Schulich school of Medicine and Dentistry logo Department of Biochemistry Schulich School of Medicine & Dentistry

Recent Publications

 picture of Dr. Shawn Li

 Jan 2018   Feb 2018   Mar 2018   Apr 2018   May 2018   

May 2018

  1. Kotsopoulos J, Gronwald J, Lynch HT, Eisen A, Neuhausen SL, Tung N, Ainsworth P, Weitzel JN, Pal T, Foulkes WD, Eng C, Singer CF, Senter L, Sun P, Lubinski J, Narod SA; Hereditary Breast Cancer Clinical Study Group. Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat. 2018 May 17.
  2. Karttunen M, Choy WY, Cino EA. Prediction of Binding Energy of Keap1 Interaction Motifs in the Nrf2 Antioxidant Pathway and Design of Potential High Affinity Peptides. J Phys Chem B. 2018 May 10.
  3. Plouffe RA, Hammond R, Goldberg HA, Chahine S. What Matters from Admissions? Identifying Success and Risk Among Canadian Dental Students. J Dent Educ. 2018 May;82(5):515-523.
  4. Singal SS, Nygard K, Gratton R, Jansson T, Gupta MB. Increased Insulin-like Growth Factor Binding Protein-1 Phosphorylation in Decidualized Stromal Mesenchymal Cells in Human Intrauterine Growth Restriction Placentas. J Histochem Cytochem. 2018 May 1:22155418772574.
  5. Mancini GBJ, Hegele RA. Can We Eliminate Low-Density Lipoprotein Cholesterol-Related Cardiovascular Events Through More Aggressive Primary Prevention Therapy? Can J Cardiol. 2018 May;34(5):546-551.
  6. Feldman RD, Fitchett D, Hegele RA, Poulter NR. Type 2 Diabetes and the Reduction of Cardiovascular Risk: Sorting Out the Actors and the Roles. Can J Cardiol. 2018 May;34(5):532-535.
  7. Nerenberg KA, Zarnke KB, Leung AA, Dasgupta K, Butalia S, McBrien K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Padwal RS, Tran KC, Grover S, Rabkin SW, Moe GW, Howlett JG, Lindsay P, Hill MD, Sharma M, Field T, Wein TH, Shoamanesh A, Dresser GK, Hamet P, Herman RJ, Burgess E, Gryn SE, Grégoire JC, Lewanczuk R, Poirier L, Campbell TS, Feldman RD, Lavoie KL, Tsuyuki RT, Honos G, Prebtani APH, Kline G, Schiffrin EL, Don-Wauchope A, Tobe SW, Gilbert RE, Leiter LA, Jones C, Woo V, Hegele RA, Selby P, Pipe A, McFarlane PA, Oh P, Gupta M, Bacon SL, Kaczorowski J, Trudeau L, Campbell NRC, Hiremath S, Roerecke M, Arcand J, Ruzicka M, Prasad GVR, Vallée M, Edwards C, Sivapalan P, Penner SB, Fournier A, Benoit G, Feber J, Dionne J, Magee LA, Logan AG, Côté AM, Rey E, Firoz T, Kuyper LM, Gabor JY, Townsend RR, Rabi DM, Daskalopoulou SS; Hypertension Canada. Hypertension Canada's 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children. Can J Cardiol. 2018 May;34(5):506-525.
  8. Cvetkovska M, Szyszka-Mroz B, Possmayer M, Pittock P, Lajoie G, Smith DR, Hüner NPA. Characterization of photosynthetic ferredoxin from the Antarctic alga Chlamydomonas sp. UWO241 reveals novel features of cold adaptation. New Phytol. 2018 May 8.
  9. Balasuriya N, Kunkel MT, Liu X, Biggar KK, Li SS, Newton AC, O'Donoghue P. Genetic code expansion and live cell imaging reveal that Thr308 phosphorylation is irreplaceable and sufficient for Akt1 activity. J Biol Chem. 2018 May 17. pii: jbc.RA118.002357.
  10. Albatany M, Li A, Meakin S, Bartha R. In vivo detection of acute intracellular acidification in glioblastoma multiforme following a single dose of cariporide. Int J Clin Oncol. 2018 May 10.
  11. Grishin AM, Barber KR, Gu RX, Peter Tieleman D, Shaw GS, Cygler M. Regulation of Shigella Effector Kinase OspG through Modulation of its Dynamic Properties. J Mol Biol. 2018 May 16. pii: S0022-2836(18)30419-4.
  12. Morrison LM, Renaud JB, Sabourin L, Sumarah MW, Yeung KKC, Lapen DR. High-Throughput Quantitation of Neonicotinoids in Lyophilized Surface Water by LC-APCI-MS/MS. J AOAC Int. 2018 May 21.

