahao A, Briemberg H, Bourque PR, Botez S, Cashman N, Chapman K, Chrestian N, Crone M, Dobrowolski P, Dojeiji S, Dowling JJ, Dupré N, Genge A, Gonorazky H, Grant I, Hasal S, Izenberg A, Kalra S, Katzberg H, Krieger C, Leung E, Linassi G, Mackenzie A, Mah JK, Marrero A, Massie R, Matte G, McAdam L, McMillan H, Melanson M, Mezei MM, O'Connell C, Pfeffer G, Phan C, Plamondon S, Poulin C, Rodrigue X, Schellenberg K, Selby K, Sheriko J, Shoesmith C, Smith RG, Taillon M, Taylor S, Venance S, Warman-Chardon J, Worley S, Zinman L, Korngut L. The Canadian Neuromuscular Disease Registry 2010-2019: A Decade of Facilitating Clinical Research Througha Nationwide, Pan-NeuromuscularDisease Registry. J Neuromuscul Dis. 2021;8(1):53-61. doi: 10.3233/JND-200538. PMID: 32925088; PMCID: PMC7902956.

Tavares TP, Mitchell DGV, Coleman KK, Coleman BL,Shoesmith C,, Butler CR, Santana I, Danek A, Gerhard A, de Mendonca A, Borroni B, Tartaglia MC, Graff C, Galimberti D, Tagliavini F, Moreno F, Frisoni G, Rowe JB, Levin J, Van Swieten JC, Otto M, Synofzik M, Sanchez-Valle R, Vandenberghe R, Laforce RJ, Ghidoni R, Sorbi S, Ducharme S, Masellis M, Rohrer J, Finger E. Early symptoms in symptomatic and preclinical genetic frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry. 2020 Sep;91(9):975-984. doi: 10.1136/jnnp-2020-322987. Epub 2020 Aug 7. PMID: 32769115; PMCID: PMC7611534. 

Hodgkinson VL, Oskoui M, Lounsberry J, M'Dahoma S, Butler E, Campbell C, MacKenzie A, McMillan HJ, Simard L, Vajsar J, Brais B, Chapman KM, Chrestian N, Crone M, Dobrowolski P, Dojeiji S, Dowling JJ, Dupré N, Genge A, Gonorazky H, Hasal S, Izenberg A, Johnston W, Leung E, Lochmüller H, Mah JK, Marerro A, Massie R, McAdam L, McCormick A, Melanson M, Mezei MM, Nguyen CE, O'Connell C, O'Ferrall EK, Pfeffer G, Phan C, Plamondon S, Poulin C, Rodrigue X, Schellenberg KL, Selby K, Sheriko J, Shoesmith C, Smith G, Taillon M, Taylor S, Warman Chardon J, Worley S, Korngut L. A National Spinal Muscular Atrophy Registry for Real-World Evidence. Can J Neurol Sci. 2020 Nov;47(6):810-815. doi: 10.1017/cjn.2020.111. Epub 2020 Jun 4. PMID: 32493524; PMCID: PMC7656664.

Barnett C, Green JR, Marzouqah R, Stipancic KL, Berry JD, Korngut L, Genge A, Shoesmith C, Briemberg H, Abrahao A, Kalra S, Zinman L, Yunusova Y. Reliability and validity of speech & pause measures during passage reading in ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Feb;21(1-2):42-50. doi: 10.1080/21678421.2019.1697888. Epub 2019 Dec 6. PMID: 32138555; PMCID: PMC7080316. 

Dilliott AA, Evans EC, Farhan SMK, Ghani M, Sato C, Zhang M, McIntyre AD, Cao H, Racacho L, Robinson JF, Strong MJ, Masellis M, Bulman DE, Rogaeva E, Black SE, Finger E, Frank A, Freedman M, Hassan A, Lang A, Shoesmith CL, Swartz RH, Tang-Wai D, Tartaglia MC, Turnbull J, Zinman L; ONDRI Investigators, Hegele RA. Genetic Variation in the Ontario Neurodegenerative Disease Research Initiative. Can J Neurol Sci. 2019 Sep;46(5):491-498. doi: 10.1017/cjn.2019.228. Epub 2019 Aug 15. PMID: 31217043.

Downar J, Shemie SD, Gillrie C, Fortin MC, Appleby A, Buchman DZ, Shoesmith C, Goldberg A, Gruben V, Lalani J, Ysebaert D, Wilson L, Sharpe MD; for Canadian Blood Services, the Canadian Critical Care Society, the Canadian Society of Transplantation and the Canadian Association of Critical Care Nurses. Deceased organ and tissue donation after medical assistance in dying and other conscious and competent donors: guidance for policy. CMAJ. 2019 Jun 3;191(22):E604-E613. doi: 10.1503/cmaj.181648. Erratum in: CMAJ. 2019 Jul 2;191(26):E745. PMID: 31160497; PMCID: PMC6546574.

Budhram A, Liu Y, Krawczyk M, Chan TLH, Burneo JG, Hosseini-Moghaddam SM, Shoesmith C. High-dose corticosteroids for acute cytomegalovirus-associated transverse myelitis in the immunocompetent patient: a case report and systematic review. J Neurovirol. 2019 Jun;25(3):405-409. doi: 10.1007/s13365-018-0717-2. Epub 2019 Jan 4. PMID: 30610740.

Hodgkinson VL, Lounsberry J, Mirian A, Genge A, Benstead T, Briemberg H, Grant I, Hader W, Johnston WS, Kalra S, Linassi G, Massie R, Melanson M, O'Connell C, Schellenberg K, Shoesmith C, Taylor S, Worley S, Zinman L, Korngut L. Provincial Differences in the Diagnosis and Care of Amyotrophic Lateral Sclerosis. Can J Neurol Sci. 2018 Nov;45(6):652-659. doi: 10.1017/cjn.2018.311. PMID: 30430962.

Markovic N, Povitz M, Smith J, Leasa D, Shoesmith C, Gofton TE. Patterns of Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis. Can J Neurol Sci. 2018 Jul;45(4):445-450. doi: 10.1017/cjn.2018.25. Epub 2018 Jun 6. PMID: 29871704.

Mitsumoto H, Nagy PL, Gennings C, Murphy J, Andrews H, Goetz R, Floeter MK, Hupf J, Singleton J, Barohn RJ, Nations S, Shoesmith C, Kasarskis E, Factor-Litvak P. Phenotypic and molecular analyses of primary lateral sclerosis. Neurol Genet. 2015 Apr 14;1(1):e3. doi: 10.1212/01.NXG.0000464294.88607.dd. eCollection 2015 Jun. PubMed PMID: 27066542; PubMed Central PMCID: PMC4821084.

Ives CT, Findlater K, Shoesmith CL, Doherty TJ. Preliminary evaluation of the sensitivity to change of DE-STA motor unit number estimation in the upper trapezius muscle in amyotrophic lateral sclerosis. Clin Neurophysiol. 2015 Jul;126(7):1427-34. doi: 10.1016/j.clinph.2014.10.013. Epub 2014 Oct 19. PubMed PMID: 25453610.

Kertesz A, Ang LC, Jesso S, MacKinley J, Baker M, Brown P, Shoesmith C, Rademakers R, Finger EC. Psychosis and hallucinations in frontotemporal dementia with the C9ORF72 mutation: a detailed clinical cohort. Cogn Behav Neurol. 2013 Sep;26(3):146-54. doi: 10.1097/WNN.0000000000000008. PubMed PMID: 24077574; PubMed Central PMCID: PMC4090685.

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