Dr. Tirona Rommel
Associate Professor, Department of Physiology & Pharmacology and Medicine
Office: C9-100D, University Hospital
Phone: 519.685.8500 ex 32102
Dr. Tirona is Associate Professor in the Departments of Physiology & Pharmacology and Medicine at the University of Western Ontario. He received both his Pharmacy degree and Ph.D. in Pharmaceutical Sciences at the University of Toronto. This was followed by a Clinical Pharmacology fellowship at Vanderbilt University Medical Center, Nashville, TN. Subsequently, Dr. Tirona was Research Scientist at Amgen Inc., Thousand Oaks, CA. After returning to Vanderbilt University as a faculty member in the Department of Pharmacology, Dr. Tirona moved to his current position at the University of Western Ontario. His research interests include drug transport and drug metabolism, regulation of gene expression and pharmacogenetics/pharmacokinetics as determinants of drug response and toxicity. Current research projects include the effects of non-alcoholic fatty liver disease on pharmacokinetics and the role of Organic Anion Transporting Polypeptides in drug disposition. Dr. Tirona’s research is supported by the Canadian Institutes of Health Research (CIHR).
Selected Recent Publications
Woolsey SJ, Beaton MD, Choi YH, Dresser GK, Gryn SE, Kim RB, Tirona RG (2015). Relationships between endogenous plasma biomarkers of constitutive CYP3A activity with single time-point oral midazolam microdose phenotype in healthy subjects. Basic Clin Pharmacol Toxicol. doi: 10.1111/bcpt.12492.
Woosley SJ, Mansell SE, Kim RB, Tirona RG, Beaton MD (2015). Cytochrome P450 3A Activity and Expression in Non-Alcoholic Fatty Liver Disease. Drug Metab Dispos 43:1484-90.
Huang SH, Tirona RG, Reid-Wilkinson F, Thomson BK, Filler G, Stodilka R, Lindsay RM (2014). The kinetics of cystatin C removal by hemodialysis. Am J Kidney Dis 65(1):174-5.
Knauer MJ, Girdwood AJ, Kim RB, Tirona RG (2013). Transport Function and Transcriptional Regulation of a Liver-Enriched Organic Anion Transporting Polypeptide 2B1 Transcriptional Start Site Variant. Mol Pharmacol 83(6):1218-28.