Publications


  1. *Singh S, *Nguyen HC, *Ehsan M, *Michels DCR, *Singh P, Qadura M, Singh KK. (2021). Pravastatin-induced changes in expression of long non-coding and coding RNAs in endothelial cells. Physiol Rep. 9(1):e14661.
  2. Ye L, Hu X, Hu X, Yin S, He K, Hong S, Jin L, Yang B, Singh KK, Feng J, Wang Y, Luo W. (2021) Curcumin Analogue C66 Attenuates Obesity-induced Renal Injury by inhibiting Chronic Inflammation. Biomed Pharmacother. (in press)
  3. *Singh S, *Adam M, *Matkar P, *Bugyei-Twum A, Desjardins J-F, *Chen H, *Nguyen H, *Bazinet H, *Michels D, *Liu Z, *Mebrahtu E, *Esene L, *Joseph J, *Ehsan M, Qadura M, Connelly K, Leong-Poi H, Singh KK. (2020). Endothelial-specific Loss of IFT88 Promotes EndMT and Exacerbates Bleomycin-induced Pulmonary Fibrosis. Scientific Reports. 10(1)(4466): 1-14.
  4. *Nguyen HC, Qadura M, Singh KK. (2020). Role of the Fatty Acid Binding Proteins in Cardiovascular Diseases: A Systematic Review. J Clin Med. 2020 Oct 22;9(11):3390. doi: 10.3390/jcm9113390.
  5. *Singh S, *Nguyen H, *Michels D, *Bazinet H, *Matkar P, *Liu Z, *Esene L, *Adam M, *Bugyei-Twum A, *Mebrahtu E, *Joseph J, *Ehsan M, *Chen HH, Qadura M, Singh KK. (2020). BReast CAncer Susceptibility Gene 2 Deficiency Exacerbates Oxidized LDL-induced DNA Damage and Endothelial Apoptosis. Physiol Rep. 8(13)(e14481): 1-14.
  6. Syed MH, Zamzam A, Valencia J, Khan H, Jain S, Singh KK, Abdin R, Qadura M. (2020). MicroRNA Profile of Patients with Chronic Limb Threatening Ischemia. Diagnostics (Basel). 17(10): 1-11.
  7. Zamzam A, Syed MH, Rand ML, Singh KK, Hussain MA, Jain S, Khan H, Verma S, Al-Omran M, Abdin R, Qadura M. (2020). Altered Coagulation Profile in Peripheral Artery Disease Patients. 28(4): 368-377.
  8. Syed MH, Zamzam A, Khan H, Singh KK, Forbes TL, Rotstein O, Abdin R, Eikelboom J, Qadura M. (2020). Fatty Acid Binding Protein 3 is Associated with Peripheral Arterial Disease. JVS-Vascular Science. 1(1):168-175.
  9. Zamzam A, Syed MH, Greco E, Wheatcroft M, Jain S, Khan H, Singh KK, Forbes TL, Rotstein O, Abdin R, Qadura M. (2020). Fatty Acid Binding Protein 4 - A Circulating Protein Closely Associated with Peripheral Arterial Disease in Diabetic Patients. Journal of Clinical Medicine. 9(9):E2843:1-8.
  10. *Singh S, Singh KK. (2020). Valproic Acid in Prevention and Treatment of COVID-19. International Journal of Respiratory and Pulmonary Medicine. 7(138): 1-7.
  11. *Mauro A, Nga R, Lia JY, Guana R, Wanga Y, Singh KK, Wen XY. (2019). Protocol Development for Discovery of Angiogenesis Inhibitors via Automated Methods Using Zebrafish. PLoS One. 14(11) (e0221796): 1-14.
  12. *Altamimi TR, *Chowdhury B, Singh KK, Zhang L, Mahmoud MU, Pan Y, Quan A, Teoh H, Verma S, Lopaschuk GD. (2019). A Novel Role of Endothelial Autophagy as a Regulator of Myocardial Fatty Acid Oxidation. The Journal of Thoracic and Cardiovascular Surgery. 157(1): 185-193.
