S. Jeffrey Dixon
Ph.D. University of Toronto
D.D.S. University of Western Ontario
M.Sc. University of Western Ontario
B.Sc. Carleton University
Office: Dental Sciences Building, Room 0075
See Publications by Jeff Dixon on PubMed
Visit: The Bone and Joint Institute
Dr. Jeff Dixon is a Distinguished University Professor in the Department of Physiology and Pharmacology, and School of Dentistry at Western University in London, Canada. He studies the cellular and molecular mechanisms underlying the resorption and formation of mineralized tissues. Collaboratively, he is investigating mechanotransduction in skeletal cells and developing advanced materials for bone regeneration and dental applications. Dixon has served on the Advisory Board of the Institute of Musculoskeletal Health and Arthritis (one of the Canadian Institutes of Health Research, CIHR) and as president of the Canadian Association for Dental Research. From 2001-2009, he directed the CIHR Group in Skeletal Development and Remodeling, an interdisciplinary team focusing on musculoskeletal and dental health research. Dr. Dixon currently serves on the leadership team of the Bone and Joint Institute at Western University.
Grol MW, Brooks PJ, Pereverzev A, Dixon SJ. P2X7 nucleotide receptor signaling potentiates the Wnt/β-catenin pathway in cells of the osteoblast lineage. Purinergic Signal. 2016 Sep;12(3):509-20.
Beaucage KL, Xiao A, Pollmann SI, Grol MW, Beach RJ, Holdsworth DW, Sims SM, Darling MR, Dixon SJ. Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice. Purinergic Signal. 2014;10(2):291-304.
Costa DO, Prowse PD, Chrones T, Sims SM, Hamilton DW, Rizkalla AS, Dixon SJ. The differential regulation of osteoblast and osteoclast activity by surface topography of hydroxyapatite coatings. Biomaterials. 2013 Oct;34(30):7215-26.
Grol MW, Pereverzev A, Sims SM, Dixon SJ. P2 receptor networks regulate signaling duration over a wide dynamic range of ATP concentrations. J Cell Sci. 2013 Aug 15;126(Pt 16):3615-26.
Sims SM, Panupinthu N, Lapierre DM, Pereverzev A, Dixon SJ. Lysophosphatidic acid: a potential mediator of osteoblast-osteoclast signaling in bone. Biochim Biophys Acta. 2013 Jan;1831(1):109-16.
Grol MW, Zelner I, Dixon SJ. P2X7-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells. Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E561-75.
Tanabe N, Wheal BD, Kwon J, Chen HH, Shugg RP, Sims SM, Goldberg HA, Dixon SJ. Osteopontin signals through calcium and nuclear factor of activated T cells (NFAT) in osteoclasts: a novel RGD-dependent pathway promoting cell survival. J Biol Chem. 2011 Nov 18;286(46):39871-81.
Panupinthu N, Rogers JT, Zhao L, Solano-Flores LP, Possmayer F, Sims SM, Dixon SJ. P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. J Cell Biol. 2008 Jun 2;181(5):859-71.
Komarova SV, Pereverzev A, Shum JW, Sims SM, Dixon SJ. Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2643-8.