Structure-function Relationship in Epilepsy: How Brain MRI features influences EEG Activity (MRI2EEG)
This study seeks to investigate the correlation between brain structure and activity in individuals with epilepsy, a neurological disorder impacting approximately 0.7% of the global population. Epilepsy, characterized by recurrent seizures, poses various challenges, including social stigma, cognitive and psychiatric comorbidities, and significant economic burdens. As a network disorder, epilepsy involves changes in both brain structure and function across interconnected regions. Understanding this relationship is crucial for advancing knowledge and improving clinical management. Quantitative analysis of MRI images has revealed progressive atrophy in epileptic brains. The proposed cohort study will involve quantitative analysis of MRI and EEG data from patients at London Health Sciences Centre (LHSC) undergoing clinical management for epilepsy. Patients with epilepsy or suspected epilepsy, evaluated as outpatients or inpatients, will constitute the study population. The standard of care, including clinical information, brain MRI, and EEG, will be quantitatively analyzed for research purposes.
Inclusion criteria:
- Patients with epilepsy, who are ≥18 years.
- Patients with a suspected or defined epilepsy condition.
- Patients who have an availability of clinical MRI and EEG.
Exclusion criteria:
- Patients who are less than 18 years old.
- Patients without a suspected or defined epilepsy condition.
- Patients with no availability of clinical MRI and EEG.
Principal Investigator: Dr. Giovanni Pellegrino
Suzan Brown (Research Coordinator) is collecting written consent from patients in the outpatient clinic.