  13. *Murugavel S, *Bugyei-Twum A, *Matkar PN, Al-Mubarak H, *Chen HH, *Adam M, Jain S, *Narang T, Abdin RM, Qadura M, Connelly KA, Leong-Poi H, Singh KK. (2018). Valproic Acid Induces Endothelial-toMesenchymal Transition-like Phenotypic Switching. Frontiers in Pharmacology. 9(737): 1-14.
  14. *Ramadan A, Singh KK, Quan A, Al-Omran M, Verma S. (2018). Loss of Vascular Smooth Muscle Cell Autophagy Exacerbates Ang II Associated Aortic Remodelling. Journal of Vascular Surgery. 68(3): 859-871.
  15. *Matkar P, *Jong ED, Ariyagunarajah R, Prud'homme GJ, $Singh KK, Leong-Poi H ($Co-corresponding Author). (2018). Jack of many Trades: Multifaceted Role of Neuropilins in Pancreatic Cancer. Cancer Medicine. 7(10): 5036-5046.
  16. *Bugyei-Twum A, Ford C, Civitarese R, Seegobin J, Advani SL, Desjardins JF, Kabir G, Zhang Y, Mitchell M, Switzer J, Thai K, Shen V, Abadeh A, Singh KK, Billia F, Advani AA, Gilbert RE, Connelly KA. (2018). Sirtuin 1 Activation Attenuates Cardiac Fibrosis in a Rodent Pressure Overload Model by Modifying Smad2/3 Transactivation. Cardiovascular Research. 114(12): 1629-1641.
  17. Quan A, Pan Y, Singh KK, Polemidiotis J, Teoh H, Leong-Poi H, Verma S. (2017). Cardiovascular Inflammation is Reduced with Methotrexate in Diabetes. Molecular and Cellular Biochemistry. 432(1-2):159-167.
  18. *Matkar PN, Ariyagunarajah R, Leong-Poi H, Singh KK. (2017). Friends Turned Foes: Angiogenic Growth Factors beyond Angiogenesis. 4(2): 1-46.
  19. Shi X, Verma S, Yun J, Brand-Arzamendi K, Singh KK, Liu X, Garg A, Quan A, Wen XY. (2017). Effect of Empagliflozin on Cardiac Biomarkers in a Zebrafish Model of Heart Failure:Clues to the EMPA-REG OUTCOME Trial? . Molecular and Cellular Biochemistry. 433(1-2): 97-102
  20. $Singh KK, *Matkar PN, Pan Y, Quan A, Gupta V, Teoh H, Al-Omran M, Verma S ($Co-corresponding author). (2017). Endothelial Long Non-coding RNAs Regulated by Oxidized LDL. Molecular and Cellular Biochemistry. 431(1-2): 139-149.
  21. *Yau JW, $Singh KK, Hou Y, Lei X, Ramadan A, Quan A, Teoh H, Kuebler WM, Al-Omran M, Yanagawa B, Ni H, Verma S ($Co-corresponding author). (2017). Endothelial-specific Deletion of Autophagy-related 7 (ATG7) Attenuates Arterial Thrombosis in Mice. The Journal of Thoracic and Cardiovascular Surgery. 154(3): 978-988.
  22. *Mantella LE, Singh KK, *Sandhu P, Kantores C, *Ramadan A, Khyzha N, Quan A, Al-Omran M, Fish JE, Jankov RP, Verma S. (2017). Fingerprint of Long Non-coding RNA Regulated by Cyclic Mechanical Stretch in Human Aortic Smooth Muscle Cells: Implications for Hypertension. Molecular and Cellular Biochemistry. 435(1-2): 163-173.
