2021 Publications

    1. Lin LT, Razzaq A, Di Gregorio SE, Hong S, Charles B, Lopes MH, Beraldo F, Prado VF, Prado MAM, Duennwald ML. Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity. FASEB J. 2021 May;35(5):e21594. doi: 10.1096/fj.202002645R. PMID: 33908654

2020 Publications

    1. Petropavlovskiy AA, Tauro MG, Lajoie P, Duennwald ML. A Quantitative Imaging-Based Protocol for Yeast Growth and Survival on Agar Plates. STAR Protoc. 2020 Nov 25;1(3):100182. doi: 10.1016/j.xpro.2020.100182. eCollection 2020 Dec 18. PMID: 33377076

    2. Lackie RE, Razzaq AR, Farhan SMK, Qiu LR, Moshitzky G, Beraldo FH, Lopes MH, Maciejewski A, Gros R, Fan J, Choy WY, Greenberg DS, Martins VR, Duennwald ML, Lerch JP, Soreq H, Prado VF, Prado MAM. Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co-chaperone STI1. J Neurochem. 2020 Jun;153(6):727-758. doi: 10.1111/jnc.14882. Epub 2019 Oct 31. PMID: 31562773

    3. Chadwick SR, Fazio EN, Etedali-Zadeh P, Genereaux J, Duennwald ML, Lajoie P. A functional unfolded protein response is required for chronological aging in Saccharomyces cerevisiae. Curr Genet. 2020 Feb;66(1):263-277. doi: 10.1007/s00294-019-01019-0. Epub 2019 Jul 25. PMID: 31346745

    4. Di Gregorio SE, Volkening K, Strong MJ, Duennwald ML. Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network. Int J Mol Sci. 2020 Aug 5;21(16):5597. doi: 10.3390/ijms21165597.PMID: 32764283 

2019 Publications

    1. Jiang Y, Berg MD, Genereaux J, Ahmed K, Duennwald ML, Brandl CJ, Lajoie P. Sfp1 links TORC1 and cell growth regulation to the yeast SAGA-complex component Tra1 in response to polyQ proteotoxicity. Traffic. 2019 Apr;20(4):267-283. DOI: 10.1111/tra.12637. PMID: 30740854

    2. Spratt DE, Barber KR, Marlatt NM, Ngo V, Macklin JA, Xiao Y, Konermann L, Duennwald ML, Shaw GS. A subset of calcium-binding S100 proteins show preferential heterodimerization. FEBS J. 2019 Feb 4. DOI: 10.1111/febs.14775. [Epub ahead of print] PMID: 30719832

    3. Chung CZ, Jaramillo JE, Ellis MJ, Bour DYN, Seidl LE, Jo DHS, Turk MA, Mann MR, Bi Y, Haniford DB, Duennwald ML, Heinemann IU. RNA surveillance by uridylation-dependent RNA decay in Schizosaccharomyces pombe. Nucleic Acids Res. 2019 Apr 8;47(6):3045-3057. DOI: 10.1093/nar/gkz043. PMID: 30715470

2018 Publications

    1. Jiang Y, Di Gregorio S, Albakri MB, Duennwald ML, Lajoie P. Effect of Fluorescent Proteins on Fusion Partners Using Polyglutamine Toxicity Assays in Yeast. J Vis Exp. 2018 Nov 28;(141). DOI: 10.3791/58748. PMID: 30582582

    2. Duennwald ML, Di Gregorio S. ALS Yeast Models – past success stories and new opportunities. Front. Mol. Neurosci. DOI: 10.3389/fnmol.2018.00394

    3. Di Gregorio SE, Duennwald ML. Yeast as a model to study protein misfolding in aged cells. FEMS Yeast Res. 2018 Sep 1;18(6). DOI: 10.1093/femsyr/foy054. PMID: 29905793

    4. Zhao Y, Zurawel AA, Jenkins NP, Duennwald ML, Cheng C, Kettenbach AN, Supattapone S. Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species. Sci Rep. 2018 Jun 22;8(1):9554. DOI: 10.1038/s41598-018-27900-5. PMID: 29934597

