Adrian Budhram, MD, FRCPC

budhram headshotAssistant Professor of Neurology, Western University
Office: London Health Sciences Centre, University Hospital C7-131
Phone: 519-663-3615
Fax: 519-663-3525
Secretary: Kim Masseo

 

Bio Sketch

Dr. Adrian Budhram obtained his medical degree from McMaster University, followed by residency training in neurology at Western University. He then went on to complete fellowship training in Autoimmune Neurology at the Mayo Clinic in Rochester, Minnesota. He has expertise in both the laboratory diagnosis and clinical management of patients with autoimmune neurological diseases. Alongside the Clinical Immunology Laboratory, Dr. Budhram facilitated the launch of comprehensive neural antibody testing for autoimmune encephalitis at London Health Sciences Centre. He also runs the Autoimmune Neurology Clinic, which specializes in the evaluation of patients with diseases that include autoimmune encephalitis, stiff-person spectrum disorders and paraneoplastic neurological syndromes. He has authored over 50 peer-reviewed publications, with his primary research interests being the diagnostic utility of neural antibody testing and the clinico-radiographic characterization of autoimmune neurological diseases.

Research

Dr. Budhram's main research interests are in diagnostic utility of neural antibody testing and neuroimaging of autoimmune neurological diseases.


Medical Interests

Autoimmune neurological diseases


Honours and Awards

  • 2020, Anti-NMDA Receptor Encephalitis Foundation Prize, Canadian Neurological Sciences Federation Congress (presentation deferred to 2021 due to COVID-19)
  • 2018, Distinguished Reviewer of the Year, Canadian Journal of Neurological Sciences
  • 2018, Research Award, Best Neurology Poster Presentation, Department of Clinical Neurological Sciences Research Day
  • 2017 - 2018, First Prize, Neurology Grand Rounds Presentation Awards, Department of Clinical Neurological Sciences

Publications

PubMed Publications Listing

Publications

Mirian A, Sharma M, Budhram A. Linear Radial Brainstem Enhancement in Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy. JAMA Neurol. 2021 Nov 8. doi: 10.1001/jamaneurol.2021.4054. Epub ahead of print. PMID: 34747976.

 Li CMF, Romsa JG, Budhram A, Fraser JA. Fixating with the Paretic Eye: Evidence of "Fixation Duress" on PET Imaging. Ann Neurol. 2021 Oct 30. doi: 10.1002/ana.26261. Epub ahead of print. PMID: 34716720.

Santyr B, Pejhan S, Zhang Q, Budhram A,. Unilateral Primary Angiitis of the Central Nervous System. Ann Neurol. 2021 Sep 28. doi: 10.1002/ana.26234. Epub ahead of print. PMID: 34585428.

Leonard S, Budhram A,, Shevell M, Nouri MN. A Story That Begins Too Soon: A case of a girl with untreated Anti-N-methyl-d-aspartate receptor encephalitis for fourteen years. Can J Neurol Sci. 2021 Sep 29:1-6. doi: 10.1017/cjn.2021.225. Epub ahead of print. PMID: 34583790.

Mirian A, Le C, Sharma M, Budhram A, Markovic N. Hypercalcemia-Associated Posterior Reversible Encephalopathy Syndrome. Neurohospitalist. 2021 Oct;11(4):373-374. doi: 10.1177/19418744211000974. Epub 2021 Mar 11. PMID: 34539967; PMCID: PMC8442161.

Budhram A,, Ang LC, Debicki DB. Radio-Pathologic Correlation of the "Pig's Snout" Sign in Osmotic Demyelination Syndrome. Can J Neurol Sci. 2021 Sep 13:1-2. doi: 10.1017/cjn.2021.217. Epub ahead of print. PMID: 34511155.

Mirian A, Yu YJ, Casserly CS, Budhram A,. FLAIR-hyperintense Lesion in Anti-MOG-associated Encephalitis with Seizures (FLAMES). Can J Neurol Sci. 2021 Jun 14:1-2. doi: 10.1017/cjn.2021.134. Epub ahead of print. PMID: 34121651.

Mirian A, Nicolle MW, Budhram A,. Syndrome de Guillain–Barré. CMAJ. 2021 May 25;193(21):E786-E787. French. doi: 10.1503/cmaj.202710-f. PMID: 34035063; PMCID: PMC8177920.

