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Dentistry Seminar Series - David Holdsworth, PhD

Holdsworth Dec 17 - Schulich Dentistry Research Seminar Series presents a lecture by David W. Holdsworth, PhD, Dr. Sandy Kirkley Chair in Musculoskeletal Research, Professor, Departments of Medical Biophysics and Surgery, Scientist, Robarts Research Institute, Western University. 
Title: Micro-CT and 3D Printing for Dental Applications. 
12:30pm | MSB 148 | All Welcome

Invited Lecturer

Walter Siqueira, DDS, PhD, Schulich Dentistry Oral Biology, was invited to the USA to present two lectures:
     New York University - Dental School | December 10 2015
     Topic: Deciphering the clinical relevance of the acquired enamel pellicle

     Johnson & Johnson Inc. | December 11 2015
     Topic: Acquired enamel pellicle: a multiprotein layer with "bipolar disorder"


Dentistry Seminar Series - Douglas Hamilton, PhD

drh Nov 11 - Schulich Dentistry Research Seminar Series presents a lecture by Douglas Hamilton, PhD, Chair and Associate Professor of Oral Biology, Dentistry, Western University. 

Title: Multifaceted role of the matricellular protein periostin in dental health, disease and healing. 12:30pm | MSB 148 | All Welcome

Invited Panelist 

Walter Siqueira, DDS, PhD. Schulich Dentistry Oral Biology, was an Invited Panelist for Western Graduate & Postdoctoral Studies, Western University. November 17, 2015
Topic: Enhancing Western's Graduate Programs Through International Collaboration


Vida Lam attends Colgate Dental Students' Conference on Research

The American Dental Association (ADA) Foundation (ADAF) held their 51st Annual Colgate Dental Students’ Conference in Maryland as a way to invest in the future of oral health care by introducing outstanding dental students across North America to scientists from the ADAF Dr. Anthony Volpe Research Center, the ADA, Oral Health industry leaders, and the National Institute of Dental and Craniofacial Research (NIDCR).  One of the goals of the conference was to raise the participants’s awareness of the wide-ranging careers available in oral health research.

Vida Lam (DDS 2017), was presented with this travel award for her poster “Role of bone sialoprotein in stabilizing tendon insertion into bone.”  Vida was supervised by Dr. Harvey Goldberg in Dentistry's Summer Research Program, and competed for this travel award at Schulich Dentistry's 2014 Annual Research Day. Lam disclosed, "Thanks to the Student Summer Research Program with Schulich Dentistry, I had the opportunity to become involved with scientific research for the first time. Not only was I able to present our lab's findings to colleagues and faculty members at Western University, I also had the honour of meeting and presenting to esteemed members of the dental research community in Bethesda, Maryland. The ADAF conference allowed me to connect with some of the most innovative and inquisitive minds in the field of dental research from across North America.

Lam further remarked, "Touring the National Institute of Standards and Technology, as well as the National Institutes of Health campus, gave the student attendees a first-hand glimpse of cutting edge dental research projects. Leaders in the field of dental research spoke to us regarding their personal experiences in balancing their research interests and their clinical work, and how one does not preclude the other. I left with a deeper appreciation of the impact that dental research has on day-to-day clinical practice, and the importance of keeping a spirit of curiosity alive throughout my dental career."

The ADAF strongly supports today’s dental students as they pursue tomorrow’s scientific explorations in oral health research for the benefit of the general public and future generations.
 Vida Lam

Dentistry Seminar Series - Matthias Hannig, DDS, PhD

dr hOct 27 - Schulich Dentistry Research Seminar Series presents a lecture on October 27th by Matthias Hannig, DDS, PhD, Professor & Director, Clinic of Operative Dentistry, Periodontology & Preventive Dentistry, Former Vice-President, Research and Technology Transfer Vice-Dean, Medical Faculty, Saarland University, Homburg.
Title: Function and Modification of the Salivary Pellicle.  12:30pm | MSB 193AB | All Welcome

Schulich Dentistry Annual Research Day

The Schulich School of Medicine & Dentistry celebrated the research, innovation and collaboration of faculty and students at Schulich Dentistry Annual Research Day on October 14.

 Drs. Goldberg, Giannobile, Strong, Bohay, HamiltonThe day featured student poster presentations and the 14th John T. Hamilton Lecture, delivered by Dr. William V. Giannobile, DDS, DMSc. 

