Dr. Séguin’s research includes a number of interrelated projects that use novel genetic mouse strains, and in vivo and ex vivo model systems.

Our Goals

  1. To understand how the notochord directs embryonic intervertebral disc formation;

  2. To establish the phenotype of distinct disc cell types and understand how cell function is altered with age and mechanical load;

  3. To determine if processes associated with disc formation can be re-initiated for tissue repair or to treat disc degeneration


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