Recent Publications

picture of Dr. Shawn Li

2025

Jan 2025   Feb 2025   Mar 2025   Apr 2025   May 2025   June 2025

July 2025   Aug 2025   Sept 2025   Oct 2025   Nov 2025   Dec 2025

2026

Jan 2026

 

Archives

 

Jan 2026

  1. Pena-Ortiz MA, Sunstrum JK, Ghahramani A, McConkey H, Dumeaux V, Inoue W, Bérubé NG. Astrocytic Chromatin Remodeler ATRX Gates Hippocampal Memory Consolidation Through Metabolic and Synaptic Regulation. Glia. 2026 Jan;74(1):e70098. 

Dec 2025

  1. Boffa MB, Koschinsky ML, Hegele RA. Evolving guidelines on lipoprotein(a). Curr Opin Lipidol. 2025 Dec 1;36(6):300-309. 

Nov 2025

  1. Koschinsky ML, Kalra DK, Boffa MB. Lipoprotein(a): An Underappreciated Inherited Risk Factor for Atherosclerosis, Aortic Stenosis, and Abdominal Aortic Aneurysm. Annu Rev Med. 2025 Nov 13.
  2. Garg AX, McArthur E, Sontrop JM, Boudville N, Connaughton DM, Cuerden MS, Feldman LS, Lam NN, Lentine KL, Nguan C, Parikh CR, Segev DL, Sener A, Smith G, Wang C, Weir MA, Yohanna S, Young A, Naylor KL. Risk for Scrotal Surgery After Laparoscopic Donor Nephrectomy : A Population-Based Cohort Study. Ann Intern Med. 2025 Nov 11.
  3. Meawad M, Singh D, Deng A, Sonthalia R, Cai E, Dumeaux V. Functional archetypes in the human gut microbiome reveal metabolic diversity, stability, and influence disease-associated signatures. Microbiome. 2025 Nov 26;13(1):241.
  4. Loedige KW, White AL, McMurrough TA, Stead BE, Edgell DR. A buffer-tuning strategy to profile domain-specific activity of chimeric I-TevI/CRISPR gene editors in vitro. Sci Rep. 2025 Nov 28;15(1):42742.
  5. Charron CA, Kaldis A, Shamriz S, Renaud JB, Diarra MS, Garnham CP, Menassa R. Plant-produced encapsulin displays non-typhoidal Salmonella enterica antigens and assembles into mosaic nanoparticles. FEBS J. 2025 Nov 20.
  6. VanderBurgt JT, Strasser R, Zhu H, Kaldis A, Garnham CP, Menassa R. Protein nanoparticles assemble in plants, display antigenic viral peptides, and produce an epitope-specific immune response. FEBS J. 2025 Nov 17.
  7. John Mancini GB, Ryomoto A, Ruel I, Iatan I, Raal FJ, Santos RD, Marte AP, Hegele RA, Kennedy BA, Brunham LR, Gaudet D, Larouche M, Brisson D, Schonck W, Reeskamp LF, Genest J; Canadian Homozygous Familial Hypercholesterolemia Registry and the Homozygous Familial Hypercholesterolemia International Clinical Collaboration. Imputation of untreated LDL-C in treated subjects with homozygous familial hypercholesterolaemia: An international collaboration. Atherosclerosis. 2025 Nov 19;412:120590.
  8. Sun Y, Chen L, Jing Z, Li YY, Kim D, Gao JY, Noroozi R, Yi GY, Tetsassi Feugmo CG, Klinkova A, Sask K, Kristiadi A, Wang B, Gillies ER, Lu KP, Shi HH, Hu P. Generative AI for the Design of Molecules: Advances and Challenges. J Chem Inf Model. 2025 Nov 18.

Oct 2025

  1. Taylor SA, Bader GD, MacParland S, Mullen AC, Andrews T, Cuenca AG, DasGupta R, Gehring AJ, Grün D, Guilliams M, Gulamhusein A, Henderson NC, Hirschfield G, Huppert SS, Itzkovitz S, Jiang ZG, Lauer GM, McGilvray I, Mysore KR, Pirola CJ, Quon G, Rahbari M, Regev A, Ricciuto A, Scott CL, Sharma A, Sookoian S, Tana MM, Teichmann SA, Vallier L, Vlachos IS, Wang B, Zhen M. Towards a reference cell atlas of liver diversity over the human lifespan. Nat Rev Gastroenterol Hepatol. 2025 Oct 13.
  2. Taylor SA, Bader GD, MacParland S, Mullen AC, Andrews T, Cuenca AG, DasGupta R, Gehring AJ, Grün D, Guilliams M, Gulamhusein A, Henderson NC, Hirschfield G, Huppert SS, Itzkovitz S, Jiang ZG, Lauer GM, McGilvray I, Mysore KR, Pirola CJ, Quon G, Rahbari M, Regev A, Ricciuto A, Scott CL, Sharma A, Sookoian S, Tana MM, Teichmann SA, Vallier L, Vlachos IS, Wang B, Zhen M. Author Correction: Towards a reference cell atlas of liver diversity over the human lifespan. Nat Rev Gastroenterol Hepatol. 2025 Oct 23. Erratum for: Nat Rev Gastroenterol Hepatol. 2025 Oct 13.
  3. Onuska KM, Devito LA, Shanks HR, Qi Q, Crooks AM, Haast RA, Andrews TS, Williams KM, Beraldo FH, Qiu T, Fajardo-Valdez A, Wearn A, Turner GR, Aumont E, Thiessen JD, Fox MS, Hicks JW, Bussey TJ, Saksida LM, Tremblay-Mercier J, Breitner JC, Soucy JP, Poirier J, Bedard MA, Villeneuve S, Prado VF, Prado MA, Spreng RN, Schmitz TW; PREVENT-AD Research Group. Cholinergic synaptic plasticity shapes resilience and vulnerability to tau. bioRxiv [Preprint]. 2025 Oct 15:2025.05.27.656174.
  4. Ryoo SW, Lin WZ, Magliocco A, Ruthirakuhan M, Wong YY, Perfetto SE, Huang C, Anita NZ, Arnott SR, Lang AE, Symons S, Hegele RA, Goubran M, Ramirez J, Ottoy J, Rabin JS, MacIntosh BJ, Lanctôt KL, Liang N, Cogo-Moreira H, Taha AY, Swardfager W; ONDRI Investigators. Metabolic and vascular contributions to dementia: Soluble epoxide hydrolase-derived linoleic acid oxylipins and glycemic status are related to cerebral small vessel disease markers, atrophy, and cognitive performance. Alzheimers Dement. 2025 Oct;21(10):e70718.
  5. MacKay-Barr EH, Konermann L. Heat-Induced Protein Oxidation as an Impediment for Thermal Stability Measurements: A Case Study on Cytochrome c. Anal Chem. 2025 Oct 6.
  6. Watt K, Dauber B, Szkop KJ, Lee L, Jovanovic P, Chen S, Palia R, Vassalakis JA, Cooper TT, Papadopoli D, Masvidal L, Jewer M, Tandoc K, Plummer H, Lajoie GA, Topisirovic I, Larsson O, Postovit LM. Epigenetic alterations facilitate transcriptional and translational programs in hypoxia. Nat Cell Biol. 2025 Oct 16.
  7. Graff RE, Chen DM, Swinnerton KN, Ackley SF, Ospina-Romero M, Zimmerman SC, Wang J, Buto P, Nierenberg JL, Elahi FM, Lu KP, Witte JS, Glymour MM. Evaluation of Polygenic Risk Scores for a Possible Genetic Basis of the Inverse Association Between Cancer and Cognitive Decline. Alzheimer Dis Assoc Disord. 2025 Oct 23.
  8. Szkudlarek HJ, Singh Mann R, Wieczerzak K, Sarikahya MH, Uzuneser TC, De Felice M, Rodríguez-Ruiz M, Galindo JP, Pusparajah M, Whitehead SN, Rushlow WJ, Hardy DB, Schmid S, Yeung KK, Laviolette SR. The antioxidant N-acetylcysteine prevents cortical neuropathological phenotypes caused by adolescent Δ-9-tetrahydrocannabinol exposure in male rats. Transl Psychiatry. 2025 Oct 6;15(1):374.