Over 300 faculty, staff and students attended the presentations and the Hamilton Lecture entitled 'Future Prospects for Oral and Periodontal Regenerative Medicine'. Dr. Giannobile is the Najjar Endowed Professor of Dentistry & Biomedical Engineering, Chair of the Department of Periodontics and Oral Medicine at the University of Michigan School of Dentistry, and also a Professor of Biomedical Engineering at the College of Engineering. Dr. Giannobile is also the Editor-in-Chief of the Journal of Dental Research.

Dentistry's Research Day Poster Presentations

CongratulaM Gebril, J Hutchenreuther, M Na, Dr JT Hamilton, K Beaucage, D Feere, M Tiedemanntions to the following students who received awards for their Poster Presentations at Dentistry's Research Day on Oct 14, 2015: 

Junior Category - Travel Awards 
- CDA/Dentsply Travel Award - Michael Tiedemann, DDS 2017, Supervised by Dr. Douglas Hamilton
“Modulation of myofibroblast differentiation on nanometric topographies”. To represent Schulich Dentistry in the Student Clinician competition at the 2016 CDA National Oral Health Conference.
- Hinman Student Research Travel Award - David Feere, DDS 2018,  Supervised by Dr. Andrew Leask
“The effect of NADPH oxidase 4 inhibition on the expression of fibrotic genes in human gingival fibroblast". To represent Schulich Dentistry at the 2016 Hinman Student Research Symposium in Memphis, Tennessee.
- ADA Foundation Travel Award -  Kim Beaucage, DDS 2018, Supervised by Dr. Jeff Dixon.
“Role of equilibrative nucleoside transporter 1 in the mineralization of orofacial tissues”. To represent Schulich Dentistry at the 2016 ADA Dental Student Research Conference in Maryland.

Senior Category - Merit Awards
- James Hutchenreuther - Dr. Andrew Leask Lab. "CCN2 Expression by Tumor Stroma Is Required for Melanoma Metastasis"
- Mohamed Gebril - Dr. Amin Rizkalla Lab. "Sol gel hydrothermal bioactive glass-ceramic coating on titanium substrate"
- Meena Na, Grad Ortho 2016 - Dr. Jeff Dixon Lab. "Dexamethasone regulates gene expression induced by the mechanosensitive P2X7 receptor in osteoblasts"

Kimberly Williams toured Memphis while attending the Hinman Student Research Symposium

wKimberly Williams, DDS 2017 attended the Hinman Student Research Symposium in Memphis in October to present her poster entitled: “Diphenyleneiodonium inhibits TGFß-induced expression in gingival fibroblasts.”  Kimberley (supervised by Dr. Andrew Leask in Dentistry's Summer Research Program), competed for this travel award at Schulich Dentistry's 2014 Annual Research Day.
Williams remarks, "I had a fantastic time at the Hinman Student Dental Research Symposium! Memphis was full of history, Elvis souvenirs, blues music, and the most delicious BBQ ribs. I heard many interesting presentations, promoted my own research (and dental school), and further confirmed that research is an aspect of dentistry I would like to be involved with in the future, both as a student and dentist."  HinmanGroup

The Hinman Student Research Symposium is a national meeting featuring presentations of research studies undertaken by dental students and graduate trainees from dental schools across North America. The goal of this symposium is to help raise and maintain the quality of dental research and education by encouraging participation of dental students, graduate trainees and dental school faculty in research to improve oral health care.

Dentistry Seminar Series - Zeeshan Sheikh, BDS, MSc, PhD

Dr. SheikhOct 1 - Schulich Dentistry Research Seminar Series presents a lecture on October 1st by Zeeshan Sheikh, BDS, MSc, PhD. Dr. Sheikh is a Post-Doctoral Fellow at the Faculty of Dentistry, University of Toronto. Title (1): Overcoming the challenge of periodontal regeneration: Monetite cement grafts for achieving more predictable alveolar ridge augmentation prior to dental implant placement. Title (2): Is a generation of spoon-fed and coddled researchers being prepared? Why it is important to be more pro-active with regards to acquiring funding and scholarships as graduate students and post-doctoral trainees.

Dental Academic Research Trainee (DART) Group presents:

Oct 20 12:30-1:30 pm | Room HSA 101
Dr. Jake Bartlett - McGill Dentistry
Translational research/innovation and industry

Dental Academic Research Trainee (DART) Group presents:

Oct 13 10:30-12pm, UH Aud B
Dental Students are invited to the inaugural event led by the Dental Academic Research Trainee (DART) group. This event will focus on developing your leadership character. Learn how to hone your skills and apply them towards being the best leader in your future dental practice, research and/or teaching.

This unique seminar and workshop will be run by a Distinguished University Professor from the Ivey Business School, Dr. Mary Crossan. As there are no classes in the morning, all dentistry trainees including students, post-grad, graduate, and ITD are welcome to attend.