Apr 2018

  1. Aref-Eshghi E, Schenkel LC, Ainsworth P, Lin H, Rodenhiser DI, Cutz JC, Sadikovic B. Genomic DNA Methylation-Derived Algorithm Enables Accurate Detection of Malignant Prostate Tissues. Front Oncol. 2018 Apr 23;8:100.
  2. Berg MD, Genereaux J, Karagiannis J, Brandl CJ. The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes. G3 (Bethesda). 2018 Apr 6. pii:g3.200288.2018.
  3. Dick FA, Goodrich DW, Sage J, Dyson NJ. Non-canonical functions of the RB protein in cancer. Nat Rev Cancer. 2018 Apr 24.
  4. Bogiatzi C, Gloor G, Allen-Vercoe E, Reid G, Wong RG, Urquhart BL, Dinculescu V, Ruetz KN, Velenosi TJ, Pignanelli M, Spence JD. Metabolic products of the intestinal microbiome and extremes of atherosclerosis. Atherosclerosis. 2018 Apr 17;273:91-97.
  5. Hegele RA, Berberich AJ, Ban MR, Wang J, Digenio A, Alexander VJ, D'Erasmo L, Arca M, Jones A, Bruckert E, Stroes ES, Bergeron J, Civeira F, Witztum JL, Gaudet D. Clinical and biochemical features of different molecular etiologies of familial chylomicronemia. J Clin Lipidol. 2018 Apr 4. pii: S1933-2874(18)30198-3.
  6. Parajuli RP, Goodrich JM, Chan LHM, Ayotte P, Lemire M, Hegele RA, Basu N. Genetic polymorphisms are associated with exposure biomarkers for metals and persistent organic pollutants among Inuit from the Inuvialuit Settlement Region, Canada. Sci Total Environ. 2018 Apr 7;634:569-578.
  7. Diabetes Canada Clinical Practice Guidelines Expert Committee, Mancini GBJ, Hegele RA, Leiter LA. Dyslipidemia. Can J Diabetes. 2018 Apr;42 Suppl 1:S178-S185.
  8. Dilliott AA, Farhan SMK, Ghani M, Sato C, Liang E, Zhang M, McIntyre AD, Cao H, Racacho L, Robinson JF, Strong MJ, Masellis M, Bulman DE, Rogaeva E, Lang A, Tartaglia C, Finger E, Zinman L, Turnbull J, Freedman M, Swartz R, Black SE, Hegele RA. Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease. J Vis Exp. 2018 Apr 4;(134).
  9. Mach F, Ray KK, Wiklund O, Corsini A, Catapano AL, Bruckert E, De Backer G, Hegele RA, Hovingh GK, Jacobson TA, Krauss RM, Laufs U, Leiter LA, März W, Nordestgaard BG, Raal FJ, Roden M, Santos RD, Stein EA, Stroes ES, Thompson PD, Tokgözoglu L, Vladutiu GD, Gencer B, Stock JK, Ginsberg HN, Chapman MJ; European Atherosclerosis Society Consensus Panel. Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract. Eur Heart J. 2018 Apr 27.
  10. Konermann L, Metwally H, McAllister RG, Popa V. How to Run Molecular Dynamics Simulations on Electrospray Droplets and Gas Phase Proteins: Basic Guidelines and Selected Applications. Methods. 2018 Apr 17. pii: S1046-2023(17)30464-4.
  11. Jha V, Ling H. Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender. J Mol Biol. 2018 Apr 28. pii: S0022-2836(18)30296-1.
  12. Abdallah MN, Abughanam G, Tran SD, Sheikh Z, Mezour MA, Basiri T, Xiao Y, Cerruti M, Siqueira WL, Tamimi F. Comparative adsorption profiles of basal lamina proteome and gingival cells onto dental and titanium surfaces. Acta Biomater. 2018 Apr 13. pii: S1742-7061(18)30220-4.

