Schulich school of Medicine and Dentistry logo Gastroenterology Schulich School of Medicine & Dentistry

Vipul Jairath

V. Jairath

Contact Information

Room A10-228, University Hospital
Phone: 519.685.8500 ext. 33655
Fax: 519.663.3658
Admin Asst: Carrie.Reed@lhsc.on.ca

Research Interests/Specializations

Dr Jairath holds the John and Susan McDonald chair in inflammatory bowel disease. Referrals accepted throughout the province for management of Crohn’s disease, ulcerative colitis, pouchitis and all aspects of general gastroenterology and endoscopy including diarrhea, anemia, celiac disease, bleeding, reflux disease, abdominal pain, constipation, malnutrition. Procedures performed include colonoscopy, gastroscopy, push enteroscopy, dilatation and feeding tubes.

Dr. Jairath trained in the United Kingdom and has degrees in pharmacology and medicine from the University of Leeds, a PhD (DPhil) from the University of Oxford and diploma in clinical trials from the London School of Hygiene and Tropical Medicine. He is Associate Professor of Medicine, Epidemiology and Biostatistics at Western University and also a practicing Gastroenterologist at University Hospital, where he specialises in inflammatory bowel disease, general gastroenterology and endoscopy. 

His research interests are in the design, conduct and implementation of randomized controlled trials, index development and outcomes research. He has successfully obtained several peer reviewed grants from government funding agencies to conduct clinical studies and he supervises several research fellows. He holds professional memberships with the College of Physicians and Surgeons of Ontario, Royal College of Physicians (UK), British Society of Gastroenterology, American Gastroenterology Association, Canadian Association of Gastroenterology and European Crohn’s and Colitis Organization.

Selected Publications

Mohammed Vashist N, Samaan M, Mosli MH, Parker CE, MacDonald JK, Nelson SA, Zou GY, Feagan BG, Khanna R, Jairath V. Endoscopic scoring indices for evaluation of disease activity in ulcerative colitis. Jan 16, 2018.

Hindryckx P, Vande Casteele N, Novak G, Khanna R, D’Haens G, Sandborn WJ, Danese S, Jairath V, Feagan BG. The expanding therapeutic armamentarium for inflammatory bowel disease: how to choose the right drug(s) for our patients? Jan 5, 2018.

Hindryckx P, Levesque BG, Holvoet T, Durand S, Tang CM, Parker C, Khanna R, Shackelton LM, D’Haens G, Sandborn WJ, Feagan BG, Lebwohl B, Leffler DA, Jairath V. Disease activity indices in coeliac disease: systematic review and recommendations for clinical trials. Jan 5, 2018.

Hindryckx P, Levesque BG, Holvoet T, Durand S, Tang CM, Parker C, Khanna R, Shackelton LM, D’Haens G, Sandborn WJ, Feagan BG, Lebwohl B, Leffler DA, Jairath V. Disease activity indices in coeliac disease: systematic review and recommendations for clinical trials. Jan 1, 2018.

Warners MJ, Ambarus CA, Bredenoord AJ, Verheij J, Lauwers GY, Walsh JC, Katzka DA, Nelson S, van Viegen T, Furuta GT, Gupta SK, Stitt L, Zou GY, Parker CE, Shackelton LM, D’Haens GR,
Sandborn WJ, Dellon ES, Feagan BG, Collins MH, Jairath V, Pai RK. Reliability of Histologic Assessment in Patients with Eosinophilic Oesophagitis. Jan 1, 2018. In Press.

Lee MJ, Parker CE, Taylor SR, Guizzetti L, Feagan BG, Lobo AJ, Jairath V. Efficacy of Medical Therapies for Fistulizing Crohn’s Disease: A Systemic Review and Meta-Analysis. Jan 1, 2018. In Press.

Paramabir SD, Jairath V. Acute Severe Ulcerative Colitis: Latest Evidence and Therapeutic Implications. Jan 1, 2018. In Press.

Wilson A, Jansen LE, Rose RV, Gregor JC, Ponich T, Chande N, Khanna R, Yan B, Jairath V, Khanna N, Sey M, Beaton M, McIntosh K, Teft WA, Kim RB. HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease. Jan 1, 2018. In Press.

Novel Therapies and Treatment Strategies for Patients with Inflammatory Bowel Disease. Jan 1, 2018. In Press.

