Schulich school of Medicine and Dentistry logo Chakrabarti Lab Schulich School of Medicine & Dentistry



2019 Publications

    1. Thomas AA, Biswas S, Feng B, Chen S, Gonder J, Chakrabarti S.  lncRNA H19 prevents endothelial-mesenchymal transition in diabetic retinopathy.  Diabetologia. 2019 Jan 5. DOI: 10.1007/s00125-018-4797-6. [Epub ahead of print] PMID: 30612136

2018 Publications

    1. Jackson AO, Regine MA, Subrata C, Long S.  Molecular mechanisms and genetic regulation in atherosclerosis.  Int J Cardiol Heart Vasc. 2018 Sep 25;21:36-44. DOI: 10.1016/j.ijcha.2018.09.006. eCollection 2018 Dec. Review. PMID: 30276232
    2. Biswas S, Thomas AA, Chen S, Aref-Eshghi E, Feng B, Gonder J, Sadikovic B, Chakrabarti S.  MALAT1: An Epigenetic Regulator of Inflammation in Diabetic Retinopathy.  Sci Rep. 2018 Apr 25;8(1):6526. DOI: 10.1038/s41598-018-24907-w. PMID: 29695738
    3. Biswas S, Thomas AA, Chakrabarti S.  LncRNAs: Proverbial Genomic "Junk" or Key Epigenetic Regulators During Cardiac Fibrosis in Diabetes?  Front Cardiovasc Med. 2018 Apr 4;5:28. doi: 10.3389/fcvm.2018.00028. eCollection 2018. PMID: 29670886
    4. Sullivan R, McGirr R, Hu S, Tan A, Wu D, Charron C, Lalonde T, Arany E, Chakrabarti S, Luyt L, Dhanvantari S.  Changes in the Cardiac GHSR1a-Ghrelin System Correlate With Myocardial Dysfunction in Diabetic Cardiomyopathy in Mice.  J Endocr Soc. 2017 Dec 28;2(2):178-189. DOI: 10.1210/js.2017-00433. eCollection 2018 Feb 1. PMID: 29450407
    5. Abdelhameed M, Martir DR, Chen S, Xu WZ, Oyeneye OO, Chakrabarti S, Zysman-Colman E, Charpentier PA.  Tuning the Optical Properties of Silicon Quantum Dots via Surface Functionalization with Conjugated Aromatic Fluorophores.  Sci Rep. 2018 Feb 14;8(1):3050. DOI: 10.1038/s41598-018-21181-8. PMID: 29445234
    6. Adams P, Howlett C, Xenocostas A, Chakrabarti S.  Sex-specific analysis post-liver transplantation in hemochromatosis with aplastic anemia and hepatocellular carcinoma.  Hepatol Commun. 2017 Nov 11;2(1):13-15. DOI: 10.1002/hep4.1122. eCollection 2018 Jan. PMID: 29404507
    7. Gordon A, Biswas S, Feng B, Chen S, Chakrabarti S.  MALAT1: A Regulator of Inflammatory Cytokines in Diabetic Complications. Endocrinology, Diabetes & Metabolism; 2017. doi:10.1002/edm2.10.
    8. Biswas S, Feng B, Thomas AA, Chen S, Aref-Eshghi E, Sadikovic B, Chakrabarti S.  Endothelin-1 regulation is entangled in a complex web of epigenetic mechanisms in diabetes. Physiological Research: 2018;67(Supplementum 1): S115-S125. 

2017 Publications

    1. Chakrabarti S, Sen S, Lui E.  Effect of ginseng therapy on diabetes and its chronic complications: lessons learned.  J Complement Integr Med. 2017 May 11;14(4). pii: /j/jcim.2017.14.issue-4/jcim-2016-0166/jcim-2016-0166.xml. DOI: 10.1515/jcim-2016-0166. PMID: 29345436
    2. Thomas AA, Feng B, Chakrabarti S.  ANRIL regulates production of extracellular matrix proteins and vasoactive factors in diabetic complications.  Am J Physiol Endocrinol Metab. 2018 Mar 1;314(3):E191-E200. DOI: 10.1152/ajpendo.00268.2017. Epub 2017 Nov 7. PMID: 29118015
    3. Pena AM, Chen S, Feng B, Cai L, Li X, Liang G, Chakrabarti S.  Prevention of Diabetic Nephropathy by Modified Acidic Fibroblast Growth Factor.  Nephron. 2017;137(3):221-236. doi: 10.1159/000478745. Epub 2017 Jul 29. PMID: 28768285
    4. Beamish CA, Mehta S, Strutt BJ, Chakrabarti S, Hara M, Hill DJ.  Decrease in Ins+Glut2LO β-cells with advancing age in mouse and human pancreas.  J Endocrinol. 2017 Jun;233(3):229-241. DOI: 10.1530/JOE-16-0475. Epub 2017 Mar 27. PMID: 28348115
    5. Chen S, Feng B, Thomas AA, Chakrabarti S.  miR-146a regulates glucose induced upregulation of inflammatory cytokines extracellular matrix proteins in the retina and kidney in diabetes.  PLoS One. 2017 Mar 16;12(3):e0173918. DOI: 10.1371/journal.pone.0173918. eCollection 2017. PMID: 28301595
    6. Feng B, Chen S, Gordon AD, Chakrabarti S.  miR-146a mediates inflammatory changes and fibrosis in the heart in diabetes.  J Mol Cell Cardiol. 2017 Apr;105:70-76. DOI: 10.1016/j.yjmcc.2017.03.002. Epub 2017 Mar 6. PMID: 28279663
    7. Thomas AA, Feng B, Chakrabarti S.  ANRIL: A Regulator of VEGF in Diabetic Retinopathy.  Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):470-480. DOI: 10.1167/iovs.16-20569. PMID: 28122089
    8. Joy TR, McKenzie CA, Tirona RG, Summers K, Seney S, Chakrabarti S, Malhotra N, Beaton MD.  Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial.  World J Gastroenterol. 2017 Jan 7;23(1):141-150. DOI: 10.3748/wjg.v23.i1.141. PMID: 28104990
    9. Biswas S, Chakrabarti S.  Pathogenetic Mechanisms in Diabetic Retinopathy: From Molecules to Cells to Tissues.  In: Kartha CC, Ramachandran S, Pillai RM, eds. Mechanisms of Vascular Defects in Diabetes Mellitus. Cham: Springer International Publishing; 2017:209-247. DOI:10.1007/978-3-319-60324-7_9. 

