PhD McGill University
Office: Dental Sciences Building, Room 4037
Phone: (519) 661-2111 Ext. 84305
Keywords: inflammation, functional genetics, molecular regulation, Th2 immunity, allergic disease
Description of Research Activities: Dr. Cameron's laboratory is focused on understanding how naturally occurring genetic variation influences development and trajectory of inflammatory disease. Her research relies on expertise in the areas of cellular and molecular immunology, functional genetics/genomics and translational science, including patient recruitment and clinical characterization. Dr. Cameron's work on CRTh2, a prostaglandin D 2 (PGD2) receptor expressed by Th2 cells, has shown that single nucleotide polymorphisms (SNPs) in CRTh2 are associated with increased frequency of allergic conditions including asthma due to elevated CRTh2 expression and function. Dr. Cameron is also studying the role of CRTh2 in severe asthma and whether environmental factors such as diet and viral infection may interact with CRTh2 and its variants to modulate disease susceptibility and symptoms. Techniques used to perform this research include: i) isolation and culture of primary human T cells, ii) flow cytometry, iii) molecular cloning, iv) reporter assays, v) EMSA and ChIP, vi) RNA/DNA isolation and qRT-PCR, vii) microarray analyses, viii) patient recruitment and database management/analysis.
Research Opportunities: Technologist/Post-Doctoral Fellow/Graduate Student/Volunteer positions are currently available, for the right person.