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Fundamental Sciences & Surgical Innovation Node

Node Chair: Dr. Jeremy Burton, Urology and Microbiology and Immunology

This Node will continue to be a flagship for the Department of Surgery as most of the successful, externally funded ongoing research projects within our individual Divisions are based upon laboratory/bench research. Although there are successful silos of ongoing basic science research within the Department of Surgery, their expertise is often not publicized or shared with the larger group.  Surgical innovation depends upon key advancements in surgical techniques and the development of novel biomaterials and bio-technologies. Members in our Department have previously shown excellent productivity and innovation in these facets of research.  Creating an environment which brings together basic science laboratories and biotechnology research facilities with these clinical innovators will lead to accelerated translation to mainstream clinical and educational practice through close collaboration with the Innovations Fellows program and World Discoveries.

Research Areas that would be Included in this Node:

Upcoming Node Meeting: Thursday, January 18, 2018 at 6 PM in Room E1-126, St. Joseph's Health Care London. All are welcome to attend.

Alison Allan

Alison Allan

Associate Professor

Research Interests / Specializations: Cancer metastasis; Breast cancer; Blood-based biomarkers; Prostate cancer in vivo animal models of cancer
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My translational research program is focused on cellular and molecular mechanisms of cancer metastasis; in particular the study of circulating tumor cells (CTCs) and cancer stem cells (CSCs) and how the knowledge gained from experimental studies in these areas can be translated to the clinic to benefit patients. I am a Canadian leader in the area of CTC analysis and technology development, and my research group is actively involved in several collaborative local and multi-centre cancer clinical trials.
Tom Appleton

Tom Appleton

Assistant Professor

Research Interests / Specializations: Osteoarthritis; Rheumatology; Macrophages synovitis cartilage
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My research program focuses on the role of synovium in the development and progression of osteoarthritis, the pathophysiology of joint damage and symptoms in early osteoarthritis, and clinical classification of different OA phenotypes. Key research tools include patient cohorts with different types of OA, animal models of OA, and immunophenotyping.

Eric Arts

Professor

Research Interests / Specializations: Virus; Immunology
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: I am the department chair and would be representing our department's research which would related to infections and immunity.
519-661-2111 ext. 83427
earts@uwo.ca

External link
Muriel Brackstone

Muriel Brackstone

Associate Professor

Research Interests / Specializations: Preoperative Window of Opportunity Trials; Breast Cancer Clinical Trials; Translational Phase I/II Neoadjuvant Trials; Health Outcomes Database Research; Biospecimen Repository Collaborations
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: Having developed the London Tumour Biobank as a flexible platform for serial biospecimen collection from patients at diagnosis, opportunities exist for preoperative window of opportunity trials or novel therapeutic research while cancers remains in situ. These trials in collaboration with translational scientists, paired with comprehensive databases developed with lifelong patient outcomes, provides a real opportunity for novel and rapid bench to bedside innovation.
519-685-8500 ext. 58712
muriel.brackstone@lhsc.on.ca

Gerald  Brock

Gerald Brock

Professor

Research Interests / Specializations: Impotence; Erectile dysfunction; Prosthetics
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: We evaluate the physiology of erectile dysfunction and the biological mechanisms which can be targeted as treatment, using animal models and human volunteers
519-646-6100 ext. 66042
gebrock@sympatico.ca

Arthur Brown

Associate Professor

Research Interests / Specializations: Spinal cord injury; Stroke; Brain injury; Neuroplasticity
Biography: Research Overview: My laboratory is interested in developing therapies for the treatment of CNS trauma and stoke. Therapies that are currently being explored include immunomodulatory therapies and therapies that increase neuroplastlcity.
519-931-5777 ext. 24308
abrown@robarts.ca

Jeremy Burton

Jeremy Burton

Associate Professor

Research Interests / Specializations: Microbiome; Urology; Biomaterial; Microbiology
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My major research focus is the microbiome in urologic diseases, but he has multiple collaborative projects, including microbiome research in infectious, metabolic, cardiovascular and rheumatologic diseases.
Gediminas Cepinskas