2016 Publications

    1. Chakrabarti S.  MicroRNA15a - A Molecule Modulating Multiple Pathologies in Diabetic Retinopathy.  EBioMedicine. 2016 Sep;11:13-14. DOI: 10.1016/j.ebiom.2016.08.017. Epub 2016 Aug 13. No abstract available. PMID: 27546691

    2. Ujjawal R, Koushik P, Ajay P, Subrata C.  A Case of Wegener's Granulomatosis Presenting with Unilateral Facial Nerve Palsy.  Case Rep Med. 2016;2016:9153625. DOI: 10.1155/2016/9153625. Epub 2016 Mar 24. PMID: 27110249

    3. Li B, Iordanous Y, Wang Y, Chakrabarti S, Allen LH.  Adenoid cystic carcinoma presenting as an orbital apex mass with intracranial extension.  Can J Ophthalmol. 2016 Apr;51(2):e65-7. DOI: 10.1016/j.jcjo.2015.12.012. No abstract available. PMID: 27085282

    4. Newburg DS, Tanritanir AC, Chakrabarti S.  Lactodifucotetraose, a human milk oligosaccharide, attenuates platelet function and inflammatory cytokine release.  J Thromb Thrombolysis. 2016 Jul;42(1):46-55. DOI: 10.1007/s11239-015-1331-2. PMID: 26743063

    5. Feng B, Cao Y, Chen S, Chu X, Chu Y, Chakrabarti S.  miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy.  Diabetes. 2016 Mar;65(3):768-79. DOI: 10.2337/db15-1033. Epub 2015 Dec 30. PMID: 26718496

2015 Publications

    1. Chakrabarti S. Unacylated Ghrelin: a gut-limb connection (Invited commentary). Diabetes 64:1097-98, 2015
    2. Puthanveetil P, Chen S, Feng B, Gautam A, Chakrabarti S Long non coding RNA MALAT1 regulates glucose induced inflammatory mediator induction in the endothelial cells. J Cell Mol Med. DOI: 10.1111/jcmm.12576
    3. Wu Y, Chakrabarti S ERK5 mediated signaling in Diabetic Retinopathy. Med. Hypothesis. Discov. Innov. Ophthalmol. 4:17-26, 2015
    4. Balint B, Yin H, Chakrabarti S, Chu M, Sims S, Pickering JG. Collectivization of vascular smooth muscle cells via TGF-ß - cadherin-11-dependent adhesive switching. Arterioscler Thromb Vasc Biol. 2015 Mar 12. pii: ATVBAHA.115.305310.
    5. Yin H, Frontini MJ, Arpino JM Nong Z, O'Neil C1 Xu Y, Balint B, Ward AD, Chakrabarti S, Ellis CG, Gros R, Pickering JG.. Fibroblast Growth Factor 9 Imparts Hierarchy and Vasoreactivity to the Microcirculation of Renal Tumors and Suppresses Metastases. J Biol Chem.  2015 Sep 4;290(36):22127-42.  DOI:   10.1074/jbc.M115.652222. Epub 2015 Jul 16.   PMID:  26183774.
    6. Feng B, Cao Y, Chakrabarti S. miR-200b regulates glucose induced EndMT in heart of diabetic animal. Diabetes, Volume 64 (supplementary 1).
    7. Zuo Y, Wu Y, Wehrli B, Chakrabarti S, Chakraborty C. Modulation of ERK5 is a novel mechanism by which Cdc42 regulates migration of breast cancer cells.. J Cell Biochem.  2015 Jan;116(1):124-32  DOI:   10.1002/jcb.24950.   PMID:  25160664.
    8. Iordanous Y, Belrose JC, Cadieux DC, Chakrabarti S, Farmer JP, Allen LH. P63 positive mucoepidermoid tumour of the lacrimal sac with associated papilloma orbit. Orbit.  2015;34(4):220-2  Epub 2015 06 29  DOI:   10.3109/01676830.2015.1049370.   PMID:  26121166.
    9. Ruiz M, Feng B, Chakrabarti S. Polycomb Repressive Complex 2 regulates miR-200b in retinal endothelial cells: potential relevance in diabetic retinopathy.. PloS One  2015; 10(4): e0123987.  DOI:   10.1371/journal.pone.0123987   PMID:  4401764.
    10. Pena AM, Feng B, Chen S, Cai L, Liang G, Li X, Chakrabarti S. Protective effect of modified human acidic fibroblast growth factor on diabetic nephropathy. Diabetes, Volume 64 (supplementary 1).
    11. Mortuza R, Feng B, Chakrabarti S. SIRT1 Reduction Causes renal and retinal injury in diabetes through endothelin 1 (ET-1) and transforming growth factor B1 (TGF-B1). J. Cell. Mol. Med  Vol 19, No 8, 2015 pp. 1857-1867  DOI:   10.1111/jcmm.12557.
    12. Frontini M, Yin H, Nong Z, O’Neil C, Arpino JM , Xu Y, Balint B, Ward A, Chakrabarti S, Ellis C, Gros R, Pickering JG. Normalization of Tumor Microvessels and Suppression of Metastasis by Fibroblast Growth Factor 9 . Journal of biological Chemistry 2015 Jul 16. pii: jbc.M115.6522227.