Sept 2025

  1. Mucaki EJ, Zhang W, Saha A, Trebinjac S, Nofech-Mozes S, Rakovitch E, Dumeaux V, Hallett MT. Generative and integrative modeling for transcriptomics with formalin fixed paraffin embedded material. J Transl Med. 2025 Sep 30;23(1):1023.
  2. Foo GW, Uruthirapathy AS, Zhang CQ, Batko IZ, Heinrichs DE, Edgell DR. Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut. ACS Synth Biol. 2025 Sep 7.
  3. Andersson ER, Bayless AL, Brua RB, Casu F, Cheng LL, Choo M, Edison AS, Eghbalnia HR, Fleischer CC, Gouveia GJ, Hoch JC, Kaur G, Li DW, Pathmasiri W, Pelczer I, Probert F, Raftery D, Rovnyak D, Secreto M, Schock TB, Takis PG, Uchimiya M, Wishart DS, Yılmaz A, Sumner LW, Powers R, Copié V, Gebregiworgis T. Securing the Future of NMR Metabolomics Reproducibility: A Call for Standardized Reporting. Anal Chem. 2025 Sep 15.
  4. Jang C, Iosef C, Renaud SJ, Han VKM. Amino Acid Restriction Impairs Human Endometrial Stromal Cell Decidualization and Is Rescued by Proline Supplementation. J Cell Mol Med. 2025 Sep;29(18):e70821.
  5. Hegele RA, Feldman RD. In Memoriam: J. David Spence (1944-2025). Can J Cardiol. 2025 Sep 3:S0828-282X(25)01049-9.
  6. Canadian Cardiovascular Society, European Association for the Study of Diabetes, and the Latin American Academy for the Study of Lipids and Cardiometabolic Risk; Patel SB, Belalcazar LM, Afreen S, Balderas R, Hegele RA, Karpe F, Ponte-Negretti CI, Rajpal A. American Association of Clinical Endocrinology Consensus Statement: Algorithm for Management of Adults with Dyslipidemia - 2025 Update. Endocr Pract. 2025 Sep 14:S1530-891X(25)00972-3.
  7. Khan MW, Cruz de Jesus V, Mittermuller BA, Schroth RJ, Hu P, Chelikani P. Integrative analysis of taste genetics and the dental plaque microbiome in early childhood caries. Cell Rep. 2025 Sep 9;44(9):116245.
  8. Sun Y, Lu Y, Li YY, Jing Z, Leung CK, Hu P. MolGraph-xLSTM as a graph-based dual-level xLSTM framework for enhanced molecular representation and interpretability. Commun Chem. 2025 Sep 29;8(1):286.
  9. Kernohan KD, Gallagher L, Pigeon M, Yeh E, Lacaria M, Axford MM, MacCormick J, Papaioannou V, Quercia N, Rupar C, Zimmerman K, Weber S, Cushing SL, Chakraborty P. Newborn screening for common genetic variants associated with permanent hearing loss: Implementation in Ontario and a review of the first 3 years. Genet Med. 2025 Sep 7;27(10):101497. doi: 10.1016/j.gim.2025.101497. Epub ahead of print. Erratum for: Genet Med. 2025 Apr;27(4):101364.
  10. Cousineau SL, Sarikahya MH, Jurcic K, Laviolette SR, Hardy DB, Yeung KK. Monitoring the degree of in-source phospholipid fragmentation during MALDI mass spectrometry imaging. Anal Chim Acta. 2025 Sep 15;1367:344297.