Gediminas Cepinskas

Associate Professor

Research Interests / Specializations: Sepsis/Trauma/Inflammation; Ischemia/Reperfusion; Vascular Endothelium Leukocytes; Gaseous transmitters
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: Cellular and molecular mechanisms of systemic inflammation. Organ-specific vascular endothelial cell injury/dysfunction. Gaseous transmitters (e.g. carbon monoxide/carbon monoxide releasing molecules) in modulation of inflammatory response.
519-685-8500 ext. 55073
gcepinsk@uwo.ca

External link

Subrata Chakrabarti

Professor

Research Interests / Specializations: Vascular biology; miRNA; Angiogenesis; lncRNA; Epigenetics
Biography: Research Overview: Chronic diseases, vascular biology, tumoral and non-tumoral angiogenesis.
Ryan Degen

Ryan Degen

Assistant Professor

Research Interests / Specializations: Biomechanics; Hip; Clinical outcome; Shoulder; Knee
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My research interests focus primarily on lower extremity biomechanics, specifically focusing on hip and knee joint kinematics following various orthopedic surgical procedures. Additionally, I have an interest in associated clinical outcomes following similar procedures.
519-661-2111 ext. 88052
ryan.degen@lhsc.on.ca

Tanya DeLyzer

Tanya DeLyzer

Assistant Professor

Research Interests / Specializations: Breast reconstruction; Microsurgery: CBME
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: Research interests include improving outcomes in breast reconstruction, in particular improving outcomes in the setting of radiation. As well as medical education and CBME, in particular, teaching and evaluation methods for microsurgery.
519-646-6100 ext. 64397
dogorman@uwo.ca

External link
John Denstedt

John Denstedt

Professor

Research Interests / Specializations: Biomaterials; Urolithiasis
Biography: Research Overview: Clinical and basic science investigations into urolithiasis. Biomaterials research.
519-646-6100 ext. 66036
john.denstedt@sjhc.london.on.ca

Aaron Fenster

Aaron Fenster

Professor

Research Interests / Specializations: Robotics; Ultrasound Imaging; Minimally invasive therapy
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My lab is developing robotic systems for image-guided interventions.
Khadry Galil

Khadry Galil

Professor

Research Interests / Specializations: Gross anatomy; Anatomical studies; Maxillofacial surgery
Biography: Research Overview: here are examples: . J.Rootu.,C.Moore.,M.johnson.,L.swarby.,K.willmore.,K.galil.,Tjenkyn. Does sinus surgery increase risk of Orbital fracture in patients? American Association of Anatomists, Sandiego , 20`16 Optimization of bone grafting from the mandibular body via anatomical dissection and micro-computer tomography -Swarts, Z.1, Wilson, T. Ph. D1, Willmore, K. Ph. D1, Perinpanayagam, H. DDS, Ph. D2, Merrifield, P. Ph. D1, Galil, K. DDS, Ph. D1,2 Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University1 Department of Dentistry, Schulich School of Medicine and Dentistry, Western University2 -. P.Gill.,. T.Wilson, K.Willmore. H.Peripanayagam.,K.Galil. Hemorrhage Secondary to interforaminal implant surgery anatomical consideration. American Association of Anatomists, Sandiego , (Submitted)2016
519-661-2111 ext. 86810
kgalil@uwo.ca

External link
Alan Getgood

Alan Getgood

Associate Professor

Research Interests / Specializations: Joint Preservation; Knee Biomechaincs; Post Traumatic Osteoarthritis; Ligament Reconstruction; Animal Models
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: I have a clinical practice that focuses on soft tissue reconstruction of the knee, underpinned by a multifaceted research program that focuses on joint preservation, translating biomechanics and large animal studies into clinical trials with the ultimate aim of improving knee function into later life.
519-661-2111 ext. 87900
alan.getgood@uwo.ca

