Dr. Cindy Hutnik

Dr. Cindy Hutnik

Dr. C.M.L. Hutnik BSc, MD, PhD, FRCS(C)

Ivey Eye Institute
St. Joseph's Hospital
268 Grosvenor Street
London, Ontario N6A 4V2
Phone: 519.646.6100 x.66272
Fax: 519.646.6410

Specialty: Glaucoma and Comprehensive Ophthalmology
Clinical Focus:
Adult Glaucoma and Cataracts
Western University

Depts of Ophthalmology and Pathology,
Schulich School of Medicine & Dentistry,
Western University

Diplomate of American Board of Ophthalmology

Adjunct Professor,
Dept of Chemistry & Biochemistry,
University of Windsor
Associate Scientist, Centre for Clinical Investigation and Therapeutics, Lawson Health Research Institute

Dr. Hutnik is a full professor in the Departments of Ophthalmology and Pathology at the Schulich School of Medicine & Dentistry. She served as Medical Director of the Ophthalmology Basic Science Laboratory at the Lawson Health Research Institute in the Center for Clinical Investigation and Therapeutics for 18 years and Chair of Research in the Department of Ophthalmology for 15 years. She earned her doctoral degree at the National Research Council followed by undergraduate medical training, both in Ottawa, Canada. She then obtained her ophthalmology training at the University of Western Ontario, in London, Canada followed by subspecialty glaucoma training under the mentorship of Dr. Paul Kaufman at the University of Wisconsin, Madison, USA. She currently is a member of a number of editorial and research review boards. She has served as medical education section editor for the Canadian Journal of Ophthalmology. She supervises an independent program of clinical, basic science, educational research and collaborates with local colleagues engaged in health economics research.

Her administrative roles have included Faculty Chair of the Summer Research Training Program at the University of Western Ontario as well as membership on the Faculty Clinician-Scientist committee, MD/PhD selection committee, medical advisory committee of the Canadian National Institute for the Blind Mobile Eye Care Program, councilor and secretary/treasurer of the Canadian Glaucoma Society and co-chair of the Canadian Glaucoma Clinical Research Council. She also served on the clinical expert panel for the creation of Ontario glaucoma quality standards and was both the provincial glaucoma representative on the Tariff Committee of the Eye Physician and Surgeons of Ontario (EPSO) and clinical advisor to the Canadian Agency for Drugs and Technologies in Health (CADTH). She has been elected as the Chair of the National Research Award Committee of the Canadian Ophthalmological Society. She has worked closely with the Faculty of Health Sciences to create a business plan and proposal for Interprofessional Health Education Undergraduate Curriculum in the Schulich School of Medicine & Dentistry at Western University. She is currently Chair of the Governing Committee of the Academic Medical Organization of Southwestern Ontario (AMOSO).

Her major research interest is focused on the pathophysiology and management of glaucoma with a sub-interest in ocular surface and macular disease. She has supervised and mentored in focused research activities more than 175 students at all levels of training ranging from high school to graduate science and medicine. Her work has been presented and published both nationally and internationally and has been recognized with over 90 awards. She continues to have keen interest in the development of novel and/or optimization of existing treatments for patients with glaucoma. Believing strongly in collaborative models of eye care she is proud of the global partnerships she has developed between the Schulich School of Medicine & Dentistry and key centers in China, Italy and the United States.


Medical Education and Mentorship

Lim, C. and Hutnik, C.M.L. Soft skill development in Ophthalmology and its importance to aspiring Canadian medical students. UOJM 2018;8(1);17-22.

Nasrallah G, Arora, S, Kulkarni, S, Hutnik CML. Perspective on a formal mentorship program in Ophthalmology residency. Can J Ophthal 2017;52(4):321-322.

Liu, E., Li, B., Hutnik, C.M.L. A Canadian ophthalmic microsurgery course: An innovative spin on wet-lab based surgical education. Can J Ophthal 2016;51:315-320.


Kansal, V., Armstrong, J.J., Hutnik, C.M.L. Trends in glaucoma filtration Procedures: A retrospective administrative health records analysis over a 13-year period in Canada. Clinical Ophthalmology 2020:14;501-508.