Aug 2025

  1. Del Zompo F, Crouchet E, Ostyn T, Nehme Z, Messé M, Juehling F, Désert R, Vieira AT, Moehlin J, Nakib D, Andrews T, Perciani C, Chung S, Bader G, McGilvray I, Caime C, Scaravaglio M, Carbone M, Invernizzi P, Yaqub S, Folseraas T, Karlsen TH, Shankar G, Primeaux M, Dhawan P, Banales JM, Roehlen N, Iacone R, Teixeira G, Heikenwälder M, Mailly L, MacParland S, Roskams T, Govaere O, Schuster C, Baumert TF. Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis. J Hepatol. 2025 Aug 20:S0168-8278(25)02440-7.
  2. Assini JM, Boffa MB, Koschinsky ML. The complex pro-atherosclerotic role of lipoprotein(a): a multiplicity of cellular targets. Curr Opin Lipidol. 2025 Aug 4.
  3. Koschinsky ML, Boffa MB. Lp(a) as a Risk Factor for Peripheral Artery Disease: Context Is Everything. Arterioscler Thromb Vasc Biol. 2025 Aug 7.
  4. Novikov V, Timothy LTC, Fan J, Sadek K, Cowan MF, Onuska KM, Duennwald M, Prado VF, Prado MAM. A Longitudinal Study of Sex Differences in a TDP-43 Mouse Model Reveals STI1 Regulation of TDP-43 Proteinopathy and Motor Deficits. J Neurochem. 2025 Aug;169(8):e70204.
  5. Gloor GB, Nixon MP, Silverman JD. Explicit Scale Simulation for analysis of RNA-sequencing count data with ALDEx2. NAR Genom Bioinform. 2025 Aug 19;7(3):lqaf108.
  6. Trussler RS, Scherba NQ, Kooshapour H, Ellis MJ, Förstner KU, Albert M, Westermann AJ, Haniford DB. A Small RNA Derived From the 5' End of the IS200 tnpA Transcript Regulates Multiple Virulence Regulons in Salmonella typhimurium. Mol Microbiol. 2025 Aug 13.
  7. Brown AS, Moulin P, Dibble A, Alexander VJ, Li L, Gaudet D, Witztum JL, Tsimikas S, Hegele RA. Brief communication: Strong concordance of the North American Familial Chylomicronemia Syndrome Score with a positive genetic diagnosis in patients from the Balance study. J Clin Lipidol. 2025 Jul 23:S1933-2874(25)00349-6.
  8. Fung DL, Khan MW, Leung CK, Hu P. Enhanced Interpretable Neural Network Approach for Unified Batch Effect Mitigation and Disease Classification Using Cross-Cohort Microbiome Profiles. J Comput Biol. 2025 Aug 8.
  9. Lu Y, Li YY, Sun Y, Hu P. FusionCLM: enhanced molecular property prediction via knowledge fusion of chemical language models. J Cheminform. 2025 Aug 29;17(1):133.
  10. Moroney M, Casey JH, Teoh H, Krishnaraj A, Pan Y, Quan A, Patel SK, Dennis F, He AZ, Park B, Verma R, Misner E, Seguchi R, Hassan SMA, Dennis CJ, Meglis G, Pandey A, Butler J, Mazer CD, Byrne RA, Koschinsky ML, Hess DA, Verma S. Vascular regenerative deficiencies in people with elevated lipoprotein(a): the Lp(a)-VRCE CardioLink-16 translational study. Cardiovasc Res. 2025 Aug 30:cvaf142.
  11. Sleapnicov N, Ha SD, Zhong SJ, Duchscher J, Ezra S, Li SS, Kim SO. Inhibition of the Transcription Factor PU.1 Suppresses Tumor Growth in Mice by Promoting the Recruitment of Cytotoxic Lymphocytes Through the CXCL9-CXCR3 Axis. Cancers (Basel). 2025 Aug 18;17(16):2684.
  12. Koszela J, Rintala-Dempsey A, Salzano G, Pimenta V, Kamarainen O, Gabrielsen M, Parui AL, Shaw GS, Walden H. A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1. J Cell Biol. 2025 Aug 4;224(8):e202408025.
  13. Connelly EM, Shaw GS. Complex Conformational Interplay for Parkin Activation is Revealed by 19F NMR Spectroscopy. J Mol Biol. 2025 Aug 19:169397.
  14. Basilone NT, Pimenta VM, Shaw GS. Canonical and alternate mechanisms that regulate ubiquitylation by the E3 ligase parkin. Biochem Soc Trans. 2025 Aug 18:BST20253050.
  15. Loebsack G, Yeung KK, Berruti F, Klinghoffer NB. Adsorption of Organic Pollutants From Wastewater Using Biochar: A Mechanistic Study on Competitive Adsorption Behavior. Water Environ Res. 2025 Aug;97(8):e70164.

July 2025

  1. Connaughton DM, Mallett AJ. Models of Care for the Implementation of Genetic Testing in Nephrology. Semin Nephrol. 2025 Jul 15:151649.
  2. Du A, Lemay K, Bagga A, Bhola PT, Brown PA, Colaiacovo S, Charames GS, Lemaire M, Lanktree MB, Schenkel L, Peña LG, Riddell S, Watkins N, Young T, Yu W, Bell K, Kim RH, Connaughton DM; Ontario Health Provincial Genetics Program Renal Genetics Expert Group. Framework for standardized genetic testing recommendations for chronic kidney disease in Ontario. Genet Med Open. 2025 Jul 5;3:103442.
  3. Rizvi N, Mucaki EJ, Salmini EL, Zhang M, Trebinjac S, Hahn E, Paszat L, Nofech-Mozes S, Hallett MT, Rakovitch E, Dumeaux V. Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy. Breast Cancer Res. 2025 Jul 8;27(1):127.
  4. Mone K, Singh S, Abdullatif F, Sur M, Rasquinha MT, Seravalli J, Zinniel DK, Mukhopadhyay I, Barletta RG, Gebregiworgis T, Reddy J. Immunization with Complete Freund's Adjuvant Reveals Trained Immunity-like Features in A/J Mice. Vaccines (Basel). 2025 Jul 21;13(7):768.
  5. Lavie CJ, Hegele RA, Poirier P, Thompson JA. Obesity in Cardiovascular Disease Prevention and Treatment - A Topic Getting "Heavier" as We Speak. Can J Cardiol. 2025 Jul 15:S0828-282X(25)00545-8.
  6. Bashir B, Forrester N, Downie P, Marsh S, Dent C, Wierzbicki AS, Dawson C, Schofield J, Jenkinson F, Mansfield M, Datta D, Delaney H, Teoh Y, Hamilton P, Cegla J, Ferdousi M, Kamath A, Gupta P, Luvai A, O'Sullivan D, Mamood D, Wang J, Durrington PN, Hegele RA, Soran H. Rare variant genetic landscape of familial chylomicronemia syndrome (FCS) in the United Kingdom. Genet Med Open. 2025 Jul 14;3:103445.
  7. O'Donoghue P, Heinemann IU. The IUBMB Focused Meeting on Aminoacyl-tRNA Synthetases 2023. IUBMB Life. 2025 Jul;77(7):e70041.
  8. Konermann L. A Simple Method for Determining Charge Distributions, Potentials, and Electric Fields Associated with an Electrospray Capillary. J Am Soc Mass Spectrom. 2025 Jul 31.
  9. Myette RL, Holterman CE, Trentin-Sonoda M, Cooper TT, Lajoie GA, Cairns G, Burelle Y, El Khatib N, Raman-Nair J, Burger D, Kennedy CRJ. Extracellular Vesicle Mitochondrial DNA Reflects Podocyte Mitochondrial Stress and Is Associated with Relapse in Nephrotic Syndrome. Int J Mol Sci. 2025 Jul 26;26(15):7245.
  10. Chafe SC, Zhai K, Aghaei N, Miletic P, Huang Z, Brown KR, Mobilio D, Young D, Suk Y, Grewal S, McKenna D, Alizada Z, Kieliszek AM, Lam FC, Escudero L, Huang Q, Huebner A, Lu J, Ang P, Anand A, Custers S, Apel E, Slassi S, Brakel B, Kim J, Liu JKC, Bassey-Archibong BI, Abdo R, Shargall Y, Lu JQ, Cutz JC, Zhang Q, Li SS, Venugopal C, Hynds RE, Dufour A, Moffat J, Swanton C, Bao S, Singh SK. A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis. Sci Transl Med. 2025 Jul 2;17(805):eadu2459.
  11. Beharry A, Ward C, Moore H, Hoffman KS, Chan PP, Lowe TM, O'Donoghue P. High-fidelity and differential nonsense suppression in live cells and a frontotemporal dementia allele with human transfer RNAs. Nucleic Acids Res. 2025 Jul 19;53(14):gkaf730.
  12. Almudhry M, Prasad C, Tay KY, Rupar CA, Atkins H, Prasad AN. Outcome of two siblings with late-onset Krabbe disease following allogeneic hematopoietic stem cell transplantation: And review of literature. Mol Genet Metab Rep. 2025 Jul 18;44:101242.
  13. Sarikahya MH, Cousineau SL, De Felice M, Szkudlarek HJ, Lee K, Doktor A, Alcaide A, DeVuono MV, Dembla A, Wong K, Balarajah M, Vanin S, Youssef M, Zhaksylyk K, Machado M, Mahmood H, Schmid S, Yeung KK, Hardy DB, Rushlow W, Laviolette SR. Perinatal omega-3 sex-selectively mitigates neuropsychiatric impacts of prenatal THC in the cortico-striatal-hippocampal circuit. Mol Psychiatry. 2025 Jul 28.