2014 Publications

    1. Beaton MD, Chakrabarti S. Adams PC. Inflammation is not the cause of an elevated serum ferritin in non-alcoholic fatty liver disease.  Ann Hepatol 2014; 13:353-6.
    2. Cao Y, Feng B, Chen S, Chu Y  and Chakrabarti S. Mechanisms of endothelial to mesenchymal transition in the retina in diabetes.   Invest Ophthalmol Vis Sci. 2014 Oct 21;55 :7321-31. doi: 10.1167/iovs.14-15167.
    3. Cong W, Zhao T, Zhu Z, Huang B, Ma W, Wang Y, Chakrabrti S, Li X, Jin L, Cai L.  Metallothionein prevents cardiac pathological changes in diabetes by modulating nitration and inactivation of cardiac ATP synthase.  J. Nut. Biochem. 25(4):463-74, 2014.
    4. Chakrabarti S. Heparanase shakes hands with lipoprotein lipase - a tale of two cells. (Invited commentary). Diabetes:63(8):2600-2, 2014.
    5. Chen S, Puthanveetil P, Feng B, Matkovich SJ, Dorn GW, Chakrabarti S. Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes. J Cell Mol Med. 16 JAN 2014, DOI: 10.1111/jcmm.12218.
    6. Feng B, Cao Y, Chen S, Ruiz M, Chakrabarti S. miRNA-1 regulates endothelin-1 in diabetes.  Life. Sc.  DOI  10.1016/j.lfs.2013.12.199, 2014.
    7. Feng B, Chen S, Zhang L, Cao Y, Chakrabarti S. miRNA-146a and miRNA-200b antagomirs accelerate wound healing through the regulation of VEGF and fibronectin. J. Pharm. Pharmacol. 2:104-113, 2014
    8. Mortuza R, Feng B  Chakrabarti S. MiR-195 Regulates SIRT1 Mediated Changes in Diabetic Retinopathy. Diabetologia DOI 10.1007/s00125-014-3197-9, 2014.
    9. Puthanveetil P,  Thomas AA,  Chakrabarti S. microRNAs in diabetes- are they perpetrators in disguise or just epiphenomena? ncRNA in Endocrinol 1;31-43, 2014.
    10. Xiao J, Li J, Cai L, Chakrabarti S, Li X. Cytokines and Diabetes Research. J. Diab. Res. (2014), Article ID 920613,
    11. Zeng C, Zhong P, Zhao Y, Kanchana K, Zhang Y, Khan ZA, Chakrabarti S, Wu L, Wang J, Liang G. Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo.  J Mol Cell Cardiol. 2015 ;79:1-12. Epub 2014 Oct 16.
    12. Zhao YZ, Tian XQ, Zhang M, Cai L, Ru A, Shen XT, Jiang X, Jin RR, Zheng L, Hawkins K, Charkrabarti S, Li XK, Lin Q, Yu WZ, Ge S, Lu CT, Wong HL. Functional and pathological improvements of the hearts in diabetes model by the combined therapy of bFGF-loaded nanoparticles with ultrasound-targeted microbubble destruction. J Control Release. 2014 186:22-31. doi: 10.1016/j.jconrel.2014.04.054. Epub 2014 May 9.
    13. Zhao YZ, Tian XQ, Zhang M, Cai L, Ru A, Shen XT, Jiang X, Jin RR, Zheng L, Hawkins K, Charkrabarti S, Li XK, Lin Q, Yu WZ, Ge S, Lu CT, Wong HL. Functional and pathological improvements of the hearts in diabetes model by the combined therapy of bFGF-loaded nanoparticles with ultrasound-targeted microbubble destruction. J Control Release. 2014 186:22-31. doi: 10.1016/j.jconrel.2014.04.054. Epub 2014 May 9.
    14. Zuo Y1, Wu Y, Wehrli B, Chakrabarti S, Chakraborty C. Modulation of ERK5 Is a Novel Mechanism by Which Cdc42 Regulates Migration of Breast Cancer Cells. J Cell Biochem 2014  doi: 10.1002/jcb.24950. [Epub ahead of print].

