Dr. Ruud Veldhuizen, PhD



Rank / Affiliations

  • Associate Professor of Medicine
  • Cross Appointment, Department of Physiology & Pharmacology
  • Program of Experimental Medicine (POEM), Member
  • Lawson Health Research Institute (LHRI), Scientist



  • Undergraduate, Dr Ir Gijssen Intituut, Utrecht, The Netherlands
  • PhD, Western University
  • Fellowship, Surfactant in Acute Lung Injury, Western University
  • Post Doctoral Fellowship, Surfactant in Acute Lung Injury, University of Toronto
  • Post-Doctoral Fellowship, Surfactant in Inflammation, Utrecht University


Research Interest

  • Our lab is interested in using exogenous surfactant as a delivery tool to administer pulmonary therapeutics
  • We also investigate the mechanisms by which lung injury develops, specifically the effects of sex/gender, exercise status, and growth restriction.
  • Our third interest is the biophysical mechanisms by which pulmonary surfactant reduces surface tension. 
  • Key words: Surfactant, Pulmonary drug delivery, Acute lung Injury, Pulmonary inflammation, ARDS, surface tension.
  • For more information: https://sites.google.com/view/thelunglab/home


Research Funding

  • NSERC, OTS, Women's Development Fund, LHRI, Western



Selected Publications

  • Veldhuizen RAW, McCaig LA, Pape C and Gill SE. (2019) The effects of aging and exercise on lung mechanics, surfactant and alveolar macrophages. Exp Lung Res 45;113-122. doi: 10.1080/01902148.2019.1605633
  • Baer B, Souza LMP, Pimentel AS, Veldhuizen RAW. (2019) New insights into exogenous surfactant as a carrier of pulmonary therapeutics. Biochem Pharmacol. 164:64-73. doi: 10.1016/j.bcp.2019.03.036.
  • Khazaee R, McCaig LA, Yamashita C, Hardy DB, and Veldhuizen RAW. (2019) Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats. PLoS One. 19;14(4):e0215611.  doi: 10.1371/journal.pone.0215611. eCollection 2019.
  • Baer B, Veldhuizen EJA, Possmayer F, Yamashita C, and Veldhuizen RAW. (2018) The Wet Bridge Transfer System: A Novel Tool to Assess Exogenous Surfactant as a Vehicle for Intrapulmonary Drug Delivery. Discovery Medicine 26, 207-218.
  • Czyzewski AM,  McCaig LM, Broering LA, Yao LJ, Dohm MT, Brown NJ, Didwania MK, Lin JS, Lewis JF, Veldhuizen RAW, and Barron AE.  (2018) Effective in vivo treatment of acute lung injury with helical, amphipathic peptoid mimics of pulmonary surfactant proteins. Sci Rep. (2018) 8:6795.  DOI:10.1038/s41598-018-25009-3
  • Al-Saiedy M, Pratt R, Lai P, Kerek E, Joyce H, Prenner E, Green F, Ling CC, Veldhuizen RAW, Ghandorah S, and Amrein M. Dysfunction of pulmonary surfactant mediated by phospholipid oxidation is cholesterol-dependent. (2018) Biochim Biophys Acta 1862, 1040-1049. doi: 10.1016/j.bbagen.2018.01.008
  • Ford N, McCaig L, Jeklin A, Lewis J, Veldhuizen RAW, Holdsworth D, and Drangova M. (2017) A respiratory-gated micro-CT comparison of respiratory patterns in free-breathing and mechanically ventilated rats. Physiological Reviews e13074. DOI:10.14814/phy2.13074
  • Tyml K, Swarbreck S, Pape C, Koropatnick J, Feng Q, Veldhuizen RAW, and Gill SE. (2017) Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice. Crit Care. 21(1):210. doi: 10.1186/s13054-017-1783-1.
  • Milos S#, Khazaee R#, McCaig LA, Nygard K, Gardiner RB, Zuo YY, Yamashita C, Veldhuizen RAW. (2017) Impact of ventilation induced lung injury on the structure and function of lamellar bodies. Am J Physiol Lung Cell Mol Physiol 313:L524-L533 doi: 10.1152/ajplung.00055.2017
  • Coorens M#, Banaschewski BJH#, Baer BJ, Yamashita C, Van Dijk A, Haagsman HP, Veldhuizen RAW*, and Veldhuizen EJA*. (2017) Killing of P. aeruginosa by chicken cathelicidin-2 prevents lung inflammation in vivo. Infection and Immunity 85(12): e00546-17  doi: 10.1128/IAI.00546-17. 
  • Banaschewski BJH, Baer B, Arsenault C, Jazey T, Veldhuizen EJA, Delport J, Gooyers T, Lewis JF, Haagsman HP, Veldhuizen RAW, and Yamashita C. (2017) The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens. Sci Rep. 14;7:15545. doi: 10.1038/s41598-017-15558-4.
  • Rindler TN, Stockman C, Filuta A, Brown K, Snowball JM, Zhou W, Veldhuizen RAW,
  • Zink E, Dautel SE, Clair G, Ansong CK, Xu Y, Bridges J, and Whitsett J. (2017) Alveolar Injury and Regeneration Following Deletion of ABCA3. JCI Insight 2(24) :e97381. doi:10.1172/jci.insight.97381. 
  • Gill SE, Yamashita CM and Veldhuizen RAW. (2017) Lung Remodeling Associated with the Recovery from Acute Lung Injury. Cell and Tissue Res. 367(3):495-509. doi: 10.1007/s00441-016-2521-8
  • Nakajima D, Liu M, Ohsumi A, Kalaf R, Iskender I, Hsin M, Kanou T, Chen M, Baer B, Coutinho R, Maahs L, Behrens P, Azad S, Martinu T, Waddell TK, Lewis JF, Post M, Veldhuizen RAW, Cypel M, Keshavjee S. (2017) Lung Lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury. J Heart Lung Transplant. 36:577-585 doi: 10.1016/j.healun.2016.11.010. 

Contact Information

Lawson Health Research Institute

St. Joseph's Health Centre

Phone: (519) 646-6000, x64092

Email: rveldhui@uwo.ca