2017 Publications

    1. Lant JT, Berg MD, Sze DHW, Hoffman KS, Akinpelu IC, Turk MA, Heinemann IU, Duennwald ML, Brandl CJ, O'Donoghue P. Visualizing tRNA-dependent mistranslation in human cells. RNA Biol. 2017 Sep 21:1-9. DOI: 10.1080/15476286.2017.1379645. [Epub ahead of print] PMID: 28933646

    2. Leach MD, Kim T, DiGregorio SE, Collins C, Zhang Z, Duennwald ML, Cowen LE. Candida albicans Is Resistant to Polyglutamine Aggregation and Toxicity. G3 (Bethesda), 2017 Jan 5; 7 (1): 95-108, DOI: 10.1534/g3.116.035675. PMID: 27807047

    3. Lackie RE, Maciejewski A, Ostapchenko VG, Marques-Lopes J, Choy WY, Duennwald ML, Prado VF, Prado MAM. The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases. Front Neurosci. 2017 May 16;11:254. DOI: 10.3389/fnins.2017.00254. eCollection 2017. Review. PMID: 28559789

    4. Jiang Y, Di Gregorio SE, Duennwald ML, Lajoie P. Polyglutamine toxicity in yeast uncovers phenotypic variations between different fluorescent protein fusions. Traffic. 2017 Jan;18(1):58-70. DOI: 10.1111/tra.12453. Epub 2016 Nov 1. PMID: 27734565

2016 Publications

    1. Hoffmann KS, Duennwald ML, Karagiannis J, Genereaux J, McCarton AS, Brandl CJ.  Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response. G3 (Bethesda). 2016 Jun 1;6(6):1649-59. DOI: 10.1534/g3.116.029520. PMID: 27172216

    2. Chadwick SR, Pananos AD, Di Gregorio SE, Park AE, Etedali-Zadeh P, Duennwald ML, Lajoie P. A Toolbox for Rapid Quantitative Assessment of Chronological Lifespan and Survival in Saccharomyces cerevisiae. Traffic. 2016 Jun;17(6):689-703. DOI: 10.1111/tra.12391. Epub 2016 Apr 1. PMID: 26939796

    3. Zurawel AA, Kabeche R, DiGregorio SE, Deng L, Menon KM, Opalko H, Duennwald ML, Moseley JB, Supattapone S. CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins. MBio. 2016 Sep 27;7(5). pii: e01367-16. doi: 10.1128/mBio.01367-16. PMID: 27677791

2013 Publications

    1. Duennwald ML. Yeast as a platform to explore polyglutamine toxicity and aggregation.  Methods Mol Biol. 2013;1017:153-61. doi: 10.1007/978-1-62703-438-8_11. Review.  PMID: 23719914

2012 Publications

    1. Riva L, Koeva M, Yildirim F, Pirhaji L, Dinesh D, Mazor T, Duennwald ML, Fraenkel E.  Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1. J Huntingtons Dis. 2012;1(1):33-45.  DOI: 10.3233/JHD-2012-120020  PMID: 23293686
    2. Duennwald ML, Echeverria A, Shorter J.  Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans. PLoS Biol. 2012;10(6):e1001346. doi: 10.1371/journal.pbio.1001346. Epub 2012 Jun 19. PMID: 22723742
    3. Chafekar SM, Wisén S, Thompson AD, Echeverria A, Walter GM, Evans CG, Makley LN, Gestwicki JE, Duennwald ML.  Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation. ACS Chem Biol. 2012 Sep 21;7(9):1556-64. Epub 2012 Jun 22. PMID: 22709427
    4. Chafekar SM, Duennwald ML. Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin. PLoS One. 2012;7(5):e37929. doi: 10.1371/journal.pone.0037929. Epub 2012 May 23. PMID: 22649566
    5. Duennwald ML.  Growth assays to assess polyglutamine toxicity in yeast. J Vis Exp. 2012 Mar 5;(61):e3461. doi: 10.3791/3461. PMID: 22415521

2011 Publications

    1. Duennwald ML. Polyglutamine misfolding in yeast: toxic and protective aggregation. Prion. 2011 Oct-Dec;5(4):285-90. doi: 10.4161/pri.18071. Epub 2011 Oct 1. Review. PMID:22052348
    2. Walter GM, Smith MC, Wisén S, Basrur V, Elenitoba-Johnson KS, Duennwald ML, Kumar A, Gestwicki JE. Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes. J Biol Chem. 2011 Nov 25;286(47):40486-93. doi: 10.1074/jbc.M111.284448. Epub 2011 Oct 3. PMID: 21969373 