2015 CMHR Training Award

Congratulations to Karrington McLeod on achieving a Western Bone & Joint CMHR Training Award of $13,000. McLeod is supervised by Dr. Douglas Hamilton, Chair and Associate Professor of Oral Biology, Dentistry.


G LuvisonGreg Luvison, DDS 2017 attends CDA Conference

Greg Luvison attended the Canadian Dental Association’s National Conference in St. John’s, Newfoundland in August 2015. This trip was made possible through the CDA/DENTSPLY Student Clinician Research Program Travel Award which was presented to Greg for his Summer Research poster presented at Schulich Dentistry's 2014 Annual Research Day, entitled "Bioactive, fast-setting and injectable bone cements for craniofacial reconstruction". Greg's work was supervised by Drs. Amin Rizkalla and Jeff Dixon.

Since the conference was held in Newfoundland this year, organizers provided a Newfoundland Screech-In ceremony where willing participants were 'screeched in" as "Honourary Newfies". Luvison remarks, "The trip was an opportunity to meet fellow student clinicians from across Canada and see their respective research. The conference also allowed me to interact with clinicians at a variety of stages in their careers and has given me more exposure to professional life after school".  Luvison further commented, "Both taking part in the summer research program and attending the Canadian Dental Association’s conference are two experiences I will always remember from my time here at the Schulich School of Medicine and Dentistry".  

2015 Students

Dentistry Summer Research Presentations

Our Summer Research Program students presented their accomplishments/conclusions of their projects on August 14th.  In addition, other dental students currently involved in research projects in our School presented their work.  Attending Dental faculty, staff and lab members were impressed with the various research topics and the amount of research completed in the 12-week program.

2015 JULY

NCOHR Workshop

The Network for Canadian Oral Health and Research (NCOHR) recently sponsored a Summer Workshop on Technology Transfer and Commercialization (TTC) hosted by the University of Toronto, July 30-31, 2015. Two Schulich Dentistry research trainees (Rajesh Gupta and Yara Hosein) and two faculty members (Drs. Les Kalman and Ali Tassi) attended the workshop, all with an interest in translational impact and technology transfer. The workshop focused on opportunities for introducing research commercialization to dental training programs, thereby providing opportunities for real world applications of academic research, and growth in research careers.

Dr. Hosein, a Schulich Dentistry postdoctoral fellow commented, “Programs that support research commercialization can be beneficial to the future of academic research, equipping trainees with tools for advancing and translating their research into real-world applications. This workshop was quite helpful in presenting the programs and resources available to academic researchers for the appropriate training, funding, and infrastructure to support research innovation.” Similarly, Rajesh Gupta, a PhD candidate who is already involved in research commercialization, having recently filed a US patent based on his graduate research with Dr. Walter Siquiera, said, “It was truly an eye opener to see firsthand, how the fundamental and applied research in dentistry and medicine provided solutions to the real life challenges, thus paving the way to translate and commercialize novel technologies with endless opportunities for the youngsters like me. Additionally this workshop was a very good platform to learn about the dissemination of our research to wider audiences, in addition to various funding opportunities available in Ontario for the young entrepreneurs”. Dr. Kalman commented, "The workshop brought awareness to funding sources, agencies and collaborators. While it is always interesting to connect with old colleagues, it's very beneficial to make newer connections with new investigators. Research is definitely heading toward industry translation and these workshops will help with the transition".

Invited speakers for the TTC workshop included government funding agencies that support research commercialization, such as Mitacs, Natural Sciences and Engineering Research Council and Ontario Centres of Excellence, as well as representatives from start–up companies founded from academic dental research. One such representative was Schulich Dentistry’s Associate Professor Dr. Walter Siqueira, founder of start-up company SalivaMatters, who gave a keynote presentation on his experience translating academic research into a commercial setting. In addition, speakers from MaRS Innovation and University of Toronto, Ontario Campus Linked Accelerator Program highlighted university-based entrepreneurship, where case studies were presented on student entrepreneurs and companies.

CIHR Funding Success for Oral Biology

Congratulations to Dr. Walter Siqueira  (Oral Biology) for obtaining major operating research funding from the Canadian Institutes of Health Research (CIHR).  Dr. Siqueira was awarded a 5 year grant totaling $614,880 for his project titled 'Novel Salivary Peptides and Their Functions on Dental Caries’.