Oakland K, Desborough MJ, Murphy MF, Schachter M, Jairath V. Re-bleeding and Mortality After Lower Gastrointestinal Bleeding in Patients Taking Anti-platelets or Anti-coagulants. Dec 22, 2017.

Westera L, van Viegen T, Jeyarajah J, Azad A, Bilsborough J, van den Brink GR, Cremer J, Danese S, D’Haens G, Eckmann L, Faubion W, Filice M, Korf H, McGovern D, Panes J, Salas A, Sandborn WJ, Silverberg MS, Smith MI, Vermeire S, Vetrano S, Shackelton LM, Stitt L, Jairath V, Levesque BG, Spencer DM, Feagan BG, Vande Casteele N. Centrally Determined Standardization of Flow Cytometry Methods Reduces Interlaboratory Variation in a Prospective Multicenter Study. Nov 2, 2017.

Warners MJ, Hindryckx P, Levesque BG, Parker CE, Shackelton LM, Khanna R, Sandborn WJ, D’Haens GR, Feagan BG, Bredenoord AJ, Jairath V. Systematic Review: Disease Activity Indices in Eosinophilic Esophagitis. Nov 1, 2017.

Oakland K, Isherwood J, Lahiff C, Goldsmith P, Desborough M, Colman KS, Guy R, Uberoi R, Murphy MF, East JE, Hopewell S, Jairath V. Diagnostic and therapeutic treatment modalities for acute lower gastrointestinal bleeding: a systematic review. Oct 1, 2017.

Guizzetti L, Zou G, Khanna R, Dulai PS, Sandborn WJ, Jairath V, Feagan BG. Development of Clinical Prediction Models for Surgery and Complications in Crohn’s Disease. Sep 19, 2017.

Samaan MA, Puylaert CAJ, Levesque BG, Zou GY, Stitt L, Taylor SA, Shackelton LM, Vandervoort MK, Khanna R, Santillan C, Rimola J, Hindryckx P, Nio CY, Sandborn WJ, D’Haens G, Feagan BG, Jairath V, Stoker J. The development of a magnetic resonance imaging index for fistulising Crohn’s disease. Sep 1, 2017.

Oakland K, Jairath V, Uberoi R, Guy R, Ayaru L, Mortensen N, Murphy MF, Collins GS. Derivation and validation of a novel risk score for safe discharge after acute lower gastrointestinal bleeding: a modelling study. Sep 1, 2017.

Vipul Jairath, Ingrid Ordas, Guangyong Zou, Julian Panes, J Stoker, Stuart A Taylor, Cynthia Santillan, Karin Horsthuis, Mark Samaan, Lisa Shackelton, Larry W Stitt, Pieter Hindryck, Reena Khanna, William J Sandborn, Geert D’Haens, Brian G Feagan, Barrett G Levesque,  Jordi Rimola. Reliability of Measuring Ileo-colonic Disease Activity in Crohn’s Disease by Magnetic Resonance Enterography. Aug 24, 2017. In Press.

D'Haens GR, Sandborn WJ, Zou G, Stitt LW, Rutgeerts PJ, Gilgen D, Jairath V, Hindryckx P, Shackelton LM, Vandervoort MK, Parker CE, Muller C, Pai RK, Levchenko O, Marakhouski Y, Horynski M, Mikhailova E, Kharchenko N, Pimanov S, Feagan BG. Randomised non-inferiority trial: 1600 mg versus 400 mg tablets of mesalazine for the treatment of mild-to-moderate ulcerative colitis. Aug 1, 2017.

Yan BM, Feagan B, Teriaky A, Mosli M, Mohamed R, Williams GS, Yeung E, Yong E, Haig A, Sey M, Stitt L, Zou GY, Jairath V. Reliability of EUS indices to detect inflammation in ulcerative colitis. Jul 28, 2017.

Sey MSL, Liu A, Asfaha S, Siebring V, Jairath V, Yan B. Performance report cards increase adenoma detection rate. Jul 1, 2017.

Ma C, Panaccione R, Fedorak RN, Parker CE, Khanna R, Levesque BG, Sandborn WJ, Feagan BG, Jairath V. Development of a core outcome set for clinical trials in inflammatory bowel disease: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey. Jun 9, 2017.

Kahan BC, Feagan B, Jairath V. A comparison of approaches for adjudicating outcomes in clinical trials. Jun 8, 2017.

