Schulich school of Medicine and Dentistry logo Li Lab Schulich Medicine & Dentistry



Kyle K. Biggar, Francois Charih, Huadong Liu, Yasser B. Ruiz-Blanco, Leanne Stalker, Anand Chopra, Justin Connolly, Hemanta Adhikary, Kristin Frensemier, Matthew Hoekstra, Marek Galka, Qi Fang, Christopher Wynder, William L. Stanford, James R. Green, and Shawn S.-C. Li (2020) Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome. Cell Reports 32, 107896, July 14, 2020 [ Link ]

Liya Ming, Yang Zou, Yiming Zhao, Luna Zhang, Ningning He, Zhen Chen, Shawn S‐C. Li, Lei Li (2020) MMS2plot: An R Package for Visualizing Multiple MS/MS Spectra for Groups of Modified and Non-Modified Peptides. Proteomics. 2020 Jul 8:e2000061. [ PubMed ]

Rakesh Joshi, Lyugao Qin, Xuan Cao, Shanshan Zhong, Courtney Voss, Weiping Min and Shawn S. C. Li (2020) DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA. J Biol Chem. 2020 Jan 10;295(2):645-656. [ PubMed ]

Nileeka Balasuriya, Norman E. Davey, Jared L. Johnson, Huadong Liu, Kyle K. Biggar, Lewis C. Cantley, Shawn Shun-Cheng Li and Patrick O'Donoghue (2020) Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1). J Biol Chem. 2020 Jun 12;295(24):8120-8134. [ PubMed ]



Ran Wei, Xuguang Liu, Courtney Voss, Wentao Qin, Lina Dagnino, Lei Li, Marc Vigny, Shawn Shun-Cheng Li (2019) NUMB regulates the endocytosis and activity of the anaplastic lymphoma kinase in an isoform-specific manner. J Mol Cell Biol. 2019 Dec 23;11(11):994-1005. [ PubMed ]

Sally Esmail, Shawn S.-C. Li (2019) Single-Layer β Sheets as Versatile Protein-Binding Modules. Structure. 2019 Sep 3;27(9):1352-1354. [ PubMed ]

Christina Z. Chung, Nileeka Balasuriya, Emad Manni, Xuguang Liu, Shawn Shun-Cheng Li, Patrick O’Donoghue & Ilka U. Heinemann (2019) Gld2 activity is regulated by phosphorylation in the N-terminal domain. RNA Biol. 2019 Aug;16(8):1022-1033. [ PubMed ]

Frederick A. Dick and Shawn Shun-Cheng Li (2019) Drugging RB1 Deficiency: Synthetic Lethality with Aurora Kinases. Cancer Discov. 2019 Feb;9(2):169-172. [ PubMed ]

Huadong Liu, Haiming Huang, Courtney Voss, Tomonori Kaneko, Wentao Qin, Sachdev Sidhu and Shawn Shun-Cheng Li (2019) Surface loops in a single SH2 domain are capable of encoding the spectrum of specificity of the SH2 family. Mol Cell Proteomics. 2019 Feb;18(2):372-382. [ PubMed ]

Jie Deng, An-Dong Liu, Guo-Qing Hou, Xi Zhang, Kun Ren, Xuan-Zuo Chen, Shawn S. C. Li, Yao-Song Wu and Xuan Cao (2019) N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling. J Exp Clin Cancer Res. 2019 Jan 3;38(1):2 [ PubMed ]

Gianluca Veggiani, Haiming Huang, Bradley P. Yates, Jiefei Tong, Tomonori Kaneko, Rakesh Joshi, Shawn S-C Li, Michael F. Moran, Gerald Gish, Sachdev S. Sidhu (2019) Engineered SH2 domains with tailored specificities and enhanced affinities for phosphoproteome analysis. Protein Science. Feb;28(2):403-413 [ PubMed ]



Pengzhi Wang, Jing Liang, Linda Z. Shi, Yi Wang, Ping Zhang, Mingxing Ouyang, Daryl Preece, Qin Peng, Lunan Shao, Jason Fan, Jie Sun, Shawn S. Li, Michael W. Berns, Huimin Zhao, and Yingxiao Wang (2018) Visualizing Spatiotemporal Dynamics of Intercellular Mechanotransmission upon Wounding. ACS Photonics. 2018 Sep 19;5(9):3565-3574. [ PubMed ]

