Christina Castellani


Assistant Professor
Cross-Appointment, Department of Epidemiology and Biostatistics

MSc Western University
PhD Western University
Postdoctoral Fellowship Johns Hopkins University School of Medicine

Office: Dental Sciences Building, Room 4011
Phone: (519) 661-2111 Ext. 89069
Visit: Castellani Lab

Research Activities

Keywords: Cardiovascular Disease, Mitochondrial DNA, Computational Genomics, Epigenomics, Transcriptomics, Complex Disease, Gene-Environment Interactions, Bioinformatics

Description of Research Activities: The Castellani Lab is interested in the contribution of mitochondrial nuclear multiomic signalling to cardiovascular disease. We use both bioinformatic and cell culture approaches to assess the dynamic relationships between mitochondria quality/quantity and nuclear DNA at the level of the genome, epigenome, transcriptome, metabolome and proteome. The lab is specifically focused on: 1. Integration across large-scale multiomic datasets to determine the dynamic relationship of mitochondrial DNA copy number (mtDNA-CN), heteroplasmy and nuclear epigenomic/transcriptomic patterns in cardiovascular disease, 2. Implementing and developing models that modify mtDNA-CN and heteroplasmy in culture to uncover mechanisms behind mitochondrial and nuclear cross-talk contributing to cardiovascular disease, and 3. Assessing the impact of environmental stimuli on mitochondrial DNA signalling to nuclear DNA and its impact on health and disease.

Research Opportunities: Positions are available for undergraduate and graduate students.