 Chang YC, Sharma M, Budhram A,. Unilateral cortical FLAIR-hyperintense Lesion in Anti-MOG-associated Encephalitis with Seizures (FLAMES) on TNF inhibitor therapy. J Neurol Neurosurg Psychiatry. 2021 Mar 30:jnnp-2021-326401. doi: 10.1136/jnnp-2021-326401. Epub ahead of print. PMID: 33785577.

Mirian A, Nicolle MW, Budhram A,. Guillain-Barré syndrome. CMAJ. 2021 Mar 15;193(11):E378. doi: 10.1503/cmaj.202710. PMID: 33722829; PMCID: PMC8096408. 

Budhram A,, Sechi E, Flanagan EP, Dubey D, Zekeridou A, Shah SS, Gadoth A, Naddaf E, McKeon A, Pittock SJ, Zalewski NL. Clinical spectrum of high-titre GAD65 antibodies. J Neurol Neurosurg Psychiatry. 2021 Feb 9;92(6):645–54. doi: 10.1136/jnnp-2020-325275. Epub ahead of print. PMID: 33563803; PMCID: PMC8142435.

Budhram A,, Simpson HD, Bower JH, Hassan A, Conway BL, Flanagan EP. Holmes Tremor With Perirolandic Demyelinating Lesions: A Distinct Clinicoradiographic Syndrome. Neurology. 2021 Feb 2;96(5):231-232. doi: 10.1212/WNL.0000000000011235. Epub 2020 Nov 20. PMID: 33219140. 

Budhram A,, Shettar B. Cerebral Metastases. N Engl J Med. 2020 Apr 23;382(17):e36. doi: 10.1056/NEJMicm1906257. PMID: 32320572.

Budhram A,. Reader response: A multicenter comparison of MOG-IgG cell-based assays. Neurology. 2020 Mar 17;94(11):501. doi: 10.1212/WNL.0000000000009100. PMID: 32179642.

Krawczyk M,Budhram A,, Sposato LA. Ischemic Stroke From Libman-Sacks Endocarditis Not Associated With Antiphospholipid Antibodies: Good Clinical Outcome Without Anticoagulation. JACC Case Rep. 2019 Sep 11;1(3):297-300. doi: 10.1016/j.jaccas.2019.06.032. PMID: 34316811; PMCID: PMC8288987.

Budhram A,, Pelz DM, Ang LC, Fisher BJ, MacDonald M. Limbic encephalitis following intracranial radiation for suprasellar meningioma. Neurooncol Pract. 2019 Mar;6(2):156-158. doi: 10.1093/nop/npy055. Epub 2019 Jan 2. PMID: 31386004; PMCID: PMC6656332.

Kim DD, Budhram A,, Haji FA, Leung A, Khaw A, Ramsay D. Leptomeningeal metastasis of classical Hodgkin lymphoma in a patient with malignant posterior reversible encephalopathy syndrome. Lancet Oncol. 2019 Jul;20(7):e397. doi: 10.1016/S1470-2045(19)30299-2. PMID: 31267974.

Budhram A,, Taylor RG, Fuller J, Burneo JG, Knox JD, Pasternak SH. The Predictive Value of Endpoint Quaking-Induced Conversion in Creutzfeldt-Jakob Disease. Can J Neurol Sci. 2019 Sep;46(5):595-598. doi: 10.1017/cjn.2019.72. Epub 2019 Jul 3. PMID: 31266552.

Budhram A,, Mirian A, Le C, Hosseini-Moghaddam SM, Sharma M, Nicolle MW. Unilateral cortical FLAIR-hyperintense Lesions in Anti-MOG-associated Encephalitis with Seizures (FLAMES): characterization of a distinct clinico-radiographic syndrome. J Neurol. 2019 Oct;266(10):2481-2487. doi: 10.1007/s00415-019-09440-8. Epub 2019 Jun 26. PMID: 31243540.

Budhram A, Leung A, Nicolle MW, Burneo JG. Diagnosing autoimmune limbic encephalitis. CMAJ. 2019 May 13;191(19):E529-E534. doi: 10.1503/cmaj.181548. PMID: 31085562; PMCID: PMC6520067.

Budhram A, Silverman M, Burneo JG. Neurosyphilis mimicking autoimmune encephalitis in a 52-year-old man. CMAJ. 2017 Jul 24;189(29):E962-E965. doi: 10.1503/cmaj.170190. PMID: 28739848; PMCID: PMC5524577.

