Schulich school of Medicine and Dentistry logo Seguin Lab Schulich Medicine & Dentistry

Recent Publications

recentpub700x300.jpg

2020

Veras MA, McCann MR, Tenn NA, Séguin CA. (2020) Transcriptional profiling of the murine intervertebral disc and age-associated changes in the nucleus pulposus. Connective Tissue Research, doi: 10.1080/03008207.2019.1665034

Fournier DE, Kiser PK, Beach RJ, Dixon SJ, Séguin CA. (2020) Dystrophic calcification and heterotropic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis (DISH).  Bone Res, doi: 10.1038/s41413-020-0091-6

2019

Esseltine JL, Brooks C, Edwards NA, Subasri M, Sampson J, Séguin CA, Betts DH, Laird DW. (2019) Dynamic regulation of connexins in stem cell pluripotency. Stem Cells, doi; 10.1002/stem.3092

Fournier DE, Norley CJD, Pollman, SI, Bailey CS, Helal FA, Willmore KE, Holdsworth DW, Dixon SJ, Séguin CA. (2019) Ectopic spinal calcification associated with diffuse idiopathic skeletal hyperostosis (DISH): a quantitative micro-ct analysis.  J Orthop Res, doi: 10.1002/jor.24247

2018

Ulici V, Kelley KL, Longobardi L, McNulty MA, Livingston EW, Bateman TA, Séguin CA, Louer CR, Loeser RF. (2018) Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of JNK1 and JNK2. Am J Pathol, doi: 10.1016/j.ajpath.2018.12.010

Séguin CA, Chan D, Dahia CL, Gazit Z. (2018) Latest advances in intervertebral disc development and progenitor cells. JOR Spine, doi: 10.1002/jsp2.1030

Zheng L, Cao Y, Ni S, Qi H, Ling Z, Xu X, Zou X, Wu T, Deng R, Hu B, Gao B, Chen H, Li Y, Zhu J, Tintani F, Demehri S, Jain A, Kebaish KM, Liao S, Séguin CA, Crane JL, Wan M, Lu H, Sponseller PD, Riley LH 3rd, Zhou X, Hu J, Cao X. (2018) Ciliary parathyroid hormone signaling activates transforming growth factor-B to maintain intervertebral disc homeostasis during aging. Bone res, doi: 10.1038/s41413-018-0022-y

2017

Tam V, Chan WCW, Leung VYL, Cheah KSE, Cheung KMC, Sakai D, McCann MR, Bedore J, Séguin CA, Chan D. (2017) Histological and reference system for the analysis of mouse intervertebral disc. J Orthop Res, doi: 10.1002/jor.23637. [Epub ahead of print]

Bian Q, Ma L, Jain A, Crane JL, Kebaish K, Wan M, Zhang Z, Edward Guo X, Sponseller PD, Séguin CA, Riley LH, Wang Y, Cao X. (2017) Mechanosignaling activation of TGFB maintains intervertebral disc homeostasis. Bone Res, 5:17008

Gsell KY, Zwambag DP, Fournier DE, Séguin CA, Brown SH. (2017) Paraspinal Muscle Passive Stiffness Remodels in Direct Response to Spine Stiffness: A Study Using the ENT1 Deficient Mouse. Spine (Phila Pa 1976), doi: 10.1097/BRS.0000000000002132. [Epub ahead of print].

Esseltine JL, Shao Q, Brooks C, Sampson J, Betts DH, Séguin CA, Laird DW. (2017) Connexin43 Mutant Patient-Derived Induced Pluripotent Stem Cells Exhibit Altered Differentiation Potential. J Bone Miner Res, 32(6):1368-1385.

McCann MR, Veras MA, Yeung C, Lalli G, Patel P, Leitch KM, Holdsworth DW, Dixon SJ, Séguin CA. (2017) Whole-body vibration of mice induces progressive degeneration of intervertebral discs associated with increased expression of IL-1B and multiple matrix degrading enzymes. Osteoarthritis Cartilage, 25(5):779-789.

Kerr GJ, McCann MR, Branch JK, Ratneswaran A, Pest MA, Holdsworth DW, Beier F, Dixon SJ, Séguin CA. (2017) C57BL/6 mice are resistant to joint degeneration induced by whole-body vibrationOsteoarthritis Cartilage, 25(3):421-425.

Kerr GJVeras MAKim MKSéguin CA. (2017) Decoding the intervertebral disc: Unravelling the complexities of cell phenotypes and pathways associated with degeneration and mechanotransduction. Semin Cell Dev Biol, 62:94-103.

Veras MA, Tenn NA, Kuljanin M, Lajoie GA, Hammond JR, Dixon SJ, Séguin CA. (2017) Loss of ENT1 increases cell proliferation in the annulus fibrosus of the intervertebral disc.  J Cell Physiol, doi:  10.1002/jcp.28051

2016

McCann MR, Yeung C, Pest MA, Ratneswaran A, Pollmann SI, Holdsworth DW, Beier F, Dixon SJ, Séguin CA. (2016) Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone. Osteoarthritis and Cartilage, doi: 10.1016/j.joca.2016.11.001 

Tobias IC, Brooks CR, Teichroeb JH, Villagoméz DA, Hess DA, Séguin CA, Betts DH. (2016) Small-Molecule Induction of Canine Embryonic Stem Cells Toward Naive Pluripotency. Stem Cells Dev, 25(16):1208-1222.

McCann MRSéguin CA. (2016) Notochord Cells in Intervertebral Disc Development and Degeneration. J Dev Biol, 4(1):1-18.

Ii HWarraich STenn N, Quinonez D, Holdsworth DW, Hammond JR, Dixon SJ, Séguin CA. (2016) Disruption of biomineralization pathways in spinal tissues of a mouse model of diffuse idiopathic skeletal hyperostosis. Bone, 90:37-49.

Bedore J, Quesnel K, Quinonez DSéguin CA, Leask A. (2016) Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus. J Cell Commun Signal, 10(2):137-42.

2015

McCann MRPatel P, Pest MA, Ratneswaran A, Lalli G, Beaucage KL, Backler GB, Kamphuis MP, Esmail Z, Lee J, Barbalinardo M, Mort JS, Holdsworth DW, Beier F, Dixon SJ, Séguin CA. (2015) Repeated exposure to high-frequency low-amplitude vibration induces degeneration of murine intervertebral discs and knee joints. Arthritis Rheumatol, 67(8):2164-75. 

McCann MRPatel P, Frimpong A, Xiao Y, Siqueira WL, Séguin CA. (2015) Proteomic signature of the murine intervertebral disc. PLoS One, 10(2):e0117807.