Dean Betts

Dean Betts

Professor

PH.D. University of Guelph

M.Sc. University of Western Ontario
B.Sc. University of Western Ontario

Office:  Dental Sciences Building, Room 2022
The Susan Vitali-Lovell Laboratory for Studies in
Fetal Programming of Human Health Risks



p. 519.661.2111 x. 83786

f. 519.661-3827

e. dean.betts@schulich.uwo.ca
Visit:  The Betts Lab Homepage

See Publications by Dean Betts on PubMed

My research program is aimed at understanding the molecular and cellular mechanisms of early embryo development and pluripotent stem cells.  We use unique cell models and molecular cell biology tools to study cellular aging, stem cell function and cellular reprogramming / aging reversal events during early embryo development and in the generation of induced pluripotent stem cells.

Current Projects:

  • Discovering the extra-telomeric roles of telomerase reverse transcriptase (TERT) isoforms in pluripotent stem cellls
  • Deciphering the functional roles of the stress adaptor protein p66Shc in redox regulation of early embryo development and pluripotent stem cell generation/function
  • Examining the biology and utility of canine embryonic stem cells (cESCs) and induced pluripotent stem cells (ciPSCs) for clinical applications
  • Teasing apart the mechanistic roles of metabolism in regulating pluripotent stem cell state and function
  • To determine the utility of microRNAs derived from secreted exosomes as markers of developmental competence of preimplantation embryos


Selected Publications

Tobias IC, Brooks CR, Teichroeb JH, Villagómez DA, Hess DA, Séguin CA, Betts DH (2016). Small molecule induction of canine embryonic stem cells towards naïve pluripotency. Stem Cells and Development 25(16): 1208-1222.

Edwards NA, Watson AJ, Betts DH (2016). P66Shc, a key regulator of metabolism and mitochondrial ROS production is dysregulated by mouse embryo culture. Mol Hum Reprod. 2016 Jul 6. [Epub ahead of print] PMID: 27385725.

Teichroeb JH, Kim J, Betts DH (2016). The Role of Telomeres and Telomerase Reverse Transcriptase Isoforms in Pluripotency Induction and Maintenance. RNA Biol  13(8):707-719.

Betts DH and Tobias IC (2015). Canine embryonic stem cells: Are they ready for clinical applications? Frontiers in Veterinary Science 2, Article 41.

Radan L, Hughes CS, Teichroeb JH, Postovit L-M, Betts DH (2015). Delivering Antisense Morpholino Oligonucleotides to Target Telomerase Splice Variants in Human Embryonic Stem Cells. Methods in Molecular Biology 1341:133-42.

Radan L, Hughes CS, Teichroeb JH, Vieira Zamora FM, Jewer M, Postovit L-M, Betts DH (2014). Microenvironmetal regulation of telomerase isoforms in human embryonic stem cells. Stem Cells and Development 23(17):2046-66.

Betts DH, Bain NT, Madan P (2014). The p66Shc adaptor protein controls oxidative stress response in early bovine embryos. PLoS One 9(1):e86978.

Tobias IC, Brooks CR, Teichroeb JH, Betts DH (2013). Derivation and culture of canine embryonic stem cells. Methods Mol Biol 1074:69-83.

Hall V*, Hinrichs K*, Lazzari G*, Betts DH*, Hyttel P (2013).  Early embryonic development, assisted reproductive technologies, and pluripotent stem cell biology in domestic mammals. Vet J 197(2):128-42. *Equal contributions.

Bain NT, Madan P, Betts DH (2013). Elevated p66Shc is associated with intracellular redox imbalance in developmentally compromised bovine embryos. Mol Reprod Dev 80(1): 22-34.

Hallows SE, Regnault TR, Betts DH (2012). The Long and Short of it: The Role of Telomeres in Fetal Origins of Adult Disease.  Journal of Pregnancy 638476.

Hughes C, Radan L, Stanford W, Betts DH, Postovit L-M, Lajoie GA (2012). Mass Spectrometry-Based Proteomics Analysis of the Matrix Microenvironment in Pluripotent Stem Cell Culture. Mol Cell Proteomics 11(12):1924-1936.

Taboski MAS, Sealey DCF, Tayade C, Betts DH=, and Harrington LA= (2012). Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis.  Cell Reports 1:91-98. =Co-senior authors.

Teichroeb JH, Betts DH & Vaziri H (2011). Suppression of the imprinted gene NNAT and X-chromosome gene activation in isogenic human iPS cells. PLoS ONE 6(10):e23436.

Hughes CS, Radan L, Betts DH, Postovit, LM, Lajoie GA (2011). Proteomic Analysis of Extracellular Matrices used in Human Embryonic Stem Cell Culture. Proteomics 11(20)3983-91.

Wilcox J, Lai JKY, Semple E, Brisson BA, Gartley C, Armstrong JN, Betts DH (2011). Synaptically-Competent Neurons Derived from Canine Embryonic Stem Cells by Lineage Selection with EGF and Noggin. PLoS ONE 6(5):e19768.

Dyce PW, Liu J, Tayade C, Kidder GM, Betts DH, Li J (2011). In Vitro and In Vivo Germ Line Potential of Stem Cells Derived from Newborn Mouse Skin. PLoS ONE 6(5):e20339.

Figueroa RJ, Koch TG, and Betts DH (2011). Osteogenic differentiation of equine cord blood MSCs within coralline hydroxyapatite scaffolds in vitro. Vet Comp Orthop Traumatol 24(5):354-62.

Bain NT, Madan P and Betts DH (2011). The early embryo response to intracellular ROS is developmentally regulated.  Reprod Fertil Dev 23(4):561-575.