Schulich school of Medicine and Dentistry logo Seguin Lab Schulich Medicine & Dentistry
  • Meet Dr. Cheryle Seguin

    Meet Dr. Cheryle Séguin

  • Explore the areas of research in the Séguin lab

    Explore the areas of research in the Séguin lab

  • Radio Canada International - Canadian research toward unlocking a common back pain disease

Our Goals

Trainee working in Dr. Seguin's lab

Dr. Séguin’s research includes a number of interrelated projects that use novel genetic mouse strains, and in vivo and ex vivo model systems.

Our ultimate goals are:
1. To understand how the notochord directs embryonic intervertebral disc formation;
2. To establish the phenotype of distinct disc cell types and understand how cell function is altered with age and mechanical load;
3. To determine if processes associated with disc formation can be re-initiated for tissue repair or to treat disc degeneration

Learn more about our research.

Recent Publications

Publications on shelf

Ii HWarraich STenn N, Quinonez D, Holdsworth DW, Hammond JR, Dixon SJ, Séguin CA. (2016) Disruption of biomineralization pathways in spinal tissues of a mouse model of diffuse idiopathic skeletal hyperostosis. Bone, 90:37-49.

Kerr GJVeras MAKim MKSéguin CA. (2016) Decoding the intervertebral disc: Unravelling the complexities of cell phenotypes and pathways associated with degeneration and mechanotransduction. Semin Cell Dev Biol, doi: 10.1016/j.semcdb.2016.05.008. [Epub ahead of print].

View more publications