Dr. David McCormack, MD, FRCPC



Rank / Affiliations
§ Chair, Division of Respirology
§ Professor of Medicine
§ Undergraduate, Queen's University
§ MD, Queen's University
§ Internal Medicine, Western University
§ Respirology, Western University
§ Fellowship, Pulmonary vascular disease & Acute lung injury, Brompton Chest Hospital, London, UK
Clinical Interest
§ General Respirology
§ Bronchoscopy, EBUS
Research Interest
§ Lung Imaging, MR imaging of the lung
§ Evaluating newer lung modalities
§ Translational clinical research involving the use of hyperpolarized gas as an inhaled contract agent in MR imaging
Research Funding
§ Canadian Institutes of Health Research
Selected Publications (past 5 years)

1. Eddy RL, McIntosh MJ, Matheson AM, McCormack DG, Licskai C, Parraga G. Pulmonary MRI and Cluster Analysis Help Identify Novel Asthma Phenotypes. J Magn Reson Imaging, 2022 Mar 12, Coauthor, DOI: doi: 10.1002/jmri.28152.

2. Kassirian S, Mitchell MA, McCormack DG, Zeman-Pocrnich C, Dhaliwal I. Rapid On-site Evaluation (ROSE) in Capillary Pull Versus Suction Biopsy Technique With Endobronchial Ultrasound - Transbronchial Needle Aspiration (EBUS-TBNA): Clinical Trial. J Bronchology Interv Pulmonol, 2022 Jan 1; 29 (1): 48-53, Coauthor, DOI: 10.1097/LBR.0000000000000776.

3. Svenningsen S, Nair P, Eddy RL, McIntosh MJ, Kjarsgaard M, Lim HF, McCormack DG, Cox G, Parraga G. Bronchial thermoplasty guided by hyperpolarised gas magnetic resonance imaging in adults with severe asthma: a 1-year pilot randomised trial. ERJ Open Research, 2021 Sep 27; 2021 (7): 00268-2021, Coauthor, Available from: https://openres.ersjournals.com/content/7/3/00268-2021, DOI: doi.org/10.1183/23120541.00268-2021.

4. Guo F, Capaldi DPI, McCormack DG, Fenster A, Parraga G. Ultra-short echo-time magnetic resonance imaging lung segmentation with under-Annotations and domain shift. Med Image Anal, 2021 Aug; 72, Coauthor, DOI: https://doi.org/10.1016/j.media.2021.102107.

5. Westcott A, Capaldi DPI, Ouriadov A, McCormack DG, Parraga G. Hyperpolarized 3He MRI ventilatory apparent diffusion coefficient of alpha-1 antitrypsin deficiency. J Magn Reson Imaging, 2021 Apr 12; 49 (1): 311-313, Coauthor

6. Barker AL, Eddy RL, MacNeil JL, McCormack DG, Kirby M, Parraga G. CT Pulmonary Vessels and MRI Ventilation in Chronic Obstructive Pulmonary Disease: Relationship with worsening FEV1 in the TINCan cohort study. Acad Radiol, 2021 Apr 12; 28 (4): 495-506, Coauthor, DOI: 10.1016/j.acra.2020.03.006.

7. Ouriadov A, Guo F, McCormack DG, Parraga G. Accelerated 129 Xe MRI morphometry of terminal airspace enlargement: Feasibility in volunteers and those with alpha-1 antitrypsin deficiency. Magn Reson Med, 2020 Jul 1; 84 (1): 416-426, Coauthor, DOI: 10.1002/mrm.28091.

8. Svenningsen S, McIntosh M, Ouriadov A, Matheson AM, Konyer NB, Eddy RL, McCormack DG, Noseworthy MD, Nair P, Parraga G. Reproducibility of Hyperpolarized 129Xe MRI Ventilation Defect Percent in Severe Asthma to Evaluate Clinical Trial Feasibility. Acad Radiol, 2020 May 14; 28 (6): 817-26, Coauthor, DOI: 10.1016/j.acra.2020.04.025.

9. Eddy RL, Svenningsen S, Kirby M, Knipping D, McCormack DG, Licskai C, Nair P, Parraga G. Is Computed Tomography Airway Count Related to Asthma Severity and Airway Structure and Function? Am J Respir Crit Care Med, 2020 Apr 15; 201 (8): 923-933, Coauthor, DOI: 10.1164/rccm.201908-1552OC.

10. MacNeil JL, Capaldi DPI, Westcott AR, Eddy RL, Barker AL, McCormack DG, Kirby M, Parraga G. Pulmonary Imaging Phenotypes of Chronic Obstructive Pulmonary Disease Using Multiparametric Response Maps. Radiology, 2020 Apr 1; 295 (1): 227-236, Coauthor, DOI: 10.1148/radiol.2020191735.

11. Eddy RL, Matheson AM, Svenningsen S, Knipping D, Licskai C, McCormack DG, Parraga G. Nonidentical Twins With Asthma: Spatially Matched CT Airway and MRI Ventilation Abnormalities. Chest, 2019 Dec 1; 156 (6): e111-e116, Coauthor, DOI: 10.1016/j.chest.2019.08.004.

