Postdoc: Howard Hughes Medical Institute, The University of Chicago, USA
PhD: Western University, Canada
Office: Dental Sciences Building 3007K
Lab Website: http://publish.uwo.ca/~rdekoter/
Area of Study:
Specializes in nuclear proteins called transcription factors, using animal models and various methods to better understand how gene mutations can disrupt those proteins and subsequently cause immune system diseases such as leukemia and primary immunodeficiency.
The goal of our research is to identify genetic causes of diseases affecting the immune system, including primary immunodeficiency and leukemia. These diseases can be caused by mutation of genes encoding transcription factors. We are particularly interested in highly related transcription factors of the E26 transformation-specific (ETS) family called PU.1, Spi-B, and Spi-C. These proteins play diverse roles in regulating development and function of B lymphocytes and myeloid cells. We use a variety of methods to perform these studies including genetically modified mouse models, primary cell culture, chromatin immunoprecipitation, and gene expression analysis.