Ali Zhang, Tanner M. Tessier, Kristianne J. C. Galpin, Cason R. King, Steven F. Gameiro, Wyatt W. Anderson, Ahmed F. Yousef, Wen T. Qin, Shawn S. C. Li and Joe S. Mymryk (2018) The Transcriptional Repressor BS69 is a Conserved Target of the E1A Proteins from Several Human Adenovirus Species. Viruses, 10, 662 [ PubMed ]

Rui Wang, Mei Huang, Linting Li, Tomonori Kaneko, Courtney Voss, Liang Zhang, Jiang Xia, and Shawn S.C. Li (2018) Affinity Purification of Methyllysine Proteome by Site-Specific Covalent Conjugation. Anal. Chem. 90, 23, 13876-13881 [ PubMed ]

Tomonori Kaneko, Peter J. Stogios, Xiang Ruan, Courtney Voss, Elena Evdokimova, Tatiana Skarina, Amy Chung, Xiaoling Liu, Lei Li, Alexei Savchenko, Alexander W. Ensminger & Shawn S.-C. Li (2018) Identification and characterization of a large family of superbinding bacterial SH2 domains. Nature Communications 9:4549 [ PubMed ]

Enhui Wu, Kun Feng, Rui Shi, Rui Lv, Fuzhong Ouyang, Shawn S. C. Li, Jun Zhong and Jian Liu (2018) Hybrid CuCoO–GO enables ultrasensitive detection of antibiotics with enhanced laser desorption/ionization at nano-interfaces. Chem. Sci. [ Link ]

Ran Wei, Tomonori Kaneko, Xuguang Liu, Huadong Liu, Lei Li, Courtney Voss, Eric Liu, Ningning He, Shawn S.-C. Li (2018) Interactome mapping uncovers a general role for Numb in protein kinase regulation. Mol Cell Proteomics. Nov;17(11):2216-2228. [ PubMed ]

Claudia Walliser, Martin Wist, Elisabeth Hermkes, Yuan Zhou, Anja Schade, Jennifer Haas, Julia Deinzer, Laurent Désiré, Shawn S.C. Li, Stephan Stilgenbauer, Joshua D. Milner and Peter Gierschik (2018) Functional characterization of phospholipase C-γ2 mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder. Oncotarget. 9:34357-34378. [ PubMed ]

Nileeka Balasuriya, McShane McKenna, Xuguang Liu, Shawn S. C. Li and Patrick O’Donoghue (2018) Phosphorylation-Dependent Inhibition of Akt1. Genes (Basel). Sep 7;9(9). pii: E450. [ PubMed ]

Bizhu Chu, An He, Yeteng Tian, Wan He, Peizhong Chen, Jintao Hu, Ruilian Xu, Wenbin Zhou, Mingjie Zhang, Pengyuan Yang, Shawn S. C. Li, Ying Sun, Pengfei Li, Tony Hunter, and Ruijun Tian (2018) Photoaffinity-engineered protein scaffold for systematically exploring native phosphotyrosine signaling complexes in tumor samples. Proc Natl Acad Sci U S A. Sep 18;115(38):E8863-E8872. [ PubMed ]

Rui Wang, Pete Y. M. Leung, Feng Huang, Qingzhuang Tang, Tomonori Kaneko, Mei Huang, Zigang Li, Shawn S. C. Li, Yi Wang, and Jiang Xia (2018) Reverse Binding Mode of Phosphotyrosine Peptides with SH2 Protein. Biochemistry. Sep 4;57(35):5257-5269. [ PubMed ]

An-dong Liu, Hui Xu, Ya-nan Gao, Dan-ni Luo, Zhao-feng Li, Courtney Voss, Shawn S. C. Li and Xuan Cao (2018) (Arg)9-SH2 superbinder: a novel promising anticancer therapy to melanoma by blocking phosphotyrosine signaling. J Exp Clin Cancer Res. Jul 5;37(1):138. [ PubMed ]

Nileeka Balasuriya, Maya T. Kunkel, Xuguang Liu, Kyle K. Biggar, Shawn S.-C. Li, Alexandra C. Newton and Patrick O'Donoghue (2018) Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity. J Biol Chem. Jul 6;293(27):10744-10756. [ PubMed ]

