Schulich school of Medicine and Dentistry logo Gastroenterology Schulich School of Medicine & Dentistry

Nilesh Chande

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Contact Information

London Health Sciences Centre-Victoria Hospital
800 Commissioners Rd. E.
London, ON, Canada N6A 5W9
Tel: 519.667.6582
Fax: 519.667.6820

Research Interests/Specialization

Inflammatory Bowel Diseases
Cochrane Review IBD Editor

Dr. Nilesh Chande is an Associate Professor of Medicine at Western University, and past Director of the Gastroenterology Training Program at Western. He is also the past Coordinating Editor of the Cochrane Library Inflammatory Bowel Disease and Functional Bowel Disorders Review Group. He completed his MD, his Internal Medicine residency and his Gastroenterology fellowship at Western University. His clinical interests include inflammatory bowel disease and general gastroenterology. His research interests include inflammatory bowel disease and evidence-based gastroenterology practice.

Selected Publications

Teriaky A, Driman DK, Chande N. Outcomes of a 5-year follow-up of patients with sessile serrated adenomas. Scand J Gastroenterol 2012;47(2):178-83. PMID: 22229626.

Nensi A, Chande N. A survey of digital rectal exam training in Canadian medical schools. Can J Gastroenterol 2012 ;26(7):441-4. PMID: 22803019.

Wells M, Roth L, McWilliams M, Thompson K, Chande N. A cross-sectional study of the association of overnight call with irritable bowel syndrome in medical students. Can J Gastroenterol 2012;26(5):281-4. PMID: 22590702.

Wells M, Roth L, Chande N. Sleep disruption secondary to overnight call shifts is associated with irritable bowel syndrome in residents: a cross-sectional study. Am J Gastroenterol 2012;107(8):1151-6.

Teriaky A, Gregor J, Chande N. Percutaneous endoscopic gastrostomy tube placement for end-stage palliation of malignant gastrointestinal obstructions. Saudi J Gastroenterol 2012;18(2):95-8. PMID: 22421713.

Mosli M, Chande N, Lannigan R, Gregor J. Non-utility of routine testing of stool for ova and parasites in a tertiary care Canadian centre. Can J Microbiol 2012;58(5):653-9.  PMID: 22540429.

Roth L, MacDonald JK, McDonald JWD, Chande N. Sargramostim (GM-CSF) for induction of remission in Crohn's disease:  A Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders systematic review of randomized trials. Inflamm Bowel Dis 2012;18(7):1333-9. PMID: 22552871.

Wells M, Chande N, Adams P, Beaton M, Levstik M, Boyce E, Mrkobrada M. Meta-Analysis: Vasoactive medications for the management of acute variceal bleeds: a systematic review and meta-analysis. Aliment Pharmacol Ther 2012;35(11):1267-78. PMID: 22486630.

Thirumaran RK, Lamba JK, Kim RB, Urquhart BL, Gregor JC, Chande N, Fan Y, Qi A, Cheng C, Thummel KE, Hall SD, Schuetz EG. Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation. Biochem Pharmacol 2012;84(1):104-12. PMID: 22484315.

Sandhu A, AlAmeel T, Dale C, Levstik M, Chande N. The safety and efficacy of anti-tumor necrosis factor-alpha therapy for inflammatory bowel disease in patients post-liver transplantation: a case series. Aliment Pharmacol Ther 2012;36(2):159-65. PMID: 22616981.

Sey M, Gregor J, Adams P, Khanna N, Vinden C Driman D, Chande N. Wait times for diagnostic colonoscopy among patients with colorectal cancer: a comparison with Canadian Association of Gastroenterology Targets. Can J Gastroenterol 2012;26(12):894-6. PMID: 23248790.

Wilson A, Patel V, Chande N, Ponich T, Urquhart B, Asher L, Choi Y, Tirona R, Kim RB, Gregor JC. Pharmacokinetic profiles for oral and subcutaneous methotrexate in patients with Crohn's disease. Aliment Pharmacol Ther 2013;37(3):340-5. PMID: 23190184.

Chande N. Prevention of venous thromboembolism in hospitalized patients with inflammatory bowel disease. Inflamm Bowel Dis 2013;19:669-71. PMID: 23385239.

Chande N, Tsoulis DJ, MacDonald JK. Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2013(4):CD000545. PMID: 23633304.

Xiong X, Barkun AN, Waschke K, Martel M, and the Canadian Gastroenterology Training Program Directors. Current status of core and advanced adult gastrointestinal endoscopy training in Canada: Survey of existing accredited programs. Can J Gastroenterol 2013;27(5):267-72. PMID: 23712301.

Segal D, Chande N. The management of eosinophilic esophagitis in adults. J Clin Gastroenterol 2013;47(7):570-7. PMID: 23507765.

Feagan BG, Chande N, MacDonald JK. Are there any differences in the efficacy and safety of different formulations of oral 5-ASA used for induction and maintenance of remission in ulcerative colitis? Evidence from Cochrane Reviews. Inflamm Bowel Dis 2013;19(9):2031-40. PMID: 23811638.

Sey MS, Gregor J, Chande N, Ponich T, Bhaduri M, Lum A, Zaleski W, Yan B. Transcutaneous bowel sonography for inflammatory bowel disease is sensitive and specific when performed in a nonexpert low-volume North American center. J Ultrasound Med 2013;32(8):1413-7. PMID: 23887951.

Khanna R, Chande N, Nelson RL. Treatment of an initial infection with Clostridium difficile in patients with inflammatory bowel disease. Inflamm Bowel Dis 2013;19(10):2223-6. PMID: 23929262.