2010 Publications

    1. Duennwald ML. Monitoring polyglutamine toxicity in yeast. Methods. 2011 Mar;53(3):232-7. doi: 10.1016/j.ymeth.2010.12.001. Epub 2010 Dec 6. PMID: 21144902
    2. Duennwald ML, Shorter J. Countering amyloid polymorphism and drug resistance with minimal drug cocktails.Prion. 2010 Oct-Dec;4(4):244-51. Epub 2010 Oct 12. PMID: 20935457

2009 Publications

    1. Roberts BE, Duennwald ML, Wang H, Chung C, Lopreiato NP, Sweeny EA, Knight MN, Shorter J. A synergistic small-molecule combination directly eradicates diverse prion strain structures. Nat Chem Biol. 2009 Dec;5(12):936-46. doi: 10.1038/nchembio.246. Epub 2009 Nov 1. PMID: 19915541

2008 Publications

    1. Duennwald ML, Lindquist S. Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes Dev. 2008 Dec 1;22(23):3308-19. doi: 10.1101/gad.1673408. Epub 2008 Nov 17. PMID: 19015277
    2. Wang H, Duennwald ML, Roberts BE, Rozeboom LM, Zhang YL, Steele AD, Krishnan R, Su LJ, Griffin D, Mukhopadhyay S, Hennessy EJ, Weigele P, Blanchard BJ, King J, Deniz AA, Buchwald SL, Ingram VM, Lindquist S, Shorter J. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64. doi: 10.1073/pnas.0801934105. Epub 2008 May 14. PMID: 18480256
    3. Douglas PM, Treusch S, Ren HY, Halfmann R, Duennwald ML, Lindquist S, Cyr DM.  Chaperone-dependent amyloid assembly protects cells from prion toxicity. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7206-11. doi: 10.1073/pnas.0802593105. Epub 2008 May 14. PMID: 18480252

2006 Publications

    1. Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE.  Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum Mol Genet. 2006 Sep 15;15(18):2743-51. Epub 2006 Aug 7. PMID: 16893904
    2. Duennwald ML, Jagadish S, Muchowski PJ, Lindquist S.  Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11045-50. Epub 2006 Jul 10.  PMID: 16832050
    3. Duennwald ML, Jagadish S, Giorgini F, Muchowski PJ, Lindquist S.  A network of protein interactions determines polyglutamine toxicity. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11051-6. Epub 2006 Jul 10.  PMID: 16832049

2005 Publications

    1. Cashikar AG, Duennwald M, Lindquist SL.  A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104. J Biol Chem. 2005 Jun 24;280(25):23869-75. Epub 2005 Apr 20. Erratum in: J Biol Chem. 2006 Mar 31;281(13):8996.  PMID:15845535

2004 Publications

    1. Colby DW, Chu Y, Cassady JP, Duennwald M, Zazulak H, Webster JM, Messer A, Lindquist S, Ingram VM, Wittrup KD.  Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17616-21. Epub 2004 Dec 14. Erratum in: Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):955.   PMID: 15598740 

2002 Publications

    1. Wittke S, Dünnwald M, Albertsen M, Johnsson N.  Recognition of a subset of signal sequences by Ssh1p, a Sec61p-related protein in the membrane of endoplasmic reticulum of yeast Saccharomyces cerevisiae.  Mol Biol Cell. 2002 Jul;13(7):2223-32. PMID: 12134063 

2000 Publications

    1. Wittke S, Dünnwald M, Johnsson N.  Sec62p, a component of the endoplasmic reticulum protein translocation machinery, contains multiple binding sites for the Sec-complex. Mol Biol Cell. 2000 Nov;11(11):3859-71. PMID: 11071912 

1999 Publications

    1. Dünnwald M, Varshavsky A, Johnsson N.  Detection of transient in vivo interactions between substrate and transporter during protein translocation into the endoplasmic reticulum.  Mol Biol Cell. 1999 Feb;10(2):329-44.  PMID: 9950680