Vice Dean, Basic Medical Sciences
PH.D. University of Calgary
M.Sc. University of Alberta
B.Sc. (H.) University of Alberta
Office: Medical Sciences Building Rm. 262
p. 519.661.2111 x. 83480
See Publications by Doug Jones on PubMed
My research focuses on determining physiology and pathophysiology of cardiovascular function. Recent studies have focussed on substrates associated with arrhythmia in atrial fibrillation, mechanisms of, and development of procedures and tools for minimally-invasive, robotically-assisted cardiac surgery, and neurophysiological regulatory mechanisms of cardiovascular control as well as pathophysiological factors in cardiac development.
Mechanisms of arrhythmia studies have determined the role of tissue, cellular and subcellular altered ionic basis of electrical instability in arrhythmia, and gap junction alterations. In addition, there is an apparent regional disparity rendering the left atrium as the "driving" area for the induction and maintenance of atrial fibrillation - the tissue and cellular basis of this regional difference is unknown. A major contributor to the induction and maintenance of atrial arrhythmia is due to altered autonomic function. Part of this work has involved the development of novel surgical procedures for arrhythmia therapy: we have been investigating optimization of novel surgical approaches which are applicable to minimally invasive robot-assisted surgery.
Additional studies have involved insults during gestation which alter cardiac development. Studies involving transgenic and knock-out mouse models have been utilized to determine the signalling pathways involved in this regulation.
Guiraudon, G. M., Jones, D. L., Bainbridge, D., Cohen, L., Lecompte, Y., Hidden-Lucet, F., Frank, R. and Pavie, A. Hybrid Access Atria via the Universal Cardiac Introducer™ For Arrhythmia Ablation after Total Cavo-Pulmonary Derivation. Innovations 7(3): 217-222, 2012.
Jones, D. L., Chidiac, P. and Tuomi, J. M. Role of Cholinergic Innervation and RGS2 in Atrial Arrhythmia. Front. Card. Electrophy. Vol 3, Article 239: 1-12. Online June 29, 2012.
Lang, P., Chu, , M. W. A., Bainbridge, D., Guiraudon, G. M., Jones, D. L., Peters, T. M. Surface-based CT-TEE registration of the aortic root. IEEE Trans Biomed Eng.2013 Mar 7. [Epub ahead of print].
Guiraudon, G. M., Jones, D. L., Skanes, A., Bainbridge, Tweedie, E. J, and Klein, G. J. Revisiting right atrial isolation rationale for atrial fibrillation: Operative anatomy of interatrial connections. J. Intervention. Cardiac Electrophys.37(3):267-273, 2013.
Guiraudon, G. M. and Jones, D. L. Revisiting heart activation-conduction physiology, Part I: atria. J. Intervention. Cardiac Electrophys. 40(1):9-15, 2014, 2014.
Xiang, F.-L., Liu, Y., Lu, X., Jones, D. L. and Feng. Q. Cardiac-specific overexpression of human stem cell factor promotes epicardial activation and arteriogenesis after myocardial infarction. Circulation Heart Failure7:831-842, 2014
Aschar-Sobbi, R., Izaddoustdar, F., Korogyi, A. S., Farman, G. P., Yang, F. H., Yeng, W., Dorian, D., Simpson, J. A., Tuomi, J. M., Jones, D. L., Nanthakumar, K., Cox, B., Dorian, P. and Backx, P. H. "Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα. Nature Communications. 6 (6018): doi: 10.1038/ncomms7018. 19 January, 2015.
Ciriello, J., Moreau, J. M., McCoy, A. and Jones, D. L. Leptin dependent changes in the expression of tropomyosin receptor kinase B protein in nucleus of the solitary tract to acute intermittent hypoxia. Neurosci. Lett.602:115-119, 2015.
Tavallaei, M. A., Gelman, D., Lavdas, M. K., Skanes, A. C., Jones, D. L., Bax, J. A. and Drangova. Design, development and evaluation of a compact tele-robotic catheter navigation system. Int. J. Med. Robot. 12(3): 442-452, 2016.
Ciriello, J., Moreau, J. M., McCoy, A. and Jones, D. L. Effect of Intermittent Hypoxia on Arcuate Nucleus in the Leptin-Deficient Rat. Neurosci. Lett.626: 112-118, 2016.
Bober, S., Ciriello, J. and Jones, D. L., Atrial Arrhythmias and Autonomic Dysfunction in Rats Exposed to Chronic Intermittent Hypoxia. Am. J. Physiol. (Heart Circ. Physiol.)Feb 9. 2018 doi: 10.1152/ajpheart.00173.2017. [Epub ahead of print].
Tuomi, J. Jones, D. L. and Xenocostas, A. Increased susceptibility for atrial and ventricular cardiac arrhythmias in mice treated with a single high dose of Ibrutinib. Can. J. Cardiol.34(3): 337-341, 2018.
Krishnan, R., Jones, D. L., Jawaid, N. and Steele, M. Mentoring Needs of Distributed Medical Education Faculty at one Canadian Medical School. Can. J. Rural Med.23(3): 68-75, 2018.
Saiyin, T., Engineer, A., Lu, X., Greco, E., Younkung, M., Jones, D.L. and Feng, Q. The effect of exercise on congenital heart defects induced by pregestational diabetes. Cardiovascular Diabetology(Submitted).