Luciano Sposato, MD, MBA, FRCPC


Associate Professor of Neurology, Western University
Office: University Hospital A10-322
Phone: 519-663-3110
Secretary: Jennifer Moussa




Bio Sketch

Dr. Luciano Sposato is a stroke neurologist and clinician-researcher in the Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON, Canada. He holds the Kathleen and Henry Barnett Chair in Stroke Research, Western University, London, Ontario, Canada.

Dr. Sposato earned a medical degree from the University of Buenos Aires in Argentina in 1993. Subsequently, he served as Chief Resident in Internal Medicine (1997) and Neurology (2003) at the Hospital de Clínicas, University of Buenos Aires.

In 2007, he earned a Master’s in Business Administration from the IAE Business School (Ranked 26th in the overall listing and number one in the International Clients category of Financial Times’ Executive Education Ranking).

Dr Sposato was the Head of the Stroke Center at the Institute of Neurosciences, Favaloro Foundation University Hospital, and Chair of the Department of Neurology at the Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina. He joined the Department in 2015.



Dr. Sposato’s research focuses on the heart and brain connection, including, stroke, atrial fibrillation, dementia, heart failure, and on stroke epidemiology. Dr. Sposato founded the Stroke, Dementia & Heart Disease Lab at Western University and leads PARADISE (Pathophysiology and Risk of Atrial Fibrillation Detected after Ischemic Stroke), a multidisciplinary and translational research initiative which involves epidemiological, clinical, and experimental studies investigating atrial fibrillation diagnosed after stroke.

Dr. Sposato’s research profile has been highlighted by the Lancet Neurology (Lifeline, 2015) and International Journal of Stroke / World Stroke Organization (Seven minutes in stroke, 2016). He has presented over 200 scientific papers in international conferences and lectured in more than 180 conferences.  He has authored over 75 scientific papers in first-line journals (i.e. The Lancet, The Lancet Neurology, Annals of Neurology, Brain, JAMA Neurology, Neurology, Stroke, Alzheimer’s & Dementia) and chapters in several books of neurology.

Dr. Sposato led two major projects in Argentina: (1) the Argentinean National Stroke Registry, ReNACer and (2) the Program for the Evaluation of Stroke in Tandil, Argentina, PrEViSTA, which resulted in multiple peer-reviewed international publications.

Medical Interests

Stroke, Atrial fibrillation, Cerebral amyloid angiopathy, and Stroke and atrial fibrillation related dementia.

 Honours and Awards

  • 2017, Co-Chair's Award for Impact, Canadian Stroke Congress
  • 2016, Researcher Profile Highlight, International Journal of Stroke
  • 2015, Researcher Profile Highlight, Lancet Neurology
  • 2008, Mentoring Program Research Award, American Heart Association
  • 2001, Casasco Award, Hospital de Clinicas Medical Association
  • 2001, CEO's Annual Award, Hospital de Clinicas Medical Association
  • 1997, Best Scientific Study in Oncology, National Congress of Internal Medicine
  • 1997, Best Scientific Study in Dermatology, National Congress of Internal Medicine


PubMed Publications Listing


Budhram A, Climans SA, Le C, Casserly CS , Mayich M, Lownie SP , Sposato LA . Aseptic meningitis due to reperfusion injury after carotid artery stenting. J Neurol Sci. 2017 Oct 15;381:269-271. doi: 10.1016/j.jns.2017.08.3255. Epub 2017 Aug 31. PubMed PMID: 28991696.

Azarpazhooh MR, Avan A, Cipriano LE, Munoz DG, Sposato LA , Hachinski V . Concomitant vascular and neurodegenerative pathologies double the risk of dementia. Alzheimers Dement. 2017 Sep 30. pii: S1552-5260(17)33686-5. doi: 10.1016/j.jalz.2017.07.755. [Epub ahead of print] PubMed PMID: 28974416.