2013 Publications

    1. Al-Judaibi B, Chandok N, Chakrabarti N. Shedding Light on a Painful Rash. Arab J. Gastroenterology 14(2):83-84, 2013.
    2. Beaton M, Chakrabarti S, Speechley M, Marotta P, Levstik M, Adams PA. Phase II clinical trial of phlebotomy for non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2013;37(7):720-9.
    3. Caragea M, Smith P, Parfitt J, Howlett C, Chakrabarti S. Progressing Multicystic Mesothelioma of the Liver. Canad. J. Pathol 5(2) 60-64, 2013.
    4. Feng B, Ruiz MA, Chakrabarti S. Oxidative stress-induced epigenetic changes in chronic diabetic complications. Canadian Journal of Physiology and Pharmacology, 2013 Mar;91(3):213-20. Epub 2012 Dec 17. PMID: 23537434.
    5. Mortuza R, Chen S, Feng B, Sen S, Chakrabarti S. High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway. PLoS One. 2013;8(1):e54514. doi: 10.1371/journal.pone.0054514.
    6. Mortuza R, Chakrabarti S. Glucose-induced cell signaling in the pathogenesis of diabetic cardiomyopathy. Heart Fail Rev. 2013 Feb 21. [Epub ahead of print] PMID:23430126.
    7. Ogbogu U, Mengel, M , on behalf of the Canadian Chairs of Pathology and Laboratory Medicine. Who Owns Diagnostic Specimens in the Era of Personalized Medicine? Canad. J. Pathol 5(5):86-87, 2013.
    8. Ruiz MA, Chakrabarti S. microRNAs: the underlying mediators of pathogenetic processes in vascular complications of diabetes. Can J Diabetes 37 (2013) 339-344.
    9. Sen S, Chen S, Wu YX, Feng B, Lui E, Chakrabarti S. Preventive effects of North American ginseng (Panax quinquefolius) on diabetes-induced retinopathy and cardiomyopathy. Phytother Res. 2013 Feb;27:290-8. doi: 10.1002/ptr.4719. Epub 2012 May 8.
    10. Sen S. Querques MA, Chakrabarti S. North American ginseng (Panax quinquefolius) prevents hyperglycemia and associated pancreatic abnormalities in diabetes. J. 2013 l;16(7):587-92. doi: 10.1089/jmf.2012.0192.
    11. Zhang C,  Zhang L, Chen S, Feng B, Bai Y, Liang G, Tan Y, Shao M, Skibba M, Jin L, Lu X, Li X, Chakrabarti S, Lu Cai L. The Prevention of Diabetic Cardiomyopathy by Non-Mitogenic Acidic Fibroblast Growth Factor Is Probably Mediated by the Suppression of Oxidative Stress and Damage. PLoS ONE 8(12): e82287. oi:10.1371/journal. pone. 0082287, 2013.

2012 Publications

    1. Chandok N, Speechley M, Ainsworth PJ, Chakrabarti S, Adams PC. The Impact of Population-Based Screening Studies on Hemochromatosis Screening Practices. Dig Dis Sci. 2011 57(5)1420-22, 2012.
    2. Chen S, Sen S, Feng B, Iglarz M, Chakrabarti S. Renal, retinal and cardiac changes in type 2 diabetes are prevented by macitentan, a dual endothelin receptor antagonist.  Life Sci. 2012 Oct 15;91(13-14):658-68. doi: 10.1016/j.lfs.2012.03.032.
    3. Chen S, Chakrabarti R, Keats EC, Chen M, Chakrabarti S, Khan ZA. Regulation of vascular endothelial growth factor expression by extra domain B segment of fibronectin in endothelial cells. Invest Ophthalmol Vis Sci. 2012 Dec 17;53(13):8333-43. doi: 10.1167/iovs.12-9766.
    4. Feng B, Chakrabarti S. miR-320 regulates glucose induced gene expression in diabetes.  ISRN Endocrinology 2012: Article ID 549875, doi:10.5402/2012/549875.
    5. Khan Z A, Chakrabarti S. Glucose induced cellular signaling in diabetic retinopathy. In: Visual dysfunction in diabetes.  Tombran-tink J, Barnstable CJ, Gardner TW(Eds), Humana  Press, Chap 13:pp 211-222, 2012.12.13.
    6. Kurdi M, Allen L, Wehrli B, Chakrabarti S. Solitary Fibrous Tumour of the Lacrimal Sac Presenting with Recurrent Dacryocystitis: Case Report and Literature Review. Canad. J. Ophthalmol 49(5):e109-110, 2012,
    7. Sen S, Chen S, Feng B, Wu Y, Lui E, Chakrabarti S. Preventive effects of North American ginseng (Panax quinquefolium) on diabetic nephropathy.  Phytomedicine. 2012 Apr 15;19(6):494-505. Epub 2012 Feb 10.
    8. Wang C, George B, Chen S, Feng B, Li X, Chakrabarti S. Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. Diabetes Metab Res Rev. 2012 Jan 6. doi: 10.1002/dmrr.2279
    9. Wu Y, Feng B, Chen S, Chakrabarti S. ERK5 Regulates glucose-induced increased fibronectin production in the endothelial cells and in the retina in diabetes. Invest Ophthalmol Vis Sci. 2012 Dec 19;53(13):8405-13. doi: 10.1167/iovs.12-10553.

2011 Publications

    1. Chakrabarti S. Molecular Mechanisms in the Pathogenesis of Diabetic Cardiomyopathy. In: Molecular defects in Heart disease. Dhalla Ns, Nagano M, Ostadal B (Eds.) Springerpp. 365-378, 2011.
    2. Feng B, Chen S,  McArthur K,  Wu YX,  Sen S, Chakrabarti S. miR-146a mediated extracellular matrix protein production in chronic diabetic complications. Diabetes 60:2975-84, 2011.
    3. Francis SM, Chakrabarti S, Dick FA. A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis. PLoS One. 2011 Feb 22; 6(2):e16434.
    4. McArthur K, Feng B, Wu YX, Chen S, Chakrabarti S. microRNA 200b regulates VEGF mediated alterations in diabetic retinopathy. Diabetes;60:1314-23. 2011.
    5. Rai A,  Al-Jaradi M, Burnier M, Chakrabarti S. Congenital choroidal melanoma in an infant. Can. J. Ophthalmol. 46:203-204, 2011.
    6. Sen S, Chen S, Feng B, Wu YX, Lui E, Chakrabarti S. American ginseng (Panax quinquefolius) prevents glucose induced oxidative stress and associated endothelial abnormalities. Phytomedicine 18:1110-17, 2011.  

