Orthobiologics
Cervical facet joints often drive chronic neck pain that is disabling and costly. While corticosteroid injections and radiofrequency ablation can relieve pain, they carry risks such as tissue damage, systemic side effects, or procedural complexity. Our lab is exploring a regenerative, autologous approach using platelet-rich plasma (PRP) to harness growth factors and the joint’s own endogenous healing mechanisms.
In a randomized clinical trial comparing intra-articular PRP to corticosteroid injection, PRP produced similar reductions in pain and disability over six months. However, the PRP group reported higher pain self-efficacy at one month and less discomfort during injection. Adverse events were rare and equivalent, establishing PRP as a safe alternative.
Building on these findings, we explored the impact of leukocyte content in PRP injections by comparing leukocyte-rich and leukocyte-poor PRP. Both reduced pain and improved function at three months, but at six months, leukocyte-rich PRP delivered greater, longer-lasting improvements and no adverse events, suggesting that higher leukocyte concentration may enhance regeneration.
Together, these trials lay the groundwork for a biologically based, joint-preserving alternative to traditional interventions. By refining PRP preparation, we aim to offer a low-risk, non-pharmacological option that relieves cervical pain and supports long-term joint health.
