Schulich school of Medicine and Dentistry logo Schulich Department of Pathology and Laboratory Medicine

Tao Rui

rui

Assistant Professor, Scientist

MD, Nanjing Medical University
MSc, Shanghai Medical University
PhD, Wuhan University

Office: VRL A6-138, LHSC-VH
Phone: (519) 685-8500 Ext. 55075
Fax: (519) 685-8341
E-mail: trui@uwo.ca

Research Activities

Keywords: myocardial dysfunction, ischemia/reperfusion-injury, cardiomyocyte-cardiac fibroblast interaction

Description of Research Activities: Research in my group focuses on understanding molecular mechanisms involved in myocardial dysfunction/injury related to sepsis, ischemia/reperfusion and diabetic myocardial fibrosis.  With a cardiomyocyte-fibroblast co-culture system, we are currently investigating role of cell-cell interactions in the induction of myocardial dysfunction in various pathological conditions . Specifically, 1) we are studying how cardiomyocyte to affect the function of fibroblast to increase collagen production in diabetic condition; 2) we are addressing how fibroblast to decrease cardiomyocyte contractility under septic condition. In this topic, we aim to understand the role of NLRP3 inflammasome activation in fibroblast and its impact on the myocardial function in sepsis.