2010 Publications

    1. Coschi CH, Martens AL,  Ritchie K,  Francis SM,  Chakrabarti S, Berube NG,. Dick FA. Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor suppressive. Genes and Devp 24:1351-63, 2010.
    2. Feng B, Chen S, George B,  Chakrabarti S. miR133a regulates cardiomyocyte hypertrophy in diabetes. Diabetes Metab Res Rev. 26:40-9, 2010.
    3. Khan ZA, Chakrabarti S. Chronic Diabetic Complications: Endothelial Cells at theFrontline. In Frontiers in Cardiovascular Drug Discovery,  Rahman AU and  Choudhary I. EdsBentham Science publishers; Chap 9, pp121-137;  2010.
    4. Koutsogiannis D, Summers K, George B, Adams P,   Marotta P, Chakrabarti S. Identification of serum biomarkers in end stage liver disease. The Open Biomarkers Journal 3:1-6, 2010.
    5. Wu Y, Feng B, Chen S, Chakrabarti S. ET-1 is regulated by Erk5 in diabetic retinopathy.  Canad. J. Physiol. Pharmacol  88:607-615, 2010.
    6. Wu Y, Zuo Y, Chakrabarti R, Feng B, Chen S, Chakrabarti S. ERK5 contributes to VEGF alteration in diabetic retinopathy. J. Ophthalmol 2010: Article ID 465824, 2010.

2009 Publications

    1. Chakrabarti S. Editorial: Steatosis is a Lot More than Holes in Hepatocytes. Saudi. J. Gastroenterol.15:1, 2009.
    2. Chen S, Feng B, George B, Chakrabarti R, Chen M, Chakrabarti S. Transcriptional Co-activator p300 regulates Glucose Induced Gene Expression in the Endothelial Cells. Am J Physiol Endocrinol Metab.2010; 298: E127-E137 [Epub Nov 10,2009].
    3. Chiu J, Khan ZA, Farhangkhoee H, Chakrabarti S. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. Nutrition. 2009 Sep;25(9):964-72. Epub 2009 Mar 5.
    4. Francis SM, Bergsied J, Isaac CE, Coschi CH, Martens AL, Hojilla CV, Chakrabarti S, DiMattia GE, Khoka R, Wang JYJ, Dick FA .A functional connection between pRB and TGF- in growth inhibition and mammary gland development  Mol. Cell. Biol. 29:4455-66,2009.
    5. George B, Chen S, Chaudhary V, Gonder J, Chakrabarti S. Extracellular matrix proteins in epiretinal membranes and in diabetic retinopathy. Curr Eye Res. 2009 Feb;34(2):134-44.
    6. Khan ZA, Chakrabarti S. Response: Inhibition of p300 and nuclear factor-κB by curcumin and its role in diabetic nephropathy. Nutrition 25:975-6, 2009.
    7. Majumdar P, Chen S, George B, Sen S, Karmazyn M, Chakrabarti S. Leptin and endothelin-1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease. Diabetes Metab Res Rev. 2009 Jul;25(5):452-63.
    8. Ulici V, Hoenselaar KD, Agoston H, McErlain DD, Umoh J, Chakrabarti S, Holdsworth DW, Beier F The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification. Bone.:45:1133-45, 2009.

2008 Publications

    1. Adams PC, McAlister V, Chakrabarti S, Levstik M, Marotta P. Is serum hepcidin causative in hemochromatosis? Novel analysis from a liver transplant with hemochromatosis of the liver.Can J Gastroenterol. 22:851-3,2008.
    2. Chiu J, Farhangkhoee H, Xu BY, Chen S, George B, Chakrabarti S. PARP mediates structural alterations in diabetic cardiomyopathy. J Mol Cell Cardiol. 2008 Sep;45(3):385-93. Epub 2008 Jul 8.
    3. Chiu J, Xu BY, Chen S, Feng B, Chakrabarti S. Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications. Can J Physiol Pharmacol. 2008 Jun;86(6):365-72.
    4. Feng B, Chen S, Chiu J, George B, Chakrabarti S. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1119-26. Epub 2008 Apr 15.
    5. Xu B, Chiu J, Feng B, Chen S, Chakrabarti S. PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):404-12.
    6. Zeidan A, Javadov S, Chakrabarti S, Karmazyn M Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei. Cardiovasc Res. 2008 Jan; 77(1):64-72.  

2007 Publications

    1. Chakrabarti S. Editorial: Diabetic Retinopathy: From Pathogenesis to Treatment. Exp. Diab. Res, 2007: ID 69527, 2007.
    2. Chen S, Khan ZA, Karmazyn M, Chakrabarti S.  Role of endothelin-1, sodium hydrogen exchanger-1 and mitogen activated protein kinase (MAPK) activation in glucose-induced cardiomyocyte hypertrophy. Diabetes Metab Res Rev. 2007 Jul;23(5):356-67.  
    3. Khan Z A, Chakrabarti S. Cellular signaling and poetntial new treatment targets for diabetic retinopathy. 2007: Exp. Diab. Res ID: 31867, 2007.
    4. Moussa B, Hooper P, Chakrabarti S.  Uveal metastasis from pulmonary large-cell neuroendocine carcinoma. Can J Ophthalmol. 2007 Oct;42(5):757-8. No abstract available. 
    5. Parfitt JR, Marotta P, Alghamdi M, Wall W, Khakhar A, Suskin NG, Quan D, McAllister V, Ghent C, Levstik M, McLean C, Chakrabarti S, Garcia B, Driman DK.  Recurrent hepatocellular carcinoma after transplantation: use of a pathological score on explanted livers to predict recurrence. Liver Transpl. 2007 Apr;13(4):543-51.
    6. Temple CLF, Snell LJ, Power SM, Parfitt JR,  Scilley C,  Engel CJ,  Shum D, Chakrabarti S, Joseph MG,  Lohmann RC,   Ainsworth P. The Clinical Significance of the RT-PCR Positive Sentinel Node in Melanoma. J. Surg. Oncol.95:546-54, 2007. 2007;Jan 11; [Epub].
    7. Xin X, Chen S, Khan ZA, Chakrabarti S. Akt activation and augmented fibronectin production in hyperhexosemia. Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E1036-44. Epub 2007 Jul 31.
    8. Zeidan A, Paylor B, Steinhoff KJ, Javadov S, Rajapurohitam V, Chakrabarti S, Karmazyn M.  Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK- and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways. J Pharmacol Exp Ther. 2007 Sep;322(3):1110-6. Epub 2007 Jun 11.

