Recent research achievements

Fall 2021 and Winter 2022

  • Lakshman Gunaratnam, LHRI funding for a project entitled “Understanding the molecular signaling mechanisms of KIM-1-mediated phagocytosis in acute kidney injury”, $15,000, 1 year, Studentship
  • Richard Kim was awarded funding from the OICR Clinical Translation Pathway for his study entitled “Patient-specific prediction of fluoropyrimidine dose and toxicity risk based on circulating micro RNA and NextGen exome sequencing coupled to functional validation in vitro and in vivo”, $745,543, 3 years.
  • Richard Kim, Glenn Bauman, Amit Garg, Ute Schwarz, Rommel Tirona, Stephen Welch, Eric Winquist, Yun-Hee Choi, Sisira Sarma, David Barrett, and Mark Levine, as well as Martie Grof-Iannelli and Bronagh Morgan were awarded a CIHR Team Grant in Personalized Health for their study entitled “Integrated Precision Medicine Technology and Approach for Optimal Drug Therapy for Canadians”, $1,995,001 over 4 years.
  • Manuel Montero-Odasso was awarded a grant as part of the Brain Health: Lifestyle Approaches and Microbiome Contributions 2021 program from the Weston Family Foundation for his proposal entitled “SYNERGIC 2. A Home-based RCT from the Canadian Therapeutic Platform for Multidomain Interventions to Prevent Dementia (CAN-Thumbs UP)”, $1,497,758 over 3 years.
  • Tianqing Peng, LHRI funding for a project entitled “Targeting DDIT3-mediated necroptosis as a new strategy to project cardiomyocytes under stress”, $15,000, 2 years
  • Ruud Veldhuizen, LHRI funding for a project entitled “The effect of e-cigarette vapour exposure on the function of pulmonary surfactant”, $15,000, 1 year, Studentship
  • Carol Wang (Supervisor – Dr. Amit Garg), PSI Foundation 2022 Research Trainee Awards, $50,000 over 2 years

CIHR Project Grants, Fall 2021

  • Richard Kim, "Organic Anion Transporting Polypeptide (OATP), P-glycoprotein (Pgp), and Breast Cancer Resistance Protein (BCRP) transporters modulate tamoxifen response during breast cancer therapy", $657,900, 5 years.
  • Tianqing Peng, "Preventing organ failure in sepsis by NAD(+) repletion: mechanistic insights and therapeutic potential", $711,450, 5 years.
  • Geoffrey Pickering, "Smooth muscle cell diversity and thoracic aorta vulnerability", $852,975, 5 years.
  • Frank Beier, Thomas Appleton, Cheryle Séguin and Matthew Grol, "The role of PGC1alpha in osteoarthritis", $745,875, 5 years.
  • Rithwik Ramachandran, Thomas Appleton, Alan Getgood and Frank Beier, “Targeting the Protease Activated Receptor (PAR) - Transient Receptor Potential Vanilloid-4 (TRPV4) signalling axis in osteoarthritis”, $711,450, 5 years.

Academic Medical Organization of Southwestern Ontario (AMOSO) Funding

  • Jaspreet Bhangu, “The Association of Orthostatic Hypotension and Cognitive Performance in older adults with Cognitive impairment (OHCog): A sub-study of the Canadian Consortium on Neurodegeneration in Aging (CCNA)”, $97,500, 3 years
  • Sarah Blissett, “An innovative, virtual, interdisciplinary curriculum for Cardio-Obstetrics Education”
  • Tristan Boyd, “Best practices clinic in psoriatic arthritis”, $97,500, 3 years
  • Paul Cameron, Kimia Honarmand, and Karen Bosma, “The Critical Illness Recovery Program: A Knowledge Synthesis and Translation Project“, $130,000 over 2 years
  • Kristin Clemens and Amit Garg, “Denosumab for the prevention of fragility fractures in hemodialysis: a pilot study for an innovative, randomized-controlled trial, embedded in routine care (PREFERRED-1)”, $40,881, 2 years
  • Dervla Connaughton, “Integrating genomic medicine into the clinical care of patients with chronic kidney disease”, $155,104, 2 years
  • Inderdeep Dhaliwal and David Palma, “Endoscopic nodal staging in oligometastatic non-small cell lung cancer being treated with stereotactic ablative radiotherapy (ENDO-SABR)”, $44,790, 1 year
  • Amit Garg, "Personalized proton pump inhibitor (PPI) dosing for gastroesophageal reflux disease (GERD)"
  • Mark Goldszmidt and Ravi Taneja, “Development and validation of a resuscitation preferences video decision aid at the London Health Sciences Center (LHSC)”, $144,263, 2 years
  • Robert Hegele, “Genetic diagnosis of dyslipidemia”, $140,000, 2 years
  • Samira Jeimy, “Moving towards personalized management of food allergy”, $111,002, 2 years
  • Habib Khan, "Year 2 of 2 Funding: Diagnostic Working Group for Epilepsy: Investigation of the Utility of Pediatric Autoimmune and Genetic Testing in Drug-Resistant Epilepsy - The PAGE study"
  • Richard Kim, "Medication Determinants of Ascending Aortic Aneurysm Structural Risk"
  • Geoff Pickering and Michael Chu, "Identifying and closing information gaps in best practice therapeutics for pregnant women"
  • Naveen Poonai, "High-throughput computing to improve prescription-drug safety in older adults"
  • Michael Rieder and Alejandro Lazo-Langner, “Real time continuous non-invasive monitoring and classification of peripheral white blood cells”, $149,600, 2 years
  • Aze Wilson, “Building the evidence for biomarker testing for drug safety and efficacy in inflammatory bowel disease: personalizing patient care”, $148,800, 2 years
  • Justin Yan, “Derivation and internal validation of a clinical prognostic tool for recurrent emergency department visits for hyperglycemia in patients with diabetes mellitus: A prospective cohort study”, $149,500, 2 years