PhD University of Cologne, Germany
Dipl Biologist (Master of Science)
Office: Health Sciences Addition, Room 408A
Phone: (519) 661-2111 Ext. 86874
Fax: (519) 661-3370
Visit: The Duennwald Lab Website
Keywords: protein misfolding, neurodegenerative diseases, cellular protein quality control, protein-protein interactions, yeast models
Description of Research Activities: Environmental factors, genetic mutations, and aging impair cellular protein quality control in many diseases, predominantly neurodegenerative diseases causing protein misfolding and its pathological consequences. Our research aims to decipher the cellular mechanisms underpinning the interplay of failing cellular protein quality control and protein misfolding in neurodegenerative diseases, such as Huntington’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis (ALS). In a combination of approaches, we work to address basic questions regarding the pathogenesis of these protein misfolding diseases.