2006 Publications

    1. Adams P, Passmore L, Chakrabarti S, Rebussin DM, Acton RT, Barton JC, McLaren GD, Eckfedt JH, Dawkins FW, Gordeuk VR, Harris EL, Leiendecker-Foster C, Gossman, Sholinsky P. Liver disease in the hemochromatosis and iron overload screening. Study Clin Gastro Hepatol. 2006 Jul;4(7):918-23;quiz 807.
    2. Farhangkhoee H, Khan ZA, Chen S, Chakrabarti S. Differential effects of curcumin on vasoactive factors in the diabetic rat heart. Nutr Metab (Lond). 2006 Jul 18; 3:27.
    3. Farhangkhoee H, Khan ZA, Kaur H, Xin X, Chen S, Chakrabarti, S. Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets. Pharmacol Ther. 2006 Aug;111(2):384-99. Epub 2005 Dec 15.
    4. Kaur H, Chen S, Xin X, Chiu J, Khan ZA, Chakrabarti S. Diabetes-induced extracellular matrix protein expression is mediated by transcription co-activator p300. Diabetes. 2006 Nov;55(11):3104-11.
    5. Khan ZA, Farhangkhoee H, Chakrabarti S. Towards newer molecular targets for chronic diabetic complications. Curr Vasc Pharmacol. 2006 Jan;4(1):45-57. Review.
    6. Khan ZA, Farhangkhoee H, Mahon JL, Bere L, Gonder JR, Chan BM, Uniyal S, Chakrabarti S. Endothelins: regulators of extracellular matrix protein production in diabetes. Exp Biol Med (Maywood). 2006 Jun;231(6):1002-9.
    7. Khan ZA, Farhangkhoee H, kaur H, Xin XP, Chen S, Chakrabarti S. Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets. Pharmacol Ther. 111:384-99, 2005.
    8. Khan Z A, Chakrabarti S. Therapeutic Targeting of Endothelial Dysfunction in Chronic Diabetic Complications. Rec. Pat. Cardiovas. Drug. Dis 1:167-175, 2006 
    9. Siddiqui I, Khan ZA, Lian D, Jiang J, Zhong R, Garcia B, Chakrabarti S. Endothelin-mediated oncofetal fibronectin expression in chronic allograft nephropathy. Transplantation. 2006 Aug 15;82(3):406-14.

2005 Publications

    1. Bedard EL, Jiang J, Parry N, Wang H, Liu W, Garcia B, Kim P, Chakrabarti S, Buelow R, Zhong R. Peritransplant treatment with cobalt protoporphyrin attenuates chronic renal allograft rejection. Transpl Int. 2005 Mar;18(3):341-9.
    2. Cuertero J, Khan ZA, Barbin Y, Adams P Chakrabarti S Oncofetal fibronectin in non small    cell lung carcinoma. Exp. Lung. Res 31:701-11, 2005.
    3. Farhangkhoee H, Khan ZA, Barbin Y, Chakrabarti S. Glucose-induced up-regulation of CD36 mediates oxidative stress and microvascular endothelial cell dysfunction. Diabetologia. 2005 May 25.
    4. Farhangkhoee H, Khan ZA, Kaur H, Xin X, Chen S, Chakrabarti S. Vascular endothelial dysfunction in diabetic cardiomyopathy: Pathogenesis and potential treatment targets.  Pharmacology and Therapeutics, 2005.
    5. Fukuda G, Khan ZA, Barbin YP, Farhangkhoee H, Tilton RG, Chakrabarti S. Endothelin-mediated remodeling in aortas of diabetic rats. Diabetes Metab Res Rev. 2005 Jul-Aug;21(4):367-75.
    6. Fukuda G, Yoshitake N, Khan ZA, Kanazawa M, Notoya Y, Che XF, Akiyama S, Tomoda A, Chakrabarti S, Odawara M. 2-amino-phenoxazine-3-one attenuates glucose-induced augmentation of embryonic form of myosin heavy chain, endothelin-1 and plasminogen activator inhibitor-1 in human umbilical vein endothelial cells. Biol Pharm Bull. 2005 May;28(5):797-801.
    7. Fukuda G, Khan ZA, Tilton R, Chakrabarti S.  Endothelins in Diabetes-Induced Extracellular   Matrix Protein Production and Increased Medial Thickness Diabetes Metab Res Rev. 21:367-75, 2005.
    8. Khan ZA, Barbin YP, Farhangkhoee H, Beier N, Scholz W, Chakrabarti S. Glucose-induced serum- and glucocorticoid-regulated kinase activation in oncofetal fibronectin expression. Biochem Biophys Res Commun. 2005 Apr 1;329(1):275-80.
    9. Khan ZA, Chan BM, Uniyal S, Barbin YP, Farhangkhoee H, Chen S, Chakrabarti S.  EDB fibronectin and angiogenesis - a novel mechanistic pathway. Angiogenesis 8:183-196, 2005.
    10. Khan ZA, Farhangkhoee H, Barbin YP, Adams PC, Chakrabarti S. Glucose-induced regulation of novel iron transporters in vascular endothelial cell dysfunction. Free Radical Research, 39(11): 1203-1210, 2005.
    11. Khan ZA, Caurtero J, Barbin YP, Chan BM, Uniyal S, Chakrabarti S. ED-B fibronectin in non-small cell lung carcinoma. Experimental Lung Research, 31:701-711, 2005.
    12. Khan Z A, Chakrabarti S. Endothelins and microvascular endothelial responses in diabetes. In: microvascular research - biology and pathology’. (Shepro D, ed., D’Amore P, section ed.) Elsevier Academic press, Chap 99, pp671-676, 2005.
    13. Khan ZA, Farhangkhoee H, Barbin YP, Adams PC, Chakrabarti S. Glucose-induced regulation of novel iron transporters in vascular endothelial cell dysfunction. Free Radic Res. 2005 Nov;39(11):1203-10.
    14. Khakhar AK , Chan NG, Allan DS, Chakrabarti S, McAlister VC. Catastrophic microangiopathy induced by high-titre factor VIII inhibitors after liver transplantation for haemophilia A with cirrhosis. Haemophilia 2005 Nov; 11(6):623-8.
    15. Scott JR, Gray DK, Bihari A, Badhwar A, Zhang X, Shan P Lee PJ, Chakrabarti S, Harris KA, Potter RF.  Heme oxygenase modulates small intestine leukocyte adhesion following hindlimb ischemia/reperfusion by regulating the expression of intercellular adhesion molecule-1. Crit Care Med. 2005 Nov;33(11):2563-70.
    16. Sham TK, Kim PSG, Ngo H Chakrabarti S, Adams P. An X-ray microspectroscopic study of hemochromatosis liver and diabetic mice kidney tissues: preliminary observations. Physica Scripta T115, 1047-1049, 2005
    17. Wong K, Barbin YP, Cukiernik M, Chakrabarti S, Adams P. A point mutation in the non-responsive element of the L-ferritin gene in a familly of hyperferritinemia cataract syndrome. Canad. J. Gastroenterol 19:251-52, 2005.
    18. Xin X, Khan ZA, Chen S, Chakrabarti S. Glucose-induced Akt1 activation mediates fibronectin synthesis in endothelial cells. Diabetologia 48:2428-2436, 2005.
    19. Zeidan A, Purdham DM, Rajapurohitam V, Javadov S, Chakrabarti S, Karmazyn M. Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy. J Pharmacol and Exp Therapeut (JPET) 315:1075-1084, 2005.