Mar 2018

  1. Boffa MB, Koschinsky ML. The journey towards understanding lipoprotein(a) and cardiovascular disease risk: are we there yet? Curr Opin Lipidol. 2018 Mar 9.
  2. Wang LR, McIntyre AD, Hegele RA. Complex genetic architecture in severe hypobetalipoproteinemia. Lipids Health Dis. 2018 Mar 14;17(1):48.
  3. McQuaid JB, Kustka AB, Oborník M, Horák A, McCrow JP, Karas BJ, Zheng H, Kindeberg T, Andersson AJ, Barbeau KA, Allen AE. Carbonate-sensitive phytotransferrin controls high-affinity iron uptake in diatoms. Nature. 2018 Mar 14.
  4. Aguirre JD, Dunkerley KM, Lam R, Rusal M, Shaw GS. Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin. J Biol Chem. 2018 Mar 12. pii: jbc.RA117.000605.
  5. Tikhonova S, Booij L, D'Souza V, Crosara KTB, Siqueira WL, Emami E. Investigating the association between stress, saliva and dental caries: a scoping review. BMC Oral Health. 2018 Mar 13;18(1):41.
  6. Jarrett P, Easton A, Rockwood K, Dyack S, McCollum A, Siu V, Mirsattari SM, Massot-Tarrús A, Beis MJ, D'Souza N, Darvesh S. Evidence for Cholinergic Dysfunction in Autosomal Dominant Kufs Disease. Can J Neurol Sci. 2018 Mar;45(2):150-157.
  7. Caughlin S, Maheshwari S, Agca Y, Agca C, Harris AJ, Jurcic K, Yeung KK, Cechetto DF, Whitehead SN. Membrane-lipid homeostasis in a prodromal rat model of Alzheimer's disease: Characteristic profiles in ganglioside distributions during aging detected using MALDI imaging mass spectrometry. Biochim Biophys Acta. 2018 Mar 12. pii: S0304-4165(18)30073-4.
  8. Wang JSH, Freitas-Andrade M, Bechberger JF, Naus C, Yeung KK, Whitehead SN. MALDI IMS of Intraperitoneally Injected Danegaptide (ZP1609) for Treatment of Stroke-Reperfusion Injury in Mice. Rapid Commun Mass Spectrom. 2018 Mar 25.