12. Westcott A, Capaldi DPI, McCormack DG, Ward AD, Fenster A, Parraga G. Chronic Obstructive Pulmonary Disease: Thoracic CT Texture Analysis and Machine Learning to Predict Pulmonary Ventilation. Radiology, 2019 Dec 1; 293 (3): 676-684, Coauthor, DOI: 10.1148/radiol.2019190450.

13. Eddy RL, Svenningsen S, Licskai C, McCormack DG, Parraga G. Hyperpolarized Helium 3 MRI in Mild-to-Moderate Asthma: Prediction of Postbronchodilator Reversibility. Radiology, 2019 Oct 1; 293 (1): 212-220, Coauthor, DOI: 10.1148/radiol.2019190420.

14. Westcott A, McCormack DG, Parraga G, Ouriadov A. Advanced pulmonary MRI to quantify alveolar and acinar duct abnormalities: Current status and future clinical applications. J Magn Reson Imaging, 2019 Jul; 50 (1): 28-40, Coauthor, DOI: 10.1002/jmri.26623.

15. Guo F, Capaldi DPI, McCormack DG, Fenster A, Parraga G. A framework for Fourier-decomposition free-breathing pulmonary 1H MRI ventilation measurements. Magn Reson Med, 2019 Mar; 81 (3): 2135-2146, Coauthor, DOI: 10.1002/mrm.27527.

16. Capaldi DPI, Eddy RL, Svenningsen S, Guo F, Baxter JSH, McLeod AJ, Nair P, McCormack DG, Parraga G, Canadian Respiratory Research Network. Free-breathing Pulmonary MR Imaging to Quantify Regional Ventilation. Radiology, 2018 May; 287 (2): 693-704, Coauthor, DOI: 10.1148/radiol.2018171993.

17. Adams CJ, Capaldi DPI, Di Cesare R, McCormack DG, Parraga G, Canadian Respiratory Research Network. On the Potential Role of MRI Biomarkers of COPD to Guide Bronchoscopic Lung Volume Reduction. Acad Radiol, 2018 Feb 1; 25 (2): 159-168, Coauthor, DOI: 10.1016/j.acra.2017.08.010.

18. Lessard E, Young HM, Bhalla A, Pike D, Sheikh K, McCormack DG, Ouriadov A, Parraga G. Pulmonary 3He Magnetic Resonance Imaging Biomarkers of Regional Airspace Enlargement in Alpha-1 Antitrypsin Deficiency. Acad Radiol, 2017 Nov 1; 24 (11): 1402-1411, Coauthor, DOI: 10.1016/j.acra.2017.05.008.

19. Capaldi DPI, Sheikh K, Eddy RL, Guo F, Svenningsen S, Nair P, McCormack DG, Parraga G, Canadian Respiratory Research Network. Free-breathing Functional Pulmonary MRI: Response to Bronchodilator and Bronchoprovocation in Severe Asthma. Acad Radiol, 2017 Oct 1; 24 (10): 1268-1276, Coauthor, DOI: 10.1016/j.acra.2017.04.012.

20. Pike D, Kirby M, Eddy RL, Guo F, Capaldi DP, Ouriadov A, McCormack DG, Parraga G. Regional Heterogeneity of Chronic Obstructive Pulmonary Disease Phenotypes: Pulmonary (3)He Magnetic Resonance Imaging and Computed Tomography. COPD, 2016 Oct 1; 13 (5): 601-9, Coauthor, DOI: 10.3109/15412555.2015.1123682.

21. Svenningsen S, Nair P, Guo F, McCormack DG, Parraga G. Is ventilation heterogeneity related to asthma control? Eur Respir J, 2016 Aug 1; 48 (2): 370-9, Coauthor, DOI: 10.1183/13993003.00393-2016.

22. Osmond A, Filter E, Joseph M, Inculet R, Kwan K, and McCormack D. Endobronchial Carcinoid Tumour with Extensive Ossification: An Unusual Case Presentation. Case Reports in Medicine, 2016 Jul 1; 2016: 1-4, Coauthor, DOI: doi: 10.1155/2016/5984671.

23. Capaldi DP, Zha N, Guo F, Pike D, McCormack DG, Kirby M, Parraga G. Pulmonary Imaging Biomarkers of Gas Trapping and Emphysema in COPD: (3)He MR Imaging and CT Parametric Response Maps. Radiology, 2016 May 1; 279 (2): 597-608, Coauthor, DOI: 10.1148/radiol.2015151484.

24. Davis C, Sheikh K, Pike D, Svenningsen S, McCormack DG, O’Donnell D, Neder JA, Parraga G, Canadian Respiratory Research Network. Ventilation Heterogeneity in Never-smokers and COPD:: Comparison of Pulmonary Functional Magnetic Resonance Imaging with the Poorly Communicating Fraction Derived From Plethysmography. Acad Radiol, 2016 Apr 1; 23 (4): 398-405, Coauthor, DOI: 10.1016/j.acra.2015.10.022.

25. Zha N, Pike D, Svenningsen S, Capaldi DP, McCormack DG, Parraga G. Second-order Texture Measurements of (3)He Ventilation MRI: Proof-of-concept Evaluation of Asthma Bronchodilator Response. Acad Radiol, 2016 Feb 1; 23 (2): 176-85, Coauthor, DOI: 10.1016/j.acra.2015.10.010.

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