Saman Maleki


Assistant Professor,
Departments of Oncology, Pathology and Laboratory Medicine, and Medical Biophysics

MSc University of Isfahan (Iran)
PhD Western University

Office: CRLP, LRCP, A4-102
Phone: (519) 685-8500 Ext.55769
Visit: The Maleki Lab Website

Clinical Activities

Keywords: cancer, immuno-oncology, cancer immunotherapy, microbiome, translational research, immune-related adverse events, melanoma, renal cell carcinoma, lung cancer

Description of Research Activities: Phase I clinical trials in Immuno-Oncology and Microbiome Modifications via Fecal Microbiota Transplantation.

Current Clinical Trial: NCT03772899 (Melanoma), NCT04163289 (Renal Cell Carcinoma)

Research Activities

Keywords: tumor immunology, neoantigen, T-cells, microbiome, fecal microbiota transplantation, neuroblastoma, breast cancer, colorectal cancer, pancreatic cancer, melanoma, head and neck cancer

Description of Research Activities: Dr. Maleki’s research is focused on understanding how to sensitize hard-to-treat cancers to immunotherapy with immune checkpoint inhibitors. In particular, inducing neoantigen formation in tumor cells by blocking their DNA repair pathways and studying the effect of changing the gut microbiome on anti-tumor immunity and immune-related toxicities.

Publications on PubMed:

Research Opportunities

We are always looking for graduate students, post-doctoral fellows, and residents who share our passion for translational research in Immuno-Oncology.