  23. Singh KK, *Matkar PN, Quan A, *Mantella LE, Teoh H, Al-Omran M, Verma S. (2016). Investigation of TGFb1-induced Long Non-Coding RNAs in Endothelial Cells. International Journal of Vascular Medicine. 2016(2459687): 1-12.
  24. Singh KK#, Torisu K#, Torisu T#, Lovren F, Liu J, Pan Y, Quan A, Ramadan A, Al-Omran M, Pankova N, Boyd SR, Verma S, Finkel T (# 1st equal author). (2016). Intact Endothelial Autophagy is Required to Maintain Vascular Lipid Homeostasis. Aging Cell. 15(1): 187-191.
  25. $Singh KK, *Matkar P, *Muhammad S, Quan A, Gupta V, Teoh H, Al-Omran M, Verma S ($Cocorresponding author). (2016). Investigation of LPS-induced Long Non-Coding RNAs in Endothelial Cells. Molecular and Cellular Biochemistry. 421(1-2): 157-168.
  26. Singh KK, *Mantella LE, Pan Y, Quan A, Sabongui S, Sandhu P, Teoh H, Al-Omran M, Verma S. (2016). Global Profile of Glucose-sensitive Endothelial-expressed Long Non-coding RNAs. Canadian Journal of Physiology and Pharmacology. 94(9): 1007-1014.
  27. *Matkar P, $Singh KK, Rudenko D, Kim YJ, Kuliszewsky AJ, Prud'homme GJ, Hedley D, Leong-Poi H ($Co-corresponding author). (2016). Novel Regulatory Role of Neuropilin-1 in Endothelial-to-Mesenchymal Transition and Fibrosis in Pancreatic Ductal Adenocarcinoma. 2016: 1-18.
  28. *Matkar P, Leong-Poi H, Singh KK. (2016). Cardiac gene therapy: Are we there yet?. Gene Therapy. 23(8-9): 635-648.
  29. *Ehsan M, Singh KK, Lovren F, Pan Y, Quan A, *Mantella LE, Sandhu P, Teoh H, Al-Omran M, Verma S. (2015). Adiponectin Limits Monocytic Microparticle-induced Endothelial Activation by Modulation of AMPK, Akt and NFkB Signaling Pathways. 25(245): 1-11.
  30. *Matkar PN, Chen HH, *Bugyei-Twum A, Leong-Poi H, Singh KK. (2015). Targeting Fibrosis in Pancreatic Ductal Adenocarcinoma: Emerging Role of Endothelial-to-Mesenchymal Transition. Journal of Cell Science & Therapy. 6(6): 1-2.
  31. *Ramadan A, Wheatcroft MD, Quan A, Singh KK, Lovren F, Dhingra N, Teoh H, Al-Omran M, Leong-Poi H, Verma S. (2015). Role of Autophagy in the Natural History and Complications of Aortic Aneurysms. Canadian Journal of Physiology and Pharmacology. 93(8): 641-648.
  32. Singh KK, Lovren F, Pan Y, Quan A, *Ramadan A, *Matkar PN, *Ehsan M, Sandhu P, *Mantella LE, Gupta N, Teoh H, Parotto M, Tabuchi A, Kuebler WM, Al-Omran M, Finkel T, Verma S. (2015). The Essential Autophagy Gene ATG7 Modulates Organ Fibrosis via Regulation of Endothelial-to-Mesenchymal Transition. The Journal of Biological Chemistry. 290(5): 2547-59.
  33. *Matkar PN, Chen HH, Leong-Poi H, Singh KK. (2015). Overview of Marfan Syndrome: Knowns and Unknowns. Journal of Controversies in Biomedical Research. 1(1): 51-66.
  34. Singh KK, Yanagawa B, Quan A, Wang R, *Garg A, *Khan R, Pan Y, Wheatcroft MD, Lovren F, Teoh H, Verma S. (2014). Autophagy Gene Fingerprint in Human Ischemia and Reperfusion. Journal of Thoracic and Cardiovascular Surgery. 147(3): 1065-72.