Sahil S. Singal, Karen Nygard, Manthan R. Dhruv, Kyle Biggar, Majida A. Shehab, Shawn S.-C. Li, Thomas Jansson, and Madhulika B. Gupta (2018) Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2β, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay. Am J Pathol. Jan;188(1):111-124. [ PubMed ]


Jinwei Zhu, Qingqing Zhou, Yuan Shang, Hao Li, Mengjuan Peng, Xiao Ke, Zhuangfeng Weng, Rongguang Zhang, Xuhui Huang, Shawn S.C. Li, Guoping Feng, Youming Lu, and Mingjie Zhang. (2017) Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs. Cell Rep. Dec 26;21(13):3781-3793 [ PubMed ]

Kyle K. Biggar, Zhentian Wang, and Shawn S.-C. Li (2017) SnapShot: Lysine Methylation beyond Histones. Mol Cell. 2017 Dec 7;68(5):1016-1016.e1 [ PubMed ]

Majida Abu Shehab, Kyle Biggar, Sahil Sagar Singal, Karen Nygard, Shawn Shun-Cheng Li, Thomas Jansson, Madhulika B. Gupta (2017)  Exposure of decidualized HIESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity. Mol Cell Endocrinol. Sep 5;452:1-14. [ PubMed ]

Palaniraja Thandapani, Anthony M. Couturier, Zhenbao Yu, Xing Li, Jean-François Couture, Shawn Li, Jean-Yves Masson and Stéphane Richard (2017) Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress. Oncotarget. May 22;8(39):64918-64931 [ PubMed ]

Zhenzhen Deng, Mingming Dong, Yan Wang, Jing Dong, Shawn S.-C. Li, Hanfa Zou, and Mingliang Ye (2017) Biphasic Affinity Chromatographic Approach for Deep Tyrosine Phosphoproteome Analysis. Anal Chem. Feb 21;89(4):2405-2410 [ PubMed ]

Haiming Huang , Tomonori Kaneko , Sachdev S. Sidhu , Shawn S. C. Li (2017) Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain. Methods Mol Biol. 1555:225-254 [ PubMed ]

Huadong Liu, Courtney Voss, Shawn S. C. Li (2017) Using Reciprocal Protein-Peptide Array Screening to Unravel Protein Interaction Networks. Methods Mol Biol. 1555:429-436 [ PubMed ]

Shawn S. C. Li , Lei Li (2017) SH2 Ligand Prediction–Guidance for In-Silico Screening. Methods Mol Biol. 1555:77-81 [ PubMed ]

Jiefei Tong, Biyin Cao, Gregory D. Martyn, Jonathan R. Krieger, Paul Taylor, Bradley Yates, Sachdev S. Sidhu, Shawn S.C. Li, Xinliang Mao, Michael F. Moran (2017) Protein-phosphotyrosine proteome profiling by superbinder-SH2 domain affinity purification mass spectrometry, sSH2-AP-MS. Proteomics. Mar;17(6) [ PubMed ]

Roméo Sébastien Blanc, Gillian Vogel, Xing Li, Zhenbao Yu, Shawn Li and Stéphane Richard (2017) Arginine methylation by PRMT1 regulates muscle stem cell fate. Mol Cell Biol. Jan 19;37(3) [ Pubmed ]

2016 and earlier

Yangyang Bian, Lei Li, Mingming Dong, Xuguang Liu, Tomonori Kaneko, Kai Cheng, Huadong Liu, Courtney Voss, Xuan Cao, Yan Wang, David Litchfield, Mingliang Ye, Shawn S-C Li & Hanfa Zou (2016) Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder. Nature Chemical Biology Nov;12(11):959-966. [ PubMed ]

Arunas Kazlauskas, Constanze Schmotz, Tapio Kesti, Jussi Hepojoki, Iivari Kleino, Tomonori Kaneko, Shawn Shun-Cheng Li and Kalle Saksela (2016) Large-scale screening of preferred interactions of human SH3 domains using native target proteins as affinity ligands. Molecular & Cellular Proteomics Oct;15(10):3270-3281. [ PubMed ]

