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Archived Publications



Patel P, Brooks C, Seneviratne A, Hess DA, Séguin CA. (2014) Investigating microenvironmental regulation of human chordoma cell behaviour. PLoS One, 9(12):e115909.

Bedore J, Leask A, Séguin CA. (2014) Targeting the extracellular matrix: matricellular proteins regulate cell-extracellular matrix communication within distinct niches of the intervertebral disc. Matrix Biol, 37:124-30.


Bedore J, Sha W, McCann MR, Liu S, Leask A, Séguin CA. (2013) Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of  CCN2. Arthritis and Rheumatism, 65(10):2634-44.

McCann MRPatel P, Beaucage KL, Xiao Y, Bacher C, Siqueira WL, Holdsworth DW, Dixon SJ, Séguin CA. (2013) Acute vibration induces transient expression of anabolic genes in the murine intervertebral disc. Arthritis and Rheumatism, 65(7):1853-64. 

Warraich S, Bone DBJ, Quinonez DIi H, Choi D-S, Holdsworth DW, Drangova M, Dixon SJ, Séguin CA§, Hammond J§. (co-senior author) (2013) Loss of Equilibrative Nucleoside Transporter 1 (ENT1) in Mice Leads to Progressive Ectopic Mineralization of Spinal Tissues Resembling Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Humans. J Bone Miner Res, 28(5):1135-49.


McCann MR, Tamplin OJ, Rossant J, Séguin CA. (2012) Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development. Dis Model Mech, 5(1):73-82.

Paca A, Séguin CA, Clemets, Ryczko M, Rossant J, Rodriguez TA, Kunath T. (2012) Bmp4 signalling induces visceral endoderm differentiation of XEN cells and parietal endoderm cells. Developmental Biology 361(1):90-102. 


McCann MRBacher CSéguin CA. (2011) Exploiting notochord cells for stem cell-based regeneration of the intervertebral disc. J Cell Comm and Signaling Mar;5(1):39-43.