Feb 2018

  1. Schenkel LC, Aref-Eshghi E, Skinner C, Ainsworth P, Lin H, Paré G, Rodenhiser DI, Schwartz C, Sadikovic B. Peripheral blood epi-signature of Claes-Jensen syndrome enables sensitive and specific identification of patients and healthy carriers with pathogenic mutations in KDM5C. Clin Epigenetics. 2018 Feb 14;10:21.
  2. Boffa MB, Koschinsky ML. Therapeutic Lowering of Lipoprotein(a): A Role for Pharmacogenetics? Circ Genom Precis Med. 2018 Feb;11(2):e002052.
  3. Ishak CA, Cecchini MJ, Howlett CJ, Dick FA. Immunohistochemical Detection of the Retinoblastoma Protein. Methods Mol Biol. 2018;1726:65-75.
  4. Egozcue JJ, Pawlowsky-Glahn V, Gloor GB. Linear Association in Compositional Data Analysis. Austrian J Stats. 2018 Feb;47:3.
  5. Chassen SS, Ferchaud-Roucher V, Gupta MB, Jansson T, Powell TL. Alterations in Placental Long Chain Polyunsaturated Fatty Acid Metabolism in Human Intrauterine Growth Restriction. Clin Sci (Lond). 2018 Feb 20. pii: CS20171340.
  6. Linke AC, Wild C, Zubiaurre-Elorza L, Herzmann C, Duffy H, Han VK, Lee DSC, Cusack R. Disruption to functional networks in neonates with perinatal brain injury predicts motor skills at 8 months. Neuroimage Clin. 2018 Feb 3;18:399-406.
  7. Berberich AJ, Hegele RA. Secondary causes of chylomicronemia: defining the underside of the iceberg. J Intern Med. 2018 Feb 2.
  8. Berberich AJ, Ho R, Hegele RA. Whole genome sequencing in the clinic: empowerment or too much information? CMAJ. 2018 Feb 5;190(5):E124-E125.
  9. Yanagi M, Suzuki A, Hudson RHE, Saito Y. A fluorescent 3,7-bis-(naphthalen-1-ylethynylated)-2'-deoxyadenosine analogue reports thymidine in complementary DNA by a large emission Stokes shift. Org Biomol Chem. 2018 Feb 8.
  10. Burke AC, Telford DE, Sutherland BG, Edwards JY, Sawyez CG, Barrett PHR, Newton RS, Pickering JG, Huff MW. Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR(+/-) and LDLR(-/-) ) Yucatan Miniature Pigs. Arterioscler Thromb Vasc Biol. 2018 Feb 15. pii: ATVBAHA.117.310676.
  11. Leighton TL, Mok MC, Junop MS, Howell PL, Burrows LL. Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function. Sci Rep. 2018 Feb 8;8(1):2600.
  12. Metwally H, Konermann L. Crown Ethers Modulate the Location of Charge Carriers in Electrospray Droplets: Implications for the Mechanism of Protein Charging and Supercharging. Anal Chem. 2018 Feb 28.
  13. Yin H, Pickering JG. Aortic smooth muscle cells and myocardial infarction: Does the ascending aorta feel a heart attack? Atherosclerosis. 2018 Feb 10. pii: S0021-9150(18)30080-7.
  14. Zhao JZL, Mucaki EJ and Rogan PK. Predicting ionizing radiation exposure using biochemically-inspired genomic machine learning [version 1; referees: awaiting peer review]. F1000Research 2018, 7:233.
  15. Brady L, Sadikovic B, Rupar CA, Tarnopolsky MA. Complete elimination of a pathogenic homoplasmic mtDNA mutation in one generation. Mitochondrion. 2018 Feb 1. pii: S1567-7249(17)30328-8.
  16. Huang B, Siqueira W, Cvitkovitch DG, Finer Y. Esterase from a Cariogenic Bacterium Hydrolyzes Dental Resins. Acta Biomater. 2018 Feb 26. pii: S1742-7061(18)30091-6.
  17. Valente MT, Moffa EB, Crosara KTB, Xiao Y, de Oliveira TM, Machado MAAM, Siqueira WL. Acquired Enamel Pellicle Engineered Peptides: Effects on Hydroxyapatite Crystal Growth. Sci Rep. 2018 Feb 28;8(1):3766.
  18. Zarate YA, Smith-Hicks CL, Greene C, Abbott MA, Siu VM, Calhoun ARUL, Pandya A, Li C, Sellars EA, Kaylor J, Bosanko K, Kalsner L, Basinger A, Slavotinek AM, Perry H, Saenz M, Szybowska M, Wilson LC, Kumar A, Brain C, Balasubramanian M, Dubbs H, Ortiz-Gonzalez XR, Zackai E, Stein Q, Powell CM, Schrier Vergano S, Britt A, Sun A, Smith W, Bebin EM, Picker J, Kirby A, Pinz H, Bombei H, Mahida S, Cohen JS, Fatemi A, Vernon HJ, McClellan R, Fleming LR, Knyszek B, Steinraths M,  Velasco Gonzalez C, Beck AE, Golden-Grant KL, Egense A, Parikh A, Raimondi C, Angle B, Allen W, Schott S, Algrabli A, Robin NH, Ray JW, Everman DB, Gambello MJ, Chung WK. Natural history and genotype-phenotype correlations in 72 individuals with SATB2-associated syndrome. Am J Med Genet A. 2018 Feb 13.
  19. Wang JS, Whitehead SN, Yeung KK. Detection of Amyloid Beta (Aβ) Oligomeric Composition Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS). J Am Soc Mass Spectrom. 2018 Feb 20.