Taylor RG, Budhram A, Lee DH, Mirsattari SM. Opioid-associated amnestic syndrome observed with fentanyl patch use. CMAJ. 2019 Mar 25;191(12):E337-E339. doi: 10.1503/cmaj.181291. Erratum in: CMAJ. 2019 Nov 4;191(44):E1228. PMID: 30910881; PMCID: PMC6435361.

Budhram A, Mirian A, Le C, Hosseini-Moghaddam SM, Sharma M, Nicolle MW. Unilateral cortical FLAIR-hyperintense Lesions in Anti-MOG-associated Encephalitis with Seizures (FLAMES): characterization of a distinct clinico-radiographic syndrome. J Neurol. 2019 Oct;266(10):2481-2487. doi: 10.1007/s00415-019-09440-8. Epub 2019 Jun 26. PMID: 31243540.

Budhram A, Britton JW, Liebo GB, Dubey D, Zekeridou A, Flanagan EP, McKeon A, Pittock SJ, Braksick SA, Zalewski NL. Use of diffusion-weighted imaging to distinguish seizure-related change from limbic encephalitis. J Neurol. 2020 Nov;267(11):3337-3342. doi: 10.1007/s00415-020-10007-1. Epub 2020 Jun 24. PMID: 32583056.

Budhram A, Leung A, Sangle N, Khaw AV. Diffuse Large B-Cell Lymphoma of the Nasopharynx Presenting With Cluster-Like Headache. Headache. 2017 May;57(5):806-808. doi: 10.1111/head.13065. Epub 2017 Mar 13. PMID: 28295284.

Budhram A, Feng M, Mather R, Lee DH, Moulin DE. Alternating Horner Syndrome With Vegetative Alterna and Spastic Quadraparesis After Bacterial Meningitis. JAMA Neurol. 2017 Dec 1;74(12):1504-1506. doi: 10.1001/jamaneurol.2017.2865. PMID: 29052695.

Budhram A. Reader response: Anti-cytosolic 5'-nucleotidase 1A (cN1A) autoantibodies in motor neuron diseases. Neurology. 2018 May 22;90(21):990. doi: 10.1212/WNL.0000000000005572. PMID: 29784723.

Chan TLH, Budhram A. Facial Diplegia in Neuroinvasive West Nile Virus Infection. Can J Neurol Sci. 2019 Jul;46(4):453-454. doi: 10.1017/cjn.2019.46. Epub 2019 May 7. PMID: 31060643.

Budhram A, Sechi E, Nguyen A, Lopez-Chiriboga AS, Flanagan EP. FLAIR-hyperintense Lesions in Anti-MOG-associated Encephalitis With Seizures (FLAMES): Is immunotherapy always needed to put out the fire? Mult Scler Relat Disord. 2020 Jun 11;44:102283. doi: 10.1016/j.msard.2020.102283. Epub ahead of print. PMID: 32562909.

Budhram A, Mills JR, Shouman K, Dyck PJB, Hassan A, Zalewski NL. False-positive anti-neuronal nuclear antibody type 1 in a patient with RFC1 repeat expansion: Preventing "phenotype creep" in autoimmune neurology. J Neurol Sci. 2020 Jul 9;416:117018. doi: 10.1016/j.jns.2020.117018. Epub ahead of print. PMID: 32682126.

Budhram A, Parvathy S, Kremenchutzky M, Silverman M. Breaking down the gut microbiome composition in multiple sclerosis. Mult Scler. 2017 Apr;23(5):628-636. doi: 10.1177/1352458516682105. Epub 2016 Dec 12. PMID: 27956557.

Budhram A, Le C, Jenkins ME. Lyme Disease Presenting With Raeder Syndrome. Headache. 2018 Feb;58(2):317-318. doi: 10.1111/head.13220. Epub 2017 Nov 8. PMID: 29115676.

Kim DD, Budhram A, Mirsattari S. Recurrent Involuntary Contractions of the Face, Arm, and Leg in an Elderly Man. JAMA Neurol. 2019 Jun 1;76(6):728-731. doi: 10.1001/jamaneurol.2019.0452. PMID: 30933236.

Budhram A, Gabril MY, Lee DH, Fraser JA. Hypertrophic Pachymeningitis With Optic Neuropathy Heralding Systemic Vasculitis. Can J Neurol Sci. 2017 Jan;44(1):105-107. doi: 10.1017/cjn.2016.51. Epub 2016 May 17. PMID: 27184909.