‘Something Weird’ may Lead to Melanoma Breakthrough

LeaskWestern researchers look to take metastatic melanoma survival rates from a gloomy 5 per cent five years after diagnosis to almost 100 per cent, by simply looking where others haven’t. “We decided to do something weird. We focused on the things nobody knew anything about, looked at things in a slightly different fashion,” said Schulich School of Medicine & Dentistry professor Andrew Leask. Melanoma, the second most common invasive cancer in young adults, is the most dangerous form of skin cancer. Mole-like growths develop when unrepaired DNA damage to skin cells (most often caused by ultraviolet radiation from sunshine or tanning beds) triggers mutations, or genetic defects, that lead the skin cells to multiply rapidly and form malignant tumours.  It is estimated 6,800 Canadians will be diagnosed with melanoma in 2015, with 1,150 dying from the disease. One in 57 men and 1 in 74 women are expected to develop melanoma during their lifetime.

While not the most common skin cancer, it is the deadliest, Leask said. However, if melanoma is recognized and treated early, it is almost always curable. If allowed to grow unchecked, however, the cancer can spread to other parts of the body, such as the lungs and bones, where it becomes hard to treat and is often fatal.

Most researchers are focused on BRAF, a human gene that makes a protein called B-Raf, which is involved in sending signals and directing cell growth in the body. A class of drugs that targets BRAF are used to block tumour proliferation, but patients eventually acquire resistance to these drugs and metastasis occurs anyway. However, when Leask and his fellow researchers looked at “things in a slightly different fashion,” they made an interesting discovery: It was the surrounding tissue (formally called cancer-activated fibroblasts) instructing cells to metastasize and invade surrounding tissues. “It’s not just the melanoma cells that are the problem, but the surrounding tissues,” said Leask, a professor in Physiology and Pharmacology and Dentistry. “People have known there is surrounding tissue. No one actually looked at why it was important. This is the first proof it is important and the first proof these proteins are triggering cancer cells to behave badly.”

If you consider the melanoma as some weird stem cell, he said, what they are doing is secreting stuff into the environment that’s activating the cells, called fibroblast, or cancer-activated fibroblasts. “These guys are now producing signals instructing the melanoma cells how to behave,” he continued. “The kicker is we found the mechanism of how this does that.” That mechanism is due to the expression of two proteins – CCN2 and periostin. Therefore, drugs blocking CCN2 or periostin would represent a new drug treatment targeting melanomas. “The tissues are cross-talking. It’s more the surrounding tissue that is instructing the how the stem cells should behave,” he said. “If you blocked this communication, you will be able to block this whole process. It’s actual proof that it’s more the surrounding tissue instructing the bad stem cells to behave.” By not allowing the melanoma to metastasize, it can be removed far easier through surgery. “Survival rate should be awful close to 100 per cent,” Leask said.

Leask published the findings in the Journal of Investigative Dermatology, along with co-investigators James Hutchenreuther, PhD candidate; Krista Vincent, Anatomy and Cell Biology MD/PhD candidate; David Carter, Robarts Research Institute scientist and London Regional Genomics Centre; and Lynne-Marie Postovit, formerly of Western’s Department of Anatomy and Cell Biology, currently of the Department of Oncology at the University of Alberta. The team will continue their work, through clinical samples and animal models, to specifically prove the fibrotic tissue is causing or instructing the melanoma. Through a strong collaborative effort he expects clinical data could be completed within three years.

2015 JUNE

Dentistry Summer Research Presentations

Jun 17 - The first of the two summer research presentations will be held on June 17th.  It is mandatory for Dentistry Summer Research Program Students to present an introduction of their project, and supervisors are also expected to attend. In addition, other dental students currently involved in research projects in our School, are invited to present their work. Please mark your calendars for our final presentations on August 14th.  First Presentation - MSB 148 | 12-2PM / Final Presentation Aug 14 | MSB 148 | 12-2PM 

Dentistry 2015 Quintessence Research Award

K MartinThe Quintessence Research Award was presented to Kathleen Martin - DDS 2015, on the recommendation of the Research Committee, following nomination by the faculty supervisors.  This is an annual award to a graduating dental student who has been exemplary in research in the undergraduate dental program.

2015 MAY

8th Annual Suzanne M. Bernier Memorial Lecture in Skeletal Biology

We are pleased to announce that Nancy E. Lane, MD, will be the guest speaker for the 8th Annual Suzanne M. Bernier Memorial Lecture in Skeletal Biology.Dr. Lane is an Endowed Professor of Medicine and Rheumatology and Director of the Center for Musculoskeletal Health, Academic Geriatric Resource Program and the Building Interdisciplinary Research Careers in Women's Health (BIRCWH) at UC Davis. Dr. Lane is an internationally recognized scientist in the fields of both osteoporosis and osteoarthritis.