Fridman S, Saposnik G, Sposato LA. Visual Aids for Improving Patient Decision Making in Severe Symptomatic Carotid Stenosis. J Stroke Cerebrovasc Dis. 2017 Aug 7. pii: S1052-3057(17)30368-3. doi: 10.1016/j.jstrokecerebrovasdis.2017.07.011. [Epub ahead of print] PubMed PMID: 28797613.

Sposato LA , Ruíz Vargas E, Riccio PM, Toledo JB, Trojanowski JQ, Kukull WA, Cipriano LE, Nucera A, Whitehead SN, Hachinski V . Milder Alzheimer's disease pathology in heart failure and atrial fibrillation. Alzheimers Dement. 2017 Jul;13(7):770-777. doi: 10.1016/j.jalz.2016.12.002. Epub 2017 Feb 5. PMID: 28174071

Racosta JM, Sposato LA, Kimpinski K. Subcutaneous versus intravenous immunoglobulin for chronic autoimmune neuropathies: A meta-analysis. Muscle Nerve. 2017 Jun;55(6):802-809. doi: 10.1002/mus.25409. Epub 2017 Feb 9. Review. PMID: 27649063

Sposato LA , Saposnik G. Stroke rates vary substantially across cohorts of patients with atrial fibrillation. Evid Based Med. 2017 Jun;22(3):110. doi: 10.1136/ebmed-2017-110711. Epub 2017 Apr 12. No abstract available. PMID: 28404602

Sposato LA , Fridman S, Saposnik G. Letter by Sposato et al Regarding Article, "Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study". Stroke. 2017 Jun;48(6):e142. doi: 10.1161/STROKEAHA.117.017066. Epub 2017 Apr 17. No abstract available. PMID: 28416625

Birbeck GL, Sposato LA . Hypertension prevention: In need of a grain of salt knowledge. Neurology. 2016 Sep 20;87(12):1192-3. doi: 10.1212/WNL.0000000000003136. Epub 2016 Aug 24. No abstract available. PMID: 27558373

Cerasuolo JO, Montero-Odasso M, Ibañez A, Doocy S, Lip GY, Sposato LA . Decision-making interventions to stop the global atrial fibrillation-related stroke tsunami. Int J Stroke. 2017 Apr;12(3):222-228. doi: 10.1177/1747493016687579. Epub 2017 Jan 1. PMID: 28381196

Cerasuolo JO, Cipriano LE, Sposato LA , Kapral MK, Fang J, Gill SS, Hackam DG, Hachinski V. Population-based stroke and dementia incidence trends: Age and sex variations. Alzheimers Dement. 2017 Mar 28. pii: S1552-5260(17)30095-X. doi: 10.1016/j.jalz.2017.02.010. [Epub ahead of print] PMID: 28363085

Lee SA, Sposato LA , Hachinski V , Cipriano LE. Cost-effectiveness of cerebrospinal biomarkers for the diagnosis of Alzheimer's disease.  Alzheimers Res Ther. 2017 Mar 16;9(1):18. doi: 10.1186/s13195-017-0243-0. PMID: 28302164

Sposato LA , Wardlaw JM, Hachinski V . Response by Sposato et al to Letter Regarding Article, "Effect of Right Insular Involvement on Death and Functional Outcome After Acute Ischemic Stroke in the IST-3 Trial (Third International Stroke Trial)". Stroke. 2017 Mar;48(3):e92. doi: 10.1161/STROKEAHA.116.016387. Epub 2017 Feb 7. No abstract available. PMID: 28174325

Cerasuolo JO, Cipriano LE, Sposato LA. The complexity of atrial fibrillation newly diagnosed after ischemic stroke and transient ischemic attack: advances and uncertainties. Curr Opin Neurol. 2017 Feb;30(1):28-37. doi: 10.1097/WCO.0000000000000410. PMID: 27984303

Sposato LA, Hachinski V. Right insular cortex involvement is consistently associated with death after ischaemic stroke. Eur J Neurol. 2017 Jan;24(1):1-2. doi: 10.1111/ene.13174. Epub 2016 Oct 31. No abstract available. PMID: 27797138