June 2025

  1. Cuillerier A, Goodman A, Lawrence C, Villeneuve-Cloutier N, Armour CM, Bhola PT, Bourque DK, Carter MT, Lazier J, Sawyer SL, Saleh M, Prasad C, Siu VM; Care4Rare Canada Consortium; Boycott KM, Hartley T, Dyment DA, Balci TB. Diagnostic Utility of Exome Data Reanalysis After In Silico Multi-Gene Panels or Clinical Exome Testing for Patients With Epilepsy and Developmental Delay/Intellectual Disability: A Retrospective Cohort Study. Clin Genet. 2025 Jun 22.
  2. Sumra V, Hadian M, Dilliott AA, Farhan SMK, Frank AR, Lang AE, Roberts AC, Troyer A, Arnott SR, Marras C, Tang-Wai DF, Finger E, Rogaeva E, Orange JB, Ramirez J, Zinman L, Binns M, Borrie M, Freedman M, Ozzoude M, Bartha R, Swartz RH, Munoz D, Masellis M, Black SE, Dixon RA, Dowlatshahi D, Grimes D, Hassan A, Hegele RA, Kumar S, Pasternak S, Pollock B, Rajji T, Sahlas D, Saposnik G, Tartaglia MC; ONDRI Investigators. Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration. J Neurol. 2025 Jun 25;272(7):478.
  3. Hang S, Wang J, Taboun Z, McIntyre AD, Hegele RA. Heterozygous pathogenic PPARG variants in patients with severe hypertriglyceridemia. J Clin Lipidol. 2025 Jun 3:S1933-2874(25)00308-3.
  4. Silveira CRA, Coleman KKL, Borron K, Tirona RG, Rupar CA, Zou G, Hegele RA, Wellington C, Stukas S, Finger EC, Bartha R, Morrow SA, Wells JL, Borrie MJ, Mahuran D, MacDonald PA, Jenkins ME, Jog MS, Dresser G, Fox S, Camicioli R, Feagan B, Mendonça DA, Mayich M, Sharma MD, Pandey SK, Pasternak SH. Ambroxol as a Treatment for Parkinson Disease Dementia: A Randomized Clinical Trial. JAMA Neurol. 2025 Jun 30:e251687.
  5. Bashir B, Pasha R, Kamath A, Wang J, Malik RA, Hegele RA, Ferdousi M, Soran H. Neurodegeneration in familial chylomicronemia syndrome. J Clin Lipidol. 2025 Jun 2:S1933-2874(25)00312-5.
  6. Alexandre D, Polido J, Miranda A, Hudson RHE, Monchaud D, Baptista PV, Cruz C. Cellular modulation of a G-quadruplex structure found in the lung cancer-related microRNA-3196. Int J Biol Macromol. 2025 Jun 15:145263.
  7. Iatan I, Koschinsky ML, Trenaman L, Zhang W, Thanassoulis G, Brunham LR, Mancini GBJ, Francis GA. Rationale for the Routine Screening of Lipoprotein (a) in Cardiovascular Risk Assessment. Eur J Prev Cardiol. 2025 Jun 13:zwaf342.
  8. Roffey SE, Hovey O, Jurcic K, Lu KP, Zhou XZ, Litchfield DW. Covalent Inhibition of the Peptidyl-Prolyl Isomerase Pin1 by Sulfopin Results in a Broad Impact on the Phosphoproteome of Human Osteosarcoma U2-OS Cells. Proteomics. 2025 Jun 23:e13980.
  9. Li A, Stein R, Rupar CA, Prasad C. Long Term Follow up of Short-Chain-L-3-Hydroxyacyl-CoA Dehydrogenase (SCHAD) Deficiency Causing Hypoglycemia and Developmental Delays in Two Syrian Brothers. Indian J Pediatr. 2025 Jun 16.