Her translational research team has been instrumental in defining the role of glucocorticoids in bone fragility including their effects on cell stress and vulnerable cell populations including osteocytes. Dr Lane developed a novel compound to direct stem cells to the bone to grow new bone and treat osteoporosis. In addition she has uncovered novel genetic variations that predispose individuals to osteoarthritis and has studied novel treatments for osteoarthritis. Her research accomplishments have been recognized by the American College of Rheumatology for the Oscar Gluck Memorial Lecture for outstanding work in Osteoporosis (2011), the Remodeling in Bone “RIB Award” by the International Society of Bone and Mineral Research (2012), her election as a Master of the American College of Physicians (2012) and David Trentham Lectureship and Women in Medicine Lectureship at Harvard Medical School (2013). She was elected to the Association of American Physicians (2006), has been named Best Doctors in America annually since 2004, and continues to have an active rheumatology practice.  The lecture series and graduate student award was established to highlight outstanding contributions to the field of musculoskeletal research in honour of Dr. Suzanne Bernier, a wonderful colleague, collaborator and mentor, who passed away in 2007.

2015 NSERC Award - Dr. D. Hamilton

Congratulations to Dr. Douglas Hamilton (Dentistry Oral Biology) on achieving a 2015 NSERC Award ($30,000) for his project entitled, 'Investigating adhesion-based regulation of cell phenotype with nano- and micro-metric topography' 

2015 APRIL

Dentistry Seminar Series - Faleh Tamimi, BDS, MSc, MClinDent, PhD

Apr 21- Schulich Dentistry Research Seminar Series presents a lecture by Faleh Tamimi, BDS, MSc, MClinDent, PhD. Assistant Professor, Faculty of Dentistry, Division of Restorative Dentistry, McGill University.  Title: Neuroregulation of Bone: Dental Implications.  12:15pm | H101 | All Welcome

Renishaw - 3D Printing Technologies for Dental & Medical Devices

Apr 15 - A presentation will be made by Renishaw entitled 3D Printing Technologies for Dental & Medical Devices. MSB 148 | 10am-12pm. Time is also available Wed afternoon, or Thurs morning to meet with representatives of Renishaw to discuss research and educational opportunities.

Topics to be discussed include: overview of metal additive manufacturing (AM) | optimisation for dental applications | AM production routes for medical devices | dental AM devices – tooth & implant supported | clinical evidence for the safety and efficacy of these devices | novel AM device developments, e.g. cranioplasties.  For Renishaw information, please see: www.renishaw.com/en/dental-products--24217

2015 MARCH 

K Creber2014-2015 CADR-NCOHR Student Research Award

Kendal Creber was presented with the 2014-2015 CADR-NCOHR Student Research Award at the CADR Annual General Meeting in Boston, MA. Congratulations to Kendal, who had placed second in the Senior (Basic Science) Category for her work “Design of an Electrospun Collagen/Periostin Scaffold for Periodontal Regeneration”, supervised by Dr. Douglas Hamilton, Oral Biology, Schulich Dentistry. 


Schulich Dentistry Recognized by the International Association for Dental Research

The Salivary Research Group/International Association for Dental Research (IADR) offers three annual research awards for the most innovative abstracts submitted to the IADR 2015 conference. This year, representatives of Schulich Dentistry were awarded three prestigious international awards.  Dr. Walter Siqueira gave the keynote address from the cariology research group at the IADR conference: ‘Salivary Proteomics for Diagnostic and Therapeutic in Cariology’.  

Yuliya  Mulyar - Wrigley Basic Salivary Research Award for a Dental or Non-Dental Student ($2,000)
Anti-cariogenic Effect of a Novel Encapsulation System for Salivary Proteins   
Eduardo Moffa - Wrigley Clinical Salivary Research Award for Dental Scientists ($1,500)
Identification of Histatin 5 Complexes using Mass Spectrometry 
Yuliya  Mulyar - 2015 IADR Colgate Research in Prevention Travel (based on research abstract)


Dentistry Seminar Series - Henry P. Schwarcz, FRSC, DSc

Jan 28 - Schulich Dentistry Research Seminar Series presents a lecture by Henry P. Schwarcz, FRSC, DSc, University Professor Emeritus, School of Geography and Earth Sciences, McMaster University.  Title: The ultrastructure of bone and dentin revisited.  All Welcome

2015 Summer Student Research Program

Dentistry’s Summer Student Research Program provides an opportunity for students enrolled in the DDS program to contribute to clinical and basic science research being performed in Schulich Dentistry.  Each year, there are a limited number of Studentships awarded by competition. Summer Research Program