Uruthiramoorthy, L., Hutnik, C.M.L., Speechley, K.N., Malvankar-Mehta, M.S., Lizotte, D.J. Estimating Patient-Reported Outcomes for Glaucoma Management: Cross-sectional study. Journal of Evidence-Based Medicine 2020: DOI: 10.1111/jemb.12369;1-9.

Lim, C., Diaconita, V., Liu, E., Ault, N., Lizotte, D., Nguyen, M., Hutnik, C.M.L. Effect of a 6-week washout period on intraocular pressure following chronic prostaglandin analogue treatment: a randomized controlled trial. Can J Ophthal 2019:55(2);143-151.

Bao, B., Diaconita, V., Hutnik, C.M.L. Tono-pen versus Goldmann applanation tonometry: a comparison of 898 eyes. Ophthalmology Glaucoma 2019:2(6);435-439.

Malvankar-Mehta MS, Feng L, Hutnik CML. North American cost analysis of brand name versus generic drugs for the treatment of glaucoma. ClinicoEconomics and Outcomes Research 2019:11;789-798.

Poitras, V., Wells, C., Hutnik, C.M.L., Klarenback, S., So, H., Smith, A., Herington, E., Brender, N., Wells, C., Ford, C., Severn, M. Optimal use of minimally invasive glaucoma surgery: A health technology Assessment. Free Access Via Internet, Ottawa, ON. Canadian Agency for Drugs and Technologies in Health 2019 Jan.

Filek, R., Hooper, P., Sheidow, T., Gonder, J., Chakrabarti, S., Hutnik, C.M.L. Two-year analysis of changes in the optic nerve and retina following anti-VEGF treatments in diabetic macular edema patients. Clinical Ophthalmology 2019:13;1087-1096.

Kiatos, E., Armstrong, J.J., Tsioris, S.M., Hutnik, C.M.L., Malvankar-Mehta, M.S. Hodge, W.G. Of phaco and pain management: Our review and meta-analysis of intravenous sedation in modern cataract surgery. Ophthalmology Management 2019:23(1);46-54.

Basilious, A., Basilious, A., Mao, A., Hutnik, C.M.L. Trends in low vision care provided by ophthalmologists in Ontario between 2009 to 2015. Can J Ophthal 2019:54(2);229-236.

Armstrong, J.J., Welk, B.K., Reid, J.S., Kansal, V., Hutnik, C.M.L. Risk factors for secondary surgical intervention after primary glaucoma filtration surgery: An Ontario population-based study. Can J Ophthal 2019:54(2);212-222.

Hutnik, C.M.L., Crichton, A., Ford, B., Nicolela, M., Shuba, L., Birt, C., Sogbesan, E., Damji, K., Dorey, M., Saheb, H., Klar, N., Guo, H, Hodge, W. Selective laser trabeculoplasty versus argon laser trabeculoplasty in glaucoma patients treated previously with 360-degrees selective laser trabeculoplasty: A randomized, single-blind, equivalence clinical trial. Ophthalmology 2019:126(2):223-232.

Diaconita, V., Quinn, M., Jamal, D., Dishan, B., Malvankar-Mehta, M., Hutnik, C.M.L. Washout duration of prostaglandin analogues—A systematic review and meta-analysis. Journal of Ophthalmology 2018:3190684.

Fan, S.K.Y., Stojanovic, D., Malvankar-Mehta, M.S., Hutnik, C.M.L. Antiviral treatment of active herpes zoster ophthalmicus in immunocompetent adults: A systematic review and Canadian cost comparison. Canadian Journal of Ophthalmology 2018:53(2);117-123.

Armstrong, J.J and Hutnik, C.M.L. Comment on Selective Laser Trabeculoplasty, Editor’s Selection, International Glaucoma Review 2018:18-4;52.

Kansal, V., Armstrong, J., Pintwala, R., Hutnik, C.M.L. Optical coherence tomography for glaucoma diagnosis: An evidence based meta-analysis. PLOS ONE 2018:13(1):e0190621.