May 2025

  1. Rosenson RS, Tate AM, Grushko OG, Damodaran D, Chen Q, Boffa M, Koschinsky M, Narula J, Goonewardena SN. Lipoprotein (a) integrates monocyte-mediated thrombosis and inflammation in atherosclerotic cardiovascular disease. J Lipid Res. 2025 May 5:100820.
  2. Alshaikh R, Moresco A, Abujabal MM, Connaughton D, Filler G. Autosomal recessive (type 1B) pseudohypoaldosteronism: a novel mutation and its management. BMJ Case Rep. 2025 May 21;18(5):e265335.
  3. Kolendowski B, Cheng S, Valdes YR, Shepherd TG, DiMattia GE. Transcriptomic Analyses of Ovarian Clear Cell Carcinoma Spheroids Reveal Distinct Proliferative Phenotypes and Therapeutic Vulnerabilities. Cells. 2025 May 27;14(11):785.
  4. McDonald DW, Dib RN, De Luca C, Shah A, Duennwald ML. Specific branches of the proteostasis network regulate the toxicity associated with mistranslation. Nucleic Acids Res. 2025 May 10;53(9):gkaf428.
  5. Ying S, Zeng PYF, Fung K, Khan H, Cecchini MJ, Woo E, Anderson J, MacInnis P, Karimi AH, Al Jawhri M, Pan H, Le N, Joris K, Wen R, Mymryk JS, Inculet R, Dumeaux V, Barrett JW, Nichols AC, Lin RJ; Canadian Airways Research Group of the Canadian Society of Otolaryngology Collaborative Research Initiative. Transcriptomic Features of Recurrence Rates in Idiopathic Subglottic Stenosis. Laryngoscope. 2025 May 6.
  6. Zhu Y, Li A, Maji S, Lee BJ, Korn SM, Gertie JA, Dorrity TJ, Wang J, Wang KJ, Pelletier A, Moakley DF, Kelly RD, Holmes AB, Rabadan R, Edgell DR, Poulter CS, Modesti M, Steckelberg AL, Hendrickson EA, Chung H, Zhang C, Zha S. Ku limits RNA-induced innate immunity to allow Alu-expansion in primates. Nature. 2025 May 15.
  7. Nixon MP, Gloor GB, Silverman JD. Incorporating scale uncertainty in microbiome and gene expression analysis as an extension of normalization. Genome Biol. 2025 May 22;26(1):139.
  8. Burnett JR, Hooper AJ, Hegele RA. CETP-Related Hyperalphalipoproteinemia. 2025 May 8. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025.
  9. Wiegman A, Peterson AL, Hegele RA, Bruckert E, Schweizer A, Lesogor A, Wang Y, Defesche J. Efficacy and Safety of Inclisiran in Adolescents With Genetically Confirmed Homozygous Familial Hypercholesterolemia: Results From the Double-Blind, Placebo-Controlled Part of the ORION-13 Randomized Trial. Circulation. 2025 May 20.
  10. Montero-Odasso M, Pieruccini-Faria F, Black SE, Binns MA, Freedman M, Grimes DA, Hegele RA, Haddad SH, Lang AE, Masellis M, Mandzia J, Beaton D, Ramirez J, Roberts AC, McIlroy W, Pasternak SH, Zinman L, Abrahao A, Swartz RH, Symons S, Tan B, Tartaglia C, Son S, Sakurai R, Dilliott A, Cornish BF, Hezam A, Strong MJ; ONDRI Investigators; Bartha R. Association between vascular risk factors burden and neurodegenerative diseases: results from ONDRI. J Neurol. 2025 May 25;272(6):418.
  11. Mueller PA, Rosario S, Hay J, Bergstrom P, Pacheco-Velázquez SC, Hegele RA, Pamir N, Purnell JQ. Characterization of familial chylomicronemia syndrome in a compound heterozygote for 2 APOA5 nonsense variants. J Clin Lipidol. 2025 May 7:S1933-2874(25)00272-7.
  12. Shi Y, Xu W, Hu P. Out of distribution learning in bioinformatics: advancements and challenges. Brief Bioinform. 2025 May 1;26(3):bbaf294.
  13. Chu SSH, Xing G, Ling H. The role of human Shu complex in ATP-dependent regulation of RAD51 filaments during homologous recombination-associated DNA damage response. J Biol Chem. 2025 May 7:110212.
  14. Mei X, Stewart RC, Zhou XZ, Lu KP, Gillies ER. Covalent cross-linking approaches for all-trans retinoic acid-loaded thermo-responsive hydrogels. Soft Matter. 2025 May 23.
  15. Xie G, Okuda S, Gao JY, Wu T, Jeong J, Lu KP, Zhou XZ. The Central Role of Pin1 in Age-Related Cancer Signaling Pathways. Semin Cancer Biol. 2025 May 22:S1044-579X(25)00072-0.
  16. Zambom CR, Bernardes G, Fonseca FHD, Zolin GVS, Melo Faceto Portella M, Marin LM, Crusca E, Krol ES, Siqueira WL, Garrido SS. Reducing Functional Domain of Histatin 5 Improves Antifungal Activity and Prevents Proteolytic Degradation. Microorganisms. 2025 May 8;13(5):1091.