Jan 2018

  1. Aref-Eshghi E, Rodenhiser DI, Schenkel LC, Lin H, Skinner C, Ainsworth P, Paré G, Hood RL, Bulman DE, Kernohan KD; Care4Rare Canada Consortium, Boycott KM, Campeau PM, Schwartz C, Sadikovic B. Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes. Am J Hum Genet. 2018 Jan 4;102(1):156-174.
  2. Mohamed HT, El-Husseiny N, El-Ghonaimy EA, Ibrahim SA, Bazzi ZA, Cavallo-Medved D, Boffa MB, El-Shinawi M, Mohamed MM. IL-10 correlates with the expression of carboxypeptidase B2 and lymphovascular invasion in inflammatory breast cancer: The potential role of tumor infiltrated macrophages. Curr Probl Cancer. 2018 Jan 10. pii: S0147-0272(17)30120-4.
  3. Slattery SS, Diamond A, Wang H, Therrien JA, Lant JT, Jazey T, Lee K, Klassen Z, Desgagné-Penix I, Karas BJ, Edgell DR. An expanded plasmid-based genetic toolbox enables Cas9 genome editing and stable maintenance of synthetic pathways in Phaeodactylum tricornutum. ACS Synth Biol. 2018 Jan 3.
  4. Kaiser JC, King AN, Grigg JC, Sheldon JR, Edgell DR, Murphy MEP, Brinsmade SR, Heinrichs DE. Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide. PLoS Genet. 2018 Jan 22;14(1):e1007159.
  5. Zubiaurre-Elorza L, Linke AC, Herzmann C, Wild CJ, Duffy H, Lee DSC, Han VK, Cusack R. Auditory structural connectivity in preterm and healthy term infants during the first postnatal year. Dev Psychobiol. 2018 Jan 22.
  6. Aboalola D, Han VKM. Different Effects of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-2 on Myogenic Differentiation of Human Mesenchymal Stem Cells. Stem Cells Int. 2017;2017:8286248.
  7. Iacocca MA, Hegele RA. Role of DNA copy number variation in dyslipidemias. Curr Opin Lipidol. 2018 Jan 4.
  8. Clemens KK, Shariff SZ, McArthur E, Hegele RA. Ezetimibe prescriptions in older Canadian adults after an acute myocardial infarction: a population-based cohort study. Lipids Health Dis. 2018 Jan 8;17(1):8.
  9. Dron JS, Hegele RA. Polygenic influences on dyslipidemias. Curr Opin Lipidol. 2018 Jan 2.
  10. Hegele RA. Learning From Patients With Ultrarare Conditions: Cholesterol Hoof Beats. J Am Coll Cardiol. 2018 Jan 23;71(3):289-291.
  11. Paquette M, Hegele RA, Paré G, Baass A. A novel mutation in GPIHBP1 causes familial chylomicronemia syndrome. J Clin Lipidol. 2018 Jan 31. pii: S1933-2874(18)30031-X.
  12. Snir JA, Suchy M, Bindseil GA, Kovacs M, Chronik BA, Hudson RHE, Pasternak SH, Bartha R. An Aspartyl Cathepsin Targeted PET Agent: Application in an Alzheimer's Disease Mouse Model. J Alzheimers Dis. 2018;61(3):1241-1252.
  13. Morrow NM, Huff MW. Knockdown of Δ-5 Fatty Acid Desaturase Is More Than Just a Fad. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):6-8.
  14. Burke AC, Huff MW. Regression of atherosclerosis: lessons learned from genetically modified mouse models. Curr Opin Lipidol. 2018 Jan 24.
  15. Tsimikas S, Fazio S, Ferdinand KC, Ginsberg HN, Koschinsky ML, Marcovina SM, Moriarty PM, Rader DJ, Remaley AT, Reyes-Soffer G, Santos RD, Thanassoulis G, Witztum JL, Danthi S, Olive M, Liu L. NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis. J Am Coll Cardiol. 2018 Jan 16;71(2):177-192.
  16. Cooper TT, Sherman SE, Kuljanin M, Bell GI, Lajoie GA, Hess DA. Inhibition Of Aldehyde Dehydrogenase-Activity Expands Multipotent Myeloid Progenitor Cells With Vascular Regenerative Function. Stem Cells. 2018 Jan 27.
  17. Lecocq S, Spinella K, Dubois B, Lista S, Hampel H, Penner G. Aptamers as biomarkers for neurological disorders. Proof of concept in transgenic mice. PLoS One. 2018 Jan 5;13(1):e0190212.
  18. O'Connor K, Jukes T, Goobie S, DiRaimo J, Moran G, Potter BK, Chakraborty P, Rupar CA, Gannavarapu S, Prasad C. Psychosocial impact on mothers receiving expanded newborn screening results. Eur J Hum Genet. 2018 Jan 29.
  19. Datar R, Prasad AN, Tay KY, Rupar CA, Ohorodnyk P, Miller M, Prasad C. Magnetic resonance imaging in the diagnosis of white matter signal abnormalities. Neuroradiol J. 2018 Jan 1:1971400918764016.
  20. Crosara KTB, Zuanazzi D, Moffa EB, Xiao Y, Machado MAAM, Siqueira WL. Revealing the Amylase Interactome in Whole Saliva Using Proteomic Approaches. Biomed Res Int. 2018 Jan 31;2018:6346954.
  21. Kolendowski B, Hassan H, Krstic M, Isovic M, Thillainadesan G, Chambers AF, Tuck AB, Torchia J. Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization. Epigenetics Chromatin. 2018 Jan 29;11(1):5. 
  22. Hauser-Kawaguchi A, Luyt LG, Turley E. Design of peptide mimetics to block pro-inflammatory functions of HA fragments. Matrix Biol. 2018 Jan 30. pii: S0945-053X(17)30444-4.