  35. Lovren F, Pan Y, Quan A, Singh KK, *Khan R, Gupta N, Brezden-Masley C, Teoh H, Wheatcroft MD, Al-Omran M, Verma S. (2014). BRCA1 shields vascular smooth muscle cells from oxidative stress. Journal of Thoracic and Cardiovascular Surgery. 147(6): 1946-55.
  36. Singh KK#, Shukla PC#, Quan A, Al-Omran M, Lovren F, Pan Y, Brezden-Masley C, Ingram AJ, Stanford WL, Teoh H, Verma S. (2013). BRCA1 is a Novel Target to Improve Endothelial Dysfunction and Retard Atherosclerosis. Journal of Thoracic and Cardiovascular Surgery. 146(4): 949-60.
  37. Teoh H, Quan A, Creighton AK, Annie Bang KW, Singh KK, Shukla PC, Gupta N, Pan Y, Lovren F, LeongPoi H, Al-Omran M, Verma S. (2013). BRCA1 Gene Therapy Reduces Systemic Inflammatory Response and Multiple Organ Failure and Improves Survival in Experimental Sepsis. Gene Therapy. 20(1): 51-61.
  38. Singh KK, Shukla PC, Yanagawa B, Quan A, Lovren F, Pan Y, Wagg CS, Teoh H, Lopaschuk GD, Verma S. (2013). Regulating Cardiac Energy Metabolism and Bioenergetics by Targeting the DNA Damage Repair Protein BRCA1. Journal of Thoracic and Cardiovascular Surgery. 146(3): 702-9.
  39. Singh KK#, Shukla PC#, Quan A, Desjardins JF, Lovren F, Pan Y, *Garg V, Gosal S, *Garg A, Szmitko PE, Schneider MD, Parker TG, Stanford WL, Leong-Poi H, Teoh H, Al-Omran M, Verma S. (2012). BRCA2 Protein Deficiency Exaggerates Doxorubicin-induced Cardiomyocyte Apoptosis and Cardiac Failure. The Journal of Biological Chemistry. 287(9): 6604-14.
  40. Yanagawa B, Lovren F, Pan Y, *Garg V, Quan A, Tang G, Singh KK, Shukla PC, Kalra NP, Peterson MD, Verma S. (2012). miRNA-141 is a Novel Regulator of BMP-2-mediated Calcification in Aortic Stenosis. Journal of Thoracic and Cardiovascular Surgery. 144(1): 256-62.
  41. Singh KK, Schmidtke J, Keyser B, Arslan-Kirchner M. (2012). TGFBR3 Variation is not a Common Cause of Marfan-like Syndrome and Loeys-Dietz-like Syndrome. Journal of Negative Results in Biomedicine. 11(9): 1-5.
  42. Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta N, Steer BM, Ingram AJ, Gupta M, Al-Omran M, Teoh H, Marsden PA, Verma S. (2012). MicroRNA-145 Targeted Therapy Reduces Atherosclerosis. 126(11 Suppl): S81-90.
  43. Singh KK#, Shukla PC#, Quan A, Al-Omran M, Teoh H, Lovren F, Cao L, Rovira II, Pan Y, Brezden-Masley C, Yanagawa B, Gupta A, Deng CX, Coles JG, Leong-Poi H, Stanford WL, Parker TG, Schneider MD, Finkel T, Verma S. (2011). BRCA1 is an Essential Regulator of Heart Function and Survival Following Myocardial Infarction. Nature Communications. 2(593): 1-11.
  44. Singh KK, Shukla PC, Quan A, Lovren F, Pan Y, *Wolfstadt JI, Gupta M, Al-Omran M, Leong-Poi H, Teoh H, Verma S. (2011). Herceptin, a Recombinant Humanized Anti-ERBB2 Monoclonal Antibody, Induces Cardiomyocyte Death. Biochemical and Biophysical Research Communication. 411(2): 421-6.