Apr 2025

  1. Friedman C, Ari T, Ünsal G, Balci T, Morrison M, Ari N. Overlap Diagnostic Odyssey and Full Mouth Rehabilitation of a Juvenile Patient With IFIH1-Related Disorder: A Case of Aicardi-Goutières and Singleton Merten Syndromes Overlap. Spec Care Dentist. 2025 Mar-Apr;45(2):e70026. 
  2. Balci TB, Schenkel LC, Rastin C, Jones K, Boissé Lomax L, Turowec J, Kerkhof J, Bhai P, Jarinova O, Hewson S, Prasad AN, Snead OC 3rd, Dyment DA, Sadikovic B. Clinical Implementation and Outcomes of Genetic Testing for Epilepsy by the Ontario Epilepsy Genetic Testing Program. Can J Neurol Sci. 2025 Apr 14:1-34. 
  3. Lambert GC, Boffa MB. Why has the "Lp(a) receptor" proven so elusive? Atherosclerosis. 2025 Apr 8;404:119189. 
  4. Merz LM, Kolvenbach CM, Wang C, Mertens ND, Seltzsam S, Mansour B, Zheng B, Schneider S, Schierbaum L, Hölzel S, Salmanullah D, Pantel D, Kalkar G, Connaughton DM, Mann N, Wilfred Wu CH, Kause F, Nakayama M, Dai R, Schneider R, Buerger F, Nicolas-Frank C, Yousef K, Lemberg K, Saida K, Yu S, Elmubarak I, Franken GAC, Lomjansook K, Braun A, Bauer SB, Rodig NM, G Somers MJ, Traum AZ, Stein DR, Daga A, Baum MA, Daouk GH, Awad HS, Eid LA, El Desoky S, Shalaby MA, Kari JA, Ooda S, Fathy HM, Soliman NA, Nabhan M, Abdelrahman S, Hilger AC, Mane SM, Ferguson MA, Tasic V, Shril S, Hildebrandt F. Trio exome sequencing in individuals with CAKUT identifies de novo variants in potential novel candidate genes in 19.62. Genet Med. 2025 Apr 10:101432.
  5. Ying S, Zeng PYF, Fung K, Khan H, Cecchini MJ, MacInnis P, Anderson J, Karimi AH, Al Jawhri M, Pan H, Le N, Joris K, Mymryk JS, Dumeaux V, Barrett JW, Nichols AC, Lin RJ; Canadian Airways Research Group of the Canadian Society of Otolaryngology Collaborative Research Initiative. Effect of Serial Intralesional Steroid Injections on Risk of Recurrence in Idiopathic Subglottic Stenosis. Laryngoscope. 2025 Apr 16.
  6. Kim HN, Gasmi-Seabrook GMC, Uchida A, Gebregiworgis T, Marshall CB, Ikura M. Switch II pocket inhibitor allosterically freezes KRASG12Dnucleotide-binding site and arrests the GTPase cycle. J Mol Biol. 2025 Apr 21:169162.
  7. Hartjes ED, Lim YJ, Velenosi TJ, Al KF, Macklaim JM, Kucey AS, Reid G, Burton JP, Gloor GB, Urquhart BL. The impact of progressive chronic kidney disease on hepatic drug metabolism. Drug Metab Dispos. 2025 Apr 28;53(6):100085.
  8. Sanchez E, Coughlan GT, Wilkinson T, Ramirez J, Mirza SS, Baril AA, Dilliott AA, Frank A, Lang AE, Hassan A, Pollock BG, Scott CJM, Marras C, Fischer CE, Seitz D, Andriuta D, Dowlatshahi D, Grimes DA, Tang-Wai DF, Sahlas DJ, Rogaeva EA, Finger E, Robinson JF, Tan K, Binns MA, Tartaglia MC, Borrie MJ, Strong MJ, Ozzoude M, Nanayakkara ND, Goncalves RA, Bartha R, Hegele RA, Farhan SMK, Black SE, Kumar S, Symons SP, Haddad SMH, Pasternak SH, Arnott SR, Rajji TK, Steeves T, Swardfager W, Ashton NJ, Kvartsberg H, Zetterberg H, Munoz DP, Masellis M; ONDRI Investigators. Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases. Neurology. 2025 Apr 8;104(7):e213438.
  9. Watts GF, Hegele RA, Leeper NJ. Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk. Reply. N Engl J Med. 2025 Apr 10;392(14):1452-1453. 
  10. Hegele RA. What is the phenotype of heterozygous lipoprotein lipase deficiency? Curr Opin Lipidol. 2025 Apr 1;36(2):96-103. 
  11. Hegele RA. Translating genetics into clinical practice plus nonmainstream thoughts on lipoprotein(a). Curr Opin Lipidol. 2025 Apr 1;36(2):39-40. 
  12. Sarkies MN, Watts GF, Gidding SS, Santos RD, Hegele RA, Raal FJ, Sturm AC, Al-Rasadi K, Blom DJ, Daccord M, de Ferranti SD, Folco E, Libby P, Mata P, Nawawi HM, Ramaswami U, Ray KK, Yamashita S, Pang J, Thompson GR, Jones LK. Implementation strategies for improving the care of familial hypercholesterolaemia from the International Atherosclerosis Society: next steps in implementation science and practice. Am J Prev Cardiol. 2025 Apr 14;22:100993.
  13. Mahmood M, Little E, Girard N, Wu F, Samuels T, Heinemann IU, Reynolds NM. Yeast models for Charcot-Marie-Tooth disease-causing aminoacyl-tRNA synthetase alleles reveal the cellular basis of disease. IUBMB Life. 2025 Apr;77(4):e70017. 
  14. Jaafar T, Carvalhais E, Shrestha A, Cochrane RR, Meaney JS, Brumwell S, Hamadache S, Nasrollahi V, Karas B. Engineering Conjugative Plasmids for Inducible Horizontal DNA Transfer. Can J Microbiol. 2025 Apr 1.
  15. Dolatkhah Ouch Bolagh M, Konermann L. Modeling a Continuously Operating Electrospray Ionization Emitter Using Molecular Dynamics Simulations: From Bulk Solution to Gaseous Ions. J Phys Chem B. 2025 Apr 10.
  16. Meehan C, Lecocq S, Penner G. Correction: A reproducible approach for the use of aptamer libraries for the identification of Aptamarkers for brain amyloid deposition based on plasma analysis. PLoS One. 2025 Apr 30;20(4):e0320967. Erratum for: PLoS One. 2024 Aug 27;19(8):e0307678.
  17. Staples SCR, Yin H, Sutherland FSK, Prescott EK, Tinney D, Hamilton DW, Goldman D, Poepping TL, Ellis CG, Pickering JG. Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination. Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2423700122. 
  18. Dias LM, Paul P, Pavarina AC, Siqueira WL. Salivary proteins-enhanced antimicrobial photodynamic therapy: Overcoming three distinct cultures of resistant mixed biofilms. J Dent. 2025 Apr 21;157:105778. 