Hutnik, C.M.L. Efficacy and cost-comparison of Herpes Zoster Ophthalmicus treatment. Expert Comment. Eye Care 2018:www.practiceupdate.com/content/efficacy-and-cost-comparison-of-herpes-zoster-ophthalmicus-treatment/59429/65/5/1.

Michaelov, E., Armstrong, J.J., Nguyen, M., Instrum, B., Lam, T., Denstedt, J., Hutnik, C.M.L. Assessing the methodological quality of glaucoma clinical practice guidelines and their recommendations on microinvasive glaucoma surgery: a systematic review. Journal of Glaucoma 2017:doi: 10.1097/IJG.

Kiatos, E., Armstrong, J.J., Hutnik, C.M.L., Tsioros, S.M., Malvankar-Mehta, Hodge, W.G.. “The value of corneoscleral rim cultures in keratoplasty: A systematic review and cost-effectiveness analysis”. ClinicoEconomics and Outcomes Research 2017:9;459-474.

Armstrong, J.J., Wasiuta, T., Kiatsos, E., Malvankar, M., Hutnik, C.M.L. The effects of phacoemulsification on intra-ocular pressure and topical medication use in patients with glaucoma: a systematic review and meta-analysis of three-year data. J Glaucoma 2017:26(6);511-522.

Akhtar, A.O., Martin, J., Zaric, G.S., Si, F., Hutnik, C.M.L., Hodge, W.G. A comparison of clinical trial and model-based cost estimates in glaucoma—The case of repeat laser trabeculoplasty in Ontario. Journal of Hospital Administration 2017:6(3);46-57.

Filek, R., Hooper, P., Sheidow, T., Gonder, J., Varma, D., Heckler, L, Hodge, W., Chakrabarti, S., Hutnik, C.M.L. Structural and functional changes to the retina and optic nerve following panretinal photocoagulation over a 2 year time period. Eye 2017:Epub ahead of print, doi: 10.1038/eye.2017.66.

Chow, J.T.Y., Hutnik, C.M.L., Solo, K., Malvankar-Mehta, M.S. When is evidence enough evidence? A systematic review and meta-analysis of the trabectome as a solo procedure in patients with primary open angle glaucoma. J Ophthalmology 2017:2017:2965725. Doi: 10.1155/2017/2965725. Epub 2017 June 27. Review.

Patodia, Y.., Golesic, E., Mao, A., Hutnik, C.M.L. Clinical effectiveness of currently available low-vision devices in glaucoma patients with moderate to severe vision loss. Clinical Ophthalmology 2017;11:683-687.

Ahmed, S., Khan, Z., Si, F., Mao, A., Pan, I., Yazdi, F., Tsertsvadze, A., Hutnik, C.M.L., Moher, D., Tingey, D., Trope, G.E., Damji, K.F., Tarride, J.E., Goeree, R., Akhtar, T., Hodge, W. Correction: Summary of diagnostic testing accuracy: an evidence-based meta-analysis. J Clin Med Res. 2017;9(3):231.

Si, F. and Hutnik, C.M.L. Power is not Energy. J Glaucoma 2016:25(8):e762.

Li, B., Wang, G., Malvankar-Mehta, M.S., Hutnik, C.M.L. Surgical indications, outcomes, and complications with the use of a modified CTR during cataract surgery: A systematic review. Journal of Cataract and Refractive Surgery 2016;42(11):1642-1648.

Ahmed, S., Khan, Z., Si, F., Mao, A., Pan, I., Yazdi, F., Tsertsvadze, A., Hutnik, C.M.L., Moher, D., Tingey, D., Trope, G., Damji, K, Tarride, J-E., Goeree, R., Hodge, W. Summary of glaucoma diagnostic testing accuracy: An evidence based meta-analysis. J Clin Med Res 2017;9(3):231.

Iordanous, Y., Hutnik, C.M., Malvankar-Mehta, M.S. Response to “Advancing the economic assessment of microinvasive glaucoma surgery”. J Glaucoma 2016:25(7);e723-4.

