Publications

publications

2024-2025

  1. Chafe SC, Zhai K, Aghaei N, Miletic P, Huang Z, Brown KR, Mobilio, Young D, Suk Y, Grewal S, Mckenna D, Alizada Z, Kieliszek AM, Lam FC, Escudero L, Huang Q, Huebner A, Lu K, Ang P, Anand A, Custers S, Apeal E, Slassi S, Brakel B, Kim J, Liu JKC, Bassey-Archibong BI, Abdo R, Shargall Y, Lu JQ, Cutz JC, Zhang Q, Li SSC, Venugopal C, Hynds RE, Dufour A, Moffat J, Swanton C, Bao S, Singh SK (2025). A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis. Sci Transl Med. 17(805):eadu2459. [DOI]
  2. Sleapnicov N, Ha SD, Zhong SJ, Duchscher J, Ezra S, Li SSC, Kim SO. (2025). Inhibition of the Transcription Factor PU.1 Suppresses Tumor Growth in Mice by Promoting the Recruitment of Cytotoxic Lymphocytes Through the CXCL9-CXCR3 Axis. Cancers 17, 2684. [DOI]
  3. Trelford CB, Buensceso A, Tomas E, Valdes YR, Hovey OFJ, Li SSC, Shepherd TG. (2024). LKB1 and STRADα Promote Epithelial Ovarian Cancer Spheroid Cell Invasion. Cancers 16(22), 3726. [DOI]
  4. Kaneko T, Ezra S, Abdo R, Voss C, Zhong SJ, Liu X, Hovey OFJ, Slessarev M, Van Nynatten LR, Ye M, Fraser DD, Li SSC. (2024). Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients. Clin Proteom 21, [DOI]
  5. Johnson JL, Yaron TM, Joughin BA, Huntsman E, Kerelsky A, Cizin DM, Cohen BM, Regev A, Song J, Vasan N, Lin TY, Schoenherr C, Sagum C, Bedford MT, Wynn RW, Tso S, Chuang DT, Li L, Li SSC, Creixell P, Krismer K, Lee H, Zhang B, Lu J, Cossentino I, Landry SD, Uduman M, Blenis J, Elemento O, Frame MC, Hornbeck P, Turk BE, Yaffe MB, & Cantley LC. (2024). The intrinsic substrate specificity of the human tyrosine kinome. Nature 629, 1174-1181. [DOI]
  6. Zhong SJ, Liu X, Kaneko T, Feng Y, Hovey O, Yang K, Ezra S, Ha SD, Kim S, McCormick JK, Liu H, Li SSC. (2024). Peptide Blockers of PD-1-PD-L1 Interaction Reinvigorate PD-1-Suppressed T Cells and Curb Tumor Growth in Mice. Cells 13(14),1193. [DOI] 

2022-2023

  1. Frederick MI, Hovey OFJ, Kakadia JH, Shepherd TG, Li SSC, Heinemann IU. (2023). Proteomic and phosphoproteomic reprogramming in epithelial ovarian cancer metastasis. Mol Cell Proteomics 22(11), 100660. [DOI]
  2. Wang M, Liu AD, Niu Q, Feng X, Zheng YY, Chen SJ, Xu H, Li Q, Hou GQ, Bi XY, Lu YZ, Cheng PP, Liang LM, Jiang YH, Zhao LQ, Liu F, Song LJ, Zhou LL, Xiao LY, Chen F, Li SSC, Ma WL, Cao X, Ye H. (2022). Blockade of phosphotyrosine pathways suggesting SH2 superbinder as a novel therapy for pulmonary fibrosis. Theranostics 12(10): 4513-4535. [DOI]
  3. Zhang Q, Abdo R, Iosef C, Kaneko T, Cecchini M, Han VK and Li SSC (2022). Spatial transcriptomic landscape of non-small cell lung cancer brain metastasis. Nat Commun 13, 5983. [DOI]
  4. Kaneko T, Zeng P, Liu X, Abdo R, JBarrett JW, Zhang Q, Nichols AC, and Li SSC. (2022). Proteome and phosphoproteome signatures of HPV+ head and neck cancer recurrence. Commun Med. 2:95. [DOI]
  5. Zeng PYF, Cecchini MJ, Barrett JW, Shammas-Toma M, De Cecco L, Serafini MS, Cavalieri S, Licitra L, Hoebers F, Brakenhoff RH, Leemans CR, Scheckenbach K, Poli T, Wang X, Liu X, Laxague F, Prisman E, Poh C, Bose P, Dort JC, Shaikh MH, Ryan SEB, Dawson A, Khan MI, Howlett CJ, Stecho W, Plantinga P, da Silva SD, Hier M, Khan H, MacNeil D, Mendez A, Yoo J, Fung K, Lang P, Winquist E, Palma D, Ziai H, Amelio AL, Li SSC, Boutros P, Mymryk J, Nichols A. (2022). Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification. eBioMedicine 86:104373. [DOI]