External link

Lakshman Gunaratnam

Assistant Professor

Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My research program focuses on the role ischemia reperfusion injury plays in regulating innate immunity and inflammation and in renal transplantation & native acute kidney injury. My CIHR-funded basic science research laboratory is actively studying how injured kidney epithelial cells regulate inflammation by expressing Kidney Injury Molecule-1.
519-685-8500 ext. 34581
Lakshman.Gunaratnam@lhsc.on.ca

Lisa Hoffman

Assistant Professor

Research Interests / Specializations: Vasculature; Cell signaling; Targeted therapy; Neuromuscular; Regenerative medicine
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: We have novel evidence of Angiopoietin -1 (Ang-1) depletion in the Duchenne muscular dystrophy (DMD) microenvironment. While the cause of Ang-1 depletion in DMD is presently unknown, our data supports current literature linking Ang-1 depletion to vascular instability and fibrosis in other conditions (e.g. diabetes, sepsis, cerebral ischemia)4-6, leading to the central aim of our current research: to determine if Angiopoietin-1 (Ang-1) is sufficient to enhance the integrity of the microvasculature, reduce muscle ischemia and chronic inflammation and attenuate muscle fibrosis.
James Johnson

James Johnson

Professor

Research Interests / Specializations: Biomechanics; Kinematics; Implants; In-vitro; Shoulder, Elbow & Wrist
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: In collaboration with surgeons, orthopaedic biomechanical research is conducted with special interest in the upper limb. Evaluation includes fixation of implants to bone, kinematic analyses of motion, fracture fixation stability, and load transfer mechanisms across the joints. Experimental techniques include an electromagnetic tracking system to measure motion and custom-made simulators to model limb function in the laboratory. In addition, a bi-axial servo-hydraulic testing machine is used to test structures. The research laboratory which is located at the Lawson Health Research Institute, is dedicated to a “benchtop-to-bedside” approach, where discoveries in the laboratory are targeted to directly enhance patient care.
519-646-6100 ext. 64087
jajohnso@uwo.ca

External link
Douglas  Jones

Douglas Jones

Professor

Research Interests / Specializations: Cardiac Arrhythmia; Cardiac Electrophysiology; Integrative Physiology; Neuroscience Animal Models
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: Integrative Physiology from the gene to the patient. Developing procedures for diagnostic, biological, electrical and surgical therapies for cardiac arrhythmia. Interactions between the autonomic and limbic system in brain-behaviour and brain cardiovascular function.
519-661-2111 ext. 83480
dljones@uwo.ca

External link
Murray Junop

Murray Junop

Associate Professor

Research Interests / Specializations: DNA Repair; Cancer;Protein Structure-Function; X-ray Crystallography
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: Research in the Junop lab focuses on understanding the molecular mechanisms governing repair of various types of DNA damage. Bacterial, yeast and human repair pathways are studied using a variety of genetic and biochemical tools, with the primary emphasis being determination of macromolecular structure using X-ray crystallography.
519-661-2111 ext. 82017
mjunop@uwo.ca

External link
Graham King

Graham King

Professor

Research Interests / Specializations: Elbow; Wrist; Biomechanics; Computer assisted surgery; Joint replacement
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My main focus is studying the biomechanics of the wrist and elbow with an interest in improving the management of patients with fractures and dislocations using rehabilitation and surgical reconstruction. I also have an ongoing interest in computer assisted surgical techniques for the upper extremity.
519-646-6100 ext. 66011
gking@uwo.ca

Takashi Kuboki

Assistant Professor

Research Interests / Specializations: Biopolymers; Biocomposites; Scaffolds; Foams; Polymers and Polymer composites
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My primary research interests are (i) to identify process-structure-property relationships of materials, and (ii) to develop novel functional materials.
519-661-2111 ext. 88519
tkuboki@uwo.ca