2004 Publications

    1. Chakrabarti S, Khan ZA, Cukiernik M, Zhang W, Sima AA. C-peptide and retinal microangiopathy in diabetes. Exp Diabesity Res. 2004 Jan-Mar;5(1):91-6.
    2. Chen S, Khan ZA, Barbin Y, Chakrabarti S. Pro-oxidant role of heme oxygenase in mediating glucose-induced endothelial cell damage. Free Radic Res. 2004 Dec;38(12):1301-10.
    3. Cukiernik M, Hileeto D, Downey D, Evans T, Khan ZA, Karmazyn M, Chakrabarti, S. The role of the sodium hydrogen exchanger-1 in mediating diabetes-induced changes in the retina. Diabetes Metab Res Rev. 2004 Jan-Feb;20(1):61-71.
    4. Cukiernik M, Hileeto D, Evans T, Mukherjee S, Downey D, Chakrabarti S. Vascular endothelial growth factor in diabetes induced early retinal abnormalities. Diabetes Res Clin Pract. 2004 Sep;65(3):197-208.
    5. Khan ZA, Cukiernik M, Gonder JR, Chakrabarti S. Oncofetal fibronectin in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2004 Jan;45(1):287-95.
    6. Khan ZA, Barbin YP, Cukiernik M, Adams PC, Chakrabarti S. Heme-oxygenase-mediated iron accumulation in the liver. Can J Physiol Pharmacol. 2004 Jul;82(7):448-456.
    7. Kowluru RA, Chakrabarti S, Chen S. Re-institution of good metabolic control in diabetic rats and activation of caspase-3 and nuclear transcriptional factor (NF-kappaB) in the retina. Acta Diabetol. 2004 Dec;41(4):194-9.
    8. Kowluru RA, Kowluru A, Chakrabarti S, Khan Z.  Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats. Diabetes. 2004 Mar;53(3):775-83.
    9. McCudden CR, Majewski A, Chakrabarti S, Wagner GF. Co-localization of stanniocalcin-1 ligand and receptor in human breast carcinomas. Mol Cell Endocrinol. 2004 Jan 15;213(2):167-72.
    10. Miura K, Uniyal S, Leabu M, Oravecz T, Chabrabarti S, Morris VL and Chan BMC, Chemokine receptor CXCR4-b1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. Biochem. Cell Biol. 83:36-48,2005.
    11. Xin X, Khan ZA, Chen S, Chakrabarti S. Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesis. Lab Invest. 2004 Sep 27 [Epub ahead of print]PMID: 15448709.