Rebecca B Delconte, Tatiana B Kolesnik, Laura F Dagley, Jai Rautela, Wei Shi, Eva M Putz, Kimberley Stannard, Jian-Guo Zhang, Charis Teh, Matt Firth, Takashi Ushiki, Christopher E Andoniou, Mariapia A Degli-Esposti, Phillip P Sharp, Caroline E Sanvitale, Giuseppe Infusini, Nicholas P D Liau, Edmond M Linossi, Christopher J Burns, Sebastian Carotta, Daniel H D Gray, Cyril Seillet, Dana S Hutchinson, Gabrielle T Belz, Andrew I Webb, Warren S Alexander, Shawn S Li, Alex N Bullock, Jeffery J Babon, Mark J Smyth, Sandra E Nicholson & Nicholas D Huntington (2016) CIS is a potent checkpoint in NK cell-mediated tumor immunity. Nature Immunology Jul;17(7):816-24 [ PubMed ]

Niyati Malkani, Kyle Biggar, Majida Abu Shehab, Shawn Shun-Cheng Li, Thomas Jansson, Madhulika B. Gupta (2016) Increased IGFBP-1 phosphorylation in response to leucine deprivation is mediated by CK2 and PKC. Mol Cell Endocrinol. 2016 Apr 15;425:48-60 [ PubMed ]

Mohammad B. Hossain, Rehnuma Shifat, David G. Johnson, Mark T. Bedford, Konrad R. Gabrusiewicz, Nahir Cortes-Santiago, Xuemei Luo, Zhimin Lu, Ravesanker Ezhilarasan, Erik P. Sulman, Hong Jiang, Shawn S. C. Li, Frederick F. Lang, Jessica Tyler, Mien-Chie Hung, Juan Fueyo, Candelaria Gomez-Manzano (2016) TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Science Advances Apr 1;2(4):e1501290. [ PubMed ]

Ian Dameril, Kyle K. Biggar, Majida Abu Shehab, Shawn Shun-Cheng Li, Thomas Jansson, and Madhulika B. Gupta (2016) Hypoxia increases IGFBP-1 phosphorylation mediated by mTOR inhibition. Mol Endocrinol. Feb;30(2):201-16 [ PubMed ]

Xuan Cao, Tomonori Kaneko, Jenny S. Li, An-Dong Liu, Courtney Voss & Shawn S. C. Li (2015) A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration. Nature Communications. Jul 13;6:7721. [ PubMed ]

Huadong Liu, Lei Li, Courtney Voss, Feng Wang, Juewen Liu, and Shawn Shun-Cheng Li (2015) A Comprehensive Immunoreceptor Phosphotyrosine-based Signaling Network Revealed by Reciprocal Protein–Peptide Array Screening. Molecular & Cellular Proteomics. Jul;14(7):1846-58. [ PubMed ]

Jonathan A. Cooper, Tomonori Kaneko, Shawn S. C. Li (2015) Cell Regulation by Phosphotyrosine-Targeted Ubiquitin Ligases. Molecular and Cellular Biology. Jun 1;35(11):1886-97. [ PubMed ]

Nicole St-Denis, Michelle Gabriel, Jacob P. Turowec, Gregory B. Gloor, Shawn S.-C. Li, Anne-Claude Gingras, David W. Litchfield (2015) Systematic investigation of hierarchical phosphorylation by protein kinase CK2. Journal of Proteomics  Apr 6;118:49-62 [ PubMed ]

Kyle K. Biggar and Shawn S.C. Li (2015) Non-histone protein methylation as a regulator of cellular signal transduction.  Nat Rev Mol Cell Biol  Jan;16(1):5-17 [  PubMed  ]

Einat Levy-Apter, Eynat Finkelshtein, Vidyasiri Vemulapalli, Shawn S. –C. Li, Mark. T. Bedford, Ari Elson (2014) Adaptor Protein GRB2 Promotes Src Tyrosine Kinase Activation and Podosomal Organization by Protein-tyrosine Phosphatase ϵ in Osteoclasts.  J Biol Chem.  Dec 26;289(52):36048-58 [ PubMed ]

Jacob P. Turowec, Stephanie A. Zukowski, James D. R. Knight, David M. Smalley, Lee M. Graves, Gary L. Johnson, Shawn S. C. Li, Gilles A. Lajoie, David W. Litchfield (2014) An Unbiased Proteomic Screen Reveals Caspase Cleavage is Positively and Negatively Regulated by Substrate Phosphorylation.  Mol Cell Proteomics.  May;13(5):1184-97 [ PubMed ]

