Synovial Translational Biology Lab in Osteoarthritis

Research Focus


The Appleton lab is focused on understanding the role of synovium in the onset and progression of OA.

We use molecular biology approaches to understand mechanisms controlling inflammation and cell physiology in the synovial environment. Model systems include post-traumatic and metabolic rodent models of knee OA, and translational work in humans, including the Western Ontario Registry for Early Osteoarthritis (WOREO) Knee Study.

Ongoing studies are aimed at understanding the pathophysiology of synovial cell types involved in OA-associated synovitis and how these mechanisms contribute to OA symptoms and disease progression.

Recent Publications

      Recent Publications

Al-Khazraji BK, Appleton CT, Beier F, Birmingham TB, Shoemaker JK.
Osteoarthritis Cartilage. 2018 Apr;26(4):462-470.

Appleton CT.
Osteoarthritis Cartilage. 2018 Mar;26(3):296-303. doi: 10.1016/j.joca.2017.10.008. Epub 2017 Oct 20. Review.

Appleton CT, Hawker GA, Hill CL, Pope JE.
Arthritis Rheumatol. 2017 Jun;69(6):1127-1130.