Mar 2025

  1. Pita-Juarez Y, Karagkouni D, Kalavros N, Melms JC, Niezen S, Delorey TM, Essene AL, Brook OR, Pant D, Skelton-Badlani D, Naderi P, Huang P, Pan L, Hether T, Andrews TS, Ziegler CGK, Reeves J, Myloserdnyy A, Chen R, Nam A, Phelan S, Liang Y, Gregory M, He S, Patrick M, Rane T, Wardhani A, Amin AD, Biermann J, Hibshoosh H, Veregge M, Kramer Z, Jacobs C, Yalcin Y, Phillips D, Slyper M, Subramanian A, Ashenberg O, Bloom-Ackermann Z, Tran VM, Gomez J, Sturm A, Zhang S, Fleming SJ, Warren S, Beechem J, Hung D, Babadi M, Padera RF Jr, MacParland SA, Bader GD, Imad N, Solomon IH, Miller E, Riedel S, Porter CBM, Villani AC, Tsai LT, Hide W, Szabo G, Hecht J, Rozenblatt-Rosen O, Shalek AK, Izar B, Regev A, Popov YV, Jiang ZG, Vlachos IS. A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients. Genome Biol. 2025 Mar 14;26(1):56.
  2. Habbous S, Montesi B, Masse C, Weernink C, Sarma S, Begen MA, Lam NN, Dipchand C, Yohanna S, Connaughton DM, Barnieh L, Garg AX. The Flow of Living Kidney Donor Candidates Through the Evaluation Process: A Single-Center Experience in Ontario, Canada. Can J Kidney Health Dis. 2025 Mar 31;12:20543581251323964.
  3. Schott C, Alajmi M, Bukhari M, Relouw S, Wang J, McIntyre AD, Baker C, Colaiacovo S, Campagnolo C, Almada Offerni G, Blake PG, Chiu M, Cowan A, Garg AX, Gunaratnam L, House AA, Huang SS, Iyer H, Jain AK, Jevnikar AM, Johnson J, Lotfy K, Moist L, Rehman F, Roshanov PS, Sultan N, Weir MA, Basharat P, Florendo-Cumbermack A, Khan T, Thain J, Kidd K, Kmoch S, Bleyer AJ, Bhangu J, Hegele RA, Connaughton DM. Genetic Testing in Adults over 50 Years with Chronic Kidney Disease: Diagnostic Yield and Clinical Implications in a Specialized Kidney Genetics Clinic. Genes (Basel). 2025 Mar 31;16(4):408. 
  4. Hoogstra SJ, Renaud JB, McMullin DR, Kelman MJ, Garnham CP, Sumarah MW. Biotransformation of Deoxynivalenol to the Novel Metabolite Deoxynivalenol-8,15-hemiketal-7-glucoside by the Bacillus subtilis Glycosyltransferase YjiC. ACS Omega. 2025 Mar 24;10(14):14496-14507. 
  5. Javed F, Hegele RA, Garg A, Patni N, Gaudet D, Williams L, Khan M, Li Q, Ahmad Z. Familial chylomicronemia syndrome: An expert clinical review from the National Lipid Association. J Clin Lipidol. 2025 Mar 22:S1933-2874(25)00066-2. 
  6. Syed-Abdul MM, Tian L, Hegele RA, Lewis GF. Futility of plasmapheresis, insulin in normoglycaemic individuals, or heparin in the treatment of hypertriglyceridaemia-induced acute pancreatitis. Lancet Diabetes Endocrinol. 2025 Mar 24:S2213-8587(25)00028-2.
  7. Ballantyne CM, Gaudet D, Rosenson RS, Hegele RA, Zhou R, Melquist S, Hellawell J, Leeper NJ. Effect of Targeting apoC-III with Plozasiran on Lipoprotein Particle Size and Number in Hypertriglyceridemia. J Am Coll Cardiol. 2025 Mar 12:S0735-1097(25)05892-9.
  8. Hadipour H, Li YY, Sun Y, Deng C, Lac L, Davis R, Cardona ST, Hu P. GraphBAN: An inductive graph-based approach for enhanced prediction of compound-protein interactions. Nat Commun. 2025 Mar 18;16(1):2541.
  9. Zhang C, Sun Y, Hu P. An interpretable deep geometric learning model to predict the effects of mutations on protein-protein interactions using large-scale protein language model. J Cheminform. 2025 Mar 21;17(1):35.
  10. Li Y, Deng L, Walker EJL, Karas BJ, Mock T. Genetic engineering in diatoms: advances and prospects. Plant J. 2025 Mar;121(6):e70102.
  11. Veliz L, Lambin C, Cooper TT, McCarvell WM, Lajoie GA, Postovit LM, Lagugné-Labarthet F. Emerging SERS and TERS MoS2 platforms for the characterization of plasma-derived extracellular vesicles. Nanoscale. 2025 Mar 31.
  12. Tennakoon R, Bily TMI, Hasan F, Hoffman KS, O'Donoghue P. Natural human tRNAAla anticodon variants mistranslate the genetic code. RNA. 2025 Mar 21:rna.080450.125.
  13. Islam F, Shilton B. Insights into the cellular function and mechanism of action of quinone reductase 2 (NQO2). Biochem J. 2025 Mar 11;482(6):BCJ20240103.  

Feb 2025

  1. Pouyabahar D, Andrews T, Bader GD. Interpretable single-cell factor decomposition using sciRED. Nat Commun. 2025 Feb 22;16(1):1878. 
  2. Borrelli MJ, Kolendowski B, DiMattia GE, Shepherd TG. Spatiotemporal analysis of ratiometric biosensors in live multicellular spheroids using SPoRTS. Cell Rep Methods. 2025 Feb 8:100987.
  3. Zhu Y, Li A, Maji S, Lee BJ, Korn SM, Gertie JA, Dorrity TJ, Wang J, Wang KJ, Pelletier A, Moakley DF, Kelly RD, Holmes AB, Rabadan R, Edgell DR, Schild Poulter C, Modesti M, Steckelberg AL, Hendrickson EA, Chung H, Zhang C, Zha S. Ku suppresses RNA-mediated innate immune responses in human cells to accommodate primate-specific Alu expansion. bioRxiv [Preprint]. 2025 Feb 1:2025.01.31.633084. 
  4. Mone K, Garcia EJT, Abdullatif F, Rasquinha MT, Sur M, Hanafy M, Zinniel DK, Singh S, Thomas R, Barletta RG, Gebregiworgis T, Reddy J. Metabolic Reprogramming in Response to Freund’s Adjuvants: Insights from Serum Metabolomics. Microorganisms. 2025; 13(3):492.
  5. Brown RJ, Akinci B, Yosef M, Phillips H, Khalatbari S, Sorkina E, Santini F, Vigouroux C, Brush M, Meral R, Ceccarini G, Zeybel M, Prodam F, von Schnurbein J, Sorice GP, Guler MC, Patni N, Tanrikulu S, Alyaarubi S, Ozgen BS, Foss-Freitas MC, Ozisik S, Segrestin B, Ozcan B, Adiyaman SC, Musolino G, Sekizkardes H, Musso C, Lebenthal Y, Ozen S, Simha V, Simsir IY, Stears A, Scherer T, Gambineri A, Lima JG, Semple R, Wabitsch M, Araujo-Vilar D, Hegele RA, Oral EA. Lipodystrophy Severity Score to Assess Disease Burden in Lipodystrophy. J Clin Endocrinol Metab. 2025 Feb 19:dgaf103.
  6. Paquette M, Trinder M, Ruel I, Guay SP, Hegele RA, Genest J, Brunham LR, Baass A. Polygenic risk score for coronary artery disease predicts atherosclerotic cardiovascular disease in familial hypercholesterolemia. J Clin Lipidol. 2025 Jan 31:S1933-2874(25)00004-2. 
  7. Mancini GBJ, Ryomoto A, Yeoh E, Iatan I, Brunham LR, Hegele RA. Reappraisal of statin primary prevention trials: implications for identification of the statin-eligible primary prevention patient. Eur J Prev Cardiol. 2025 Feb 25:zwaf048. 
  8. Walker JT, Cooper TT, Dunmore-Buyze J, Serack FE, Brooks C, Grant A, Drangova M, Lajoie G, Dekaban GA, Flynn LE. Syngeneic adipose-derived stromal cells modulate the immune response but have limited persistence within decellularized adipose tissue implants in C57BL/6 mice. Acta Biomater. 2025 Feb 6:S1742-7061(25)00100-X.
  9. Meehan C, Hamilton EL, Mansour CG, Lecocq S, Drake CJ, An Y, Rodrigues E, Penner G. A new method for the reproducible development of aptamers (Neomers). PLoS One. 2025 Feb 12;20(2):e0311497. 
  10. Daghreeri S, Bosma KJ, Hammond R, Rupar T, Pope V, Talal A, Gofton TE. New diagnosis of ornythine transcarbamylase deficiency in a 71 year old man. Can J Neurol Sci. 2025 Feb 24:1-18.
  11. Macri N, Dias LM, Pavarina AC, Siqueira WL, Sperandio FF. Saliva-derived components can enhance the performance of toluidine blue in photodynamic therapy. Front Pharmacol. 2025 Feb 13;16:1538520. 