Kim DD, Budhram A, Pelz D, MacDonald M. Teaching NeuroImages: Orbital infarction syndrome from giant cell arteritis. Neurology. 2016 Nov 29;87(22):e269. doi: 10.1212/WNL.0000000000003381. PMID: 27895251.

Budhram A, Pelikan JB, Kremenchutzky M, Sharma M. The 'across the pons' sign: A possible novel radiographic finding in natalizumab-associated progressive multifocal leukoencephalopathy. J Neurol Sci. 2017 Apr 15;375:304-306. doi: 10.1016/j.jns.2017.02.021. Epub 2017 Feb 10. PMID: 28320156.

Budhram A, Pandey SK. Activation of Cerebral X-linked Adrenoleukodystrophy After Head Trauma. Can J Neurol Sci. 2017 Sep;44(5):597-598. doi: 10.1017/cjn.2017.52. Epub 2017 May 23. PMID: 28534457.

Budhram A. Letter re: Teaching NeuroImages: Idiopathic hypertrophic pachymeningitis. Neurology. 2017 Jun 6;88(23):2238-2239. doi: 10.1212/WNL.0000000000004023. PMID: 28583934.

Kim DD, Budhram A. Opsoclonus-Myoclonus Syndrome-Additional Clinical Considerations. JAMA Otolaryngol Head Neck Surg. 2018 Apr 1;144(4):387-388. doi: 10.1001/jamaoto.2017.3427. PMID: 29522119.

Budhram A, Sharma M, Shettar B, Hosseini-Moghaddam SM, Khaw AV. Sensory and autonomic involvement in West Nile virus-associated acute flaccid paralysis. Neurol Clin Pract. 2017 Oct;7(5):394-397. doi: 10.1212/CPJ.0000000000000373. PMID: 29620087; PMCID: PMC5874468.

Budhram A, Nicolle MW, Yang L. The Positive Predictive Value of Onconeural Antibody Testing: A Retrospective Review. Can J Neurol Sci. 2018 Sep;45(5):577-579. doi: 10.1017/cjn.2018.74. PMID: 30234468.

Budhram A, Kim DD. Listeria monocytogenes-Induced Rhombencephalitis-A Paradoxical Disease of Immunocompetent Patients. JAMA Neurol. 2018 Nov 1;75(11):1442. doi: 10.1001/jamaneurol.2018.2741. PMID: 30264152.

Budhram A, Liu Y, Krawczyk M, Chan TLH, Burneo JG, Hosseini-Moghaddam SM, Shoesmith C. High-dose corticosteroids for acute cytomegalovirus-associated transverse myelitis in the immunocompetent patient: a case report and systematic review. J Neurovirol. 2019 Jun;25(3):405-409. doi: 10.1007/s13365-018-0717-2. Epub 2019 Jan 4. PMID: 30610740.

Budhram A, Taylor RG, Fuller J, Burneo JG, Knox JD, Pasternak SH. The Predictive Value of Endpoint Quaking-Induced Conversion in Creutzfeldt-Jakob Disease. Can J Neurol Sci. 2019 Sep;46(5):595-598. doi: 10.1017/cjn.2019.72. Epub 2019 Jul 3. PMID: 31266552.

Mirian A, Budhram A, Leung A, Jones ML. Trigeminal Nerve Sheath Tumor Presenting as a Cluster Headache. Headache. 2018 Jun;58(6):896-897. doi: 10.1111/head.13332. Epub 2018 May 21. PMID: 29782034.

Budhram A, Shettar B. Cerebral Metastases. N Engl J Med. 2020 Apr 23;382(17):e36. doi: 10.1056/NEJMicm1906257. PMID: 32320572.

Budhram A, Climans SA, Le C, Casserly CS, Mayich M, Lownie SP, Sposato LA. Aseptic meningitis due to reperfusion injury after carotid artery stenting. J Neurol Sci. 2017 Oct 15;381:269-271. doi: 10.1016/j.jns.2017.08.3255. Epub 2017 Aug 31. PMID: 28991696.

Chan TLH, Mayich M, Budhram A, Sallam Y, Becker WJ. Teaching Images in Headache: Concurrent Hypercalcemia-Induced Reversible Cerebral Vasoconstriction Syndrome and Posterior Reversible Encephalopathy Syndrome. Headache. 2019 Jun;59(6):933-935. doi: 10.1111/head.13528. Epub 2019 Apr 15. PMID: 30985912.

