Welcome Dr. Mohammad Ali Esmaeili


I am here in the Department of Pathology and Laboratory of Medicine, working under the supervision of Dr. Martin Duennwald exploring the role of protein misfolding, aging, and cellular quality control in human diseases, focusing on age-related neurodegenerative diseases, such as Parkinson’s disease, Huntington’s disease, and ALS.

I got my PhD in Biochemistry at the Biochemistry and Biophysics Institute, University of Tehran (Iran), working on protein refolding assisted by molecular tube based chaperones, under the supervision of Dr. Razieh Yazdanparast. I later joined the laboratory of Dr. Mahmud Kiaei at the University of Arkansas for Medical Sciences (Little Rock, Arkansas, USA) as a post-doctoral fellow, working on the role of oxidative damage, neuroinflammation, and mitochondrial dysfunction in pathogenesis of Amyotrophic lateral sclerosis (ALS). Then back to Iran to join Shahid Beheshti University (Iran) as a researcher working on Nrf2/Keap1 signaling pathway, understanding of how the Nrf2-mediatated antioxidant response is activated, and how to use this knowledge to identify/develop Nrf2-targeting compounds for disease intervention, thus improving human health.