  45. Shukla PC, Singh KK, Yanagawa B, Teoh H, Verma S. (2010). DNA Damage Repair and Cardiovascular Diseases. Canadian Journal of Cardiology. Suppl A:: 13A-16A.
  46. Lovren F, Pan Y, Quan A, Szmitko PE, Singh KK, Shukla PC, Gupta M, Chan L, Al-Omran M, Teoh H, Verma S. (2010). Adiponectin Primes Human Monocytes into Alternative Anti-inflammatory M2 Macrophages. American Journal of Physiology Heart and Circulatory Physiology. 299(3): H656-63.
  47. Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta M, Al-Omran M, Teoh H, Verma S. (2010). Adropin is a Novel Regulator of Endothelial Function. 122(11 Suppl): S185-92.
  48. Singh KK, Krawczak M, Dawson WW, Schmidtke J. (2009). Association of HTRA1 and ARMS2 Gene Variation with Drusen Formation in Rhesus Macaques. Experimental Eye Research. 88(3): 479-82.
  49. Söylen B, Singh KK, Abuzainin A, Rommel K, Becker H, Arslan-Kirchner M, Schmidtke J. (2009). Prevalence of Dural Ectasia in 63 Gene-mutation-positive Patients with Features of Marfan Syndrome type 1 and Loeys-Dietz syndrome and Report of 22 Novel FBN1 Mutations. Clinical Genetics. 75(3): 265-70.
  50. Singh KK, Shukla PC, Schmidtke J. (2008). Conservation of 5'-upstream Region of the FBN1 Gene in Primates. European Journal of Human Genetics. 16(7): 869-72.
  51. Singh KK, *Elligsen D, Liersch R, Schubert S, Pabst B, Arslan-Kirchner M, Schmidtke J. (2007). Multi-exon Out of Frame Deletion of the FBN1 Gene Leading to a Severe Juvenile Onset of Cardiovascular Phenotype in Marfan Syndrome. Journal of Molecular and Cellular Cardiology. 42(2): 352-6.
  52. Singh KK, Dawson WW, Krawczak M, Schmidtke J. (2007). IMPG1 Gene Variation in Rhesus Macular Drusen. Veterinary Ophthalmology. 10(5): 274-7.
  53. Singh KK, Rommel K, Mishra A, Karck M, Haverich A, Schmidtke J, Arslan-Kirchner M. (2006). TGFBR1 and TGFBR2 Mutations in Patients with Features of Marfan Syndrome and Loeys-Dietz Syndrome. Human Mutations. 27(8): 770-7.
  54. Singh KK, Shukla PC, Rommel K, Schmidtke J, Arslan-Kirchner M. (2006). Sequence Variations in the 5' Upstream Regions of the FBN1 Gene Associated with Marfan Syndrome. European Journal of Human Genetics. 14(7): 876-9.
  55. Singh KK, *Ristau S, Dawson WW, Krawczak M, Schmidtke J. (2005). Mapping of a Macular Drusen Susceptibility Locus in Rhesus Macaques to the Homologue of Human Chromosome 6q14-15. Experimental Eye Research. 81(4): 401-6.
  56. Rommel K, Karck M, Haverich A, von Kodolitsch Y, Rybczynski M, Müller G, Singh KK, Schmidtke J, Arslan-Kirchner M. (2005). Identification of 29 Novel and Nine Recurrent Fibrillin-1 (FBN1) Mutations and Genotype-phenotype Correlations in 76 Patients with Marfan Syndrome. Human Mutation. 26(6): 529-39.
  57. Singh KK, Schmidtke J. (2005). Single Nucleotide Polymorphisms Within the Promoter Region of the Rhesus Monkey Tumor Necrosis Factor-Alpha Gene. 57(3-4): 289-92.

*Supervised Students