2021

  1. Voss C, Esmail S, Liu X, Knauer MJ, Ackloo S, Kaneko T, Lowes L, Stogios P, Seitova A, Hutchinson A, Yusifov F, Skarina T, Evdokimova E, Loppnau P, Ghiabi P, Haijan T, Zhong S, Abdoh H, Hedley BD, Bhayana V, Martin CM, Slessarev M, Chin-Yee B, Fraser DD, Chin-Yee I, Li SSC (2021). Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern. JCI Insight. 6(13):e148855. [DOI]
  2. Esmail S, Knauer MJ, Abdoh H, Voss C, Chin-Yee B, Stogios P, Seitova A, Hutchinson A, Yusifov F, Skarina T, Evdokimova E, Ackloo S, Lowes L, Hedley BD, Bhayana V, Chin-Yee I, Li SSC (2021). Rapid and accurate point-of-care testing for SARS-CoV2 antibodies. Cell Rep Methods. 1(2):100011. [DOI]
  3. Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SSC, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE (2021). Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nat Commun. 12(1):7032. [DOI]
  4. Qin L, Cao X, Kaneko T, Voss C, Wang G, Li SSC (2021). Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors. J Biol Chem. 297(4):101161. [DOI]
  5. McKenna M, Balasuriya N, Zhong S, Li SSC, O’Donoghue P (2021). Phospho-form specific substrates of protein kinase B (AKT1). Frontiers Bioeng Biotechnol. 8:619252. [DOI]
  6. Ha SD, Lewin N, Li SSC, Kim SO (2021). HDAC8 Activates AKT through Upregulating PLCB1 and Suppressing DESC1 Expression in MEK1/2 Inhibition-Resistant Cells. Cells. 10(5):1101. [DOI]
  7. Liu AD, Zhou J, Bi XY, Hou GQ, Li SSC, Chen Q, Xu H, Cao X (2021). Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma. Clin Transl Med. 11(3):e337. [DOI]

2020

  1. Yanrong Wen, Jia Liu, Hui He, Shawn S C Li, Zhen Liu (2020) Single-Cell Analysis of Signaling Proteins Provides Insights into Proapoptotic Properties of Anticancer Drugs. Anal Chem. 2020 Sep 15;92(18):12498-12508 [ PubMed ]
  2. Kyle K. Biggar, Francois Charih, Huadong Liu, Yasser B. Ruiz-Blanco, Leanne Stalker, Anand Chopra, Justin Connolly, Hemanta Adhikary, Kristin Frensemier, Matthew Hoekstra, Marek Galka, Qi Fang, Christopher Wynder, William L. Stanford, James R. Green, and Shawn S.-C. Li (2020) Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome. Cell Reports 32, 107896, July 14, 2020 [ PubMed ]
  3. Liya Ming, Yang Zou, Yiming Zhao, Luna Zhang, Ningning He, Zhen Chen, Shawn S‐C. Li, Lei Li (2020) MMS2plot: An R Package for Visualizing Multiple MS/MS Spectra for Groups of Modified and Non-Modified Peptides. Proteomics. 2020 Jul 8:e2000061. [ PubMed ]
  4. Rakesh Joshi, Lyugao Qin, Xuan Cao, Shanshan Zhong, Courtney Voss, Weiping Min and Shawn S. C. Li (2020) DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA. J Biol Chem. 2020 Jan 10;295(2):645-656. [ PubMed ]
  5. Nileeka Balasuriya, Norman E. Davey, Jared L. Johnson, Huadong Liu, Kyle K. Biggar, Lewis C. Cantley, Shawn Shun-Cheng Li and Patrick O'Donoghue (2020) Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1). J Biol Chem. 2020 Jun 12;295(24):8120-8134. [ PubMed ]