Thomas A. Drysdale
PH.D. University of Toronto
M.Sc. University of Guelph
B.Sc. University of Guelph
Office: Victoria Research Labs, Room A5-138
p. 519.685.8500 x. 55072
See Publications by Thomas Drysdale on PubMed
The goal of my lab is to understand the molecular events that govern the development of specific organs. In particular, we are interested in the early development of the cardiovascular system, the lung and thyroid. We have found that retinoic acid is a critical signaling molecule in controlling the decisions regarding the differentiation of these organ systems. We are also trying to understand the cellular events that govern the morphogenesis of the organ.
We utilize a combination of classical embryology, molecular biology and genome manipulation to look at these challenging questions.
Wang, J.H., Deimling, S.J., D’Alessandro N., Zhao, L., Possmayer, F., and Drysdale, T.A. (2011) Retinoic acid is a key regulatory switch determining the difference between lung and thyroid fates in Xenopus laevis. BMC Developmental Biology 11: 75
Deimling, S. J. and Drysdale, T. A. (2011) FGF is required to regulate anterior-posterior patterning in the Xenopus lateral plate mesoderm. Mechanisms of Development 128: 327-341.
Chung, M-I, Nascone-Yoder, N.M., Grover, S.A., Drysdale, T.A., and Wallingford, J.B. (2010) Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut. Development 137: 1339-1349.
Deimling, S.J., and Drysdale, T.A. (2009) Retinoic acid regulates anterior-posterior pattering within the lateral plate mesoderm of Xenopus. Mechanisms of Development 126:913-923