2003 Publications

    1. Adams P, Khan ZA, Barbin YP, Chakrabarti S. Expression of ferroportin in hemochromatosis liver. Blood Cell. Mol. Dis. 31:256-61, 2003.
    2. Chakrabarti S. Endothelins and cardiovascular disease in diabetes. In: Atherosclerosis, hypertension and diabetes, Proceedings of the World Heart Congress, 2001.Pierce GN, Nagaro M, Zahardka P and Dhalla NS. (eds), Kluwer/Plenum Press, New York. Pp 301-316, 2003 
    3. Chakraborty C, Barbin YP, Chakrabarti S, Chidiac P, Dixon SJ, Lala PK. Endothelin-1 promotes migration and induces elevation of [Ca(2+)](i) and phosphorylation of MAP kinase of a human extravillous trophoblast cell line. Mol Cell Endocrinol. 2003;201(1-2):63-73.
    4. Chen S, Khan ZA, Cukiernik M, Chakrabarti S. Differential activation of NF-kappa B and AP-1 in increased fibronectin synthesis in target organs of diabetic complications. Am J Physiol Endocrinol Metab. 2003;284(6):E1089-97. Epub 2003 Feb 11.
    5. Chen S, Mukherjee S, Chakraborty C, Chakrabarti S. Glucose induced endothelin dependent increased extracellular matrix protein synthesis is mediated via NF-KB and AP-1. Am. J. Physiol (Cell Physiol.) 284:C263 – C272, 2003.
    6. Cukiernik M, Mukherjee S, Downey D, Chakabarti S. Heme oxygenase in the retina in diabetes. Curr Eye Res. 2003 Nov;27(5):301-8.
    7. Farhangkhoee H, Khan ZA, Mukherjee S, Cukiernik M, Barbin YP, Karmazyn M, Chakrabarti S. Heme oxygenase in diabetes-induced oxidative stress in the heart. J Mol Cell Cardiol. 2003 Dec;35(12):1439-48.
    8. Gan XT, Chakrabarti S, Karmazyn M. Increased endothelin-1 and endothelin receptor expression in myocytes of ischemic and reperfused rat hearts and ventricular myocytes exposed to ischemic conditions and its inhibition by nitric oxide generation. Can J Physiol Pharmacol. 2003;81(2):105-13.
    9. Gan TG, Chakrabarti S,  Karmazyn M. Increased endothelin-1 and endothelin receptor expression in myocytes of ischemic and reperfused rat hearts and ventricular myocytes exposed to ischemic conditions and its inhibition by nitric oxide generation. Ca n. J. Physiol. Pharmacol.  81:103-115, 2003.
    10. Khan ZA, Chakrabarti S. Growth factors in proliferative diabetic retinopathy. Exp Diabesity Res. 2003 Oct-Dec;4(4):287-301.
    11. Khan ZA, Chakrabarti S. Endothelins in chronic diabetic complications. Can J Physiol Pharmacol. 2003; 81(6):622-34
    12. Kowluru R, Chen S, Chakrabarti S. Diabetes induced activation of nuclear transcription - inhibition by antioxidants. Free.rad. Res 37:1169-80, 2003
    13. Luke PP, Deng JP, O'Brien CA, Everest M, Hall AV, Chakrabarti S, O'Connell PJ, Zhong R, Jevnikar AM. CD45RBhi/CD45RBlo T-cell ratio following CD45RB monoclonal-antibody therapy occurs by selective deletion of CD45RBhi effector cells. Transplantation. 76:400-9, 2003.
    14. Zhong R, Luo Y, Yang H, Garcia B, Ghanekar A, Luke P, Chakrabarti S, Lajoie G, Phillips MJ, Katopodis AG, Duthaler RO, Cattral M, Wall W, Jevnikar A, Bailey M, Levy GA, Grant DR Improvement in human decay accelerating factor transgenic porcine kidney xenograft rejection with intravenous administration of gas914, a polymeric form of alphaGAL. Transplantation. 75:10-19, 2003.

2002 Publications

    1. Beaton M, Guyader D, Deugnier Y, Moirand R, Chakrabarti S, Adams PC.  Non-invasive prediction of cirrhosis in C282Y linked hemochromatosis.  Hepatology 36:637-78, 2002.
    2. Cai L, Chen S, Evans T, Cherian MG, Chakrabarti S.  Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats. Int J Exp Diabetes Res. 2002;3(3):193-8.
    3. Cai L, Chen S, Evans T, Cherian MG, Chakrabarti S.  Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats. Int J Exp Diabetes Res. 2002;3(3):193-8.
    4. Chakrabarti S, Khan ZA, Cukiernik M, Fukuda G, Chen S, Mukherjee S.  Alteration of endothelins: a common pathogenetic mechanism in chronic diabeticcomplications. Int J Exp Diabetes Res. 2002;3(4):217-31. Review.
    5. Chen S, Mukherjee S, Chakraborty C, Chakrabarti S. High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1. Am J Physiol Cell Physiol. 2003 Feb;284(2):C263-72. Epub 2002 Sep 18.
    6. Chen S, Evans T, Deng D, Cukeirnik M, Chakrabarti S. Hyperhexosemia induced functional and structural changes in the kidneys: Role of endothelins. Nephron 90:86-94, 2002.
    7. Chau LA, Rohekar S, Wang JJ, Lian D, Chakrabarti S, Zhang L, Zhong R, Madrenas J.
    8. Hileeto D, Cukiernik M, Mukherjee S, Evans T, Barbin Y, Downey D, Karmazyn M, Chakrabarti S.  Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium. Diabetes Metab Res Rev. 2002;18(5):386-94.
    9. Luo Y, Levy G, Ding J, Qi J, Chakrabarti S, Gracia BM, Philips MJ, Kumar N, Friend P, Noble L, Macdonald J, Zhong R, Grant D. hDAF transgenic pig livers are protected from hyperacute rejection during ex vivo perfusion with human blood. Xenotransplantation 9:36-44, 2002.
    10. McGrath J, Deugnier Y, Moirand R, Jouanolle AM, Chakrabarti S, Adams PC.  A nomogram to predict C282Y hemochromatosis. J Lab Clin Med 140:6-8, 2002.
    11. Thymic re‑entry of mature activated T cells and increased negative selection in vascularized allograft recipients. Clin Exp Immunol 127:43‑52, 2002.
    12. Wojcik J, Speechley M, Kertesz AE, Chakrabarti S, Adams PC.  Natural history of C282Y for hemochromatosis.  Can J Gastroenterology 16:297-302, 2002.