James Lacefield

James Lacefield

Professor

Research Interests / Specializations: Ultrasound imaging; Preclinical imaging; Vascular imaging; Cancer imaging; Signal processing
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My research team develops signal processing methods to improve the capabilities of Doppler and contrast-enhanced ultrasound for quantitative vascular imaging. Cancer imaging, particularly assessment of treatment responses, is our primary medical application, although we are interested in extending our work to other applications that employ vascular imaging.
519-661-2111 ext. 84303
jlacefie@uwo.ca

External link
Marie-Eve  LeBel

Marie-Eve LeBel

Associate Professor

Research Interests / Specializations: Simulation; Arthroscopy Shoulder and knee; Performance Assessment; Skills development
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My research focuses on surgical simulation in the field of arthroscopic surgery, more specifically skills development and performance assessment. I develop surgical simulators and associated instruments and also have experience with force-sensing and eye-tracking.
519-646-6100 ext. 66153
mlebel4@uwo.ca

Weiping Min

Weiping Min

Professor

Research Interests / Specializations: Transplant tolerance; Ischemia/reperfustion injury; Immunomodulation; siRMA/miRMA/gRNA; Cancer immunotherapy
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My research is focused on tolerance induction through gene silencing and immune modulation. There are two major themes in our research: i) establishing tolerance for preventing graft rejection in transplantation and treatment of autoimmune diseases, and ii) breaking tumor-derived immune suppression for treatment of cancer. The ultimate goals of our research are to dissect the mechanisms underlying dendritic cell-mediated immune modulation, and to develop novel immune-based and RNAi-based therapies.
519-685-8500 ext. 32985
weiping.min@uwo.ca

External link

David O'Gorman

Assistant Professor

Research Interests / Specializations: Tissue Engineering; Joint Infection; Connective Tissue Mimetic; Tendinosis; Fibrosis
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My primary research focus in connective tissue regeneration and repair. My lab specializes in deriving primary human cells from surgical explant tissues, and using those cells to develop 3D tissue mimetic cultures to study normal and abnormal tissue regeneration in the presence or absence of inflammation, infection and other impacts on tissue repair processes.
519-646-6100 ext. 64397
dogorman@uwo.ca

External link
Rajni Patel

Rajni Patel

Professor

Research Interests / Specializations: Robotics-Assisted Surgery; Minimally Invasive Surgery ; Surgical Training and Skills; Assessment; Haptics and Teleoperation; Image-Guided Interventions
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My research over the last 15 years has focused on the design, implementation and validation of novel robotic and other mechatronic systems and devices for applications in image-guided minimally invasive medical interventions. The techniques and technologies developed to date incorporate multimodality sensing (using sensorized instruments), haptics (sense of touch), teleoperation and immersive displays. The applications include cancer tumour localization and treatment, surgical training and skills assessment for robotic as well as hand-held minimally invasive procedures, robotic cardiac surgery, catheter and needle-based percutaneous interventions, and neurosurgery.
519-685-8500 ext. 36618
rvpatel@uwo.ca

Terry Peters

Professor

Research Interests / Specializations: Image-guided interventions; Visualization; Neuro; Virtual reality; Cardiac
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My laboratory is concerned with the development and validation of tools that allow surgeons to make efficient use of images, produced by sophisticated 3-D imaging systems, during surgical procedures. The objective of minimally-invasive neurosurgery is to resect or lesion the smallest volume of brain tissue, causing the least trauma to the patient while achieving the desired therapeutic result.
519-931-5777 ext. 24159
tpeters@robarts.ca

External link
Adam Power

Adam Power

Assistant Professor

Research Interests / Specializations: Innovation; Medical devices; Intellectual property ; Entrepreneurship; Cardiovascular
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My main interests are in all aspects of medical device development from invention through to commercialization.
519-685-8500 ext. 74897
adam.power@lhsc.on.ca

Nicholas Power

Nicholas Power

Assistant Professor

Research Interests / Specializations: Kidney Cancer; Testicular Cancer; Anatomy; Patient Derived Xenograft; Biomarkers
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My main academic focus is kidney and testicular cancer. I have experience in co-pioneering a patient derived xenograft model for kidney cancer and have helped elucidate retroperitoneal anatomy for testicular cancer surgery with my team.
Parham Rasoulinejad