Jan 2025

  1. Richer J, Velchev JD, Goobie S, Boswell-Patterson CA, van de Laar IMBH, Verhagen JMA, Wessels MW, Roos-Hesselink JW, Luyckx I, Al-Amodi H, Chu MWA, Laberge AM, Sadikovic B, Balci T, Verstraeten A, Loeys B. Sexual dimorphism in SMAD3 pathogenic variant-harbouring individuals. J Med Genet. 2025 Jan 2:jmg-2024-110219. 
  2. Tennakoon R, Bily TMI, Hasan F, Syal S, Voigt A, Balci TB, Hoffman KS, O’Donoghue P. Glutamine missense suppressor transfer RNAs inhibit polyglutamine aggregation. Molecular Therapy: Nucleic Acid (2025).
  3. Karimi K, Lichtenstein Y, Reilly J, McConkey H, Relator R, Levy MA, Kerkhof J, Bouman A, Symonds JD, Ghoumid J, Smol T, Clarkson K, Drazba K, Louie RJ, Miranda V, McCann C, Motta J, Lancaster E, Sallevelt S, Sidlow R, Morrison J, Hannibal M, O'Shea J, Marin V, Prasad C, Patel C, Raskin S, Maria-Noelia SM, Diaz de Bustamante A, Marom D, Barkan T, Keren B, Poirsier C, Cohen L, Colin E, Gorman K, Gallant E, Menke LA, Valenzuela Palafoll I, Hauser N, Wentzensen IM, Rankin J, Turnpenny PD, Campeau PM, Balci TB, Tedder ML, Sadikovic B, Weiss K. Discovery of a DNA methylation profile in individuals with Sifrim-Hitz-Weiss syndrome. Am J Hum Genet. 2025 Jan 15:S0002-9297(24)00463-4.
  4. Akinlonu A, Boffa MB, Lyu C, Zhong J, Jindal M, Fadzan M, Garshick MS, Schwartzbard A, Weintraub HS, Bredefeld C, Newman JD, Fisher EA, Koschinsky ML, Goldberg IJ, Berger JS. Variation in lipoprotein(a) response to potent lipid lowering: The role of apolipoprotein (a) isoform size. J Clin Lipidol. 2024 Dec 4:S1933-2874(24)00277-0. 
  5. Schott C, Lebedeva V, Taylor C, Abumelha S, Roshanov PS, Connaughton DM. Utility of Genetic Testing in Adults with CKD: A Systematic Review and Meta-Analysis. Clin J Am Soc Nephrol. 2025 Jan 1;20(1):101-115.
  6. Tomas EJ, Valdes YR, Davis J, Kolendowski B, Buensuceso A, DiMattia GE, Shepherd TG. Exploiting Cancer Dormancy Signaling Mechanisms in Epithelial Ovarian Cancer Through Spheroid and Organoid Analysis. Cells. 2025 Jan 17;14(2):133.
  7. Grieves LA, Gloor GB. Uropygial gland microbiota of nearctic-neotropical migrants vary with season and migration distance. Anim Microbiome. 2025 Jan 30;7(1):11.
  8. Perera SD, Wang J, McIntyre AD, Hegele RA. Lipoprotein Lipase: Structure, Function, and Genetic Variation. Genes (Basel). 2025 Jan 5;16(1):55. 
  9. Ahmad M, Hegele RA. Molecular Therapeutics in Development to Treat Hyperlipoproteinemia. Mol Diagn Ther. 2025 Jan 28.
  10. Hegele RA. Protein-binding therapy: a new approach to lower cholesterol. Lancet Diabetes Endocrinol. 2025 Jan 23:S2213-8587(24)00347-4.Akanmori NN, Junop MS, Gupta RS, Park J. Conformational flexibility of human ribokinase captured in seven crystal structures. Int J Biol Macromol. 2025 Jan 19;299:140109. 
  11. Walker EJL, Karas BJ. Cloning a Chloroplast Genome in Saccharomyces cerevisiae and Escherichia coli. Bio Protoc. 2025 Jan 20;15(2):e5162.
  12. Patel SK, Badross MS, Dhingra NK, Moroney M, Casey JH, Ali Hassan SM, Khan TS, Hess DA, Koschinsky ML, Teoh H, Verma S. Emerging Implications of Elevated Lipoprotein(a) Levels in Coronary Artery Bypass Graft Surgery: A Narrative Review. Ann Thorac Surg. 2025 Jan 29:S0003-4975(25)00080-3.
  13. Chu SSH, Xing G, Jha VK, Ling H. The Shu complex is an ATPase that regulates Rad51 filaments during homologous recombination in the DNA damage response. DNA Repair. 2025; 145:103792.
  14. Khan A, Barber DL, McKillop WM, Rupar CA, Auray-Blais C, Fraser G, Fowler DH, Berger A, Foley R, Keating A, West ML, Medin JA. Lentivirus-mediated gene therapy for Fabry disease: 5-year End-of-Study results from the Canadian FACTs trial. Clin Transl Med. 2025 Jan;15(1):e70073.  
  15. Kernohan KD, Gallagher L, Pigeon M, Yeh E, Lacaria M, Axford MM, MacCormick J, Papaioannou V, Quercia N, Rupar C, Zimmerman K, Weber S, Cushing SL, Chakraborty P. Newborn screening for common genetic variants associated with permanent hearing loss: Implementation in Ontario and a review of the first 3 years. Genet Med. 2025 Jan 19:101364.
  16. Onea G, Ghahramani A, Wang X, Hassan HM, Bérubé NG, Schild-Poulter C. WDR26 depletion alters chromatin accessibility and gene expression profiles in mammalian cells. Genomics. 2025 Jan 19;117(2):111001.
  17. Dugbartey GJ, Penney LN, Mills L, Zhang MY, Juriasingani S, Major S, McLeod P, Liu W, Haig A, Wood ME, Torregrossa R, Whiteman M, Turley E, Postenka C, Sener A. AP39, a novel mitochondria-targeted hydrogen sulfide donor, promotes cutaneous wound healing in an in vivo murine model of acute frostbite injury. Biomed Pharmacother. 2025 Jan 28;183:117869.