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Recent Publications

Ulici V, Kelley KL, Longobardi L, McNulty MA, Livingston EW, Bateman TA, Séguin CA, Louer CR, Loeser RF. (2018) Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of JNK1 and JNK2. Am J Pathol, doi: 10.1016/j.ajpath.2018.12.010

Séguin CA, Chan D, Dahia CL, Gazit Z. (2018) Latest advances in intervertebral disc development and progenitor cells. JOR Spine, doi: 10.1002/jsp2.1030

Zheng L, Cao Y, Ni S, Qi H, Ling Z, Xu X, Zou X, Wu T, Deng R, Hu B, Gao B, Chen H, Li Y, Zhu J, Tintani F, Demehri S, Jain A, Kebaish KM, Liao S, Séguin CA, Crane JL, Wan M, Lu H, Sponseller PD, Riley LH 3rd, Zhou X, Hu J, Cao X. (2018) Ciliary parathyroid hormone signaling activates transforming growth factor-B to maintain intervertebral disc homeostasis during aging. Bone res, doi: 10.1038/s41413-018-0022-y

Tam V, Chan WCW, Leung VYL, Cheah KSE, Cheung KMC, Sakai D, McCann MR, Bedore J, Séguin CA, Chan D. (2017) Histological and reference system for the analysis of mouse intervertebral disc. J Orthop Res, doi: 10.1002/jor.23637. [Epub ahead of print]

Bian Q, Ma L, Jain A, Crane JL, Kebaish K, Wan M, Zhang Z, Edward Guo X, Sponseller PD, Séguin CA, Riley LH, Wang Y, Cao X. (2017) Mechanosignaling activation of TGFB maintains intervertebral disc homeostasis. Bone Res, 5:17008

Gsell KY, Zwambag DP, Fournier DE, Séguin CA, Brown SH. (2017) Paraspinal Muscle Passive Stiffness Remodels in Direct Response to Spine Stiffness: A Study Using the ENT1 Deficient Mouse. Spine (Phila Pa 1976), doi: 10.1097/BRS.0000000000002132. [Epub ahead of print].

Esseltine JL, Shao Q, Brooks C, Sampson J, Betts DH, Séguin CA, Laird DW. (2017) Connexin43 Mutant Patient-Derived Induced Pluripotent Stem Cells Exhibit Altered Differentiation Potential. J Bone Miner Res, 32(6):1368-1385.

McCann MR, Veras MA, Yeung C, Lalli G, Patel P, Leitch KM, Holdsworth DW, Dixon SJ, Séguin CA. (2017) Whole-body vibration of mice induces progressive degeneration of intervertebral discs associated with increased expression of IL-1B and multiple matrix degrading enzymes. Osteoarthritis Cartilage, 25(5):779-789.

Kerr GJ, McCann MR, Branch JK, Ratneswaran A, Pest MA, Holdsworth DW, Beier F, Dixon SJ, Séguin CA. (2017) C57BL/6 mice are resistant to joint degeneration induced by whole-body vibrationOsteoarthritis Cartilage, 25(3):421-425.

Kerr GJVeras MAKim MKSéguin CA. (2017) Decoding the intervertebral disc: Unravelling the complexities of cell phenotypes and pathways associated with degeneration and mechanotransduction. Semin Cell Dev Biol, 62:94-103.

Tobias IC, Brooks CR, Teichroeb JH, Villagoméz DA, Hess DA, Séguin CA, Betts DH. (2016) Small-Molecule Induction of Canine Embryonic Stem Cells Toward Naive Pluripotency. Stem Cells Dev, 25(16):1208-1222.

McCann MRSéguin CA. (2016) Notochord Cells in Intervertebral Disc Development and Degeneration. J Dev Biol, 4(1):1-18.

Ii HWarraich STenn N, Quinonez D, Holdsworth DW, Hammond JR, Dixon SJ, Séguin CA. (2016) Disruption of biomineralization pathways in spinal tissues of a mouse model of diffuse idiopathic skeletal hyperostosis. Bone, 90:37-49.

Bedore J, Quesnel K, Quinonez D, Séguin CA, Leask A. (2016) Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus. J Cell Commun Signal, 10(2):137-42.

McCann MRPatel P, Pest MA, Ratneswaran A, Lalli G, Beaucage KL, Backler GB, Kamphuis MP, Esmail Z, Lee J, Barbalinardo M, Mort JS, Holdsworth DW, Beier F, Dixon SJ, Séguin CA. (2015) Repeated exposure to high-frequency low-amplitude vibration induces degeneration of murine intervertebral discs and knee joints. Arthritis Rheumatol, 67(8):2164-75. 

McCann MRPatel P, Frimpong A, Xiao Y, Siqueira WL, Séguin CA. (2015) Proteomic signature of the murine intervertebral disc. PLoS One, 10(2):e0117807.

Patel P, Brooks C, Seneviratne A, Hess DA, Séguin CA. (2014) Investigating microenvironmental regulation of human chordoma cell behaviour. PLoS One, 9(12):e115909.

Bedore J, Leask A, Séguin CA. (2014) Targeting the extracellular matrix: matricellular proteins regulate cell-extracellular matrix communication within distinct niches of the intervertebral disc. Matrix Biol, 37:124-30.

Bedore J, Sha W, McCann MR, Liu S, Leask A, Séguin CA. (2013) Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of  CCN2. Arthritis and Rheumatism, 65(10):2634-44.

McCann MRPatel P, Beaucage KL, Xiao Y, Bacher C, Siqueira WL, Holdsworth DW, Dixon SJ, Séguin CA. (2013) Acute vibration induces transient expression of anabolic genes in the murine intervertebral disc. Arthritis and Rheumatism, 65(7):1853-64. 

Warraich S, Bone DBJ, Quinonez D, Ii H, Choi D-S, Holdsworth DW, Drangova M, Dixon SJ, Séguin CA§, Hammond J§. (co-senior author) (2013) Loss of Equilibrative Nucleoside Transporter 1 (ENT1) in Mice Leads to Progressive Ectopic Mineralization of Spinal Tissues Resembling Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Humans. J Bone Miner Res, 28(5):1135-49.

McCann MR, Tamplin OJ, Rossant J, Séguin CA. (2012) Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development. Dis Model Mech, 5(1):73-82.

McCann MRBacher CSéguin CA. (2011) Exploiting notochord cells for stem cell-based regeneration of the intervertebral disc. J Cell Comm and Signaling Mar;5(1):39-43.