Budhram A, Shettar B, Lee DH, Silverman M, Gupta K. Bilateral Cavernous Sinus Thrombosis in Lemierre's Syndrome. Can J Neurol Sci. 2017 Jul;44(4):424-426. doi: 10.1017/cjn.2016.438. Epub 2017 Feb 2. PMID: 28148337.

Budhram A, Lipson D, Nesathurai S, Harvey D, Rathbone MP. Postanoxic myoclonus: two case presentations and review of medical management. Arch Phys Med Rehabil. 2014 Mar;95(3):588-90. doi: 10.1016/j.apmr.2013.09.008. Epub 2013 Sep 21. PMID: 24060492.

Budhram A, Cebrian C. Paranoid psychosis and cognitive impairment associated with hepatitis C antiviral therapy. Gen Hosp Psychiatry. 2014 Jan-Feb;36(1):126.e3-5. doi: 10.1016/j.genhosppsych.2013.10.008. Epub 2013 Oct 14. PMID: 24210465.

Kim DD, Budhram A, Haji FA, Leung A, Khaw A, Ramsay D. Leptomeningeal metastasis of classical Hodgkin lymphoma in a patient with malignant posterior reversible encephalopathy syndrome. Lancet Oncol. 2019 Jul;20(7):e397. doi: 10.1016/S1470-2045(19)30299-2. PMID: 31267974.

Budhram A, Chu R, Rusta-Sallehy S, Ioannidis G, Denburg JA, Adachi JD, Haaland DA. Anti-cyclic citrullinated peptide antibody as a marker of erosive arthritis in patients with systemic lupus erythematosus: a systematic review and meta-analysis. Lupus. 2014 Oct;23(11):1156-63. doi: 10.1177/0961203314540967. Epub 2014 Jul 2. PMID: 24990382.

Budhram A, Butendieck RR, Duarte-Garcia A, Brinjikji W, Zalewski NL. Striatal Encephalitis: Potential Inflammatory Vasculopathy in Systemic Lupus Erythematosus. Can J Neurol Sci. 2020 Sep 11:1-2. doi: 10.1017/cjn.2020.198. Epub ahead of print. PMID: 32912371.

Budhram A. Understanding the application of diagnostic criteria for multiple sclerosis helps prevent misdiagnosis. CMAJ. 2020 Aug 4;192(31):E894. doi: 10.1503/cmaj.76124. PMID: 32753464.

Budhram A, Mirian A, Flanagan EP. Unilateral Cortical Fluid-Attenuated Inversion Recovery-Hyperintense Lesions in Anti-Myelin Oligodendrocyte Glycoprotein-Associated Encephalitis With Seizures (FLAMES): An Under-recognized Entity. Pediatr Neurol. 2020 Sep;110:99-100. doi: 10.1016/j.pediatrneurol.2020.05.003. Epub 2020 May 11. PMID: 32682599.

Budhram A. Reader response: A multicenter comparison of MOG-IgG cell-based assays. Neurology. 2020 Mar 17;94(11):501. doi: 10.1212/WNL.0000000000009100. PMID: 32179642.

Budhram A, Kunchok AC, Flanagan EP. Unilateral Leptomeningeal Enhancement in Myelin Oligodendrocyte Glycoprotein Immunoglobulin G-Associated Disease. JAMA Neurol. 2020 May 1;77(5):648-649. doi: 10.1001/jamaneurol.2020.0001. PMID: 32119057.

Kim C, delaRiva-Velasco E, Budhram A, Farri F, Krich D, Nolan SS, Gjonaj S, Paul L, Dozor AJ, Welter JJ. Incidence and prevalence of common respiratory pathogens before and after implementation of the Cystic Fibrosis Foundation Infection Prevention and Control Guideline. J Infect Prev. 2020 Jan;21(1):7-13. doi: 10.1177/1757177419872538. Epub 2019 Sep 25. PMID: 32030098; PMCID: PMC6978569.

Budhram A, Pelz DM, Ang LC, Fisher BJ, MacDonald M. Limbic encephalitis following intracranial radiation for suprasellar meningioma. Neurooncol Pract. 2019 Mar;6(2):156-158. doi: 10.1093/nop/npy055. Epub 2019 Jan 2. PMID: 31386004; PMCID: PMC6656332.