PH.D. University of Western Ontario
M.Sc. University of Western Ontario
B.Sc. University of Western Ontario
Office: Medical Sciences Building, Room 260
p. 519.661.3484 x. 83484
See Publications by John Ciriello on PubMed
The overall objective of the research program is the elucidation of central and peripheral neuronal mechanisms that control arterial pressure and cardiac function during the development of hypertension and obesity in males and females during intermittent hypoxia, the primary physiological consequence of sleep apnea using a multidisciplinary approach. The techniques employed in the laboratory include:
- neuroanatomical tract tracing methods combined with immunocytochemistry for the identification of neurotransmitters contained within neural pathways
- the identification of gene expression in central structures (real time PCR and Western Immunoblotting)
- ELISA for the identification of neurotransmitters and hormones in the circulation
- the recording of electrical activity from functionally identified single neurons in the central nervous system to investigate their role in circulatory control
- the recording of neuronal membrane properties using patch-clamp techniques
- the recording of cardiovascular variables in the conscious and anesthetized animal
Moreau JM, Ciriello J. Effects of Acute Intermittent Hypoxia on Energy Balance and Hypothalamic Feeding Pathways. Neuroscience. 2013 Sep 13. doi:pii: S0306-4522(13)00778-1. 10.1016/j.neuroscience.2013.09.007. [Epub ahead of print].
Iqbal W, Ciriello J. Effect of maternal chronic intermittent hypoxia during gestation on offspring growth in the rat. Am J Obstet Gynecol. 2013 Aug 24. doi:pii: S0002-9378(13)00867-3. 10.1016/j.ajog.2013.08.027. [Epub ahead of print]
Ciriello J, Caverson MM, McMurray JC, Bruckschwaiger EB. Co-localization of hypocretin-1 and leucine-enkephalin in hypothalamic neurons projecting to the nucleus of the solitary tract and their effect on arterial pressure. Neuroscience. 2013 Oct 10;250:599-613.
Ciriello J, Roder S 17β-Estradiol alters the response of subfornical organ neurons that project to supraoptic nucleus to plasma angiotensin II and hypernatremia. Brain Res. 2013 Aug 14;1526:54-64.
Ciriello J. Plasma leptin inhibits the response of nucleus of the solitary tract neurons to aortic baroreceptor stimulation. Brain Res Bull. 2013 Aug;97:96-103.
Messenger SA, Moreau JM, Ciriello J. Effect of chronic intermittent hypoxia on leptin and leptin receptor protein expression in the carotid body. Brain Res. 2013 Jun 4;1513:51-60.
Ciriello J Leptin in nucleus of the solitary tract alters the cardiovascular responses to aortic baroreceptor activation. Peptides. 2013 Jun;44:1-7.
Ciriello J, Moreau JM. Systemic administration of leptin potentiates the response of neurons in the nucleus of the solitary tract to chemoreceptor activation in the rat. Neuroscience. 2013 Jan 15;229:88-99. doi: 10.1016/j.neuroscience.2012.10.065. Epub 2012 Nov 14.
Ciriello J. Caudal ventrolateral medulla mediates baroreceptor afferent inputs to subfornical organ angiotensin II responsive neurons. Brain Res. 2013 Jan 23;1491:127-35.