Khanna R, Zou G, Stitt L, Feagan BG, Sandborn WJ, Rutgeerts P, McDonald JWD, Dubcenco E, Fogel R, Panaccione R, Jairath V, Nelson S, Shackelton LM, Huang B, Zhou Q, Robinson AM, Levesque BG, D’Haens G. Corrigendum: Responsiveness of Endoscopic Indices of Disease Activity for Crohn’s Disease. Jun 1, 2017.

Desborough MJR, Colman KS, Prick BW, Duvekot JJ, Sweeney C, Odutayo A, Jairath V, Doree C, Trivella M, Hopewell S, Estcourt LJ, Stanworth SJ. Effect of restrictive versus liberal red cell transfusion strategies on haemostasis: systematic review and meta-analysis. May 3, 2017.

Odutayo A, Desborough MJ, Trivella M, Stanley AJ, Dorée C, Collins GS, Hopewell S, Brunskill SJ, Kahan BC, Logan RF, Barkun AN, Murphy MF, Jairath V. Restrictive versus liberal blood transfusion for gastrointestinal bleeding: a systematic review and meta-analysis of randomised controlled trials. May 1, 2017.

Jairath V, Zou G, Parker CE, MacDonald JK, Mosli MH, AlAmeel T, Al Beshir M, AlMadi M, Al-Taweel T, Atkinson NS, Biswas S, Chapman TP, Dulai PS, Glaire MA, Hoekman D, Kherad O, Koutsoumpas A, Minas E, Restellini S, Samaan MA, Khanna R, Levesque BG, D’Haens G, Sandborn WJ, Feagan BG. Systematic review with meta-analysis: placebo rates in induction and maintenance trials of Crohn’s disease. Apr 1, 2017.

Novak G, Hindryckx P, Khanna R, Jairath V, Feagan BG. The safety of vedolizumab for the treatment of ulcerative colitis. Apr 1, 2017.

Hindryckx P, Novak G, Vande Casteele N, Khanna R, Laukens D, Jairath V, Feagan BG. Incidence, Prevention and Management of Anti-Drug Antibodies Against Therapeutic Antibodies in Inflammatory Bowel Disease: A Practical Overview. Mar 1, 2017.

Hindryckx P, Novak G, Vande Casteele N, Laukens D, Parker C, Shackelton LM, Narula N, Khanna R, Dulai P, Levesque BG, Sandborn WJ, D’Haens G, Feagan BG, Jairath V. Review article: dose optimisation of infliximab for acute severe ulcerative colitis. Mar 1, 2017.

Oakland K, Guy R, Uberoi R, Hogg R, Mortensen N, Murphy MF, Jairath V, UK Lower GI Bleeding Collaborative. Acute lower GI bleeding in the UK: patient characteristics, interventions and outcomes in the first nationwide audit. Feb 1, 2017.

Panes J, Jairath V, Levesque BG. Advances in Use of Endoscopy, Radiology, and Biomarkers to Monitor Inflammatory Bowel Diseases. Feb 1, 2017.

Jairath V, Levesque BG, Vande Casteele N, Khanna R, Mosli M, Hindryckx P, Travis S, Duijvenstein M, Rimola J, Panes J, D’Haens G, Sandborn WJ, Feagan BG. Evolving Concepts in Phases I and II Drug Development for Crohn’s Disease. Feb 1, 2017.

Morgan KE, Forbes AB, Keogh RH, Jairath V, Kahan BC. Choosing appropriate analysis methods for cluster randomised cross-over trials with a binary outcome. Jan 30, 2017.

Khanna R, Zou G, Stitt L, Feagan BG, Sandborn WJ, Rutgeerts P, McDonald JW, Dubcenco E, Fogel R, Panaccione R, Jairath V, Nelson S, Shackelton LM, Huang B, Zhou Q, Robinson AM, Levesque BG, D’Haens G. Responsiveness of Endoscopic Indices of Disease Activity for Crohn’s Disease. Jan 10, 2017.

Mosli MH, Feagan BG, Zou G, Sandborn WJ, D’Haens G, Khanna R, Shackelton LM, Walker CW, Nelson S, Vandervoort MK, Frisbie V, Samaan MA, Jairath V, Driman DK, Geboes K, Valasek MA, Pai RK, Lauwers GY, Riddell R, Stitt LW, Levesque BG. Development and validation of a histological index for UC. Jan 1, 2017.