Dr. Cory Yamashita, MD, FRCPC



Rank/ Affiliations:

  • Assistant Professor
  • Lawson Health Research Institute (LHRI), Scientist


  • Undergraduate, University of Manitoba
  • MD, University of Manitoba
  • Internal Medicine, University of Western Ontario
  • Respirology, University of Western Ontario
  • Research Fellowship, Acute Lung Injury, University of Western Ontario
  • Research Fellowship, Lung Injury & Repair, National Jewish Health, Denver, CO

Clinical Interest:

  • General Respirology
  • Asthma

Research Interest:

  • Antimicrobial Peptides/ Pulmonary Surfactant
  • Mechanisms of Acute Lung Injury and Multiple Organ Failure
  • The Role of MMP-3 in Acute Lung Injury
  • Ventilator Induced Lung Injury

Research Funding:

  • Cystic Fibrosis Canada
  • PSI Foundation
  • Ontario Thoracic Society
  • UWO Department of Medicine, Program of Experimental Medicine


  • Parker B. Francis Foundation Fellowship (2009-2012)
  • Honour Roll Certificate, University Students’ Council, The University of Western            Ontario Excellence in Teaching Undergraduate Medical Education, 2011-13
  • Honour Roll Certificate, University Students' Council, Undergraduate, Department of Physiology & Pharmacology, 2012

Selected Publications (past 5 years):

  • Banaschewski B, Veldhuizen E , Keating E, Haagsman HP, Zuo YY , Yamashita CM, Veldhuizen RAW. Surfactant supplemented with a host defense peptide for the treatment of bacterial pneumonia: antimicrobial and biophysical properties. (Submitted December 2014)
  • Qua Hiansen J, Keating E, Aspros A, Yao LJ, Bosma K, Yamashita CM, Lewis JF, and Veldhuizen RAW.  Cholesterol-mediated surfactant dysfunction is mitigated by surfactant protein A. (In press, December 2014, Biochemica et Biophysica Acta)
  • Aschner Y, Zemans RL, Yamshita CM, Downey GP.  Matrix Metalloproteinases and Protein Tyrosine Kinases: Potential Novel Targets in Acute Lung Injury.  Chest 2014 Oct;144(4):1081-91
  • Yamashita CM, Radisky DC, Yael Aschner Y and Downey GP.  The Importance of MMP3 in Respiratory Disorders.  Expert Review in Respiratory Medicine. 2014 Aug;8(4):411-21
  • Radhakrishnan, D, Yamashita, CM, Gillio-Meina, C, Fraser DD.  Translational Research in Pediatrics III: Flexible Bronchoscopy and Bronchoalveolar Lavage.  Pediatrics 2014 Jul;134(1):135-54
  • Yamashita CM, Fessler MB, Vasanthamohan L, Lac J, Madenspacher J, McCaig L, Yao LJ, Wang LF, Mehta S, Lewis JF and Veldhuizen RAW.  Apolipoprotein E Deficient Mice are Susceptible to the Development of Acute Lung Injury.  Respiration 2014;87(5):416-27
  • Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP.  Protein Tyrosine Phosphatase-α Mediates Pro-Fibrotic Signaling in Lung Fibroblasts through TGF-β Responsiveness.  Am J Pathol. 2014 May;184(5):1489-502
  • Gill SE, Veldhuizen RAW, Yamashita CM.  Alveolar Macrophages and Pulmonary Surfactant - More Than Just Friendly Neighbors.  OA Biology 2013; Dec01;1(1):6
  • Skeith L, Yamashita C, Mehta S, Farquhar D, Kim RB. Sildenafil and Furosemide Associated Ototoxicity: Considerations of Drug-drug Interactions, Synergy, and Broader Clinical Implications.  J Popul Ther Clin Pharmacol 2013;20(2):128-31
  • EK Patterson, LJ Yao, JF Lewis, G Cepinskas, L McCaig, RAW Veldhuizen and CM Yamashita. Lung Derived Mediators Induce Cytokine Production in Downstream Organs via an NF-κB Dependent Mechanism. Mediators Inflamm 2013;2013/586895
  • Yamashita CM, Lewis JF.  Emerging Therapies for Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome.  Expert Opin Emerg Drugs 2012;17(1):1-4
  • Schmidt EP, Lee WL, Zemans RL, Yamashita CM, Downey GP.  On, Around and Through: Neutrophil-Endothelial Interactions in Innate Immunity.  Physiology 2011;26(5):334-347
  • Yamashita CM, Dolgonos L, Young S, Robertson J, Briones N, Suzuki T, Gauldie J, Radisky D, Yu G, Kaminski N, Laschinger C, McCulloch C, Downey GP.  Matrix Metalloproteinase-3 is a Mediator of Pulmonary Fibrosis.  Am J Pathol 2011;179(4):1733-45
  • Walker MG, Yao L, Patterson E, Joseph M, Cepinskas G, Veldhuizen RA, Lewis J, Yamashita CM.  The Effect of Tidal Volume on Systemic Inflammation in Acid-Induced Lung Injury.  Respiration 2011;81(4):333-42
  • Yamashita CM, Veldhuizen RA.  Swept Under the Carpet?  The Role of Mucocilliary Clearance in Ventilator-Induced Lung Injury.  Intensive Care Med 2011;37(1):4-6
  • Yamashita CM, Langridge J, Hergott C, Malthaner R, Inculet R, Mahon J, Mehta S, Lefcoe M, McCormack D.  Predicting Postoperative FEV1 Using Spiral Computed Tomography to Measure Regional Perfused Blood Volume.  Acad Radiol 2010; 17(5):607-613
  • Suzuki T, Yamashita CM, Zemans R, Briones N, Van Linden A, Downey GP.  Leukocyte Elastase Induces Lung Epithelial Apoptosis via a PAR-1, NF-kB, and P53-dependent Pathway. Am J Respir Cell Mol Biol 2009 41(6):742-755

Contact Information:


St. Joseph's Health Centre

          Room B3-116, 268 Grosvenor St.

          Phone: (519) 646-6000, x65283

          Administrative Assistant: Cathy Ede




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