Harasymowycz, P., Birt, C., Gooi, P., Heckler, L., Hutnik, C.M.L., Jinapriya, D., Shuba, L., Yan, D., Day, R. Medical management of glaucoma in the 21st century from a Canadian perspective. Journal of Ophthalmology 2016:dx.doi.org/10.1155/2016/ 6509809.

Translational: Basic Science

Trelford, C.B., Denstedt, J., Armstrong, J.J., Hutnik, C.M.L. The pro-fibrotic behavior of human Tenon’s capsule fibroblasts in medically treated glaucoma patients. Clinical Ophthalmology 2020;14;1391-1402.

Filek, R., Hooper, P., Sheidow, T., Liu, H., Chakrabarti, S., Hutnik, C.M.L. Safety of anti-VEGF treatments in a diabetic rat model and retinal cell culture. Clinical Ophthalmology 2019:13;1097-1114.

Tellios, N., Feng, M., Chen, N., Liu, H., Tellios, V., Wang, M., Li, X., Chang, C., Hutnik, C.M.L. Mechanical stretch upregulates Connexin43 in human trabecular meshwork cells. Clinical and Experimental Ophthalmology 2019:47(6):787-794. doi: 10.1111.ceo. 13492 [Epub ahead of print].

Armstrong, J.J., Denstedt, J.T., Trelford, C.B., Hutnik, C.M.L. Differential effects of dexamethasone and indomethacin on Tenon’s capsule fibroblasts: implications for glaucoma filtration surgery. Experimental Eye Research 2019;182:65-73.

Li., X., Xie, L., Pan, F., Wang, Y., Liu, H., Tang, Y., Hutnik, C.M.L. A feasibility study of using biodegradable magnesium alloy in glaucoma drainage devices. International Journal of Ophthalmology 2018;11(1):135-142.

Tellios, V., Liu, H., Tellios, N., Hutnik, C.M.L. Administration of nitric oxide through a novel copper-chitosan delivery system in human corneal and limbal epithelial cellular injury. IOVS 2018;59:967-977.

Tellios, N., Belrose, J.C.., Tokarewicz, A.C., Hutnik, C.M.L., Leask, A., Motolko, M. Iijima, M. Parapuram, S,K. TGF-Beta induces phosphorylation of phosphatase and tensin homolog: Implications for fibrosis of the trabecular meshwork tissue in glaucoma. Scientific Reports 2017:7(1):812. Doi:10.1038/s41598-017-00845-x.

Lin, T, Filek, R., Wang, J., Wu, C.H., Liu, H., Hutnik, C.M.L. Impression cytology implicates cell autophagy in aqueous deficiency dry eye. Clinical Ophthalmology 2017:11;773-779.

Ahmed, S., Khan, Z., Si, F., Mao, A., Pan, I., Yazdi, F., Tsertsvadze, A., Hutnik, C.M.L., Moher, D., Tingey, D., Trope, G., Damji, K, Tarride, J-E., Goeree, R., Hodge, W. Summary of glaucoma diagnostic testing accuracy: An evidence based meta-analysis. J Clin Med Res 2017;9(3):231.

Wang, W.W., Watson, K.A., Dixon, S.J., Liu, H., Rizkalla, A., Hutnik, C.M.L. Interaction of primary human trabecular meshwork cells with metal alloy candidates for micro-invasive glaucoma surgery. Clin Exp Ophthalmology 2016;DOI:10.1111/ceo.12911 and print 2017;45:520-528.

Tsui, E. and Hutnik, C.M.L. To bridge the gap, make a proper connexin. Journal of Pediatric Ophthalmology and Strabismus 2016;53(2):77-78.

Lee J, Kagan D, Roumeliotis G, Liu H, Hutnik CML. Secretion of MMP-3 by co-cultured pigmented and non-pigmented human trabecular meshwork cells following selective laser trabeculoplasty. Clinical and Experimental Ophthalmology 2016;44:33-42 doi: 10.1111/ceo.12591.