Razik R, Cino M, the Canadian Gastroenterology Program Directors, Nguyen G. Employment prospects and trends for gastroenterology trainees in Canada: A nationwide survey. Can J Gastroenterol 2013;27(11):647-52. PMID: 24199210.

Teriaky A, Gregor J, Yan B, Ponich T, Chande N, Mosli M. The safety and efficacy of adalimumab in patients with Crohn's disease: the experience of a single Canadian tertiary care centre. Scand J Gastroenterol 2014;49(3):280-6. PMID: 24329040.

Nguyen GC, Bernstein CN, Bitton A, Chan AK, Griffiths AM, Leontiadis GI, Geerts W, Bressler B, Butzner JD, Carrier M, Chande N, Marshall JK, Williams C, Kearon C. Consensus statements on the risk, prevention, and treatment of venous thromboembolism in inflammatory bowel disease: Canadian Association of Gastroenterology. Gastroenterol 2014;146(3):835-48. PMID: 24462530.

Segal D, Macdonald JK, Chande N. Low dose naltrexone for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2014;2:CD010410. PMID: 24558033.

Sanford D, Thornley P, Teriaky A, Chande N, Gregor J. Opioid use is associated with decreased quality of life in patients with Crohn's disease. Saudi J Gastroenterol 2014;20(3):182-7. PMID 24976282.

Akobeng AA, Sandborn WJ, Bickston SJ, Chande N, Shackelton LM, Nelson S, Feagan BG. Tumor necrosis factor-alpha antagonists twenty years later:  what do Cochrane reviews tell us? Inflamm Bowel Dis 2014;20(11):2132-41. PMID 25299543.

Teriaky A, Tangri V, Chande N. Use of internet resources by patients awaiting gastroenterology consultation. Turk J Gastroenterol 2015;26(1):49-52. PMID 25698271

Sandhu A, Mosli M, Yan B, Wu T, Gregor J, Chande N, Ponich T, Beaton M, Rahman A. Self-screening for malnutrition risk in outpatient inflammatory bowel disease patients using the Malnutrition Universal Screening Tool (MUST). JPEN J Parenter Enteral Nutr 2016;40(4):507-10. PMID 25632031.

Malhotra N, Chande N. Venous thromboprophylaxis in gastrointestinal bleeding. Can J Gastroenterol Hepatol 2015;29(3):145-8.  PMID 25855878

Mosli MH, Zou G, Garg SK, Feagan SG, MacDonald JK, Chande N, Sandborn WJ, Feagan BG. C-reactive protein, fecal calprotectin, and stool lactoferrin for detection of endoscopic activity in  symptomatic inflammatory bowel disease patients: a systematic review and meta-analysis. Am J Gastroenterol 2015;110(6):802-19. PMID 25964225.

Chande N, Wang Y, McDonald JW, MacDonald JK.  Unfractionated or low-molecular weight heparin for induction of remission in ulcerative colitis.  Cochrane Database Syst Rev. 2015 Aug 5;8:CD006774. doi: 10.1002/14651858.CD006774.pub4. Review.  PMID:26246130.

Chande N, Marshall JK, Seow CH, Sandborn WJ, Parker CE, Nelson S, Feagan BG. New applications for traditional drugs in inflammatory bowel disease: what do Cochrane reviews tell us? Inflamm Bowel Dis 2015;21(12):2948-57. PMID 26540276.

Kwapisz L, Mosli M, Chande N, Yan B, Beaton M, Micsko J, Mennill PW, Barnett W, Bax K, Ponich T, Howard J, Tirolese A, Lannigan R, Gregor J. Rapid fecal calprotectin testing to assess for endoscopic disease activity in inflammatory bowel disease: A diagnostic cohort study. Saudi J Gastroenterol 2015;21(6):360-366. PMID 26655130.

Al-Judaibi B, Schwarz UI, Huda N, Dresser GK, Gregor JC, Ponich T, Chande N, Mosli M, Kim RB. Genetic predictors of azathioprine toxicity and clinical response in patients with inflammatory bowel disease. J Popul Ther Clin Pharmacol 2016;23(1):e26-36. PMID 26950049.

Timmer A, Patton PH, Chande N, McDonald JW, MacDonald JK. Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev 2016;5:CD000478. PMID 27192092.

Khanna R, Chande N, Vermeire S, Sandborn WJ, Parker CE, Feagan BG. The next wave of biological agents for the treatment of IBD:  evidence from Cochrane Reviews. Inflamm Bowel Dis 2016;22(7):1737-43. PMID 27306074.

Patton PH, Parker CE, MacDonald JK, Chande N. Anti-tuberculous therapy for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2016;7:CD000299. PMID 27444319.

Chande N, Townsend CM, Parker CE, MacDonald JK. Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2016;10:CD000545. PMID 27783843.

Kwapisz L, Gregor J, Chande N, Yan B, Ponich T, Mosli M. The utility of fecal calprotectin in predicting the need for escalation of therapy in inflammatory bowel disease. Scan J Gastroenterol 2017;52(8):846-50. PMID 28423962.

Chande N. Al Yatama N. Bhanji T, Nguyen TM, McDonald JW, MacDonald JK. Interventions for treating lymphocytic colitis. Cochrane Database Syst Rev 2017;7:CD006096. PMID 28702956.

Kafil TS, Nguyen TM, Patton PH, MacDonald JK, Chande N, McDonald JW. Interventions for treating collagenous colitis. Cochrane Database Syst Rev 2017;(11):CD003575.  PMID 29127772.