Parham Rasoulinejad

Assistant Professor

Research Interests / Specializations: Spine; Surgery; Biomechanics
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My primary research interest is in the area of spinal bio-mechanics which include both cadaveric testing as well as computer aided analysis .
519-685-8500 ext. 55360
prasoulinejad@gmail.com

Hassan Razvi

Hassan Razvi

Professor

Research Interests / Specializations: Urinary Stones; Surgical Therapies for Stone Disease; Metabolic Stone Disease; Diagnosis & Treatment of Stone Disease; Basic Science of Stone Formation
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: All aspects of urinary stone disease including basic science, translational investigation, new device assessments and clinical trials.
519-646-6100 ext. 66259
hrazvi@uwo.ca

Gregor Reid

Gregor Reid

Professor

Research Interests / Specializations: Probiotics; Microbiome; Environmental toxins; Urogenital health in women; Fermented food
Biography: Research Overview: Our lab is interested in using beneficial microbes, especially lactobacilli, as a vehicle to improve health and well-being. We study the ability of these organisms to counter pesticides, heavy metals, aflatoxins and other chemicals, and look for practical ways to apply our science to humans.
519-646-6100 ext. 65256
gregor@uwo.ca

External link
Christopher Schlachta

Christopher Schlachta

Associate Professor

Research Interests / Specializations: Computer assisted surgery; Surgical simulation; Robotic surgery; Surgical Training
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: Our research is focused on computer assisted technologies to enhance surgical therapeutics and training.
519-685-8500 ext. 33478
christopher.schlachta@lhsc.on.ca

Susanne Schmid

Associate Professor

Research Interests / Specializations: Sensory filtering; Autism; Prepulse inibition; Neurodevelopmental disorder; Schizophrenia
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: We study mechanisms of sensory filtering in animal models for schizophrenia/autism/neurodevelopmental disorders using multiple approaches (Behaviour, electrophysiology, histology, DREADD, optogentics). We mostly work with rat models.
Alp Sener

Alp Sener

Assoicate Professor

Research Interests / Specializations: Kidney; Hydrogen sulphide; Transplant; Ischemia reperfusion injury
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: Our laboratory is focused on establishing novel strategies of minimizing post-transplant graft rejection as well as in developing cutting-edge organ preservation techniques to promote improved early and late allograft function and survival.
519-685-8500 ext. 33352
alp.sener@lhsc.on.ca

External link
Matthew Teeter

Matthew Teeter

Assistant Professor

Research Interests / Specializations: Imagining; Biomechanics; 3D Printing; Surgical Device Design; Clinical Trials
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My research involves the application of medical imaging techniques to design or evaluate orthopaedic implants and other interventions for treating musculoskeletal disorders.
Eva Turley

Eva Turley

Professor

Research Interests / Specializations: Hyaluronic acid; Hyaluronic acid receptors; Tissue reconstruction; Signalling mesenchymal and adipose derived stem cells
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: My laboratory is currently utilizing antagonists of hyaluronic acid receptors to modify stem cell differentiation in order to promote better tissue reconstruction. We are also pursuing the molecular signalling pathways that regulate stem cell lineage choices. Finally, we are investigating how these choices impact the microenvironment that regulates prostate and breast cancer aggression.
519-685-8500 ext. 53677
eva.turley@lhsc.on.ca

Ryan Willing

Ryan Willing

Assistant Professor

Research Interests / Specializations: Biomechanics; Arthroplasty; Design: Experiment; Simulation
Teaching: Currently Accepting Graduate Students
Biography: Research Overview: I'm interested in better understanding the biomechanics of intact and reconstructed joints, from the perspective of design. This can include evaluation and optimization of orthopaedic implants, or developing techniques to predict outcomes of surgical procedures.
519-661-2111 ext. 80295
rwilling@uwo.ca