Inflammation and Tissue Repair 2024

Leuky’s Journey through the Cellular Events of Acute Inflammation - Team 22

Media Type: Video

Summary

team_22_image.jpgOur PULSE assignment explored acute inflammation in a play format with a narrator (“Pathology Professor”) and characters for the main cell types (“Leukocyte” and “Endothelial Cell”). Leukocytes are cells that are part of your immune system and endothelial cells are a layer of cells that line the inside of your blood vessels. We demonstrated the cellular events that occur when there is an injury to the body. The cellular events we explored included margination, rolling, adhesion, transmigration, chemotaxis, and phagocytosis. Margination is the process of the leukocytes traveling to the edges of the blood vessel towards the endothelium. Rolling is the process of the leukocyte weakly interacting with the endothelial cell to slow its speed. Adhesion is the process of the leukocyte firmly adhering to the endothelial cell before exiting the blood vessel. Transmigration is the process of the leukocyte squeezing between two endothelial cells to exit the blood vessel and enter the tissue. Chemotaxis is the process of the leukocyte moving toward the site of injury by following a trail of chemical signals released near the injury site. Phagocytosis is the process of the leukocyte becoming activated and then taking in injured cells, foreign material or disease-causing agents nearby to help repair the injury site. We chose this format for our assignment, as we believed acting out the physical interactions between the different cell types would further solidify viewers' engagement and understanding of the concepts and the narration provided. The topic of acute inflammation is crucial to understand since it is your body’s initial response to most types of injury to cells and tissues. This topic and format can serve as a foundation for incoming pathology students, as acute inflammation is a recurring concept discussed in the course.

Keywords: Margination, Rolling, Adhesion, Diapedesis, Chemotaxis, Phagocytosis