Ylva Ivarsson, Roland Arnold, Megan McLaughlin, Satra Nim, Rakesh Joshi, Debashish Ray, Bernard Liu, Joan Teyra, Tony Pawson, Jason Moffat, Shawn Shun-Cheng Li, Sachdev S. Sidhu and Philip M. Kim (2014) Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. Proc Natl Acad Sci U S A  Feb 18;111(7):2542-7  [ PubMed ]

Shelley DE Sandiford, Karen AM Kennedy, Xiaojun Xie, J Geoffrey Pickering and Shawn SC Li (2014) Dual Oxidase Maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation  Cell Communication and Signaling  Jan 11;12(1):5. [ PubMed

Huadong Liu, Marek Galka, Eiichiro Mori, Xuguang Liu, Yu-fen Lin, Ran Wei, Paula Pittock, Courtney Voss, Gurpreet Dhami, Xing Li, Masaaki Miyaji, Gilles Lajoie, Benjamin Chen, and Shawn Shun-Cheng Li (2013) A Method for Systematic Mapping of Protein Lysine Methylation Identifies Functions for HP1beta in DNA Damage Response  Mol. Cell  Jun 6;50(5):723-35. [ PubMed

Gurpreet K Dhami, Huadong Liu, Marek Galka, Courtney Voss, Ran Wei, Kimberly Muranko, Tomonori Kaneko, Sean P Cregan, Lin Li, Shawn Shun-Cheng Li (2013) Dynamic methylation of Numb by Set8 regulates its binding to p53 and apoptosis  Mol. Cell  May 23;50(4):565-76. [ PubMed

Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T. (2013) Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.  Cell  Feb 28;152(5):1008-20. [ PubMed

Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li SS, Teasdale RD, Collins BM. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.  Proc Natl Acad Sci U S A  Feb 19;110(8):E643-52. [ PubMed

Zhao B, Tan PH, Li SS, Pei D. (2013) Systematic characterization of the specificity of the SH2 domains of cytoplasmic tyrosine kinases.  J Proteomics.  Apr 9;81:56-69. [ PubMed

Sargeant DP, Gryk MR, Maciejewski MW, Thapar V, Kundeti V, Rajasekaran S, Romero P, Dunker K, Li SC, Kaneko T, Schiller MR. (2012) Secondary structure, a missing component of sequence-based minimotif definitions.  PLoS One.  7(12):e49957 [ PubMed

Kaneko T, Joshi R, Feller SM, Li SS. (2012) Phosphotyrosine recognition domains: the typical, the atypical and the versatile.  Cell Commun Signal.  Nov 7;10(1):32 [ PubMed

Tomonori Kaneko, Haiming Huang, Xuan Cao, Xing Li, Chengjun Li, Courtney Voss, Sachdev S. Sidhu, and Shawn S. C. Li. (2012) Superbinder SH2 Domains Act as Antagonists of Cell Signaling.  Sci. Signal.  25 September 2012 Vol. 5, Issue 243, p. ra68 [ PubMed

Cao X, Voss C, Zhao B, Kaneko T, Li SS. (2012) Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation.  Proc. Natl. Acad. Sci. USA  2012 Jan 31;109(5):1455-60  [ PubMed]

Namanja AT, Li YJ, Su Y, Wong S, Lu J, Colson LT, Wu C, Li SS, Chen Y. (2012) Insights into High Affinity Small Ubiquitin-like Modifier (SUMO) Recognition by SUMO-interacting Motifs (SIMs) Revealedby a Combination of NMR and Peptide Array Analysis.  J. Biol. Chem.  2012 Jan 27;287(5):3231-40. Epub 2011 Dec 6.  [ PubMed]

Kennedy KA, Sandiford SD, Skerjanc IS, Li SS. (2012) Reactive oxygen species and the neuronal fate.  Cell Mol Life Sci  2012 Jan;69(2):215-21  [ PubMed]

Li L, Tibiche C, Fu C, Kaneko T, Moran M, Schiller M, Li S, Wang E. (2012) The human phosphotyrosine signaling network: Evolution and hotspots of hijacking in cancer.  Genome Res.  Jul;22(7):1222-30.  [ PubMed]

Li L, Zhao B, Du J, Zhang K, Ling CX, Li SS. (2011) DomPep-A General Method for Predicting Modular Domain-Mediated Protein-Protein Interactions.  PLoS One.  2011;6(10):e25528.  [ PubMed]

