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Dr. Jim Lewis, MD, FRCPC

 

Rank/ Affiliations:

  • Professor of Medicine
  • Director of Clinical Research Training, Schulich School of Medicine and Dentistry
  • Cross Appointment, Department of Physiology & Pharmacology

Training:

  • Undergraduate, University of Western Ontario
  • MD, University of Western Ontario
  • Internal Medicine, Queen's University
  • Respirology, University of Western Ontario
  • Fellowship, Harbour UCLA Medical Centre, Torrence, California

Clinical Interest:

  • Asthma, exercise-induced asthma
  • Cystic Fibrosis
  • Lung Cancer
  • COPD

Research Interest:

  • Clinical Research: Imaging in cystic fibrosis, asthma
  • Basic Research: lung injury, ARDS, surfactant

Research Funding:

  • Canadian Institutes of Health Research
  • Ontario Thoracic Society
  • Cystic Fibrosis Canada
  • Physicians' Services Incorporated Foundation

Awards:

  • Dean’s Award of Excellence, Local, University of Western Ontario, London, Ontario, Canada, 2008
  • HUMEC Award for Excellence in Medical Education - Respiration and Airways, Division of Respirology Award, 2007

Selected Publications (past 5 years):

  • Bosma K, Read BA, Nikoo MJB, Jones PM, Priestap FA, Lewis JF.  A pilot randominzed trail comparing weaning from mechanical ventilation on pressure support vs. proportional assist ventilation.  Submitted December 2014 to Critical Care Medicine.
  • Yamashita C, Fessler M, Vasanthamohan L, Lac J, Madenspacher J, McCaig L, Yao LJ, Wang L, Mehta S, Lewis J, Veldhuizen R. Apolipoprotein E definicient mice are susceptible to the development of acute lung injury. Respiration 2014;87(5):416-27.
  • Yamashita C, Lewis J. Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opinion on Emerging Drugs Mar, 2012;17 (1): 1-4
  • Yamashita C, Patterson E, Yao L, Lewis J, Cepinskas G, Ramic N, Veldhuizen R. Lung derived mediators induce cytokine production in downstream organs via an NF-KB dependent mechanism. Mediators of Inflammation 2013 Article ID 586895
  • Thornton J, Lewis J, Lebrun CM, Licskai CJ. Clinical characteristics of women with menstrual linked asthma. Respiratory Medicine 2012. 106;1236-1243
  • Qua Hiansen JM, Aspros A, Yao LJ, Amrein M, Bosma KJ, Lewis JF, Veldhuizen RAW. Cholesterol-mediated surfactant dysfunction (In Press 2014, Biochem Biophys Acta)
  • Taut FJ, Bothe G, Schenk P, Dean N, Krell K, Gunther A, Lewis J, Spragg R. Strategies for achieving the goals of a lung-protective ventilation protocol in large clinical trials. J Clinic Trials 1:101, 2012
  • Yamashita C, Lewis J. Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opinion on Emerging Drugs In Press 2012.
  • Czyzewski AM, McCaig LM, Dohm MT, Broering LA, Yao LJ, Brown NJ, Lewis JF, Veldhuizen R, and Barron AE. The in vivo efficacy of biomimetic, peptoid-enhanced surfactants in treating acute lung injury. In Press JAP 2011.
  • Spragg RG, Taut FJH, Lewis JF, Schenk P, Ruppert C, Dean N, Krell K, Karabinis A, Gunther A. Recombinant surfactant protein C based surfactant for patients with severe direct lung injury. Am J Resp Crit Care Med 183:1055-1061, 2011.
  • Rocca N, McCaig L, Yao LJ, Potter R, Walker M, Veldhuizen R, Lewis J. The biological effects of lung-derived mediators on the liver. Exp Lung Res 37:419-426, 2011.
  • Walker M, Yao L, Paterson E, Joseph M, Cepinskas G, Veldhuizen R, Lewis J, Yamashita C. The effect of tidal volume on systemic inflammation in acid-induced lung injury. Respiration 2011;81:333-342.
  • Truscott EA, McCaig LA, Yao LJ, Veldhuizen RAW, Lewis JF. Surfactant protein-A reduces translocation of mediators from the lung into the circulation. Experimental Lung Research 26:431-436, 2010.
  • Bosma K, Taneja R, Lewis J. Pharmacotherapy for prevention and treatment of acute respiratory distress syndrome. Current and experimental approaches. Drugs 70(10):1255-1282, 2010.
  • Aspros A, Cota C, Lewis JF, Veldhuizen RAW. Evaluating the combination of high frequency oscillatory ventilation and surfactant treatment in an acid aspiration model of lung injury. Can J Phys Pharm 88:14-20 2010.
  • Ford NL, Martin EL, Lewis JF, Veldhuizen RAW, Holdsworth DW, Drangova M. Quantifying lung morphology and function using retrospectively respiratory-gated micro-CT in a murine model of emphysema. Phys Med Biol. 54:2121-2130 Feb 2009.
  • Pace P, Veldhuizen R, Lewis J. Hyperoxia-exposure produces oxidation of pulmonary surfactant in a rat model of acute lung injury. Exp Lung Res 35(5):380-398, 2009.
  • Markovic N, McCaig L, Stephen J, Mizuguchi S, Veldhuizen R, Lewis J, Cepinskas G. Mediators released from LPS-challenged lungs induce inflammatory responses in liver vascular endothelial cells and neutrophilic leukocytes. American Journal of Physiology  - Gastrointestinal and Liver Physiology 297:G1066-G1076, 2009.
  • Walker M, Tessolini J, McCaig L, Yao LJ, Lewis JF, Veldhuizen RAW. Elevated endogenous surfactant reduces inflammation in an acute lung injury model. Exp Lung Res. 35(7):591-604, 2009.

Contact Information:

 

St. Joseph's Health Centre

Room B3-115

268 Grosvenor St. London, ON

Phone: (519) 646-6288

Administrative Assistant: Cathy Ede

 

Schulich School of Medicine & Dentistry

 

Clinical Skills Bldg Rm 2709

Administrative Assistant: Stacey Bastien

Phone: 519-661-2111x87908

 

 

 

 

 

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