John McCormick

Professor (Western University)

Scientist (Lawson Health Research Institute)

Postdoc:  University of Minnesota, USA

Postdoc:  North Carolina State University, USA

BSc:  Queen's University, Canada

 

Office:  Siebens Drake Research Institute, Room 131

Phone:  519.661.3309

Email:  john.mccormick@uwo.ca  

Lab Website:  http://publish.uwo.ca/~jmccorm8/ 

Area of Study:

Bacterial toxins of Streptococcus pyogenes and Staphylococcus aureus

Fields of Interest:

-Staphylococcus aureus
-Streptococcus pyogenes
-Molecular microbiology
-Immunology
-Host-response
-Infection models

Research Profile

Our laboratory has a primary focus on bacterial exotoxins produced by the bacterial pathogens Streptococcus pyogenes and Staphylococcus aureus. One major focus is on the bacterial superantigens which function by directly activating T cells of the adaptive immune system, and we are interested in understanding how the toxins contribute to both colonization and disease. In addition, we are interested in mechanistic studies of toxic shock syndrome, and in particular the regulatory cues that control expression of the superantigen toxic shock syndrome toxin-1 (TSST-1). Lastly, we are engineering superantigens for use as targeted anti-cancer immunotherapeutics.

Publication Profile

Pubmed

Google Scholar

ORCID