Dr. Jim Lewis, MD, FRCPC

Lewis

Rank / Affiliations

  • Professor of Medicinne
  • Director of Clinical Research Training, Schulich School of Medicine and Dentistry
  • Director, MD/PhD Program
  • Director CIP program
  • Director SRTP/SROP prgroams
  • Director RRCD program
  • Cross Appointment, Department of Physiology & Pharmacology

Training

  • Undergraduate, Western University
  • MD, Western University
  • Internal Medicine, Queen's University
  • Respirology, Western University
  • Fellowship, Harbour UCLA Medical Centre, Torrence, California

Clinical Interest

  • Asthma, exercise-induced asthma
  • Cystic Fibrosis
  • Lung Cancer
  • COPD

Research Interest

  • Clinical Research: Imaging in cystic fibrosis, asthma
  • Basic Research: lung injury, ARDS, surfactant

Research Funding

  • Canadian Institutes of Health Research
  • Ontario Thoracic Society
  • Cystic Fibrosis Canada
  • Physicians' Services Incorporated Foundation

Awards

  • Dean’s Award of Excellence, Local, University of Western Ontario, London, Ontario, Canada, 2008
  • HUMEC Award for Excellence in Medical Education - Respiration and Airways, Division of Respirology Award, 2007

Selected Publications (past 5 years)

1.    A Czyzewski, L McCaig, M Dohm, L Broering, LJ Yao, N Brown, M Didwania, J Lin, Lewis J, R Veldhuizen, A Barron. Effective in vivo treatment of acute lung injury with helical, amphipathic peptoid mimics of pulmonary surfactant proteins. Scientific Reports, 2018 May 1; 17, Collaborator, Available from: DOI:10:1038/s41598-018-25009-3, DOI: SREP-17-46854B.
2.    Yin C, Blom JN, Lewis JF. The 2nd Annual Clinical Scientist Trainee Symposium. Clin Invest Med, 2018 Feb 23; 41 (1): E1-E3, Principal Author
3.    Banaschewski B, Baer B, Arsenault C, Jazey T, Veldhuzien E, Delport J, Gooyers T, Lewis J, Haagsman H, Veldhuizen R, Yamashita C. The antibacterial and anti-inflammatory activity of chicken cathelicidin-2 combined with exogenous surfactant for the treatment of cystic fibrosis associated pathogens. Scientific Report, 2017 Oct 30; 7: 15545, Coauthor, DOI: DOI:10.1038/s41598-017-15558-4.
4.    Putorieri V, McCaig L, Howlett C, Yao LJ, Lewis J, Yamashita C, Veldhuizen R. Lack of matrix metalloproteinase 3 in mouse models of lung injury ameliorates the pulmonary inflammatory response in female but not in male mice. Experimental Lung Research, 2017 May; 42 (7): 365-379, Coauthor
5.    Lingard L, Strong M, Steele M, Yoo J, Lewis J. Supporting physician-scientists in faculty roles: a narrative review. Academic Medicine, 2017 Feb 2; 92 (10): 1421-1428, Coauthor
6.    Ford N, McCaig L, Jeklin A, Lewis J, Veldhuizen R, Holdsworth D, Drangova M. A respiratory-gated micro-CT comparison of respiratory patterns in free-breathing and mechanically ventilated rats. Journal of Applied Physiology, 2017 Jan 23, Coauthor, DOI: 10.14814/phy2.13074.
7.    Milos S, Qua Hiansen J, Banaschewski B, Yao LJ, McCaig L, Lewis J, Yamashita C, Veldhuizen R. The effect of diet-induced serum hypercholesterolemia on the surfactant system and the development of lung injury. Biochemistry and Biophysics, 2016 Jun 1, Coauthor, DOI: http://dx.doi.org/10.1016/j.bbrep.2016.06.009.
8.    Bosma KJ, Read BA, Bahragard Nikoo MK, Jones PM, Priestap FA, Lewis JF. A pilot randomized trial comparing weaning from mechanical ventilation on pressure support versus proportional assist ventilation. Crit Care Med, 2016 Jun 1; 44 (6): 1098-108, Co-Principal Author
9.    Paulin GA, Svenningsen S, Jobse BN, Mohan S, Kirby M, Lewis JF, Parraga G. Differences in hyperpolarized (3) He ventilation imaging after 4 years in adults with cystic fibrosis. J Magn Reson Imaging, 2015 Jun 1; 41 (6): 1701-7, Coauthor
10.  Qua Hiansen J, Keating E, Aspros A, Yao LJ, Bosma K, Yamashita CM, Lewis JF, and Veldhuizen RAW. Cholesterol-mediated surfactant dysfunction is mitigated by surfactant protein A. Biochimica et Biophysica Acta, 2015 Mar 1; 1848 (3): 813-820, Coauthor, DOI: 25522687.
11.  Ma W, Pike D, Mohan S, Kirby M, Lewis JF, Parraga G. Pulmonary structure-function abnormalities in adult congenital emphysema. Canadian Respiratory Journal, 2015 Feb; 9 (2): 9-15, Coauthor
12.  Yamashita C, Fessler M, Vasanthamohan L, Lac J, Madenspacher J, McCaig L, Yao LJ, Wang L, Mehta S, Lewis J, Veldhuizen R. Apolipoprotein E definicient mice are susceptible to the development of acute lung injury. Respiration, 2014 Jun; 2014;87(5):416-27, Coauthor
13.  Puntorieri V, Hiansen JQ, McCaig LA, Yao LJ, Veldhuizen RA, Lewis JF. The effects of exogenous surfactant administration on ventilation-induced inflammation in mouse models of lung injury. BMC Pulm Med, 2013 Nov 20; 13 (67), Coauthor
14.  Patterson EK, Yao LJ, Lewis J, Cepinskas G, McCaig L, Veldhuizen RAW, Yamashita CM. Lung derived mediators induce cytokine production in downstream organs via /NF-kB? dependent mechanism. Mediators Inflamm. 2013 Jul 1; 2013/586895, Coauthor
15.  Yamashita C, Lewis J. Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opinion on Emerging Drugs Mar, 2012 Jul; 17 (1): 1-4, Coauthor
16.  Yamashita C, Patterson E, Yao L, Lewis J, Cepinskas G, Ramic N, Veldhuizen R. Lung derived mediators induce cytokine production in downstream organs via an NF-KB dependent mechanism. Mediators of Inflammation 2013 Article ID 586895, Coauthor
Accepted / In Press
1.    Levit A, Yin C, Lewis JF. Fourth annual clinician scientist trainee symposium at the Schulich School of Medicine & Dentistry. Clin Invest Med, 2019 Dec 1; 42 (4): TBD, Coauthor
2.    C Yin, A Levit, J Lewis. Th 4th Annual Clinician Scientist Trainee Symposium at the Schulich School of Medicine & Dentistry. Clin Invest Med, 2019 Dec, Coauthor

Contact Information

St. Joseph's Health Centre

268 Grosvenor St. London, ON

Phone: (519) 646-6288

Administrative Assistant: Cathy Ede

Schulich School of Medicine & Dentistry

Clinical Skills Bldg 

Administrative Assistant: Stacey Bastien

Phone: 519-661-2111x87908