London researchers awarded $14.2 million from CIHR to tackle health issues
Thursday, February 27, 2014
Researchers at Western University and Lawson Health Research Institute have been awarded operating grants worth nearly $14.2 million in the latest competition from the Canadian Institutes of Health Research (CIHR). Combined Western and Lawson had 20 projects approved, including one of only six large (over one million dollars) grants handed out in Canada.
Dr. Anthony Tang, a Lawson scientist and professor in the Department of Medicine at Western's Schulich School of Medicine & Dentistry will receive nearly $3.3 million over five years for a study on heart failure called "Resynchronization/defibrillation for Ambulatory Heart Failure Trial in patients with Permanent AF (RAFT-PermAF)"
"Heart failure is the most common reason for hospital admissions of patients over the age of 65. Cardiac resynchronization therapy (CRT) using a specialized pacemaker, has been demonstrated to improve symptoms, and reduce hospitalization and deaths in patients whose heart failure involves sinus rhythm, an enlarged heart or abnormal sequence of contractions," says Dr. Tang, who holds a CIHR Chair in arrhythmia management in heart failure. "However, over one quarter of heart failure patients have an abnormal heart rhythm called atrial fibrillation. It is unknown whether CRT will benefit these patients. This research is a multi-centre international study to determine if CRT will reduce hospitalization and mortality in these patients."
CRT uses a specialized pacemaker to re-coordinate the actions of the right and left ventricles, increasing the heart's efficiency.
Of the more than 25-hundred grant applications submitted across the country, 479 received CIHR funding for up to five years. Schulich Medicine & Dentistry faculty who will be receiving funding include:
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CIHR Competition Results 201309MOP Operating Grant Schulich Medicine and Dentistry |
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Nominated Principal Investigator |
Department Research |
Project Title |
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BROWN, Arthur |
Robarts Research Institute |
Investigating the role of SOX9 in recovery from spinal cord injury |
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CAIRNS, Ewa |
Medicine |
The role of anti-homocitrullinated protein/peptide immune responses in Rheumatoid Arthritis |
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CUNNINGHAM, Ian A |
Robarts Research Institute |
High-Performance X-Ray Detectors that Maximize Image Quality and Reduce Patient Exposures |
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DIXON, S. Jeffrey |
Physiology and Pharmacology |
Ion transport and signaling in skeletal cells: P2 nucleotide receptor function in bone |
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DRYSDALE, Thomas A |
Pediatrics |
The cellular basis of early cardiac morphogenesis |
|
HOLDSWORTH, David W |
Robarts Research Institute |
Dynamic micro-computed tomography for pre-clinical musculoskeletal research |
|
LI, Shun-Cheng S |
Biochemistry |
Characterizing the LeSH/LUSH superfamily of bacterial effector proteins in the pathogenesis of Legionnaires' disease |
|
LING, Hong |
Biochemistry |
Translesion DNA Replication and its Regulation |
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LITCHFIELD, David W |
Biochemistry |
Control of Cell Proliferation & Survival: Pathological Rewiring of Regulatory Pathways by Protein Kinase CK2. |
|
LU, Wei-Yang |
Robarts Research Institute |
Regulation of Pulmonary Inflammation by Alveolar GABAergic Signaling |
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PARRAGA, Grace |
Robarts Research Institute |
Structure-Function Magnetic Resonance Imaging of Asthma |
|
PENG, Tianqing |
Lawson Health Research Institute |
Calpain activation and diabetic cardiomyopathy |
|
SHAW, Gary S |
Biochemistry |
Mechanisms of Membrane Repair and Trafficking by S100 Proteins |
|
SPENCE, J. David |
Robarts Research Institute |
Intestinal microbiome and extremes of atherosclerosis: 1. TMAO |
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URQUHART, Bradley L |
Physiology and Pharmacology |
Drug Disposition in Chronic Kidney Disease |
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WEIJER, Charles E |
Epidemiology and Biostats/ Medicine |
The ethics of neuroimaging after serious brain injury |