Shen SL, Qiu FH, Dayarathna TK, Wu J, Kuang M, Li SS, Peng BG, Nie J. (2011) Identification of Dermcidin as a novel binding protein of Nck1 and characterization of its role in promoting cell migration.  Biochim Biophys Acta.  2011 Jun;1812(6):703-10. Epub 2011 Mar 21.  [ PubMed]

Duncan JS, Turowec JP, Duncan KE, Vilk G, Wu C, Lüscher B, Li SS, Gloor GB, Litchfield DW. (2011) A peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling.  Sci. Signal.  2011 May 10;4(172):ra30.  [ PubMed]

Kaneko T, Sidhu SS, Li SS. (2011) Evolving specificity from variability for protein interaction domains.  Trends Biochem Sci.  2011 Jan 10.  [ PubMed]

Shao X, Tan CS, Voss C, Li SS, Deng N, Bader GD.(2011) A regression framework incorporating quantitative and negative interaction data improves quantitative prediction of PDZ domain-peptide interaction from primary sequence.  Bioinformatics.  2011 Feb 1;27(3):383-90.  [ PubMed]

Liu H, Galka M, Iberg A, Wang Z, Li L, Voss C, Jiang X, Lajoie G, Huang Z, Bedford MT, Li SSC. (2010) Systematic Identification of Methyllysine-Driven Interactions for Histone and Nonhistone Targets.  J. Proteome Res.  29 (11), 5827¨C5836.  [ PubMed]

Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, Mackenzie F, Pan P, Li SSC*, Wang H*, Min J*. (2010) Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).  Proc. Natl. Acad. Sci. USA  . 2010 Oct 25.  [ PubMed]

Zadjali F, Pike AC, Vesterlund M, Sun J, Wu C, Li SSC, Rönnstrand L, Knapp S, Bullock AN, Flores-Morales A. (2011) Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.  J Biol Chem  . Jan 7;286(1):480-90.  [ PubMed]

Xie X, Hu J, Liu X, Qin H, Percival-Smith A, Rao Y, and Li, S.S.C. NIP/DuoxA is essential for Drosophila embryonic development and regulates oxidative stress response. (2010)  Int J Biol Sci.  11;6(3):252-67.  [ PubMed]

Tomonori Kaneko, Haiming Huang, Bing Zhao, Lei Li, Courtney Voss, Martin Schiller, Shawn SC Li (2010) Loops govern SH2 domain specificity by controlling access to binding pockets.  Science Signaling.  4 May 2010: ra34.  [ PubMed]

Karen A.M. Kennedy, Elena A Ostrakhovitch, Shelley DE Sandiford, Elaine Fok, Wing Y. Chang, Ilona S. Skerjanc, William L. Stanford, Shawn SC Li (2010) Mammalian numb interacting protein1/dual oxidase maturation factor1 directs neuronal fate in stem cells.  J. Biol. Chem.  Mar  16.  [ PubMed]

Wang Z. & Li SSC (2010) Numb: a new player in EMT.  Cell Adh. MigrApr 16;4(2).  [ PubMed]   SPA

Ostrakhovitch EA, Li SSC (2010) NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics.  Breast Cancer Res. Tr.  119(3):773-86  .  [ PubMed]   SPA

Duncan JS, Turowec JP, Vilk G, Li SSC, Gloor GB, Litchfield DW (2010) Regulation of cell proliferation and survival: Convergence of protein kinases and caspases.  Biochim Biophys Acta.  804(3):505-10.  [ PubMed]    

Iosef C. Vilk G, Gkourasas T,  LeeKJ,  Chen BJ, Fu P, Bach LA, Gupta M, Li SSC, Han VKM  . (2010) Insulin-like growth factor binding protein 6 (IGFBP-6) interacts with DNA-end binding protein Ku80 to reduce cell proliferation and induce apoptosis.  Cell Signal.  2010 Feb. 24.  [ PubMed]   C

Wang, Z., Sandiford, S., Wu, C. and Li, SSC (2009) Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling.  EMBO J.  28: 2360-73.  [ PubMed]   SPA

Wu C, Li SSC. (2009)  CelluSpots: A Reproducible Means of Making Peptide Arrays for the Determination of SH2 Domain Binding Specificity.  Methods Mol. Biol.  570:197-202.  [ PubMed]   SPA

Li SSC, Wu C. (2009)  Using Peptide array to identify binding motifs and interaction networks for modular domains.  Methods Mol Biol  . 570:67-76.  [ PubMed]   SPA

Kennedy K, Porter T, Mehta V, Ryan SD, Price F, Peshdary V, Karamboulas C, Savage J, Drysdale TA, Li SSC, Bennett SA, and Skerjanc IS (2009) Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by Bone Morphogenetic Protein 4 but not dominant negative ?-catenin.  BMC Biol.  2009 Oct 8;7:67.  [ PubMed]   CPA

Li C, Schibili D, Li SSC (2009) The XLP Syndrome protein SAP interacts with SH3 proteins to regulate T cell signaling and proliferation.  Cell Signal  .21(1):111-9.  [ PubMed]   SPA

Ostrakhovitch EA, Wang, Y. &  Li SS  C(2009) SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux.  Cell Signal.  21(4):540-50.  [ PubMed]   SPA

Cheng Z, Tang Y, Chen Y, Kim S, Liu H,  Li SSC, Gu W, Zhao Y. (2009) Molecular characterization of propionyllysines in non-histone proteins.  Mol Cell Proteomics  .8(1):45-52.  [ PubMed]   C

Li C, Chung B, Tao J, Iosef C, Aoukaty A, Wang Y, Tan R, Li SS. (2008) The X-linked lymphoproliferative syndrome gene product SAP regulates B cell function through the FcgammaRIIB receptor.  Cell Signal.  2008 Jul 6.  [ PubMed]

Vilk G, Weber JE, Turowec JP, Duncan JS, Wu C, Derksen DR, Zien P, Sarno S, Donella-Deana A, Lajoie G, Pinna LA, Li SS, Litchfield DW. (2008) Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells.  Cell Signal.  2008 Jul 6.  [ PubMed]

Blasutig IM, New LA, Thanabalasuriar A  , Dayarathna TK, Goudreault M, Quaggin SE, Li SS, Gruenheid S, Jones N, Pawson T.  (2008)Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization.  Mol Cell Biol.  28(6):2035-46.  [ PubMed]

Cheng Z, Tang Y, Chen Y, Kim S, Liu H, Li SS, Gu W, Zhao Y.  (2008)Molecular characterization of propionyllysines in non-histone proteins.  Mol Cell Proteomics.  2008 Aug 26.  [ PubMed]

Kaneko T, Li L, Li SS-C.  (2008)The SH3 domain--a family of versatile peptide- and protein-recognition module.  Front Biosci.  13:4938-52.  [ PubMed]

Miller ML, Jensen LJ, Diella F, Jorgensen C, Li L, Sicheritz-Ponten T, Knapp S, Blom N, Li SS-C, Bork P, Cesareni G, Pawson T, Turk BE, Yaffe MB, Brunak S and Linding R.  (2008)Linear motif atlas for phosphorylation-dependent signaling.  Science Signal  . 1(35):ra2.  [ PubMed]

Li L, Wu C, Huang H, Zhang K, Gan J, Li SS.  (2008)Prediction of phosphotyrosine signaling networks using a scoring matrix-assisted ligand identification approach.  Nucleic Acids Res.  2008 Apr 19.  [ PubMed]

Ai X, Semesi A, Yee A, Arrowsmith CH, Choy WY, Li SS.  (2008)The hypothetical protein Atu4866 from Agrobacterium tumefaciens adopts a streptavidin-like fold.  Protein Sci.  2008 Jan;17(1):154-8.  [ PubMed]

Iosef C, Gkourasas T, Jia CY, Li SS, Han VK.  (2008)A functional nuclear localization signal in insulin-like growth factor binding protein-6 mediates its nuclear import.  Endocrinology.  2008 Mar;149(3):1214-26.  [ PubMed]

Huang H, Li L, Wu C, Schibli D, Colwill K, Ma S, Li C, Roy P, Ho K, Songyang Z, Pawson T, Gao Y, Li SS.  (2008)Defining the specificity space of the human SRC homology 2 domain.  Mol Cell Proteomics.  2008 Apr;7(4):768-84.  [ PubMed]

Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY.  (2007)Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold.  J Biomol NMR.  2007 Aug;38(4):353-8.  [ Pubmed]

Pai MT, Tzeng SR, Kovacs JJ, Keaton MA, Li SS, Yao TP, Zhou P.  (2007)Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.  J Mol Biol.  2007 Jul 6; 370(2):290-302.  [ PubMed]

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